-
1
-
-
4544374528
-
BRCA1 and BRCA2: 1994 and beyond
-
Narod, S.A. & Foulkes, W.D. BRCA1 and BRCA2: 1994 and beyond. Nat. Rev. Cancer 4, 665-676 (2004).
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 665-676
-
-
Narod, S.A.1
Foulkes, W.D.2
-
2
-
-
33749007676
-
Mouse models of BRCA1 and BRCA2 defciency: Past lessons, current understanding and future prospects
-
Evers, B. & Jonkers, J. Mouse models of BRCA1 and BRCA2 defciency: past lessons, current understanding and future prospects. Oncogene 25, 5885-5897 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 5885-5897
-
-
Evers, B.1
Jonkers, J.2
-
3
-
-
36949026476
-
BRCA2: A universal recombinase regulator
-
Thorslund, T. & West, S.C. BRCA2: a universal recombinase regulator. Oncogene 26, 7720-7730 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 7720-7730
-
-
Thorslund, T.1
West, S.C.2
-
4
-
-
63049108452
-
Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment
-
Venkitaraman, A.R. Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment. Annu. Rev. Pathol. 4, 461-487 (2009).
-
(2009)
Annu. Rev. Pathol.
, vol.4
, pp. 461-487
-
-
Venkitaraman, A.R.1
-
5
-
-
34249936595
-
Minding the gap: The underground functions of BRCA1 and BRCA2 at stalled replication forks
-
Nagaraju, G. & Scully, R. Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks. DNA Repair (Amst.) 6, 1018-1031 (2007).
-
(2007)
DNA Repair (Amst.)
, vol.6
, pp. 1018-1031
-
-
Nagaraju, G.1
Scully, R.2
-
6
-
-
52049125947
-
Replication fork arrest, recombination and the maintenance of ribosomal DNA stability
-
Tsang, E. & Carr, A.M. Replication fork arrest, recombination and the maintenance of ribosomal DNA stability. DNA Repair (Amst.) 7, 1613-1623 (2008).
-
(2008)
DNA Repair (Amst.)
, vol.7
, pp. 1613-1623
-
-
Tsang, E.1
Carr, A.M.2
-
7
-
-
0037148281
-
Alternative lengthening of telomeres in mammalian cells
-
Henson, J.D., Neumann, A.A., Yeager, T.R. & Reddel, R.R. Alternative lengthening of telomeres in mammalian cells. Oncogene 21, 598-610 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 598-610
-
-
Henson, J.D.1
Neumann, A.A.2
Yeager, T.R.3
Reddel, R.R.4
-
8
-
-
39049125505
-
Telomere uncapping and alternative lengthening of telomere
-
Cesare, A.J. & Reddel, R.R. Telomere uncapping and alternative lengthening of telomere. Mech. Ageing Dev. 129, 99-108 (2008).
-
(2008)
Mech. Ageing Dev.
, vol.129
, pp. 99-108
-
-
Cesare, A.J.1
Reddel, R.R.2
-
9
-
-
33750801681
-
The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres
-
Verdun, R.E. & Karlseder, J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell 127, 709-720 (2006).
-
(2006)
Cell
, vol.127
, pp. 709-720
-
-
Verdun, R.E.1
Karlseder, J.2
-
10
-
-
0038700698
-
Molecular views of recombination proteins and their control
-
West, S.C. Molecular views of recombination proteins and their control. Nat. Rev. Mol. Cell Biol. 4, 1-11 (2003).
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 1-11
-
-
West, S.C.1
-
11
-
-
0038740579
-
The mammalian XRCC genes: Their roles in DNA repair and genetic stability
-
Thacker, J. & Zdzienicka, M.Z. The mammalian XRCC genes: their roles in DNA repair and genetic stability. DNA Repair (Amst.) 2, 655-672 (2003).
-
(2003)
DNA Repair (Amst.)
