-
1
-
-
84856013431
-
Clonal evolution in cancer
-
Greaves, M. & Maley, C.C. Clonal evolution in cancer. Nature 481, 306-313 (2012).
-
(2012)
Nature
, vol.481
, pp. 306-313
-
-
Greaves, M.1
Maley, C.C.2
-
2
-
-
84938799837
-
Toward understanding and exploiting tumor heterogeneity
-
Alizadeh, A.A. et al. Toward understanding and exploiting tumor heterogeneity. Nat. Med. 21, 846-853 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 846-853
-
-
Alizadeh, A.A.1
-
3
-
-
84936890500
-
Subclonal diversification of primary breast cancer revealed by multiregion sequencing
-
Yates, L.R. et al. Subclonal diversification of primary breast cancer revealed by multiregion sequencing. Nat. Med. 21, 751-759 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 751-759
-
-
Yates, L.R.1
-
4
-
-
84895876130
-
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
-
Gerlinger, M. et al. Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing. Nat. Genet. 46, 225-233 (2014).
-
(2014)
Nat. Genet.
, vol.46
, pp. 225-233
-
-
Gerlinger, M.1
-
5
-
-
84907855592
-
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
-
de Bruin, E.C. et al. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science 346, 251-256 (2014).
-
(2014)
Science
, vol.346
, pp. 251-256
-
-
De Bruin, E.C.1
-
6
-
-
84907808265
-
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
-
Zhang, J. et al. Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing. Science 346, 256-259 (2014).
-
(2014)
Science
, vol.346
, pp. 256-259
-
-
Zhang, J.1
-
7
-
-
84928405167
-
The evolutionary history of lethal metastatic prostate cancer
-
Gundem, G. et al. The evolutionary history of lethal metastatic prostate cancer. Nature 520, 353-357 (2015).
-
(2015)
Nature
, vol.520
, pp. 353-357
-
-
Gundem, G.1
-
8
-
-
84926330368
-
Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer
-
Hong, M.K.H. et al. Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer. Nat. Commun. 6, 6605 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 6605
-
-
Hong, M.K.H.1
-
9
-
-
84959255550
-
Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer
-
Kumar, A. et al. Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer. Nat. Med. 22, 369-378 (2016).
-
(2016)
Nat. Med.
, vol.22
, pp. 369-378
-
-
Kumar, A.1
-
10
-
-
41949139438
-
Comparative lesion sequencing provides insights into tumor evolution
-
Jones, S. et al. Comparative lesion sequencing provides insights into tumor evolution. Proc. Natl. Acad. Sci. USA 105, 4283-4288 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 4283-4288
-
-
Jones, S.1
-
11
-
-
78049398107
-
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
-
Yachida, S. et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467, 1114-1117 (2010).
-
(2010)
Nature
, vol.467
, pp. 1114-1117
-
-
Yachida, S.1
-
12
-
-
78049380554
-
The patterns and dynamics of genomic instability in metastatic pancreatic cancer
-
Campbell, P.J. et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 467, 1109-1113 (2010).
-
(2010)
Nature
, vol.467
, pp. 1109-1113
-
-
Campbell, P.J.1
-
13
-
-
84940978439
-
Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination
-
Sanborn, J.Z. et al. Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination. Proc. Natl. Acad. Sci. USA 112, 10995-11000 (2015).
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 10995-11000
-
-
Sanborn, J.Z.1
-
14
-
-
79953766940
-
Tumour evolution inferred by single-cell sequencing
-
Navin, N. et al. Tumour evolution inferred by single-cell sequencing. Nature 472, 90-94 (2011).
-
(2011)
Nature
, vol.472
, pp. 90-94
-
-
Navin, N.1
-
15
-
-
84873441292
-
Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation
-
Tomasetti, C., Vogelstein, B. & Parmigiani, G. Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proc. Natl. Acad. Sci. USA 110, 1999-2004 (2013).
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 1999-2004
-
-
Tomasetti, C.1
Vogelstein, B.2
Parmigiani, G.3
-
16
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein, B. et al. Cancer genome landscapes. Science 339, 1546-1558 (2013).
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
-
17
-
-
84979255704
-
Pancreatic cancer biology and genetics from an evolutionary perspective
-
Makohon-Moore, A. & Iacobuzio-Donahue, C.A. Pancreatic cancer biology and genetics from an evolutionary perspective. Nat. Rev. Cancer 16, 553-565 (2016).
