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Volumn 12, Issue 3, 2003, Pages 711-721

Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MESSENGER RNA; RIBONUCLEASE H; RIBOZYME;

EID: 0141819093     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2003.08.010     Document Type: Article
Times cited : (586)

References (50)
  • 1
    • 0036469913 scopus 로고    scopus 로고
    • The connection between transcription and genomic instability
    • Aguilera A. The connection between transcription and genomic instability. EMBO J. 21:2002;195-201.
    • (2002) EMBO J. , vol.21 , pp. 195-201
    • Aguilera, A.1
  • 2
    • 0025212715 scopus 로고
    • HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene
    • Aguilera A., Klein H.L. HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene. Mol. Cell. Biol. 10:1990;1439-1451.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 1439-1451
    • Aguilera, A.1    Klein, H.L.2
  • 3
    • 0033756041 scopus 로고    scopus 로고
    • The absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate: Implications for roles of RNases H in DNA replication and repair
    • Arudchandran A., Cerritelli S., Narimatsu S., Itaya M., Shin D.Y., Shimada Y., Crouch R.J. The absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate. implications for roles of RNases H in DNA replication and repair Genes Cells. 5:2000;789-802.
    • (2000) Genes Cells , vol.5 , pp. 789-802
    • Arudchandran, A.1    Cerritelli, S.2    Narimatsu, S.3    Itaya, M.4    Shin, D.Y.5    Shimada, Y.6    Crouch, R.J.7
  • 4
    • 0031439267 scopus 로고    scopus 로고
    • The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability
    • Chávez S., Aguilera A. The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability. Genes Dev. 11:1997;3459-3470.
    • (1997) Genes Dev. , vol.11 , pp. 3459-3470
    • Chávez, S.1    Aguilera, A.2
  • 5
    • 0034329461 scopus 로고    scopus 로고
    • A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae
    • Chávez S., Beilharz T., Rondon A.G., Erdjument-Bromage H., Tempst P., Svejstrup J.Q., Lithgow T., Aguilera A. A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J. 19:2000;5824-5834.
    • (2000) EMBO J. , vol.19 , pp. 5824-5834
    • Chávez, S.1    Beilharz, T.2    Rondon, A.G.3    Erdjument-Bromage, H.4    Tempst, P.5    Svejstrup, J.Q.6    Lithgow, T.7    Aguilera, A.8
  • 6
    • 0034808138 scopus 로고    scopus 로고
    • Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae
    • Chávez S., Garcia-Rubio M., Prado F., Aguilera A. Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae. Mol. Cell. Biol. 21:2001;7054-7064.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 7054-7064
    • Chávez, S.1    Garcia-Rubio, M.2    Prado, F.3    Aguilera, A.4
  • 7
    • 0024277974 scopus 로고
    • Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II
    • Christman M.F., Dietrich F.S., Fink G.R. Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II. Cell. 55:1988;413-425.
    • (1988) Cell , vol.55 , pp. 413-425
    • Christman, M.F.1    Dietrich, F.S.2    Fink, G.R.3
  • 8
    • 0034803110 scopus 로고    scopus 로고
    • RNase H1 of Saccharomyces cerevisiae: Methods and nomenclature
    • Crouch R.J., Arudchandran A., Cerritelli S.M. RNase H1 of Saccharomyces cerevisiae. methods and nomenclature Methods Enzymol. 341:2001;395-413.
    • (2001) Methods Enzymol. , vol.341 , pp. 395-413
    • Crouch, R.J.1    Arudchandran, A.2    Cerritelli, S.M.3
  • 10
    • 0027965531 scopus 로고
    • Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae
    • Fan H.Y., Klein H.L. Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae. Genetics. 137:1994;945-956.
    • (1994) Genetics , vol.137 , pp. 945-956
    • Fan, H.Y.1    Klein, H.L.2
  • 11
    • 0034932941 scopus 로고    scopus 로고
    • High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability
    • Fan H.Y., Merker R.J., Klein H.L. High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability. Mol. Cell. Biol. 21:2001;5459-5470.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 5459-5470
    • Fan, H.Y.1    Merker, R.J.2    Klein, H.L.3
  • 12
    • 0035156427 scopus 로고    scopus 로고
    • A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombination
    • Gallardo M., Aguilera A. A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombination. Genetics. 157:2001;79-89.
    • (2001) Genetics , vol.157 , pp. 79-89
    • Gallardo, M.1    Aguilera, A.2
  • 13
    • 0038605527 scopus 로고    scopus 로고
    • Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism
    • Gallardo M., Luna R., Erdjument-Bromage H., Tempst P., Aguilera A. Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J. Biol. Chem. 27:2003;24225-24232.