, vol.2
, pp. 655-672
-
-
Thacker, J.1
Zdzienicka, M.Z.2
-
12
-
-
66149151303
-
RAD51C facilitates checkpoint signalling by promoting CHK2 phosphorylation
-
Badie, S. et al. RAD51C facilitates checkpoint signalling by promoting CHK2 phosphorylation. J. Cell Biol. 185, 587-600 (2009).
-
(2009)
J. Cell Biol.
, vol.185
, pp. 587-600
-
-
Badie, S.1
-
13
-
-
46249125488
-
How shelterin protects mammalian telomeres
-
Palm, W. & de Lange, T. How shelterin protects mammalian telomeres. Annu. Rev. Genet. 42, 16.1-16.34 (2008).
-
(2008)
Annu. Rev. Genet.
, vol.42
, pp. 161-1634
-
-
Palm, W.1
De Lange, T.2
-
14
-
-
11144357186
-
Telomere maintenance requires the RAD51D recombination/ repair protein
-
Tarsounas, M. et al. Telomere maintenance requires the RAD51D recombination/ repair protein. Cell 117, 337-347 (2004).
-
(2004)
Cell
, vol.117
, pp. 337-347
-
-
Tarsounas, M.1
-
15
-
-
0043133869
-
Role of mammalian Rad54 in telomere length maintenance
-
Jaco, I. et al. Role of mammalian Rad54 in telomere length maintenance. Mol. Cell. Biol. 23, 5572-5580 (2003).
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5572-5580
-
-
Jaco, I.1
-
16
-
-
25144516017
-
Recombination at mammalian telomeres: An alternative mechanism for telomere protection and elongation
-
Tarsounas, M. & West, S.C. Recombination at mammalian telomeres: an alternative mechanism for telomere protection and elongation. Cell Cycle 4, 672-674 (2005).
-
(2005)
Cell Cycle
, vol.4
, pp. 672-674
-
-
Tarsounas, M.1
West, S.C.2
-
17
-
-
3242886697
-
Telomeres and the DNA damage response: Why the fox is guarding the henhouse
-
Maser, R.S. & DePinho, R.A. Telomeres and the DNA damage response: why the fox is guarding the henhouse. DNA Repair (Amst.) 8-9, 979-988 (2004).
-
(2004)
DNA Repair (Amst.)
, vol.8-9
, pp. 979-988
-
-
Maser, R.S.1
Depinho, R.A.2
-
18
-
-
0037178761
-
Connecting chromosomes, crisis, and cancer
-
Maser, R.S. & DePinho, R.A. Connecting chromosomes, crisis, and cancer. Science 297, 565-569 (2002).
-
(2002)
Science
, vol.297
, pp. 565-569
-
-
Maser, R.S.1
Depinho, R.A.2
-
19
-
-
0033764030
-
Senescence bypass screen identifes TBX2, which represses Cdkn2a(p19ARF) and is amplifed in a subset of human breast cancers
-
Jacobs, J.J.L. et al. Senescence bypass screen identifes TBX2, which represses Cdkn2a(p19ARF) and is amplifed in a subset of human breast cancers. Nat. Genet. 26, 291-299 (2000).
-
(2000)
Nat. Genet.
, vol.26
, pp. 291-299
-
-
Jacobs, J.J.L.1
-
20
-
-
0034888424
-
Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity
-
Silver, D.P. & Livingston, D.M. Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol. Cell 8, 233-243 (2001).
-
(2001)
Mol. Cell
, vol.8
, pp. 233-243
-
-
Silver, D.P.1
Livingston, D.M.2
-
21
-
-
0035734285
-
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
-
Jonkers, J. et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat. Genet. 29, 418-425 (2001).
-
(2001)
Nat. Genet.
, vol.29
, pp. 418-425
-
-
Jonkers, J.1
-
22
-
-
0033153424
-
Disease states associated to telomere defciency appear earlier in mice with short telomeres
-
Herrera, E. et al. Disease states associated to telomere defciency appear earlier in mice with short telomeres. EMBO J. 18, 2950-2960 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 2950-2960
-
-
Herrera, E.1
-
23
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco, M.A. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25-34 (1997).
