-
1
-
-
79951497419
-
The genomic complexity of primary human prostate cancer
-
Berger, M. F. et al. The genomic complexity of primary human prostate cancer. Nature 470, 214-220 (2011).
-
(2011)
Nature
, vol.470
, pp. 214-220
-
-
Berger, M.F.1
-
2
-
-
77954255681
-
Integrative genomic profiling of human prostate cancer
-
Taylor, B. S. et al. Integrative genomic profiling of human prostate cancer. Cancer Cell 18, 11-22 (2010).
-
(2010)
Cancer Cell
, vol.18
, pp. 11-22
-
-
Taylor, B.S.1
-
3
-
-
84861581164
-
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
-
Barbieri, C. E. et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat. Genet. 44, 685-689 (2012).
-
(2012)
Nat. Genet.
, vol.44
, pp. 685-689
-
-
Barbieri, C.E.1
-
4
-
-
84873607610
-
Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer
-
Weischenfeldt, J. et al. Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell 23, 159-170 (2013).
-
(2013)
Cancer Cell
, vol.23
, pp. 159-170
-
-
Weischenfeldt, J.1
-
5
-
-
80054751998
-
Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers
-
Kumar, A. et al. Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers. Proc. Natl Acad. Sci. USA 108, 17087-17092 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 17087-17092
-
-
Kumar, A.1
-
6
-
-
84863723010
-
The mutational landscape of lethal castration-resistant prostate cancer
-
Grasso, C. S. et al. The mutational landscape of lethal castration-resistant prostate cancer. Nature 487, 239-243 (2012).
-
(2012)
Nature
, vol.487
, pp. 239-243
-
-
Grasso, C.S.1
-
7
-
-
84875757638
-
Punctuated evolution of prostate cancer genomes
-
Baca, S. C. et al. Punctuated evolution of prostate cancer genomes. Cell 153, 666-677 (2013).
-
(2013)
Cell
, vol.153
, pp. 666-677
-
-
Baca, S.C.1
-
8
-
-
78049398107
-
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
-
Yachida, S. et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467, 1114-1117 (2010).
-
(2010)
Nature
, vol.467
, pp. 1114-1117
-
-
Yachida, S.1
-
9
-
-
78049380554
-
The patterns and dynamics of genomic instability in metastatic pancreatic cancer
-
Campbell, P. J. et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 467, 1109-1113 (2010).
-
(2010)
Nature
, vol.467
, pp. 1109-1113
-
-
Campbell, P.J.1
-
10
-
-
84907855592
-
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
-
de Bruin, E. C. et al. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science 346, 251-256 (2014).
-
(2014)
Science
, vol.346
, pp. 251-256
-
-
De Bruin, E.C.1
-
11
-
-
84907808265
-
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
-
Zhang, J. et al. Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing. Science 346, 256-259 (2014).
-
(2014)
Science
, vol.346
, pp. 256-259
-
-
Zhang, J.1
-
12
-
-
84861550476
-
The life history of 21 breast cancers
-
Nik-Zainal, S. et al. The life history of 21 breast cancers. Cell 149, 994-1007 (2012).
-
(2012)
Cell
, vol.149
, pp. 994-1007
-
-
Nik-Zainal, S.1
-
13
-
-
29144490086
-
Prognostic impact of positive surgical margins in surgically treated prostate cancer: Multi-institutional assessment of 5831 patients
-
Karakiewicz, P. I. et al. Prognostic impact of positive surgical margins in surgically treated prostate cancer: multi-institutional assessment of 5831 patients. Urology 66, 1245-1250 (2005).
-
(2005)
Urology
, vol.66
, pp. 1245-1250
-
-
Karakiewicz, P.I.1
-
14
-
-
33746671852
-
The Syk tyrosine kinase: A new negative regulator in tumor growth and progression
-
Coopman, P. J. & Mueller, S. C. The Syk tyrosine kinase: a new negative regulator in tumor growth and progression. Cancer Lett. 241, 159-173 (2006).
-
(2006)
Cancer Lett.
, vol.241
, pp. 159-173
-
-
Coopman, P.J.1
Mueller, S.C.2
-
15
-
-
79961109914
-
Research on the reactivation of Syk expression caused by the inhibition of DNA promoter methylation in the lung cancer
-
Dong, S. W. et al. Research on the reactivation of Syk expression caused by the inhibition of DNA promoter methylation in the lung cancer. Neoplasma 58, 89-95 (2011).
