메뉴 건너뛰기




Volumn 46, Issue 2, 2012, Pages 115-124

R Loops: From Transcription Byproducts to Threats to Genome Stability

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; DNA; MITOCHONDRIAL DNA; MYC PROTEIN; RNA;

EID: 84860338675     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.04.009     Document Type: Review
Times cited : (761)

References (81)
  • 1
    • 0036469913 scopus 로고    scopus 로고
    • The connection between transcription and genomic instability
    • Aguilera A. The connection between transcription and genomic instability. EMBO J. 2002, 21:195-201.
    • (2002) EMBO J. , vol.21 , pp. 195-201
    • Aguilera, A.1
  • 2
    • 39449096135 scopus 로고    scopus 로고
    • Genome instability: a mechanistic view of its causes and consequences
    • Aguilera A., Gómez-González B. Genome instability: a mechanistic view of its causes and consequences. Nat. Rev. Genet. 2008, 9:204-217.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 204-217
    • Aguilera, A.1    Gómez-González, B.2
  • 3
    • 83355169557 scopus 로고    scopus 로고
    • Two pathways for RNase E action in Escherichia coli in vivo and bypass of its essentiality in mutants defective for Rho-dependent transcription termination
    • Anupama K., Leela J.K., Gowrishankar J. Two pathways for RNase E action in Escherichia coli in vivo and bypass of its essentiality in mutants defective for Rho-dependent transcription termination. Mol. Microbiol. 2011, 82:1330-1348.
    • (2011) Mol. Microbiol. , vol.82 , pp. 1330-1348
    • Anupama, K.1    Leela, J.K.2    Gowrishankar, J.3
  • 4
    • 67449113551 scopus 로고    scopus 로고
    • Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae
    • Azvolinsky A., Giresi P.G., Lieb J.D., Zakian V.A. Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae. Mol. Cell 2009, 34:722-734.
    • (2009) Mol. Cell , vol.34 , pp. 722-734
    • Azvolinsky, A.1    Giresi, P.G.2    Lieb, J.D.3    Zakian, V.A.4
  • 5
    • 4744343661 scopus 로고    scopus 로고
    • RNase HI overproduction is required for efficient full-length RNA synthesis in the absence of topoisomerase I in Escherichia coli
    • Baaklini I., Hraiky C., Rallu F., Tse-Dinh Y.C., Drolet M. RNase HI overproduction is required for efficient full-length RNA synthesis in the absence of topoisomerase I in Escherichia coli. Mol. Microbiol. 2004, 54:198-211.
    • (2004) Mol. Microbiol. , vol.54 , pp. 198-211
    • Baaklini, I.1    Hraiky, C.2    Rallu, F.3    Tse-Dinh, Y.C.4    Drolet, M.5
  • 6
    • 0021489748 scopus 로고
    • The initiation of DNA replication in the mitochondrial genome of yeast
    • Baldacci G., Chérif-Zahar B., Bernardi G. The initiation of DNA replication in the mitochondrial genome of yeast. EMBO J. 1984, 3:2115-2120.
    • (1984) EMBO J. , vol.3 , pp. 2115-2120
    • Baldacci, G.1    Chérif-Zahar, B.2    Bernardi, G.3
  • 9
    • 75649142564 scopus 로고    scopus 로고
    • The helicases DinG, Rep and UvrD cooperate to promote replication across transcription units in vivo
    • Boubakri H., de Septenville A.L., Viguera E., Michel B. The helicases DinG, Rep and UvrD cooperate to promote replication across transcription units in vivo. EMBO J. 2010, 29:145-157.
    • (2010) EMBO J. , vol.29 , pp. 145-157
    • Boubakri, H.1    de Septenville, A.L.2    Viguera, E.3    Michel, B.4
  • 10
    • 34848908787 scopus 로고    scopus 로고
    • The yeast Pif1p DNA helicase preferentially unwinds RNA DNA substrates
    • Boulé J.B., Zakian V.A. The yeast Pif1p DNA helicase preferentially unwinds RNA DNA substrates. Nucleic Acids Res. 2007, 35:5809-5818.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 5809-5818
    • Boulé, J.B.1    Zakian, V.A.2
  • 11
    • 61349102407 scopus 로고    scopus 로고
    • Ribonuclease H: the enzymes in eukaryotes
    • Cerritelli S.M., Crouch R.J. Ribonuclease H: the enzymes in eukaryotes. FEBS J. 2009, 276:1494-1505.
