Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability

Cell

Volumn 122, Issue 3, 2005, Pages 365-378

  Li, Xialu ^a   Manley, James L ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE SPLICING FACTOR; DNA DIRECTED RNA POLYMERASE III; DNA HYBRID; PROTEIN; RIBONUCLEASE; RNA; SERINE ARGININE RICH SPLICING FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; DNA DETERMINATION; DNA STRAND BREAKAGE; DNA STRUCTURE; GENE MUTATION; GENETIC TRANSCRIPTION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; HYBRID; MOLECULAR MODEL; MOLECULAR WEIGHT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA SPLICING; TRANSCRIPTION INITIATION;

METAZOA;

EID: 23744455164     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2005.06.008     Document Type: Article

References (57)

1. A. Aguilera The connection between transcription and genomic instability EMBO J. 21 2002 195 201
2. D.L. Black Mechanisms of alternative pre-messenger RNA splicing Annu. Rev. Biochem. 72 2003 291 336
3. D.G. Brown, X.M. Sun, and G.M. Cohen Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation J. Biol. Chem. 268 1993 3037 3039
4. J.F. Caceres, G.R. Screaton, and A.R. Krainer A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm Genes Dev. 12 1998 55 66
5. Z. Chen, and J.L. Manley Robust mRNA transcription in chicken DT40 cells depleted of TAF(II)31 suggests both functional degeneracy and evolutionary divergence Mol. Cell. Biol. 20 2000 5064 5076
6. Z. Chen, and J.L. Manley Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates Mol. Cell. Biol. 23 2003 7350 7362
7. B. Daneholt Assembly and transport of a premessenger RNP particle Proc. Natl. Acad. Sci. USA 98 2001 7012 7017
8. B. Daneholt Packing and delivery of a genetic message Chromosoma 110 2001 173 185
9. M. Drolet, P. Phoenix, R. Menzel, E. Masse, L.F. Liu, and R.J. Crouch Overexpression of RNase H partially complements the growth defect of an Escherichia coli delta topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase I Proc. Natl. Acad. Sci. USA 92 1995 3526 3530
10. M. Drolet, S. Broccoli, F. Rallu, C. Hraiky, C. Fortin, E. Masse, and I. Baaklini The problem of hypernegative supercoiling and R-loop formation in transcription Front. Biosci. 8 2003 210 221
11. M.L. Duquette, P. Handa, J.A. Vincent, A.F. Taylor, and N. Maizels Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA Genes Dev. 18 2004 1618 1629
12. S.M. Elbashir, J. Harborth, K. Weber, and T. Tuschl Analysis of gene function in somatic mammalian cells using small interfering RNAs Methods 26 2002 199 213
13. X.D. Fu Specific commitment of different pre-mRNAs to splicing by single SR proteins Nature 365 1993 82 85
14. J.G. Gall, M. Bellini, Z. Wu, and C. Murphy Assembly of the nuclear transcription and processing machinery: Cajal bodies (coiled bodies) and transcriptosomes Mol. Biol. Cell 10 1999 4385 4402
15. M. Gallardo, R. Luna, H. Erdjument-Bromage, P. Tempst, and A. Aguilera Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism J. Biol. Chem. 278 2003 24225 24232 10.1074/jbc.M302900200 Published online April 17, 2003
16. H. Ge, and J.L. Manley A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro Cell 62 1990 25 34
17. S. Hacker, and H. Krebber Differential export requirements for shuttling serine/arginine-type mRNA-binding proteins J. Biol. Chem. 279 2004 5049 5052
18. Y. Hirose, and J.L. Manley RNA polymerase II is an essential mRNA polyadenylation factor Nature 395 1998 93 96
19. Y. Hirose, and J.L. Manley RNA polymerase II and the integration of nuclear events Genes Dev. 14 2000 1415 1429
20. Y. Huang, R. Gattoni, J. Stevenin, and J.A. Steitz SR splicing factors serve as adapter proteins for TAP-dependent mRNA export Mol. Cell 11 2003 837 843
21. P. Huertas, and A. Aguilera Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination Mol. Cell 12 2003 711 721
22. E. Hurt, M.J. Luo, S. Rother, R. Reed, and K. Strasser Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex Proc. Natl. Acad. Sci. USA 101 2004 1858 1862
23. V.L. Johnson, S.C. Ko, T.H. Holmstrom, J.E. Eriksson, and S.C. Chow Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis J. Cell Sci. 113 2000 2941 2953
24. T.R. Kadesch, and M.J. Chamberlin Studies of in vitro transcription by calf thymus RNA polymerase II using a novel duplex DNA template J. Biol. Chem. 257 1982 5286 5295
25. J.D. Kohtz, S.F. Jamison, C.L. Will, P. Zuo, R. Luhrmann, M.A. Garcia-Blanco, and J.L. Manley Protein-protein interactions and 5′-splice-site recognition in mammalian mRNA precursors Nature 368 1994 119 124
26. A.R. Krainer, G.C. Conway, and D. Kozak The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites Cell 62 1990 35 42
