-
1
-
-
84933278862
-
Clinical management of breast cancer heterogeneity
-
Zardavas, D. et al. Clinical management of breast cancer heterogeneity. Nat. Rev. Clin. Oncol. 12, 381-394 (2015).
-
(2015)
Nat. Rev. Clin. Oncol
, vol.12
, pp. 381-394
-
-
Zardavas, D.1
-
2
-
-
84860214990
-
Intra-tumour heterogeneity: A looking glass for cancer?
-
Marusyk, A. et al. Intra-tumour heterogeneity: a looking glass for cancer? Nat. Rev. Cancer 12, 323-334 (2012).
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 323-334
-
-
Marusyk, A.1
-
3
-
-
84964240053
-
Biological and therapeutic impact of intratumor heterogeneity in cancer evolution
-
McGranahan, N. &Charles Swanton, C. Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. Cancer Cell 27, 15-26 (2015).
-
(2015)
Cancer Cell
, vol.27
, pp. 15-26
-
-
McGranahan, N.1
Charles Swanton, C.2
-
4
-
-
84915815121
-
Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks
-
Chen, J.C. et al. Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks. Cell 159, 402-414 (2014).
-
(2014)
Cell
, vol.159
, pp. 402-414
-
-
Chen, J.C.1
-
5
-
-
84929172879
-
Translational value of mouse models in oncology drug development
-
Gould, S.E., Junttila, M.R. &de Sauvage, F.J. Translational value of mouse models in oncology drug development. Nat. Med. 21, 431-439 (2015).
-
(2015)
Nat. Med
, vol.21
, pp. 431-439
-
-
Gould, S.E.1
Junttila, M.R.2
De Sauvage, F.J.3
-
6
-
-
84929173375
-
Dynamic evolution of clonal epialleles revealed by methclone
-
Li, S. et al. Dynamic evolution of clonal epialleles revealed by methclone. Genome Biol. 15, 472 (2014).
-
(2014)
Genome Biol
, vol.15
, pp. 472
-
-
Li, S.1
-
7
-
-
84909594308
-
Cisplatin-induced antitumor immunomodulation: A review of preclinical and clinical evidence
-
de Biasi, A.R., Villena-Vargas, J. &Adusumilli, P.S. Cisplatin-induced antitumor immunomodulation: a review of preclinical and clinical evidence. Clin. Cancer Res. 20, 5384-5391 (2014).
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 5384-5391
-
-
De Biasi, A.R.1
Villena-Vargas, J.2
Adusumilli, P.S.3
-
8
-
-
84857815877
-
Immunologic correlates of the abscopal effect in a patient with melanoma
-
Postow, M.A. et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N. Engl. J. Med. 366, 925-931 (2012).
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 925-931
-
-
Postow, M.A.1
-
9
-
-
84926525215
-
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
-
Twyman-Saint Victor, C. et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 520, 373-377 (2015).
-
(2015)
Nature
, vol.520
, pp. 373-377
-
-
Twyman-Saint Victor, C.1
-
10
-
-
84897476768
-
Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy
-
Zamarin, D. et al. Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy. Sci. Transl. Med. 6, 26ra32 (2014).
-
(2014)
Sci. Transl. Med
, vol.6
, pp. 26ra32
-
-
Zamarin, D.1
-
11
-
-
84933586864
-
Talimogene laherparepvec improves durable response rate in patients with advanced melanoma
-
26 May 2015
-
Andtbacka, R.H.I. et al. Talimogene laherparepvec improves durable response rate in patients with advanced melanoma. J. Clin. Oncol. doi:10.1200/JCO.2014.58.3377 (26 May 2015).
-
J. Clin. Oncol
-
-
Andtbacka, R.H.I.1
-
12
-
-
84925275401
-
Cancer Core Europe: A consortium to address the cancer care-cancer research
-
continuum challenge
-
Eggermont, A.M. et al. Cancer Core Europe: a consortium to address the cancer care-cancer research continuum challenge. Eur. J. Cancer 50, 2745-2746 (2014).
-
(2014)
Eur. J. Cancer
, vol.50
, pp. 2745-2746
-
-
Eggermont, A.M.1
-
13
-
-
84924338899
-
A community computational challenge to predict the activity of pairs of compounds
-
Bansal, M. et al. A community computational challenge to predict the activity of pairs of compounds. Nat. Biotechnol. 32, 1213-1222 (2014).
-
(2014)
Nat. Biotechnol
, vol.32
, pp. 1213-1222
-
-
Bansal, M.1
-
14
-
-
84936748494
-
Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
-
1 June 2015
-
Siravegna, G. et al. Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients. Nat. Med. doi:10.1038/nm.3870 (1 June 2015).
-
Nat. Med
-
-
Siravegna, G.1
-
15
-
-
84930755018
-
Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M
-
Thress, K.S. et al. Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M. Nat. Med. 21, 560-562 (2015).
-
(2015)
Nat. Med
, vol.21
, pp. 560-562
-
-
Thress, K.S.1
-
16
-
-
84903218109
-
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
-
Newman, A.M. et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat. Med. 20, 548-554 (2014).
-
(2014)
Nat. Med
, vol.20
, pp. 548-554
-
-
Newman, A.M.1
-
17
-
-
84875520648
-
Analysis of circulating tumor DNA to monitor metastatic breast cancer
-
Dawson, S.J. et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. N. Engl. J. Med. 368, 1199-1209 (2013).
-
(2013)
N. Engl. J. Med
, vol.368
, pp. 1199-1209
-
-
Dawson, S.J.1
-
18
-
-
84891865864
-
Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose
-
Rodrigues, T.B. et al. Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose. Nat. Med. 20, 93-97 (2014).