    • (2009) FEBS J. , vol.276 , pp. 1494-1505
    • Cerritelli, S.M.1    Crouch, R.J.2
  • 12
    • 3142765336 scopus 로고    scopus 로고
    • Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
    • Chaudhuri J., Alt F.W. Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat. Rev. Immunol. 2004, 4:541-552.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 541-552
    • Chaudhuri, J.1    Alt, F.W.2
  • 15
    • 33645052194 scopus 로고    scopus 로고
    • Growth inhibition mediated by excess negative supercoiling: the interplay between transcription elongation, R-loop formation and DNA topology
    • Drolet M. Growth inhibition mediated by excess negative supercoiling: the interplay between transcription elongation, R-loop formation and DNA topology. Mol. Microbiol. 2006, 59:723-730.
    • (2006) Mol. Microbiol. , vol.59 , pp. 723-730
    • Drolet, M.1
  • 16
    • 0028006543 scopus 로고
    • Hypernegative supercoiling of the DNA template during transcription elongation in vitro
    • Drolet M., Bi X., Liu L.F. Hypernegative supercoiling of the DNA template during transcription elongation in vitro. J. Biol. Chem. 1994, 269:2068-2074.
    • (1994) J. Biol. Chem. , vol.269 , pp. 2068-2074
    • Drolet, M.1    Bi, X.2    Liu, L.F.3
  • 17
    • 0028966185 scopus 로고
    • Overexpression of RNase H partially complements the growth defect of an Escherichia coli delta topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase I
    • Drolet M., Phoenix P., Menzel R., Massé E., Liu L.F., Crouch R.J. Overexpression of RNase H partially complements the growth defect of an Escherichia coli delta topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase I. Proc. Natl. Acad. Sci. USA 1995, 92:3526-3530.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3526-3530
    • Drolet, M.1    Phoenix, P.2    Menzel, R.3    Massé, E.4    Liu, L.F.5    Crouch, R.J.6
  • 18
    • 3042785608 scopus 로고    scopus 로고
    • Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA
    • Duquette M.L., Handa P., Vincent J.A., Taylor A.F., Maizels N. Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA. Genes Dev. 2004, 18:1618-1629.
    • (2004) Genes Dev. , vol.18 , pp. 1618-1629
    • Duquette, M.L.1    Handa, P.2    Vincent, J.A.3    Taylor, A.F.4    Maizels, N.5
  • 19
    • 34047271986 scopus 로고    scopus 로고
    • G-rich proto-oncogenes are targeted for genomic instability in B-cell lymphomas
    • Duquette M.L., Huber M.D., Maizels N. G-rich proto-oncogenes are targeted for genomic instability in B-cell lymphomas. Cancer Res. 2007, 67:2586-2594.
    • (2007) Cancer Res. , vol.67 , pp. 2586-2594
    • Duquette, M.L.1    Huber, M.D.2    Maizels, N.3
  • 20
    • 80052008241 scopus 로고    scopus 로고
    • Linking RNA polymerase backtracking to genome instability in E. coli
    • Dutta D., Shatalin K., Epshtein V., Gottesman M.E., Nudler E. Linking RNA polymerase backtracking to genome instability in E. coli. Cell 2011, 146:533-543.
    • (2011) Cell , vol.146 , pp. 533-543
    • Dutta, D.1    Shatalin, K.2    Epshtein, V.3    Gottesman, M.E.4    Nudler, E.5
  • 21
    • 77954841539 scopus 로고    scopus 로고
    • Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis
    • El Hage A., French S.L., Beyer A.L., Tollervey D. Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis. Genes Dev. 2010, 24:1546-1558.
    • (2010) Genes Dev. , vol.24 , pp. 1546-1558
    • El Hage, A.1    French, S.L.2    Beyer, A.L.3    Tollervey, D.4
  • 22
    • 80053645721 scopus 로고    scopus 로고
    • R-loop-mediated genomic instability is caused by impairment of replication fork progression
    • Gan W., Guan Z., Liu J., Gui T., Shen K., Manley J.L., Li X. R-loop-mediated genomic instability is caused by impairment of replication fork progression. Genes Dev. 2011, 25:2041-2056.
    • (2011) Genes Dev. , vol.25 , pp. 2041-2056
    • Gan, W.1    Guan, Z.2    Liu, J.3    Gui, T.4    Shen, K.5    Manley, J.L.6    Li, X.7
  • 23
    • 84859087611 scopus 로고    scopus 로고
    • R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters
    • Ginno P.A., Lott P.L., Christensen H.C., Korf I., Chédin F. R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters. Mol. Cell 2012, 45:814-825.