    • (2003) J. Biol. Chem. , vol.27 , pp. 24225-24232
    • Gallardo, M.1    Luna, R.2    Erdjument-Bromage, H.3    Tempst, P.4    Aguilera, A.5
  • 14
    • 0141467384 scopus 로고    scopus 로고
    • Recombinogenic effects of DNA damaging agents are synergistically increased by transcription. S. cerevisisae: new insights into transcription-associated recombination
    • in press.
    • García-Rubio, M., Huertas, P., González-Barrera, S., and Aguilera, A. (2003). Recombinogenic effects of DNA damaging agents are synergistically increased by transcription in S. cerevisisae: new insights into transcription-associated recombination. Genetics, in press.
    • (2003) Genetics
    • García-Rubio, M.1    Huertas, P.2    González-Barrera, S.3    Aguilera, A.4
  • 15
    • 0015057861 scopus 로고
    • Effect of gene induction on the rate of mutagenesis by ICR-191 in Escherichia coli
    • Herman R.K., Dworkin N.B. Effect of gene induction on the rate of mutagenesis by ICR-191 in Escherichia coli. J. Bacteriol. 106:1971;543-550.
    • (1971) J. Bacteriol. , vol.106 , pp. 543-550
    • Herman, R.K.1    Dworkin, N.B.2
  • 16
    • 0034659241 scopus 로고    scopus 로고
    • RNA polymerase II and the integration of nuclear events
    • Hirose Y., Manley J.L. RNA polymerase II and the integration of nuclear events. Genes Dev. 14:2000;1415-1429.
    • (2000) Genes Dev. , vol.14 , pp. 1415-1429
    • Hirose, Y.1    Manley, J.L.2
  • 17
    • 0034646628 scopus 로고    scopus 로고
    • RNase H overproduction corrects a defect at the level of transcription elongation during rRNA synthesis in the absence of DNA topoisomerase I in Escherichia coli
    • Hraiky C., Raymond M.A., Drolet M. RNase H overproduction corrects a defect at the level of transcription elongation during rRNA synthesis in the absence of DNA topoisomerase I in Escherichia coli. J. Biol. Chem. 275:2000;11257-11263.
    • (2000) J. Biol. Chem. , vol.275 , pp. 11257-11263
    • Hraiky, C.1    Raymond, M.A.2    Drolet, M.3
  • 18
    • 0018292191 scopus 로고
    • Transcription promotes recA-independent recombination mediated by DNA- dependent RNA polymerase in Escherichia coli
    • Ikeda H., Matsumoto T. Transcription promotes recA-independent recombination mediated by DNA- dependent RNA polymerase in Escherichia coli. Proc. Natl. Acad. Sci. USA. 76:1979;4571-4575.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 4571-4575
    • Ikeda, H.1    Matsumoto, T.2
  • 19
    • 0036645687 scopus 로고    scopus 로고
    • The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability
    • Jimeno S., Rondon A.G., Luna R., Aguilera A. The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. EMBO J. 21:2002;3526-3535.
    • (2002) EMBO J. , vol.21 , pp. 3526-3535
    • Jimeno, S.1    Rondon, A.G.2    Luna, R.3    Aguilera, A.4
  • 20
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna K.K., Jackson S.P. DNA double-strand breaks. signaling, repair and the cancer connection Nat. Genet. 27:2001;247-254.
    • (2001) Nat. Genet. , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 22
    • 0036889142 scopus 로고    scopus 로고
    • Interactions between mRNA export commitment, 3′-end quality control, and nuclear degradation
    • Libri D., Dower K., Boulay J., Thomsen R., Rosbash M., Jensen T.H. Interactions between mRNA export commitment, 3′-end quality control, and nuclear degradation. Mol. Cell. Biol. 22:2002;8254-8266.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 8254-8266
    • Libri, D.1    Dower, K.2    Boulay, J.3    Thomsen, R.4    Rosbash, M.5    Jensen, T.H.6
  • 23
    • 0029770436 scopus 로고    scopus 로고
    • Differential intrachromosomal hyper-recombination phenotype of spt4 and spt6 mutants of S. cerevisiae
    • Malagón F., Aguilera A. Differential intrachromosomal hyper-recombination phenotype of spt4 and spt6 mutants of S. cerevisiae. Curr. Genet. 30:1996;101-106.