-
(2014)
Nat. Med
, vol.20
, pp. 93-97
-
-
Rodrigues, T.B.1
-
19
-
-
84928927858
-
Robust enumeration of cell subsets from tissue expression profiles
-
Newman, A.M. et al. Robust enumeration of cell subsets from tissue expression profiles. Nat. Methods 12, 453-457 (2015).
-
(2015)
Nat. Methods
, vol.12
, pp. 453-457
-
-
Newman, A.M.1
-
20
-
-
84938984463
-
The prognostic landscape of genes and infiltrating immune cells across human cancers
-
Gentles, A.J. et al. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat. Med. 21, 940-947 (2015).
-
(2015)
Nat. Med
, vol.21
, pp. 940-947
-
-
Gentles, A.J.1
-
22
-
-
84929684999
-
Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
-
Macosko, E.Z. et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202-1214 (2015).
-
(2015)
Cell
, vol.161
, pp. 1202-1214
-
-
Macosko, E.Z.1
-
23
-
-
84929684998
-
Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells
-
Klein, A.M. et al. Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell 161, 1187-1201 (2015).
-
(2015)
Cell
, vol.161
, pp. 1187-1201
-
-
Klein, A.M.1
-
24
-
-
84922311090
-
Expression profiling. Combinatorial labeling of single cells for gene expression cytometry
-
Fan, H.C., Fu, G.K. &Fodor, S.P. Expression profiling. Combinatorial labeling of single cells for gene expression cytometry. Science 347, 910-914 (2015).
-
(2015)
Science
, vol.347
, pp. 910-914
-
-
Fan, H.C.1
Fu, G.K.2
Fodor, S.P.3
-
25
-
-
84877318097
-
Single-molecule analysis of combinatorial epigenomic states in normal and tumor cells
-
Murphy, P.J. et al. Single-molecule analysis of combinatorial epigenomic states in normal and tumor cells. Proc. Natl. Acad. Sci. USA 110, 7772-7777 (2013).
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 7772-7777
-
-
Murphy, P.J.1
-
26
-
-
84906852434
-
The pivotal regulatory landscape of RNA modifications
-
Li, S. et al. The pivotal regulatory landscape of RNA modifications. Annu. Rev. Genomics. Hum. Genet. 15, 127-150 (2014).
-
(2014)
Annu. Rev. Genomics. Hum. Genet
, vol.15
, pp. 127-150
-
-
Li, S.1
-
27
-
-
84924423596
-
Integrated genome and transcriptome sequencing of the same cell
-
Dey, S.S. et al. Integrated genome and transcriptome sequencing of the same cell. Nat. Biotechnol. 33, 285-289 (2015).
-
(2015)
Nat. Biotechnol
, vol.33
, pp. 285-289
-
-
Dey, S.S.1
-
28
-
-
21744457108
-
Global histone modification patterns predict risk of prostate cancer recurrence
-
Seligson, D.B. et al. Global histone modification patterns predict risk of prostate cancer recurrence. Nature 435, 1262-1266 (2005).
-
(2005)
Nature
, vol.435
, pp. 1262-1266
-
-
Seligson, D.B.1
-
29
-
-
84873383204
-
Detection of histone modifications at specific gene loci in single cells in histological sections
-
Gomez, D. et al. Detection of histone modifications at specific gene loci in single cells in histological sections. Nat. Methods 10, 171-177 (2013).
-
(2013)
Nat. Methods
, vol.10
, pp. 171-177
-
-
Gomez, D.1
-
30
-
-
84897954497
-
Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry
-
Giesen, C. et al. Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry. Nat. Methods 11, 417-422 (2014).
-
(2014)
Nat. Methods
, vol.11
, pp. 417-422
-
-
Giesen, C.1
-
31
-
-
84898402897
-
Multiplexed ion beam imaging of human breast tumors
-
Angelo, M. et al. Multiplexed ion beam imaging of human breast tumors. Nat. Med. 20, 436-442 (2014).
-
(2014)
Nat. Med
, vol.20
, pp. 436-442
-
-
Angelo, M.1
-
32
-
-
84923799606
-
Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues
-
Lee, J.H. et al. Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues. Nat. Protoc. 10, 442-458 (2015).
-
(2015)
Nat. Protoc
, vol.10
, pp. 442-458
-
-
Lee, J.H.1
-
33
-
-
84938803749
-
Spatially resolved, highly multiplexed RNA profiling in single cells
-
Chen, K.H., Boettiger, A.N., Moffitt, J.R., Wang, S. &Zhuang, X. Spatially resolved, highly multiplexed RNA profiling in single cells. Science 348, 6233 (2015).
-
(2015)
Science
, vol.348
, pp. 6233
-
-
Chen, K.H.1
Boettiger, A.N.2
Moffitt, J.R.3
Wang, S.4
Zhuang, X.5
-
34
-
-
84897090228
-
Highly multiplexed subcellular RNA sequencing situ
-
Lee, J.H. et al. Highly multiplexed subcellular RNA sequencing in situ. Science 343, 1360-1363 (2014).
-
(2014)
Science
, vol.343
, pp. 1360-1363
-
-
Lee, J.H.1
-
35
-
-
84920964255
-
Imaging intratumor heterogeneity: Role in therapy response, resistance, and clinical outcome
-
O'Connor, J.P. et al. Imaging intratumor heterogeneity: role in therapy response, resistance, and clinical outcome. Clin. Cancer Res. 21, 249-257 (2015).
-
(2015)
Clin. Cancer Res
, vol.21
, pp. 249-257
-
-
O'connor, J.P.1
-
36
-
-
84856082746
-
Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies
-
Haeno, H. et al. Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies. Cell 148, 362-375 (2012).
-
(2012)
Cell
, vol.148
, pp. 362-375
-
-
Haeno, H.1
|