    • (2012) Mol. Cell , vol.45 , pp. 814-825
    • Ginno, P.A.1    Lott, P.L.2    Christensen, H.C.3    Korf, I.4    Chédin, F.5
  • 24
    • 34347218988 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex
    • Gómez-González B., Aguilera A. Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex. Proc. Natl. Acad. Sci. USA 2007, 104:8409-8414.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 8409-8414
    • Gómez-González, B.1    Aguilera, A.2
  • 25
    • 70349335582 scopus 로고    scopus 로고
    • The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants
    • Gómez-González B., Felipe-Abrio I., Aguilera A. The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants. Mol. Cell. Biol. 2009, 29:5203-5213.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 5203-5213
    • Gómez-González, B.1    Felipe-Abrio, I.2    Aguilera, A.3
  • 27
    • 57349185689 scopus 로고    scopus 로고
    • The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability
    • González-Aguilera C., Tous C., Gómez-González B., Huertas P., Luna R., Aguilera A. The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability. Mol. Biol. Cell 2008, 19:4310-4318.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 4310-4318
    • González-Aguilera, C.1    Tous, C.2    Gómez-González, B.3    Huertas, P.4    Luna, R.5    Aguilera, A.6
  • 28
    • 37549026516 scopus 로고    scopus 로고
    • Transcription-associated recombination is dependent on replication in Mammalian cells
    • Gottipati P., Cassel T.N., Savolainen L., Helleday T. Transcription-associated recombination is dependent on replication in Mammalian cells. Mol. Cell. Biol. 2008, 28:154-164.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 154-164
    • Gottipati, P.1    Cassel, T.N.2    Savolainen, L.3    Helleday, T.4
  • 29
    • 7644223774 scopus 로고    scopus 로고
    • Why is transcription coupled to translation in bacteria?
    • Gowrishankar J., Harinarayanan R. Why is transcription coupled to translation in bacteria?. Mol. Microbiol. 2004, 54:598-603.
    • (2004) Mol. Microbiol. , vol.54 , pp. 598-603
    • Gowrishankar, J.1    Harinarayanan, R.2
  • 30
    • 34548775695 scopus 로고    scopus 로고
    • A persistent RNA.DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitro
    • Grabczyk E., Mancuso M., Sammarco M.C. A persistent RNA.DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitro. Nucleic Acids Res. 2007, 35:5351-5359.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 5351-5359
    • Grabczyk, E.1    Mancuso, M.2    Sammarco, M.C.3
  • 31
    • 84255198334 scopus 로고    scopus 로고
    • Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes
    • Helmrich A., Ballarino M., Tora L. Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes. Mol. Cell 2011, 44:966-977.
    • (2011) Mol. Cell , vol.44 , pp. 966-977
    • Helmrich, A.1    Ballarino, M.2    Tora, L.3
  • 32
    • 0029026201 scopus 로고
    • Escherichia coli RecG and RecA proteins in R-loop formation
    • Hong X., Cadwell G.W., Kogoma T. Escherichia coli RecG and RecA proteins in R-loop formation. EMBO J. 1995, 14:2385-2392.
    • (1995) EMBO J. , vol.14 , pp. 2385-2392
    • Hong, X.1    Cadwell, G.W.2    Kogoma, T.3
  • 33
    • 78650849800 scopus 로고    scopus 로고
    • DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiency
    • Houlard M., Artus J., Léguillier T., Vandormael-Pournin S., Cohen-Tannoudji M. DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiency. Cell Cycle 2011, 10:108-117.
    • (2011) Cell Cycle , vol.10 , pp. 108-117
    • Houlard, M.1    Artus, J.2    Léguillier, T.3    Vandormael-Pournin, S.4    Cohen-Tannoudji, M.5
  • 34
    • 80052698473 scopus 로고    scopus 로고
    • Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein
    • Howard J.A., Delmas S., Ivančić-Baće I., Bolt E.L. Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein. Biochem. J. 2011, 439:85-95.
    • (2011) Biochem. J. , vol.439 , pp. 85-95
    • Howard, J.A.1    Delmas, S.2    Ivančić-Baće, I.3    Bolt, E.L.4
  • 35
    • 0141819093 scopus 로고    scopus 로고
    • Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination
    • Huertas P., Aguilera A. Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination. Mol. Cell 2003, 12:711-721.