    • (1996) Curr. Genet. , vol.30 , pp. 101-106
    • Malagón, F.1    Aguilera, A.2
  • 24
    • 0033522905 scopus 로고    scopus 로고
    • Escherichia coli DNA topoisomerase I inhibits R-loop formation by relaxing transcription-induced negative supercoiling
    • Masse E., Drolet M. Escherichia coli DNA topoisomerase I inhibits R-loop formation by relaxing transcription-induced negative supercoiling. J. Biol. Chem. 274:1999;16659-16664.
    • (1999) J. Biol. Chem. , vol.274 , pp. 16659-16664
    • Masse, E.1    Drolet, M.2
  • 25
    • 0034737294 scopus 로고    scopus 로고
    • Modulation of RNA polymerase by (p)ppGpp reveals a RecG-dependent mechanism for replication fork progression
    • McGlynn P., Lloyd R.G. Modulation of RNA polymerase by (p)ppGpp reveals a RecG-dependent mechanism for replication fork progression. Cell. 101:2000;35-45.
    • (2000) Cell , vol.101 , pp. 35-45
    • McGlynn, P.1    Lloyd, R.G.2
  • 26
    • 0013277286 scopus 로고    scopus 로고
    • Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope
    • Mizuta R., Iwai K., Shigeno M., Mizuta M., Uemura T., Ushiki T., Kitamura D. Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope. J. Biol. Chem. 278:2003;4431-4434.
    • (2003) J. Biol. Chem. , vol.278 , pp. 4431-4434
    • Mizuta, R.1    Iwai, K.2    Shigeno, M.3    Mizuta, M.4    Uemura, T.5    Ushiki, T.6    Kitamura, D.7
  • 27
    • 0035774922 scopus 로고    scopus 로고
    • DNA damage processing defects and disease
    • Moses R.E. DNA damage processing defects and disease. Annu. Rev. Genomics Hum. Genet. 2:2001;41-68.
    • (2001) Annu. Rev. Genomics Hum. Genet. , vol.2 , pp. 41-68
    • Moses, R.E.1
  • 28
    • 0028953840 scopus 로고
    • Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds
    • Mumberg D., Muller R., Funk M. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene. 156:1995;119-122.
    • (1995) Gene , vol.156 , pp. 119-122
    • Mumberg, D.1    Muller, R.2    Funk, M.3
  • 29
    • 0038312215 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability
    • Myung K., Pennaneach V., Kats E.S., Kolodner R.D. Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability. Proc. Natl. Acad. Sci. USA. 100:2003;6640-6645.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6640-6645
    • Myung, K.1    Pennaneach, V.2    Kats, E.S.3    Kolodner, R.D.4
  • 30
    • 0026446059 scopus 로고
    • Transcription enhances intrachromosomal homologous recombination in mammalian cells
    • Nickoloff J.A. Transcription enhances intrachromosomal homologous recombination in mammalian cells. Mol. Cell. Biol. 12:1992;5311-5318.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5311-5318
    • Nickoloff, J.A.1
  • 31
    • 0019889717 scopus 로고
    • Switch region of immunoglobulin Cmu gene is composed of simple tandem repetitive sequences
    • Nikaido T., Nakai S., Honjo T. Switch region of immunoglobulin Cmu gene is composed of simple tandem repetitive sequences. Nature. 292:1981;845-848.
    • (1981) Nature , vol.292 , pp. 845-848
    • Nikaido, T.1    Nakai, S.2    Honjo, T.3
  • 32
    • 0037154982 scopus 로고    scopus 로고
    • A unified theory of gene expression
    • Orphanides G., Reinberg D. A unified theory of gene expression. Cell. 108:2002;439-451.
    • (2002) Cell , vol.108 , pp. 439-451
    • Orphanides, G.1    Reinberg, D.2
  • 33
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • Peters A., Storb U. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity. 4:1996;57-65.
    • (1996) Immunity , vol.4 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 34
    • 0010173139 scopus 로고    scopus 로고
    • A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination
    • Piruat J.I., Aguilera A. A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination. EMBO J. 17:1998;4859-4872.
    • (1998) EMBO J. , vol.17 , pp. 4859-4872
    • Piruat, J.I.1    Aguilera, A.2
  • 35
    • 0030959070 scopus 로고    scopus 로고
    • Recombination between DNA repeats in yeast hpr1delta cells is linked to transcription elongation
    • Prado F., Piruat J.I., Aguilera A. Recombination between DNA repeats in yeast hpr1delta cells is linked to transcription elongation. EMBO J. 16:1997;2826-2835.
    • (1997) EMBO J. , vol.16 , pp. 2826-2835
    • Prado, F.1    Piruat, J.I.2    Aguilera, A.3
  • 36
    • 0037154967 scopus 로고    scopus 로고
    • Integrating mRNA processing with transcription
    • Proudfoot N.J., Furger A., Dye M.J. Integrating mRNA processing with transcription. Cell. 108:2002;501-512.