-
(2016)
Nat. Rev. Cancer
, vol.16
, pp. 553-565
-
-
Makohon-Moore, A.1
Iacobuzio-Donahue, C.A.2
-
18
-
-
84872971914
-
Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor
-
Barber, L.J. et al. Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor. J. Pathol. 229, 422-429 (2013).
-
(2013)
J. Pathol.
, vol.229
, pp. 422-429
-
-
Barber, L.J.1
-
19
-
-
84863000299
-
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
-
Diaz, L.A. Jr. et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486, 537-540 (2012).
-
(2012)
Nature
, vol.486
, pp. 537-540
-
-
Diaz, L.A.1
-
20
-
-
84862999938
-
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
-
Misale, S. et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 486, 532-536 (2012).
-
(2012)
Nature
, vol.486
, pp. 532-536
-
-
Misale, S.1
-
21
-
-
84924056345
-
Whole genomes redefine the mutational landscape of pancreatic cancer
-
Waddell, N. et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature 518, 495-501 (2015).
-
(2015)
Nature
, vol.518
, pp. 495-501
-
-
Waddell, N.1
-
22
-
-
84893671686
-
Genomic and transcriptomic plasticity in treatment-naive ovarian cancer
-
Hoogstraat, M. et al. Genomic and transcriptomic plasticity in treatment-naive ovarian cancer. Genome Res. 24, 200-211 (2014).
-
(2014)
Genome Res.
, vol.24
, pp. 200-211
-
-
Hoogstraat, M.1
-
23
-
-
84879288827
-
Target inference from collections of genomic intervals
-
Krasnitz, A., Sun, G., Andrews, P. & Wigler, M. Target inference from collections of genomic intervals. Proc. Natl. Acad. Sci. USA 110, E2271-E2278 (2013).
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. E2271-E2278
-
-
Krasnitz, A.1
Sun, G.2
Andrews, P.3
Wigler, M.4
-
24
-
-
84887992179
-
Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome
-
Davoli, T. et al. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell 155, 948-962 (2013).
-
(2013)
Cell
, vol.155
, pp. 948-962
-
-
Davoli, T.1
-
25
-
-
84954400636
-
Cancer statistics, 2016
-
Siegel, R.L., Miller, K.D. & Jemal, A. Cancer statistics, 2016. CA Cancer J. Clin. 66, 7-30 (2016).
-
(2016)
CA Cancer J. Clin.
, vol.66
, pp. 7-30
-
-
Siegel, R.L.1
Miller, K.D.2
Jemal, A.3
-
26
-
-
25144519682
-
Immortalizing the complexity of cancer metastasis: Genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy
-
Embuscado, E.E. et al. Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. Cancer Biol. Ther. 4, 548-554 (2005).
-
(2005)
Cancer Biol. Ther.
, vol.4
, pp. 548-554
-
-
Embuscado, E.E.1
-
27
-
-
84960194345
-
Genomic analyses identify molecular subtypes of pancreatic cancer
-
Bailey, P. et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature 531, 47-52 (2016).
-
(2016)
Nature
, vol.531
, pp. 47-52
-
-
Bailey, P.1
-
28
-
-
84957550528
-
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity
-
Chang, M.T. et al. Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. Nat. Biotechnol. 34, 155-163 (2016).
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 155-163
-
-
Chang, M.T.1
-
29
-
-
84874732372
-
CRAVAT: Cancer-related analysis of variants toolkit
-
Douville, C. et al. CRAVAT: cancer-related analysis of variants toolkit. Bioinformatics 29, 647-648 (2013).
-
(2013)
Bioinformatics
, vol.29
, pp. 647-648
-
-
Douville, C.1
-
30
-
-
84865076498
-
Genetic basis of pancreas cancer development and progression: Insights from whole-exome and whole-genome sequencing
-
Iacobuzio-Donahue, C.A., Velculescu, V.E., Wolfgang, C.L. & Hruban, R.H. Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing. Clin. Cancer Res. 18, 4257-4265 (2012).
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 4257-4265
-
-
Iacobuzio-Donahue, C.A.1
Velculescu, V.E.2
Wolfgang, C.L.3
Hruban, R.H.4
-
31
-
-
84992701765
-
Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review
-
Borazanci, E. et al. Adenosquamous carcinoma of the pancreas: molecular characterization of 23 patients along with a literature review. World J. Gastrointest. Oncol. 7, 132-140 (2015).
-
(2015)
World J. Gastrointest. Oncol.
