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Volumn 133, Issue 3, 2009, Pages 413-422

The pathology and genetics of metastatic pancreatic cancer

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN RECEPTOR A2; SMAD4 PROTEIN; SONIC HEDGEHOG PROTEIN;

EID: 62249108705     PISSN: 00039985     EISSN: 15432165     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (178)

References (106)
  • 2
    • 0034329115 scopus 로고    scopus 로고
    • Resected adenocarcinoma of the pancreas - 616 patients: Results, outcomes, and prognostic indicators
    • Sohn TA, Yeo CJ, Cameron JL, et al. Resected adenocarcinoma of the pancreas - 616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg. 2000;4:567-579.
    • (2000) J Gastrointest Surg , vol.4 , pp. 567-579
    • Sohn, T.A.1    Yeo, C.J.2    Cameron, J.L.3
  • 3
    • 33751212765 scopus 로고    scopus 로고
    • 1423 pancreaticoduodenectomies for pancreatic cancer: A single-institution experience
    • discussion 1210-1211
    • Winter JM, Cameron JL, Campbell KA, et al. 1423 pancreaticoduodenectomies for pancreatic cancer: a single-institution experience. J Gastrointest Surg. 2006;10:1199-1210, discussion 1210-1211.
    • (2006) J Gastrointest Surg , vol.10 , pp. 1199-1210
    • Winter, J.M.1    Cameron, J.L.2    Campbell, K.A.3
  • 4
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada clinical trials group
    • Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada clinical trials group. J Clin Oncol. 2007;25:1960-1966.
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 6
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004;10:789-799.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 7
    • 34547141891 scopus 로고    scopus 로고
    • Surgical therapy for colorectal metastases to the liver
    • PawlikTM, Choti MA. Surgical therapy for colorectal metastases to the liver. J Gastrointest Surg. 2007;11:1057-1077.
    • (2007) J Gastrointest Surg , vol.11 , pp. 1057-1077
    • Pawlik, T.M.1    Choti, M.A.2
  • 8
    • 35148834395 scopus 로고    scopus 로고
    • The management of pancreatic cancer: Current expert opinion and recommendations derived from the 8th World Congress on Gastrointestinal Cancer, Barcelona, 2006
    • Verslype C, Van Cutsem E, Dicato M, et al. The management of pancreatic cancer: current expert opinion and recommendations derived from the 8th World Congress on Gastrointestinal Cancer, Barcelona, 2006. Ann Oncol. 2007;18(suppl 7):vii1-vii10.
    • (2007) Ann Oncol , vol.18 , Issue.SUPPL. 7
    • Verslype, C.1    Van Cutsem, E.2    Dicato, M.3
  • 10
    • 0028854804 scopus 로고
    • Observations on the developmental patterns and the consequences of pancreatic exocrine adenocarcinoma: Findings of 154 autopsies
    • Mao C, Domenico DR, Kim K, Hanson DJ, Howard JM. Observations on the developmental patterns and the consequences of pancreatic exocrine adenocarcinoma: findings of 154 autopsies. Arch Surg. 1995;130:125-134.
    • (1995) Arch Surg , vol.130 , pp. 125-134
    • Mao, C.1    Domenico, D.R.2    Kim, K.3    Hanson, D.J.4    Howard, J.M.5
  • 11
    • 25144519682 scopus 로고    scopus 로고
    • Immortalizing the complexity of cancer metastasis: Genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy
    • Embuscado EE, Laheru D, Ricci F, et al. Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. Cancer Biol Ther. 2005;4:548-554.
    • (2005) Cancer Biol Ther , vol.4 , pp. 548-554
    • Embuscado, E.E.1    Laheru, D.2    Ricci, F.3
  • 12
    • 45549109634 scopus 로고    scopus 로고
    • Metastatic patterns of cancers: Results from a large autopsy study
    • Disibio G, French SW. Metastatic patterns of cancers: results from a large autopsy study. Arch Pathol Lab Med. 2008;132:931-939.
    • (2008) Arch Pathol Lab Med , vol.132 , pp. 931-939
    • Disibio, G.1    French, S.W.2
  • 13
    • 0029053468 scopus 로고
    • The time of occurrence of liver metastasis in carcinoma of the pancreas
    • Amikura K, Kobari M, Matsuno S. The time of occurrence of liver metastasis in carcinoma of the pancreas. Int J Pancreatol. 1995;17:139-146.
    • (1995) Int J Pancreatol , vol.17 , pp. 139-146
    • Amikura, K.1    Kobari, M.2    Matsuno, S.3
  • 14
    • 0344359791 scopus 로고    scopus 로고
    • Disseminated tumor cells in pancreatic cancer patients detected by immunocytology: A new prognostic factor
    • Vogel I, Kruger U, Marxsen J, et al. Disseminated tumor cells in pancreatic cancer patients detected by immunocytology: a new prognostic factor. Clin Cancer Res. 1999;5:593-599.
    • (1999) Clin Cancer Res , vol.5 , pp. 593-599
    • Vogel, I.1    Kruger, U.2    Marxsen, J.3
  • 15
    • 0032783340 scopus 로고    scopus 로고