    • (2002) Cell , vol.108 , pp. 501-512
    • Proudfoot, N.J.1    Furger, A.2    Dye, M.J.3
  • 37
    • 0025225502 scopus 로고
    • Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region
    • Reaban M.E., Griffin J.A. Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region. Nature. 348:1990;342-344.
    • (1990) Nature , vol.348 , pp. 342-344
    • Reaban, M.E.1    Griffin, J.A.2
  • 42
    • 0038046165 scopus 로고    scopus 로고
    • Transcription-dependent recombination and the role of fork collision in yeast rDNA
    • Takeuchi Y., Horiuchi T., Kobayashi T. Transcription-dependent recombination and the role of fork collision in yeast rDNA. Genes Dev. 17:2003;1497-1506.
    • (2003) Genes Dev. , vol.17 , pp. 1497-1506
    • Takeuchi, Y.1    Horiuchi, T.2    Kobayashi, T.3
  • 43
    • 0024977417 scopus 로고
    • Elevated recombination rates in transcriptionally active DNA
    • Thomas B.J., Rothstein R. Elevated recombination rates in transcriptionally active DNA. Cell. 56:1989;619-630.
    • (1989) Cell , vol.56 , pp. 619-630
    • Thomas, B.J.1    Rothstein, R.2
  • 44
    • 0034604622 scopus 로고    scopus 로고
    • Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro
    • Tian M., Alt F.W. Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro. J. Biol. Chem. 275:2000;24163-24172.
    • (2000) J. Biol. Chem. , vol.275 , pp. 24163-24172
    • Tian, M.1    Alt, F.W.2
  • 45
    • 0029133544 scopus 로고
    • Transcription-induced deletions in Escherichia coli plasmids
    • Vilette D., Ehrlich S.D., Michel B. Transcription-induced deletions in Escherichia coli plasmids. Mol. Microbiol. 17:1995;493-504.
    • (1995) Mol. Microbiol. , vol.17 , pp. 493-504
    • Vilette, D.1    Ehrlich, S.D.2    Michel, B.3
  • 46
    • 0023666141 scopus 로고
    • Recombination-stimulating sequences in yeast ribosomal DNA correspond to sequences regulating transcription by RNA polymerase I
    • Voelkel-Meiman K., Keil R.L., Roeder G.S. Recombination-stimulating sequences in yeast ribosomal DNA correspond to sequences regulating transcription by RNA polymerase I. Cell. 48:1987;1071-1079.
    • (1987) Cell , vol.48 , pp. 1071-1079
    • Voelkel-Meiman, K.1    Keil, R.L.2    Roeder, G.S.3
  • 47
    • 0042692792 scopus 로고    scopus 로고
    • Rad52 independent accumulation of DNA joint circular minichromosomes during S-phase in Saccharomyces cerevisiae
    • in press.
    • Wellinger, R.E., Schär, P., and Sogo, J.M. (2003). Rad52 independent accumulation of DNA joint circular minichromosomes during S-phase in Saccharomyces cerevisiae. Mol. Cell. Biol., in press.
    • (2003) Mol. Cell. Biol.
    • Wellinger, R.E.1    Schär, P.2    Sogo, J.M.3
  • 48
    • 0037650190 scopus 로고    scopus 로고
    • R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
    • Yu K., Chedin F., Hsieh C.L., Wilson T.E., Lieber M.R. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat. Immunol. 4:2003;442-451.
    • (2003) Nat. Immunol. , vol.4 , pp. 442-451
    • Yu, K.1    Chedin, F.2    Hsieh, C.L.3    Wilson, T.E.4    Lieber, M.R.5
  • 49
    • 0036889334 scopus 로고    scopus 로고
    • Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p
    • Zenklusen D., Vinciguerra P., Wyss J.C., Stutz F. Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Mol. Cell. Biol. 22:2002;8241-8253.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 8241-8253
    • Zenklusen, D.1    Vinciguerra, P.2    Wyss, J.C.3    Stutz, F.4
  • 50
    • 0028804630 scopus 로고
    • HPR1 encodes a global positive regulator of transcription in Saccharomyces cerevisiae
    • Zhu Y., Peterson C.L., Christman M.F. HPR1 encodes a global positive regulator of transcription in Saccharomyces cerevisiae. Mol. Cell. Biol. 15:1995;1698-1708.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1698-1708
    • Zhu, Y.1    Peterson, C.L.2    Christman, M.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.