27. R. Lemaire, J. Prasad, T. Kashima, J. Gustafson, J.L. Manley, and R. Lafyatis Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins Genes Dev. 16 2002 594 607
28. H.L. Liber, and W.G. Thilly Mutation assay at the thymidine kinase locus in diploid human lymphoblasts Mutat. Res. 94 1982 467 485
29. M.R. Lieber, Y. Ma, U. Pannicke, and K. Schwarz Mechanism and regulation of human non-homologous DNA end-joining Nat. Rev. Mol. Cell Biol. 4 2003 712 720
30. D. Longman, I.L. Johnstone, and J.F. Caceres Functional characterization of SR and SR-related genes in Caenorhabditis elegans EMBO J. 19 2000 1625 1637
31. T. Maniatis, and R. Reed An extensive network of coupling among gene expression machines Nature 416 2002 499 506
32. J.L. Manley, and R. Tacke SR proteins and splicing control Genes Dev. 10 1996 1569 1579
33. E. Masse, and M. Drolet Escherichia coli DNA topoisomerase I inhibits R-loop formation by relaxing transcription-induced negative supercoiling J. Biol. Chem. 274 1999 16659 16664
34. S. Millhouse, and J.L. Manley The C-terminal domain of RNA polymerase II functions as a phosphorylation-dependent splicing activator in a heterologous protein Mol. Cell. Biol. 25 2005 533 544
35. T. Misteli, and D.L. Spector RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo Mol. Cell 3 1999 697 705
36. M.J. O'Connell, N.C. Walworth, and A.M. Carr The G2-phase DNA-damage checkpoint Trends Cell Biol. 10 2000 296 303
37. F.N. Papavasiliou, and D.G. Schatz Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes Nature 408 2000 216 221
38. M.E. Reaban, J. Lebowitz, and J.A. Griffin Transcription induces the formation of a stable RNA.DNA hybrid in the immunoglobulin alpha switch region J. Biol. Chem. 269 1994 21850 21857
39. R. Reed Coupling transcription, splicing and mRNA export Curr. Opin. Cell Biol. 15 2003 326 331
40. J. Rehwinkel, A. Herold, K. Gari, T. Kocher, M. Rode, F.L. Ciccarelli, M. Wilm, and E. Izaurralde Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster Nat. Struct. Mol. Biol. 11 2004 558 566
41. H.Z. Ring, and J.T. Lis The SR protein B52/SRp55 is essential for Drosophila development Mol. Cell. Biol. 14 1994 7499 7506
42. E.P. Rogakou, D.R. Pilch, A.H. Orr, V.S. Ivanova, and W.M. Bonner DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 J. Biol. Chem. 273 1998 5858 5868
43. A.G. Rondon, S. Jimeno, M. Garcia-Rubio, and A. Aguilera Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation J. Biol. Chem. 278 2003 39037 39043
44. H. Sakahira, M. Enari, Y. Ohsawa, Y. Uchiyama, and S. Nagata Apoptotic nuclear morphological change without DNA fragmentation Curr. Biol. 9 1999 543 546
45. J.R. Sanford, D. Longman, and J.F. Caceres Multiple roles of the SR protein family in splicing regulation Prog. Mol. Subcell. Biol. 31 2003 33 58
46. J.R. Sanford, N.K. Gray, K. Beckmann, and J.F. Caceres A novel role for shuttling SR proteins in mRNA translation Genes Dev. 18 2004 755 768
47. K. Strasser, S. Masuda, P. Mason, J. Pfannstiel, M. Oppizzi, S. Rodriguez-Navarro, A.G. Rondon, A. Aguilera, K. Struhl, R. Reed, and E. Hurt TREX is a conserved complex coupling transcription with messenger RNA export Nature 417 2002 304 308
48. N. Sugimoto, S. Nakano, M. Katoh, A. Matsumura, H. Nakamuta, T. Ohmichi, M. Yoneyama, and M. Sasaki Thermodynamic parameters to predict stability of RNA/DNA hybrid duplexes Biochemistry 34 1995 11211 11216
49. R. Tacke, and J.L. Manley The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities EMBO J. 14 1995 3540 3551
50. R. Tacke, and J.L. Manley Determinants of SR protein specificity Curr. Opin. Cell Biol. 11 1999 358 362
51. Y. Takagaki, and J.L. Manley Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation Mol. Cell 2 1998 761 771
52. J. Wang, Y. Takagaki, and J.L. Manley Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability Genes Dev. 10 1996 2588 2599
53. J. Wang, S.H. Xiao, and J.L. Manley Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicing Genes Dev. 12 1998 2222 2233
54. J.Y. Wu, and T. Maniatis Specific interactions between proteins implicated in splice site selection and regulated alternative splicing Cell 75 1993 1061 1070
55. X. Xu, D. Yang, J. Ding, W. Wang, P. Chu, N. Dalton, H. Wang, J.R. Bermingham Jr., Z. Ye, and F. Liu ASF/SF2-regulated CaMKIIδ alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle Cell 120 2005 59 72
56. K. Yu, F. Chedin, C.L. Hsieh, T.E. Wilson, and M.R. Lieber R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells Nat. Immunol. 4 2003 442 451
57. C. Zimmer, A. von Gabain, and T. Henics Analysis of sequence-specific binding of RNA to Hsp70 and its various homologs indicates the involvement of N- and C-terminal interactions RNA 7 2001 1628 1637