    • (2003) Mol. Cell , vol.12 , pp. 711-721
    • Huertas, P.1    Aguilera, A.2
  • 37
    • 1842391776 scopus 로고
    • Formation of an RNA primer for initiation of replication of ColE1 DNA by ribonuclease H
    • Itoh T., Tomizawa J. Formation of an RNA primer for initiation of replication of ColE1 DNA by ribonuclease H. Proc. Natl. Acad. Sci. USA 1980, 77:2450-2454.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 2450-2454
    • Itoh, T.1    Tomizawa, J.2
  • 38
    • 0033517855 scopus 로고    scopus 로고
    • The sen1(+) gene of Schizosaccharomyces pombe, a homologue of budding yeast SEN1, encodes an RNA and DNA helicase
    • Kim H.D., Choe J., Seo Y.S. The sen1(+) gene of Schizosaccharomyces pombe, a homologue of budding yeast SEN1, encodes an RNA and DNA helicase. Biochemistry 1999, 38:14697-14710.
    • (1999) Biochemistry , vol.38 , pp. 14697-14710
    • Kim, H.D.1    Choe, J.2    Seo, Y.S.3
  • 39
    • 80051823466 scopus 로고    scopus 로고
    • Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast
    • Kim N., Jinks-Robertson S. Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast. DNA Repair (Amst.) 2011, 10:953-960.
    • (2011) DNA Repair (Amst.) , vol.10 , pp. 953-960
    • Kim, N.1    Jinks-Robertson, S.2
  • 40
    • 79953707188 scopus 로고    scopus 로고
    • Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast
    • Kobayashi T. Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast. Cell. Mol. Life Sci. 2011, 68:1395-1403.
    • (2011) Cell. Mol. Life Sci. , vol.68 , pp. 1395-1403
    • Kobayashi, T.1
  • 41
    • 0030737725 scopus 로고    scopus 로고
    • Stable DNA replication: interplay between DNA replication, homologous recombination, and transcription
    • Kogoma T. Stable DNA replication: interplay between DNA replication, homologous recombination, and transcription. Microbiol. Mol. Biol. Rev. 1997, 61:212-238.
    • (1997) Microbiol. Mol. Biol. Rev. , vol.61 , pp. 212-238
    • Kogoma, T.1
  • 42
    • 78649531872 scopus 로고    scopus 로고
    • Initiation of bacteriophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage T4 and its relatives
    • Kreuzer K.N., Brister J.R. Initiation of bacteriophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage T4 and its relatives. Virol. J. 2010, 7:358.
    • (2010) Virol. J. , vol.7 , pp. 358
    • Kreuzer, K.N.1    Brister, J.R.2
  • 43
    • 23744455164 scopus 로고    scopus 로고
    • Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability
    • Li X., Manley J.L. Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Cell 2005, 122:365-378.
    • (2005) Cell , vol.122 , pp. 365-378
    • Li, X.1    Manley, J.L.2
  • 47
    • 55949106494 scopus 로고    scopus 로고
    • The Rat1p 5' to 3' exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae
    • Luke B., Panza A., Redon S., Iglesias N., Li Z., Lingner J. The Rat1p 5' to 3' exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae. Mol. Cell 2008, 32:465-477.
    • (2008) Mol. Cell , vol.32 , pp. 465-477
    • Luke, B.1    Panza, A.2    Redon, S.3    Iglesias, N.4    Li, Z.5    Lingner, J.6
  • 48
    • 20444366920 scopus 로고    scopus 로고
    • Interdependence between transcription and mRNP processing and export, and its impact on genetic stability
    • Luna R., Jimeno S., Marín M., Huertas P., García-Rubio M., Aguilera A. Interdependence between transcription and mRNP processing and export, and its impact on genetic stability. Mol. Cell 2005, 18:711-722.
    • (2005) Mol. Cell , vol.18 , pp. 711-722
    • Luna, R.1    Jimeno, S.2    Marín, M.3    Huertas, P.4    García-Rubio, M.5    Aguilera, A.6
  • 49
    • 33947432388 scopus 로고    scopus 로고
    • Replication fork stalling at natural impediments
    • Mirkin E.V., Mirkin S.M. Replication fork stalling at natural impediments. Microbiol. Mol. Biol. Rev. 2007, 71:13-35.
