A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity

Nature

Volumn 525, Issue 7568, 2015, Pages 261-264

  Waclaw, Bartlomiej ^a   Bozic, Ivana ^b,c   Pittman, Meredith E ^d   Hruban, Ralph H ^d   Vogelstein, Bert ^d,e   Nowak, Martin A ^b,c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b HARVARD UNIVERSITY   (United States)

^c HARVARD UNIVERSITY   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UVOMORULIN;

CANCER; CELLS AND CELL COMPONENTS; CHEMOTHERAPY; DISEASE RESISTANCE; GENETIC VARIATION; GROWTH RATE; HETEROGENEITY; MUTATION; SPATIAL ANALYSIS; THREE-DIMENSIONAL MODELING; TUMOR;

ARTICLE; CANCER CELL; CANCER RESISTANCE; CARCINOGENESIS; CELL DEATH; CELL EXPANSION; CELL FUNCTION; CELL HETEROGENEITY; CELL MIGRATION; CELL TURNOVER; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; GENE MUTATION; HISTOPATHOLOGY; HUMAN; LIVER CELL CARCINOMA; METASTASIS; PRIMARY TUMOR; PRIORITY JOURNAL; STATISTICS; TUMOR GROWTH; TUMOR VOLUME; BIOLOGICAL MODEL; CELL DIVISION; CELL MOTION; DRUG RESISTANCE; GENETIC SELECTION; GENETIC VARIABILITY; GENETICS; METABOLISM; MOLECULAR EVOLUTION; MUTATION; NEOPLASM; PATHOLOGY; TIME;

CELL DIVISION; CELL MOVEMENT; DRUG RESISTANCE, NEOPLASM; EVOLUTION, MOLECULAR; GENETIC VARIATION; HUMANS; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; SELECTION, GENETIC; TIME FACTORS;

EID: 84941201227     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14971     Document Type: Article

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