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Volumn 11, Issue 11, 2015, Pages

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN; DNA; RNA; FANCA PROTEIN, HUMAN; FANCD2 PROTEIN, HUMAN; FANCONI ANEMIA GROUP A PROTEIN; FANCONI ANEMIA GROUP D2 PROTEIN;

EID: 84949256749     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005674     Document Type: Article
Times cited : (224)

References (45)
  • 1
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature. 2005; 434: 864–70 15829956
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1    Horejsi, Z.2    Koed, K.3    Kramer, A.4    Tort, F.5    Zieger, K.6
  • 2
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature. 2005; 434: 907–13 15829965
    • (2005) Nature , vol.434 , pp. 907-913
    • Gorgoulis, V.G.1    Vassiliou, L.V.2    Karakaidos, P.3    Zacharatos, P.4    Kotsinas, A.5    Liloglou, T.6
  • 3
    • 84887595526 scopus 로고    scopus 로고
    • Causes of genome instability
    • Aguilera A, Garcia-Muse T, Causes of genome instability. Annu Rev Genet. 2013; 47: 1–32 doi: 10.1146/annurev-genet-111212-133232 23909437
    • (2013) Annu Rev Genet , vol.47 , pp. 1-32
    • Aguilera, A.1    Garcia-Muse, T.2
  • 4
    • 84860338675 scopus 로고    scopus 로고
    • R loops: from transcription byproducts to threats to genome stability
    • Aguilera A, Garcia-Muse T, R loops: from transcription byproducts to threats to genome stability. Molecular cell. 2012; 46: 115–24 doi: 10.1016/j.molcel.2012.04.009 22541554
    • (2012) Molecular cell , vol.46 , pp. 115-124
    • Aguilera, A.1    Garcia-Muse, T.2
  • 5
    • 84923172195 scopus 로고    scopus 로고
    • R-loops induce repressive chromatin marks over mammalian gene terminators
    • Skourti-Stathaki K, Kamieniarz-Gdula K, Proudfoot NJ, R-loops induce repressive chromatin marks over mammalian gene terminators. Nature. 2014; 516: 436–9 doi: 10.1038/nature13787 25296254
    • (2014) Nature , vol.516 , pp. 436-439
    • Skourti-Stathaki, K.1    Kamieniarz-Gdula, K.2    Proudfoot, N.J.3
  • 6
    • 84903795949 scopus 로고    scopus 로고
    • A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression
    • Skourti-Stathaki K, Proudfoot NJ, A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression. Genes & development. 2014; 28: 1384–96
    • (2014) Genes & development , vol.28 , pp. 1384-1396
    • Skourti-Stathaki, K.1    Proudfoot, N.J.2
  • 7
    • 84869026790 scopus 로고    scopus 로고
    • Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes
    • Alzu A, Bermejo R, Begnis M, Lucca C, Piccini D, Carotenuto W, et al. Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes. Cell. 2012; 151: 835–46 doi: 10.1016/j.cell.2012.09.041 23141540
    • (2012) Cell , vol.151 , pp. 835-846
    • Alzu, A.1    Bermejo, R.2    Begnis, M.3    Lucca, C.4    Piccini, D.5    Carotenuto, W.6
  • 8
    • 0141819093 scopus 로고    scopus 로고
    • Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination
    • Huertas P, Aguilera A, Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination. Molecular cell. 2003; 12: 711–21 14527416
    • (2003) Molecular cell , vol.12 , pp. 711-721
    • Huertas, P.1    Aguilera, A.2
  • 9
    • 23744455164 scopus 로고    scopus 로고
    • Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability
    • Li X, Manley JL, Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Cell. 2005; 122: 365–78 16096057
    • (2005) Cell , vol.122 , pp. 365-378
    • Li, X.1    Manley, J.L.2
  • 10
    • 78650727733 scopus 로고    scopus 로고
    • Yeast Sen1 helicase protects the genome from transcription-associated instability
    • Mischo HE, Gomez-Gonzalez B, Grzechnik P, Rondon AG, Wei W, Steinmetz L, et al. Yeast Sen1 helicase protects the genome from transcription-associated instability. Molecular cell. 2011; 41: 21–32 doi: 10.1016/j.molcel.2010.12.007 21211720