-
(2011)
Neoplasma
, vol.58
, pp. 89-95
-
-
Dong, S.W.1
-
16
-
-
64249153223
-
Spleen tyrosine kinase as a novel candidate tumor suppressor gene for human oral squamous cell carcinoma
-
Ogane, S. et al. Spleen tyrosine kinase as a novel candidate tumor suppressor gene for human oral squamous cell carcinoma. Int. J. Cancer 124, 2651-2657 (2009).
-
(2009)
Int. J. Cancer
, vol.124
, pp. 2651-2657
-
-
Ogane, S.1
-
17
-
-
84898056728
-
Recurrent PTPRB and PLCG1 mutations in angiosarcoma
-
Behjati, S. et al. Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Nat. Genet. 46, 376-379 (2014).
-
(2014)
Nat. Genet.
, vol.46
, pp. 376-379
-
-
Behjati, S.1
-
18
-
-
84891102589
-
Mutational signatures: The patterns of somatic mutations hidden in cancer genomes
-
Alexandrov, L. B. & Stratton, M. R. Mutational signatures: the patterns of somatic mutations hidden in cancer genomes. Curr. Opin. Genet. Dev. 24, 52-60 (2014).
-
(2014)
Curr. Opin. Genet. Dev.
, vol.24
, pp. 52-60
-
-
Alexandrov, L.B.1
Stratton, M.R.2
-
19
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415-421 (2013).
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
-
20
-
-
84861541343
-
Mutational processes molding the genomes of 21 breast cancers
-
Nik-Zainal, S. et al. Mutational processes molding the genomes of 21 breast cancers. Cell 149, 979-993 (2012).
-
(2012)
Cell
, vol.149
, pp. 979-993
-
-
Nik-Zainal, S.1
-
21
-
-
84888869068
-
Chromothripsis and beyond: Rapid genome evolution from complex chromosomal rearrangements
-
Zhang, C. Z., Leibowitz, M. L. & Pellman, D. Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements. Genes Dev. 27, 2513-2530 (2013).
-
(2013)
Genes Dev.
, vol.27
, pp. 2513-2530
-
-
Zhang, C.Z.1
Leibowitz, M.L.2
Pellman, D.3
-
22
-
-
84877824262
-
Chromoplexy: A new category of complex rearrangements in the cancer genome
-
Shen, M. M. Chromoplexy: a new category of complex rearrangements in the cancer genome. Cancer Cell 23, 567-569 (2013).
-
(2013)
Cancer Cell
, vol.23
, pp. 567-569
-
-
Shen, M.M.1
-
23
-
-
84877769352
-
Germline and somatic polymerase epsilon and delta mutations define a new class of hypermutated colorectal and endometrial cancers
-
Briggs, S. & Tomlinson, I. Germline and somatic polymerase epsilon and delta mutations define a new class of hypermutated colorectal and endometrial cancers. J. Pathol. 230, 148-153 (2013).
-
(2013)
J. Pathol.
, vol.230
, pp. 148-153
-
-
Briggs, S.1
Tomlinson, I.2
-
24
-
-
84873096362
-
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
-
Palles, C. et al. Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nat. Genet. 45, 136-144 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 136-144
-
-
Palles, C.1
-
25
-
-
84923354398
-
Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer
-
Pritchard, C. C. et al. Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer. Nat. Commun. 5, 4988 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 4988
-
-
Pritchard, C.C.1
-
26
-
-
84906833420
-
Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA
-
Forshew, T. et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci. Transl. Med. 4, 136ra168 (2012).
-
(2012)
Sci. Transl. Med.
, vol.4
, pp. 136ra168
-
-
Forshew, T.1
-
27
-
-
84907285681
-
Tumor clone dynamics in lethal prostate cancer
-
Carreira, S. et al. Tumor clone dynamics in lethal prostate cancer. Sci. Transl. Med. 6, 254ra125 (2014).
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 254ra125
-
-
Carreira, S.1
-
28
-
-
13644260907
-
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
-
Lang, G. A. et al. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 119, 861-872 (2004).
-
(2004)
Cell
, vol.119
, pp. 861-872
-
-
Lang, G.A.1
-
29
-
-
10944236962
-
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
-
Olive, K. P. et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119, 847-860 (2004).