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
-
24
-
-
27144515686
-
XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer
-
Muñoz, P., Blanco, R., Flores, J.M. & Blasco, M.A. XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Nat. Genet. 37, 1063-1071 (2005).
-
(2005)
Nat. Genet.
, vol.37
, pp. 1063-1071
-
-
Muñoz, P.1
Blanco, R.2
Flores, J.M.3
Blasco, M.A.4
-
25
-
-
33846517601
-
Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis
-
Blanco, R., Munoz, P., Flores, J.M., Klatt, P. & Blasco, M.A. Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis. Genes Dev. 21, 206-220 (2007).
-
(2007)
Genes Dev.
, vol.21
, pp. 206-220
-
-
Blanco, R.1
Munoz, P.2
Flores, J.M.3
Klatt, P.4
Blasco, M.A.5
-
26
-
-
53049091444
-
Distinct roles of TRF1 in the regulation of telomere structure and lengthening
-
Okamoto, K., Iwano, T., Tachibana, M. & Shinkai, Y. Distinct roles of TRF1 in the regulation of telomere structure and lengthening. J. Biol. Chem. 283, 23981-23988 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 23981-23988
-
-
Okamoto, K.1
Iwano, T.2
Tachibana, M.3
Shinkai, Y.4
-
27
-
-
67649635974
-
Mammalian telomeres resemble fragile sites and require TRF1 for effcient replication
-
Sfeir, A. et al. Mammalian telomeres resemble fragile sites and require TRF1 for effcient replication. Cell 138, 90-103 (2009).
-
(2009)
Cell
, vol.138
, pp. 90-103
-
-
Sfeir, A.1
-
28
-
-
69749092744
-
Increased telomere fragility and fusions resulting from TRF1 defciency lead to degenerative pathologies and increased cancer in mice
-
Martínez, P. et al. Increased telomere fragility and fusions resulting from TRF1 defciency lead to degenerative pathologies and increased cancer in mice. Genes Dev. 23, 2060-2075 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 2060-2075
-
-
Martínez, P.1
-
30
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
d'Adda di Fagagna, F. et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature, 426, 194-198(2003).
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
D'Adda Di Fagagna, F.1
-
31
-
-
0042420304
-
DNA damage foci at dysfunctional telomeres
-
Takai, H., Smogorzewska, A. & de Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556 (2003).
-
(2003)
Curr. Biol.
, vol.13
, pp. 1549-1556
-
-
Takai, H.1
Smogorzewska, A.2
De Lange, T.3
-
32
-
-
77953291328
-
53BP1 loss rescues BRCA1 defciency and is associated with triple-negative and BRCA-mutated breast cancers
-
Bouwman, P. et al. 53BP1 loss rescues BRCA1 defciency and is associated with triple-negative and BRCA-mutated breast cancers. Nat. Struct. Mol. Biol. 17, 688-695 (2010).
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 688-695
-
-
Bouwman, P.1
-
33
-
-
12444324167
-
Immunohistochemical characteristics defned by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: Differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers
-
Palacios, J. et al. Immunohistochemical characteristics defned by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers. Clin. Cancer Res. 9, 3606-3614 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 3606-3614
-
-
Palacios, J.1
-
34
-
-
0030659153
-
Tumorigenesis and a DNA-repair defect in mice with a truncating BRCA2 mutation
-
Connor, F. et al. Tumorigenesis and a DNA-repair defect in mice with a truncating BRCA2 mutation. Nat. Genet. 17, 423-430 (1997).
-
(1997)
Nat. Genet.
, vol.17
, pp. 423-430
-
-
Connor, F.1
-
35
-
-
0031990269
-
Involvement of BRCA2 in DNA repair
-
Patel, K.J. et al. Involvement of BRCA2 in DNA repair. Mol. Cell 1, 347-357 (1998).
-
(1998)
Mol. Cell
, vol.1
, pp. 347-357
-
-
Patel, K.J.1
-
36
-
-
33746715608
-
V. Rad54 protein promotes branch migration of Holliday junctions
-
Bugreev, D.V., Mazina, O.M. & Mazin, A.V. Rad54 protein promotes branch migration of Holliday junctions. Nature 442, 590-593 (2006).