    • (2011) Molecular cell , vol.41 , pp. 21-32
    • Mischo, H.E.1    Gomez-Gonzalez, B.2    Grzechnik, P.3    Rondon, A.G.4    Wei, W.5    Steinmetz, L.6
  • 11
    • 67651119997 scopus 로고    scopus 로고
    • A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability
    • Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, et al. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Molecular cell. 2009; 35: 228–39 doi: 10.1016/j.molcel.2009.06.021 19647519
    • (2009) Molecular cell , vol.35 , pp. 228-239
    • Paulsen, R.D.1    Soni, D.V.2    Wollman, R.3    Hahn, A.T.4    Yee, M.C.5    Guan, A.6
  • 13
    • 84255177502 scopus 로고    scopus 로고
    • RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability
    • Wahba L, Amon JD, Koshland D, Vuica-Ross M, RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability. Molecular cell. 2011; 44: 978–88 doi: 10.1016/j.molcel.2011.10.017 22195970
    • (2011) Molecular cell , vol.44 , pp. 978-988
    • Wahba, L.1    Amon, J.D.2    Koshland, D.3    Vuica-Ross, M.4
  • 14
    • 84885081625 scopus 로고    scopus 로고
    • GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination
    • Ginno PA, Lim YW, Lott PL, Korf I, Chedin F, GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination. Genome Res. 2013; 23: 1590–600 doi: 10.1101/gr.158436.113 23868195
    • (2013) Genome Res , vol.23 , pp. 1590-1600
    • Ginno, P.A.1    Lim, Y.W.2    Lott, P.L.3    Korf, I.4    Chedin, F.5
  • 15
    • 84859087611 scopus 로고    scopus 로고
    • R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters
    • Ginno PA, Lott PL, Christensen HC, Korf I, Chedin F, R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters. Molecular cell. 2012; 45: 814–25 doi: 10.1016/j.molcel.2012.01.017 22387027
    • (2012) Molecular cell , vol.45 , pp. 814-825
    • Ginno, P.A.1    Lott, P.L.2    Christensen, H.C.3    Korf, I.4    Chedin, F.5
  • 16
    • 80053645721 scopus 로고    scopus 로고
    • R-loop-mediated genomic instability is caused by impairment of replication fork progression
    • Gan W, Guan Z, Liu J, Gui T, Shen K, Manley JL, et al. R-loop-mediated genomic instability is caused by impairment of replication fork progression. Genes & development. 2011; 25: 2041–56
    • (2011) Genes & development , vol.25 , pp. 2041-2056
    • Gan, W.1    Guan, Z.2    Liu, J.3    Gui, T.4    Shen, K.5    Manley, J.L.6
  • 17
    • 33645823661 scopus 로고    scopus 로고
    • Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex
    • Wellinger RE, Prado F, Aguilera A, Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex. Mol Cell Biol. 2006; 26: 3327–34 16581804
    • (2006) Mol Cell Biol , vol.26 , pp. 3327-3334
    • Wellinger, R.E.1    Prado, F.2    Aguilera, A.3
  • 19
    • 84901626668 scopus 로고    scopus 로고
    • R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome
    • Groh M, Lufino MM, Wade-Martins R, Gromak N, R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome. PLoS Genet. 2014; 10: e1004318 doi: 10.1371/journal.pgen.1004318 24787137
    • (2014) PLoS Genet , vol.10 , pp. 1004318
    • Groh, M.1    Lufino, M.M.2    Wade-Martins, R.3    Gromak, N.4
  • 20
    • 84941937809 scopus 로고    scopus 로고
    • R loops: new modulators of genome dynamics and function
    • Santos-Pereira JM, Aguilera A, R loops: new modulators of genome dynamics and function. Nature reviews Genetics. 2015; 16: 583–97 doi: 10.1038/nrg3961 26370899
    • (2015) Nature reviews Genetics , vol.16 , pp. 583-597
    • Santos-Pereira, J.M.1    Aguilera, A.2
  • 21
    • 29144522146 scopus 로고    scopus 로고
    • Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites
    • El Achkar E, Gerbault-Seureau M, Muleris M, Dutrillaux B, Debatisse M, Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites. Proc Natl Acad Sci U S A. 2005; 102: 18069–74 16330769