-
(2004)
Cell
, vol.119
, pp. 847-860
-
-
Olive, K.P.1
-
30
-
-
0023925894
-
P53 expression in breast cancer
-
Cattoretti, G., Rilke, F., Andreola, S., D'Amato, L. & Delia, D. P53 expression in breast cancer. Int. J. Cancer 41, 178-183 (1988).
-
(1988)
Int. J. Cancer
, vol.41
, pp. 178-183
-
-
Cattoretti, G.1
Rilke, F.2
Andreola, S.3
D'Amato, L.4
Delia, D.5
-
31
-
-
84901054744
-
TP53 mutations in human cancer: Database reassessment and prospects for the next decade
-
Leroy, B., Anderson, M. & Soussi, T. TP53 mutations in human cancer: database reassessment and prospects for the next decade. Hum. Mutat. 35, 672-688 (2014).
-
(2014)
Hum. Mutat.
, vol.35
, pp. 672-688
-
-
Leroy, B.1
Anderson, M.2
Soussi, T.3
-
32
-
-
84890798275
-
The prostate cancer genome: Perspectives and potential
-
Barbieri, C. E. & Tomlins, S. A. The prostate cancer genome: perspectives and potential. Urol. Oncol. 32, 53 e15-e22 (2014).
-
(2014)
Urol. Oncol.
, vol.32
, Issue.53
, pp. e15-e22
-
-
Barbieri, C.E.1
Tomlins, S.A.2
-
33
-
-
84883823918
-
The mutational landscape of prostate cancer
-
Barbieri, C. E. et al. The mutational landscape of prostate cancer. Eur. Urol. 64, 567-576 (2013).
-
(2013)
Eur. Urol.
, vol.64
, pp. 567-576
-
-
Barbieri, C.E.1
-
34
-
-
84881236533
-
Genomic profiling defines subtypes of prostate cancer with the potential for therapeutic stratification
-
Schoenborn, J. R., Nelson, P. & Fang, M. Genomic profiling defines subtypes of prostate cancer with the potential for therapeutic stratification. Clin. Cancer Res. 19, 4058-4066 (2013).
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 4058-4066
-
-
Schoenborn, J.R.1
Nelson, P.2
Fang, M.3
-
35
-
-
84869024543
-
The complexity of prostate cancer: Genomic alterations and heterogeneity
-
Boyd, L. K., Mao, X. & Lu, Y. J. The complexity of prostate cancer: genomic alterations and heterogeneity. Nat. Rev. Urol. 9, 652-664 (2012).
-
(2012)
Nat. Rev. Urol.
, vol.9
, pp. 652-664
-
-
Boyd, L.K.1
Mao, X.2
Lu, Y.J.3
-
36
-
-
84875223342
-
PTEN losses exhibit heterogeneity in multifocal prostatic adenocarcinoma and are associated with higher Gleason grade
-
Yoshimoto, M. et al. PTEN losses exhibit heterogeneity in multifocal prostatic adenocarcinoma and are associated with higher Gleason grade. Mod. Pathol. 26, 435-447 (2013).
-
(2013)
Mod. Pathol.
, vol.26
, pp. 435-447
-
-
Yoshimoto, M.1
-
37
-
-
84904167564
-
Regional biases in mutation screening due to intratumoral heterogeneity of prostate cancer
-
Kim, T. M. et al. Regional biases in mutation screening due to intratumoral heterogeneity of prostate cancer. J. Pathol. 233, 425-435 (2014).
-
(2014)
J. Pathol.
, vol.233
, pp. 425-435
-
-
Kim, T.M.1
-
38
-
-
84893243626
-
Percutaneous image-guided biopsy of prostate cancer metastases yields samples suitable for genomics and personalised oncology
-
Hong, M. K. et al. Percutaneous image-guided biopsy of prostate cancer metastases yields samples suitable for genomics and personalised oncology. Clin. Exp. Metastasis 31, 159-167 (2014).
-
(2014)
Clin. Exp. Metastasis
, vol.31
, pp. 159-167
-
-
Hong, M.K.1
-
39
-
-
84856565531
-
SomaticSniper: Identification of somatic point mutations in whole genome sequencing data
-
Larson, D. E. et al. SomaticSniper: identification of somatic point mutations in whole genome sequencing data. Bioinformatics 28, 311-317 (2012).