-
(2006)
Nature
, vol.442
, pp. 590-593
-
-
Bugreev, D.V.1
Mazina, O.M.2
Mazin, A.3
-
37
-
-
33645747064
-
Semi-conservative DNA replication through telomeres requires Taz1
-
Miller, K.M., Rog, O. & Cooper, J.P. Semi-conservative DNA replication through telomeres requires Taz1. Nature 440, 824-828 (2006).
-
(2006)
Nature
, vol.440
, pp. 824-828
-
-
Miller, K.M.1
Rog, O.2
Cooper, J.P.3
-
38
-
-
33745093483
-
Telomeric proteins: Clearing the way for the replication fork
-
Karlseder, J. Telomeric proteins: clearing the way for the replication fork. Nat. Struct. Mol. Biol. 13, 386-387 (2006).
-
(2006)
Nat. Struct. Mol. Biol.
, vol.13
, pp. 386-387
-
-
Karlseder, J.1
-
39
-
-
77954958609
-
TRF2 and apollo cooperate with topoisomerase 2α to protect human telomeres from replicative damage
-
Ye, J. et al. TRF2 and apollo cooperate with topoisomerase 2α to protect human telomeres from replicative damage. Cell 142, 230-242 (2010).
-
(2010)
Cell
, vol.142
, pp. 230-242
-
-
Ye, J.1
-
40
-
-
0030932869
-
Cancer-susceptibility genes: Gatekeepers and caretakers
-
Kinzler, K.W. & Vogelstein, B. Cancer-susceptibility genes: gatekeepers and caretakers. Nature 386, 761 (1997).
-
(1997)
Nature
, vol.386
, pp. 761
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
41
-
-
9244244706
-
Telomere shortening occurs early during breast tumorigenesis: A cause of chromosome destabilization underlying malignant transformation? J Mammary Gland Biol
-
Meeker, A.K. & Argani, P. Telomere shortening occurs early during breast tumorigenesis: a cause of chromosome destabilization underlying malignant transformation? J. Mammary Gland Biol. Neoplasia 9, 285-296 (2004).
-
(2004)
Neoplasia
, vol.9
, pp. 285-296
-
-
Meeker, A.K.1
Argani, P.2
-
42
-
-
0028118111
-
Tumor spectrum analysis in p53-mutant mice
-
Jacks, T. et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1-7 (1994).
-
(1994)
Curr. Biol.
, vol.4
, pp. 1-7
-
-
Jacks, T.1
-
43
-
-
0037686707
-
Reversal of senescence in mouse fbroblasts through lentiviral suppression of p53
-
Dirac, A.M. & Bernards, R. Reversal of senescence in mouse fbroblasts through lentiviral suppression of p53. J. Biol. Chem. 278, 11731-11734 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11731-11734
-
-
Dirac, A.M.1
Bernards, R.2
-
44
-
-
77949486429
-
P53 prevents entry into mitosis with uncapped telomeres
-
Thanasoula, M. et al. p53 prevents entry into mitosis with uncapped telomeres. Curr. Biol. 20, 521-526 (2010).
-
(2010)
Curr. Biol.
, vol.20
, pp. 521-526
-
-
Thanasoula, M.1
-
45
-
-
0037468267
-
BRCA2-dependent and independent formation of RAD51 nuclear foci
-
Tarsounas, M., Davies, D. & West, S.C. BRCA2-dependent and independent formation of RAD51 nuclear foci. Oncogene 22, 1115-1123 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 1115-1123
-
-
Tarsounas, M.1
Davies, D.2
West, S.C.3
-
46
-
-
2442511752
-
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
-
Herbig, U., Jobling, W.A., Chen, B.P., Chen, D.J. & Sedivy, J.M. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14, 501-513 (2004).
-
(2004)
Mol. Cell
, vol.14
, pp. 501-513
-
-
Herbig, U.1
Jobling, W.A.2
Chen, B.P.3
Chen, D.J.4
Sedivy, J.M.5
|