, vol.7
, pp. 132-140
-
-
Borazanci, E.1
-
32
-
-
79959353421
-
Detection and quantification of rare mutations with massively parallel sequencing
-
Kinde, I., Wu, J., Papadopoulos, N., Kinzler, K.W. & Vogelstein, B. Detection and quantification of rare mutations with massively parallel sequencing. Proc. Natl. Acad. Sci. USA 108, 9530-9535 (2011).
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 9530-9535
-
-
Kinde, I.1
Wu, J.2
Papadopoulos, N.3
Kinzler, K.W.4
Vogelstein, B.5
-
33
-
-
62249108705
-
The pathology and genetics of metastatic pancreatic cancer
-
Yachida, S. & Iacobuzio-Donahue, C.A. The pathology and genetics of metastatic pancreatic cancer. Arch. Pathol. Lab. Med. 133, 413-422 (2009).
-
(2009)
Arch. Pathol. Lab. Med.
, vol.133
, pp. 413-422
-
-
Yachida, S.1
Iacobuzio-Donahue, C.A.2
-
34
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive, K.P. et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324, 1457-1461 (2009).
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
-
35
-
-
51349126920
-
Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing
-
Campbell, P.J. et al. Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing. Proc. Natl. Acad. Sci. USA 105, 13081-13086 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 13081-13086
-
-
Campbell, P.J.1
-
36
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones, S. et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321, 1801-1806 (2008).
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
-
37
-
-
84869091997
-
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
-
Biankin, A.V. et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 491, 399-405 (2012).
-
(2012)
Nature
, vol.491
, pp. 399-405
-
-
Biankin, A.V.1
-
38
-
-
16944367477
-
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
-
Schutte, M. et al. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res. 57, 3126-3130 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 3126-3130
-
-
Schutte, M.1
-
39
-
-
72949103929
-
A census of amplified and overexpressed human cancer genes
-
Santarius, T., Shipley, J., Brewer, D., Stratton, M.R. & Cooper, C.S. A census of amplified and overexpressed human cancer genes. Nat. Rev. Cancer 10, 59-64 (2010).
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 59-64
-
-
Santarius, T.1
Shipley, J.2
Brewer, D.3
Stratton, M.R.4
Cooper, C.S.5
-
40
-
-
33645396945
-
Genetic clonal diversity predicts progression to esophageal adenocarcinoma
-
Maley, C.C. et al. Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nat. Genet. 38, 468-473 (2006).
-
(2006)
Nat. Genet.
, vol.38
, pp. 468-473
-
-
Maley, C.C.1
-
41
-
-
84952638290
-
Somatic mosaicism: On the road to cancer
-
Fernández, L.C., Torres, M. & Real, F.X. Somatic mosaicism: on the road to cancer. Nat. Rev. Cancer 16, 43-55 (2016).
-
(2016)
Nat. Rev. Cancer
, vol.16
, pp. 43-55
-
-
Fernández, L.C.1
Torres, M.2
Real, F.X.3
-
42
-
-
84991669713
-
Tissue-specific mutation accumulation in human adult stem cells during life
-
Blokzijl, F. et al. Tissue-specific mutation accumulation in human adult stem cells during life. Nature 538, 260-264 (2016).
-
(2016)
Nature
, vol.538
, pp. 260-264
-
-
Blokzijl, F.1
-
43
-
-
85011690566
-
Reconstructing metastatic seeding patterns of human cancers
-
Reiter, J.G. et al. Reconstructing metastatic seeding patterns of human cancers. Nat. Commun. http://dx.doi.org/10.1038/ncomms14114 (2017).
-
(2017)
Nat. Commun.
-
-
Reiter, J.G.1
-
44
-
-
84923952286
-
A Big Bang model of human colorectal tumor growth
-
Sottoriva, A. et al. A Big Bang model of human colorectal tumor growth. Nat. Genet. 47, 209-216 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 209-216
-
-
Sottoriva, A.1
-
45
-
-
84941201227
-
A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity
-
Waclaw, B. et al. A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity. Nature 525, 261-264 (2015).
-
(2015)
Nature
, vol.525
, pp. 261-264
-
-
Waclaw, B.1
-
46
-
-
84943327727
-
Pancreatic cancer metastases harbor evidence of polyclonality
-
Maddipati, R. & Stanger, B.Z. Pancreatic cancer metastases harbor evidence of polyclonality. Cancer Discov. 5, 1086-1097 (2015).
-
(2015)
Cancer Discov.