    • (2007) Microbiol. Mol. Biol. Rev. , vol.71 , pp. 13-35
    • Mirkin, E.V.1    Mirkin, S.M.2
  • 51
    • 84857237196 scopus 로고    scopus 로고
    • DNA-RNA hybrid formation mediates RNAi-directed heterochromatin formation
    • Nakama M., Kawakami K., Kajitani T., Urano T., Murakami Y. DNA-RNA hybrid formation mediates RNAi-directed heterochromatin formation. Genes Cells 2012, 17:218-233.
    • (2012) Genes Cells , vol.17 , pp. 218-233
    • Nakama, M.1    Kawakami, K.2    Kajitani, T.3    Urano, T.4    Murakami, Y.5
  • 52
    • 79957556530 scopus 로고    scopus 로고
    • DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase
    • Paeschke K., Capra J.A., Zakian V.A. DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase. Cell 2011, 145:678-691.
    • (2011) Cell , vol.145 , pp. 678-691
    • Paeschke, K.1    Capra, J.A.2    Zakian, V.A.3
  • 53
    • 34547726640 scopus 로고    scopus 로고
    • Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes
    • Palancade B., Liu X., Garcia-Rubio M., Aguilera A., Zhao X., Doye V. Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes. Mol. Biol. Cell 2007, 18:2912-2923.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 2912-2923
    • Palancade, B.1    Liu, X.2    Garcia-Rubio, M.3    Aguilera, A.4    Zhao, X.5    Doye, V.6
  • 56
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
    • Petersen-Mahrt S.K., Harris R.S., Neuberger M.S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 2002, 418:99-103.
    • (2002) Nature , vol.418 , pp. 99-103
    • Petersen-Mahrt, S.K.1    Harris, R.S.2    Neuberger, M.S.3
  • 58
    • 17144426028 scopus 로고    scopus 로고
    • Impairment of replication fork progression mediates RNA polII transcription-associated recombination
    • Prado F., Aguilera A. Impairment of replication fork progression mediates RNA polII transcription-associated recombination. EMBO J. 2005, 24:1267-1276.
    • (2005) EMBO J. , vol.24 , pp. 1267-1276
    • Prado, F.1    Aguilera, A.2
  • 59
    • 80052447253 scopus 로고    scopus 로고
    • Ending the message: poly(A) signals then and now
    • Proudfoot N.J. Ending the message: poly(A) signals then and now. Genes Dev. 2011, 25:1770-1782.
    • (2011) Genes Dev. , vol.25 , pp. 1770-1782
    • Proudfoot, N.J.1
  • 61
    • 0025225502 scopus 로고
    • Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region
    • Reaban M.E., Griffin J.A. Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region. Nature 1990, 348:342-344.
    • (1990) Nature , vol.348 , pp. 342-344
    • Reaban, M.E.1    Griffin, J.A.2
  • 64
    • 0027089978 scopus 로고
    • Stability and properties of double and triple helices: dramatic effects of RNA or DNA backbone composition
    • Roberts R.W., Crothers D.M. Stability and properties of double and triple helices: dramatic effects of RNA or DNA backbone composition. Science 1992, 258:1463-1466.
    • (1992) Science , vol.258 , pp. 1463-1466
    • Roberts, R.W.1    Crothers, D.M.2
  • 66
    • 77955664901 scopus 로고    scopus 로고
    • The interface between transcription and mRNP export: from THO to THSC/TREX-2
    • Rondón A.G., Jimeno S., Aguilera A. The interface between transcription and mRNP export: from THO to THSC/TREX-2. Biochim. Biophys. Acta 2010, 1799:533-538.
    • (2010) Biochim. Biophys. Acta , vol.1799 , pp. 533-538
    • Rondón, A.G.1    Jimeno, S.2    Aguilera, A.3
  • 67
    • 66349101604 scopus 로고    scopus 로고
    • G clustering is important for the initiation of transcription-induced R-loops in vitro, whereas high G density without clustering is sufficient thereafter
    • Roy D., Lieber M.R. G clustering is important for the initiation of transcription-induced R-loops in vitro, whereas high G density without clustering is sufficient thereafter. Mol. Cell. Biol. 2009, 29:3124-3133.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 3124-3133
    • Roy, D.1    Lieber, M.R.2
  • 68
    • 73649101345 scopus 로고    scopus 로고
    • Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site
    • Roy D., Zhang Z., Lu Z., Hsieh C.L., Lieber M.R. Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site. Mol. Cell. Biol. 2010, 30:146-159.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 146-159
    • Roy, D.1    Zhang, Z.2    Lu, Z.3    Hsieh, C.L.4    Lieber, M.R.5
  • 69
    • 79952266545 scopus 로고    scopus 로고
    • AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants
    • Ruiz J.F., Gómez-González B., Aguilera A. AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants. PLoS Genet. 2011, 7:e1002009.