-
(2012)
Bioinformatics
, vol.28
, pp. 311-317
-
-
Larson, D.E.1
-
40
-
-
84891804649
-
Database resources of the National Center for Biotechnology Information
-
NCBI Resource Coordinators. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 42, D7-D17 (2014).
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. D7-D17
-
-
NCBI Resource Coordinators1
-
41
-
-
74949138753
-
Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays
-
Drmanac, R. et al. Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays. Science 327, 78-81 (2010).
-
(2010)
Science
, vol.327
, pp. 78-81
-
-
Drmanac, R.1
-
42
-
-
84898847797
-
Socrates: Identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads
-
Schroder, J. et al. Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads. Bioinformatics 30, 1064-1072 (2014).
-
(2014)
Bioinformatics
, vol.30
, pp. 1064-1072
-
-
Schroder, J.1
-
43
-
-
78049248432
-
Allele-specific copy number analysis of tumors
-
Van Loo, P. et al. Allele-specific copy number analysis of tumors. Proc. Natl Acad. Sci. USA 107, 16910-16915 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 16910-16915
-
-
Van Loo, P.1
-
44
-
-
67651222400
-
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
-
Howie, B. N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009).
-
(2009)
PLoS Genet.
, vol.5
, pp. e1000529
-
-
Howie, B.N.1
Donnelly, P.2
Marchini, J.3
-
45
-
-
84860373866
-
The 1000 Genomes Project: Data management and community access
-
Clarke, L. et al. The 1000 Genomes Project: data management and community access. Nat. Methods 9, 459-462 (2012).
-
(2012)
Nat. Methods
, vol.9
, pp. 459-462
-
-
Clarke, L.1
-
46
-
-
67649884743
-
Fast and accurate short read alignment with Burrows-Wheeler transform
-
Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754-1760 (2009).
-
(2009)
Bioinformatics
, vol.25
, pp. 1754-1760
-
-
Li, H.1
Durbin, R.2
-
47
-
-
84864483625
-
RobiNA: A user-friendly, integrated software solution for RNA-Seq-based transcriptomics
-
Lohse, M. et al. RobiNA: a user-friendly, integrated software solution for RNA-Seq-based transcriptomics. Nucleic Acids Res. 40, W622-W627 (2012).
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. W622-W627
-
-
Lohse, M.1
-
48
-
-
84876996918
-
TopHat2: Accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
-
Kim, D. et al. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 14, R36 (2013).
-
(2013)
Genome Biol.
, vol.14
, pp. R36
-
-
Kim, D.1
-
49
-
-
62349130698
-
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
-
Langmead, B., Trapnell, C., Pop, M. & Salzberg, S. L. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 10, R25 (2009).
-
(2009)
Genome Biol.
, vol.10
, pp. R25
-
-
Langmead, B.1
Trapnell, C.2
Pop, M.3
Salzberg, S.L.4
-
50
-
-
84873186179
-
Deciphering signatures of mutational processes operative in human cancer
-
Alexandrov, L. B., Nik-Zainal, S., Wedge, D. C., Campbell, P. J. & Stratton, M. R. Deciphering signatures of mutational processes operative in human cancer. Cell Rep. 3, 246-259 (2013).
-
(2013)
Cell Rep.
, vol.3
, pp. 246-259
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
Campbell, P.J.4
Stratton, M.R.5
-
51
-
-
84892699941
-
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma
-
Bolli, N. et al. Heterogeneity of genomic evolution and mutational profiles in multiple myeloma. Nat. Commun. 5, 2997 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 2997
-
-
Bolli, N.1
-
52
-
-
1542515338
-
A census of human cancer genes
-
Futreal, P. A. et al. A census of human cancer genes. Nat. Rev. Cancer 4, 177-183 (2004).
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 177-183
-
-
Futreal, P.A.1
-
53
-
-
84885129618
-
Comprehensive identification of mutational cancer driver genes across 12 tumor types
-
Tamborero, D. et al. Comprehensive identification of mutational cancer driver genes across 12 tumor types. Sci. Rep. 3, 2650 (2013).
-
(2013)
Sci. Rep.
, vol.3
, pp. 2650
-
-
Tamborero, D.1
-
54
-
-
77956534324
-
ANNOVAR: Functional annotation of genetic variants from high-throughput sequencing data
-
Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164 (2010).
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. e164
-
-
Wang, K.1
Li, M.2
Hakonarson, H.3
|