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18069-18074
    • El Achkar, E.1    Gerbault-Seureau, M.2    Muleris, M.3    Dutrillaux, B.4    Debatisse, M.5
  • 22
    • 84898841862 scopus 로고    scopus 로고
    • The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts
    • Herrera-Moyano E, Mergui X, Garcia-Rubio ML, Barroso S, Aguilera A, The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts. Genes & development. 2014; 28: 735–48
    • (2014) Genes & development , vol.28 , pp. 735-748
    • Herrera-Moyano, E.1    Mergui, X.2    Garcia-Rubio, M.L.3    Barroso, S.4    Aguilera, A.5
  • 23
    • 84904459138 scopus 로고    scopus 로고
    • BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2
    • Bhatia V, Barroso SI, Garcia-Rubio ML, Tumini E, Herrera-Moyano E, Aguilera A, BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2. Nature. 2014; 511: 362–5 doi: 10.1038/nature13374 24896180
    • (2014) Nature , vol.511 , pp. 362-365
    • Bhatia, V.1    Barroso, S.I.2    Garcia-Rubio, M.L.3    Tumini, E.4    Herrera-Moyano, E.5    Aguilera, A.6
  • 24
    • 84923848772 scopus 로고    scopus 로고
    • BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair
    • Hatchi E, Skourti-Stathaki K, Ventz S, Pinello L, Yen A, Kamieniarz-Gdula K, et al. BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair. Molecular cell. 2015; 57: 636–47 doi: 10.1016/j.molcel.2015.01.011 25699710
    • (2015) Molecular cell , vol.57 , pp. 636-647
    • Hatchi, E.1    Skourti-Stathaki, K.2    Ventz, S.3    Pinello, L.4    Yen, A.5    Kamieniarz-Gdula, K.6
  • 27
    • 18444384217 scopus 로고    scopus 로고
    • FANCE: the link between Fanconi anaemia complex assembly and activity
    • Pace P, Johnson M, Tan WM, Mosedale G, Sng C, Hoatlin M, et al. FANCE: the link between Fanconi anaemia complex assembly and activity. EMBO J. 2002; 21: 3414–23 12093742
    • (2002) EMBO J , vol.21 , pp. 3414-3423
    • Pace, P.1    Johnson, M.2    Tan, W.M.3    Mosedale, G.4    Sng, C.5    Hoatlin, M.6
  • 30
    • 84887589423 scopus 로고    scopus 로고
    • Transcription-associated genome instability
    • Gaillard H, Herrera-Moyano E, Aguilera A, Transcription-associated genome instability. Chem Rev. 2013; 113: 8638–61 doi: 10.1021/cr400017y 23597121
    • (2013) Chem Rev , vol.113 , pp. 8638-8661
    • Gaillard, H.1    Herrera-Moyano, E.2    Aguilera, A.3
  • 31
    • 72249101547 scopus 로고    scopus 로고
    • FANCD2 hurdles the DNA interstrand crosslink
    • Moldovan GL, D'Andrea AD, FANCD2 hurdles the DNA interstrand crosslink. Cell. 2009; 139: 1222–4 doi: 10.1016/j.cell.2009.12.006 20064367
    • (2009) Cell , vol.139 , pp. 1222-1224
    • Moldovan, G.L.1    D'Andrea, A.D.2
  • 32
    • 84907148216 scopus 로고    scopus 로고
    • BRCA1 pathway function in basal-like breast cancer cells
    • Hill SJ, Clark AP, Silver DP, Livingston DM, BRCA1 pathway function in basal-like breast cancer cells. Mol Cell Biol. 2014; 34: 3828–42 doi: 10.1128/MCB.01646-13 25092866
    • (2014) Mol Cell Biol , vol.34 , pp. 3828-3842
    • Hill, S.J.1    Clark, A.P.2    Silver, D.P.3    Livingston, D.M.4
  • 33
    • 18544372595 scopus 로고    scopus 로고
    • BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure
    • Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, et al. BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science. 2002; 297: 1837–48 12228710
    • (2002) Science , vol.297 , pp. 1837-1848
    • Yang, H.1    Jeffrey, P.D.2    Miller, J.3    Kinnucan, E.4    Sun, Y.5    Thoma, N.H.6
  • 34
    • 0347991859 scopus 로고    scopus 로고
    • Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein
    • Lomonosov M, Anand S, Sangrithi M, Davies R, Venkitaraman AR, Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein. Genes & development. 2003; 17: 3017–22