    • (2011) PLoS Genet. , vol.7
    • Ruiz, J.F.1    Gómez-González, B.2    Aguilera, A.3
  • 70
    • 45849138859 scopus 로고    scopus 로고
    • Recognition of the unique structure of DNA:RNA hybrids
    • Shaw N.N., Arya D.P. Recognition of the unique structure of DNA:RNA hybrids. Biochimie 2008, 90:1026-1039.
    • (2008) Biochimie , vol.90 , pp. 1026-1039
    • Shaw, N.N.1    Arya, D.P.2
  • 71
    • 58149166729 scopus 로고    scopus 로고
    • Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway
    • Sikdar N., Banerjee S., Zhang H., Smith S., Myung K. Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway. PLoS Genet. 2008, 4:e1000290.
    • (2008) PLoS Genet. , vol.4
    • Sikdar, N.1    Banerjee, S.2    Zhang, H.3    Smith, S.4    Myung, K.5
  • 72
    • 79959345878 scopus 로고    scopus 로고
    • Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination
    • Skourti-Stathaki K., Proudfoot N.J., Gromak N. Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination. Mol. Cell 2011, 42:794-805.
    • (2011) Mol. Cell , vol.42 , pp. 794-805
    • Skourti-Stathaki, K.1    Proudfoot, N.J.2    Gromak, N.3
  • 76
    • 84255177502 scopus 로고    scopus 로고
    • RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability
    • Wahba L., Amon J.D., Koshland D., Vuica-Ross M. RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability. Mol. Cell 2011, 44:978-988.
    • (2011) Mol. Cell , vol.44 , pp. 978-988
    • Wahba, L.1    Amon, J.D.2    Koshland, D.3    Vuica-Ross, M.4
  • 77
    • 33645823661 scopus 로고    scopus 로고
    • Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex
    • Wellinger R.E., Prado F., Aguilera A. Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex. Mol. Cell. Biol. 2006, 26:3327-3334.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 3327-3334
    • Wellinger, R.E.1    Prado, F.2    Aguilera, A.3
  • 78
    • 1142310578 scopus 로고    scopus 로고
    • Structural basis of transcription: separation of RNA from DNA by RNA polymerase II
    • Westover K.D., Bushnell D.A., Kornberg R.D. Structural basis of transcription: separation of RNA from DNA by RNA polymerase II. Science 2004, 303:1014-1016.
    • (2004) Science , vol.303 , pp. 1014-1016
    • Westover, K.D.1    Bushnell, D.A.2    Kornberg, R.D.3
  • 79
    • 84855897667 scopus 로고    scopus 로고
    • Quantitative model of R-loop forming structures reveals a novel level of RNA-DNA interactome complexity
    • Wongsurawat T., Jenjaroenpun P., Kwoh C.K., Kuznetsov V. Quantitative model of R-loop forming structures reveals a novel level of RNA-DNA interactome complexity. Nucleic Acids Res. 2012, 40:e16.
    • (2012) Nucleic Acids Res. , vol.40
    • Wongsurawat, T.1    Jenjaroenpun, P.2    Kwoh, C.K.3    Kuznetsov, V.4
  • 80
    • 0029938513 scopus 로고    scopus 로고
    • RNA-DNA hybrid formation at the human mitochondrial heavy-strand origin ceases at replication start sites: an implication for RNA-DNA hybrids serving as primers
    • Xu B., Clayton D.A. RNA-DNA hybrid formation at the human mitochondrial heavy-strand origin ceases at replication start sites: an implication for RNA-DNA hybrids serving as primers. EMBO J. 1996, 15:3135-3143.
    • (1996) EMBO J. , vol.15 , pp. 3135-3143
    • Xu, B.1    Clayton, D.A.2
  • 81
    • 0037650190 scopus 로고    scopus 로고
    • R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
    • Yu K., Chedin F., Hsieh C.L., Wilson T.E., Lieber M.R. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat. Immunol. 2003, 4:442-451.
    • (2003) Nat. Immunol. , vol.4 , pp. 442-451
    • Yu, K.1    Chedin, F.2    Hsieh, C.L.3    Wilson, T.E.4    Lieber, M.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.