, vol.5
, pp. 1086-1097
-
-
Maddipati, R.1
Stanger, B.Z.2
-
47
-
-
84976286781
-
The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis
-
Gibson, W.J. et al. The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis. Nat. Genet. 48, 848-855 (2016).
-
(2016)
Nat. Genet.
, vol.48
, pp. 848-855
-
-
Gibson, W.J.1
-
48
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger, M. et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J. Med. 366, 883-892 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
-
49
-
-
33847065486
-
The epigenomics of cancer
-
Jones, P.A. & Baylin, S.B. The epigenomics of cancer. Cell 128, 683-692 (2007).
-
(2007)
Cell
, vol.128
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
50
-
-
84959524739
-
Identification of neutral tumor evolution across cancer types
-
Williams, M.J., Werner, B., Barnes, C.P., Graham, T.A. & Sottoriva, A. Identification of neutral tumor evolution across cancer types. Nat. Genet. 48, 238-244 (2016).
-
(2016)
Nat. Genet.
, vol.48
, pp. 238-244
-
-
Williams, M.J.1
Werner, B.2
Barnes, C.P.3
Graham, T.A.4
Sottoriva, A.5
-
51
-
-
84959564974
-
Quantifying clonal and subclonal passenger mutations in cancer evolution
-
Bozic, I., Gerold, J.M. & Nowak, M.A. Quantifying clonal and subclonal passenger mutations in cancer evolution. PLoS Comput. Biol. 12, e1004731 (2016).
-
(2016)
PLoS Comput. Biol.
, vol.12
, pp. e1004731
-
-
Bozic, I.1
Gerold, J.M.2
Nowak, M.A.3
-
52
-
-
84927144113
-
Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
-
Witkiewicz, A.K. et al. Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets. Nat. Commun. 6, 6744 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 6744
-
-
Witkiewicz, A.K.1
-
53
-
-
84888353882
-
Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas
-
Jiao, Y. et al. Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. Nat. Genet. 45, 1470-1473 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 1470-1473
-
-
Jiao, Y.1
-
54
-
-
85013781400
-
Controlling the false discovery rate: A practical and powerful approach to multiple testing
-
Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J.R. Stat. Soc. 57, 289-300 (1995).
-
(1995)
J.R. Stat. Soc.
, vol.57
, pp. 289-300
-
-
Benjamini, Y.1
Hochberg, Y.2
-
55
-
-
84887425908
-
Inference of tumor phylogenies with improved somatic mutation discovery
-
Salari, R. et al. Inference of tumor phylogenies with improved somatic mutation discovery. J. Comput. Biol. 20, 933-944 (2013).
-
(2013)
J. Comput. Biol.
, vol.20
, pp. 933-944
-
-
Salari, R.1
-
56
-
-
84931036281
-
Reconstruction of clonal trees and tumor composition from multi-sample sequencing data
-
El-Kebir, M., Oesper, L., Acheson-Field, H. & Raphael, B.J. Reconstruction of clonal trees and tumor composition from multi-sample sequencing data. Bioinformatics 31, i62-i70 (2015).
-
(2015)
Bioinformatics
, vol.31
, pp. i62-i70
-
-
El-Kebir, M.1
Oesper, L.2
Acheson-Field, H.3
Raphael, B.J.4
-
57
-
-
84937046175
-
Fast and scalable inference of multi-sample cancer lineages
-
Popic, V. et al. Fast and scalable inference of multi-sample cancer lineages. Genome Biol. 16, 91 (2015).
-
(2015)
Genome Biol.
, vol.16
, pp. 91
-
-
Popic, V.1
-
58
-
-
84856561659
-
Control-FREEC: A tool for assessing copy number and allelic content using next-generation sequencing data
-
Boeva, V. et al. Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data. Bioinformatics 28, 423-425 (2012).
-
(2012)
Bioinformatics
, vol.28
, pp. 423-425
-
-
Boeva, V.1
-
59
-
-
69649109364
-
Circos: An information aesthetic for comparative genomics
-
Krzywinski, M. et al. Circos: an information aesthetic for comparative genomics. Genome Res. 19, 1639-1645 (2009).
-
(2009)
Genome Res.
, vol.19
, pp. 1639-1645
-
-
Krzywinski, M.1
-
60
-
-
84933036123
-
The European Genome-phenome Archive of human data consented for biomedical research
-
Lappalainen, I. et al. The European Genome-phenome Archive of human data consented for biomedical research. Nat. Genet. 47, 692-695 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 692-695
-
-
Lappalainen, I.1
|