    • (2003) Genes & development , vol.17 , pp. 3017-3022
    • Lomonosov, M.1    Anand, S.2    Sangrithi, M.3    Davies, R.4    Venkitaraman, A.R.5
  • 35
    • 79955799175 scopus 로고    scopus 로고
    • Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11
    • Schlacher K, Christ N, Siaud N, Egashira A, Wu H, Jasin M, Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell. 2011; 145: 529–42 doi: 10.1016/j.cell.2011.03.041 21565612
    • (2011) Cell , vol.145 , pp. 529-542
    • Schlacher, K.1    Christ, N.2    Siaud, N.3    Egashira, A.4    Wu, H.5    Jasin, M.6
  • 36
    • 84872578210 scopus 로고    scopus 로고
    • Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
    • Kottemann MC, Smogorzewska A, Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Nature. 2013; 493: 356–63 doi: 10.1038/nature11863 23325218
    • (2013) Nature , vol.493 , pp. 356-363
    • Kottemann, M.C.1    Smogorzewska, A.2
  • 37
    • 82955235602 scopus 로고    scopus 로고
    • Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway
    • Rosado IV, Langevin F, Crossan GP, Takata M, Patel KJ, Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway. Nat Struct Mol Biol. 2011; 18: 1432–4 doi: 10.1038/nsmb.2173 22081012
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 1432-1434
    • Rosado, I.V.1    Langevin, F.2    Crossan, G.P.3    Takata, M.4    Patel, K.J.5
  • 38
    • 84855286267 scopus 로고    scopus 로고
    • Genome instability and transcription elongation impairment in human cells depleted of THO/TREX
    • Dominguez-Sanchez MS, Barroso S, Gomez-Gonzalez B, Luna R, Aguilera A, Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. PLoS Genet. 2011; 7: e1002386 doi: 10.1371/journal.pgen.1002386 22144908
    • (2011) PLoS Genet , vol.7 , pp. 1002386
    • Dominguez-Sanchez, M.S.1    Barroso, S.2    Gomez-Gonzalez, B.3    Luna, R.4    Aguilera, A.5
  • 39
    • 0036164420 scopus 로고    scopus 로고
    • The involvement of human ribonucleases H1 and H2 in the variation of response of cells to antisense phosphorothioate oligonucleotides
    • ten Asbroek AL, van Groenigen M, Nooij M, Baas F, The involvement of human ribonucleases H1 and H2 in the variation of response of cells to antisense phosphorothioate oligonucleotides. European journal of biochemistry / FEBS. 2002; 269: 583–92 11856317
    • (2002) European journal of biochemistry / FEBS , vol.269 , pp. 583-592
    • ten Asbroek, A.L.1    van Groenigen, M.2    Nooij, M.3    Baas, F.4
  • 41
    • 4043133287 scopus 로고    scopus 로고
    • ATR couples FANCD2 monoubiquitination to the DNA-damage response
    • Andreassen PR, D'Andrea AD, Taniguchi T, ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes & development. 2004; 18: 1958–63
    • (2004) Genes & development , vol.18 , pp. 1958-1963
    • Andreassen, P.R.1    D'Andrea, A.D.2    Taniguchi, T.3
  • 43
    • 10744230465 scopus 로고    scopus 로고
    • Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock
    • Liu L, Yan Y, Zeng M, Zhang J, Hanes MA, Ahearn G, et al. Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell. 2004; 116: 617–28 14980227
    • (2004) Cell , vol.116 , pp. 617-628
    • Liu, L.1    Yan, Y.2    Zeng, M.3    Zhang, J.4    Hanes, M.A.5    Ahearn, G.6
  • 45
    • 84918791689 scopus 로고    scopus 로고
    • Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability
    • Sollier J, Stork CT, Garcia-Rubio ML, Paulsen RD, Aguilera A, Cimprich KA, Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability. Molecular cell. 2014; 56: 777–85 doi: 10.1016/j.molcel.2014.10.020 25435140
    • (2014) Molecular cell , vol.56 , pp. 777-785
    • Sollier, J.1    Stork, C.T.2    Garcia-Rubio, M.L.3    Paulsen, R.D.4    Aguilera, A.5    Cimprich, K.A.6


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