    • Micrometastases in bone marrow: Prognostic indicators for pancreatic cancer
    • Roder JD, Thorban S, Pantel K, Siewert JR. Micrometastases in bone marrow: prognostic indicators for pancreatic cancer. World J Surg. 1999;23:888-891.
    • (1999) World J Surg , vol.23 , pp. 888-891
    • Roder, J.D.1    Thorban, S.2    Pantel, K.3    Siewert, J.R.4
  • 16
    • 0036230158 scopus 로고    scopus 로고
    • Implications of peritoneal washing cytology in patients with potentially resectable pancreatic cancer
    • Yachida S, Fukushima N, Sakamoto M, Matsuno Y, KosugeT, Hirohashi S. Implications of peritoneal washing cytology in patients with potentially resectable pancreatic cancer. Br J Surg. 2002;89:573-578.
    • (2002) Br J Surg , vol.89 , pp. 573-578
    • Yachida, S.1    Fukushima, N.2    Sakamoto, M.3    Matsuno, Y.4    Kosuge, T.5    Hirohashi, S.6
  • 17
    • 10744231791 scopus 로고    scopus 로고
    • The impact of liver metastasis on mortality in patients initially diagnosed with locally advanced or resectable pancreatic cancer
    • Nakahashi C, Oda T, Kinoshita T, et al. The impact of liver metastasis on mortality in patients initially diagnosed with locally advanced or resectable pancreatic cancer. Int J Gastrointest Cancer. 2003;33:155-164.
    • (2003) Int J Gastrointest Cancer , vol.33 , pp. 155-164
    • Nakahashi, C.1    Oda, T.2    Kinoshita, T.3
  • 19
    • 62249176551 scopus 로고    scopus 로고
    • Dpc4 gene status of the primary carcinoma correlates with local versus metastatic failure in patients with pancreatic cancer
    • In press
    • Iacobuzio-Donahue CA, Fu B, Yachida S, et al. Dpc4 gene status of the primary carcinoma correlates with local versus metastatic failure in patients with pancreatic cancer. J Clin Oncol. 2009. In press.
    • (2009) J Clin Oncol
    • Iacobuzio-Donahue, C.A.1    Fu, B.2    Yachida, S.3
  • 20
    • 0027228230 scopus 로고
    • An evaluation of radical resection for pancreatic cancer based on the mode of recurrence as determined by autopsy and diagnostic imaging
    • Kayahara M, Nagakawa T, Ueno K, Ohta T, Takeda T, Miyazaki I. An evaluation of radical resection for pancreatic cancer based on the mode of recurrence as determined by autopsy and diagnostic imaging. Cancer. 1993;72:2118-2123.
    • (1993) Cancer , vol.72 , pp. 2118-2123
    • Kayahara, M.1    Nagakawa, T.2    Ueno, K.3    Ohta, T.4    Takeda, T.5    Miyazaki, I.6
  • 21
    • 39649123256 scopus 로고    scopus 로고
    • Effect of neoadjuvant therapy on local recurrence after resection of pancreatic adenocarcinoma
    • Greer SE, Pipas JM, Sutton JE, et al. Effect of neoadjuvant therapy on local recurrence after resection of pancreatic adenocarcinoma. J Am Coll Surg. 2008;206:451-457.
    • (2008) J Am Coll Surg , vol.206 , pp. 451-457
    • Greer, S.E.1    Pipas, J.M.2    Sutton, J.E.3
  • 22
    • 27544500200 scopus 로고    scopus 로고
    • A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma
    • discussion 628-630
    • Farnell MB, Pearson RK, Sarr MG, et al. A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma. Surgery. 2005;138:618-628, discussion 628-630.
    • (2005) Surgery , vol.138 , pp. 618-628
    • Farnell, M.B.1    Pearson, R.K.2    Sarr, M.G.3
  • 23
    • 18544365651 scopus 로고    scopus 로고
    • Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: Randomized controlled trial evaluating survival, morbidity, and mortality
    • discussion 366-358
    • Yeo CJ, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. Ann Surg. 2002;236:355-366, discussion 366-358.
    • (2002) Ann Surg , vol.236 , pp. 355-366
    • Yeo, C.J.1    Cameron, J.L.2    Lillemoe, K.D.3
  • 24
    • 38949178861 scopus 로고    scopus 로고
    • Absence of e-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer
    • Winter JM, Ting AH, Vilardell F, et al. Absence of e-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer. Clin Cancer Res 2008;14:412-418.
    • (2008) Clin Cancer Res , vol.14 , pp. 412-418
    • Winter, J.M.1    Ting, A.H.2    Vilardell, F.3
  • 25
    • 34548329486 scopus 로고    scopus 로고
    • Differentiation plasticity regulated by TGF-beta family proteins in development and disease
    • Derynck R, Akhurst RJ. Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nat Cell Biol. 2007;9:1000-1004.
    • (2007) Nat Cell Biol , vol.9 , pp. 1000-1004
    • Derynck, R.1    Akhurst, R.J.2
  • 26
    • 27844478189 scopus 로고    scopus 로고
    • TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN
    • Vogelmann R, Nguyen-Tat MD, Giehl K, Adler G, Wedlich D, Menke A. TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN. J Cell Sci. 2005;118:4901-4912.
    • (2005) J Cell Sci , vol.118 , pp. 4901-4912
    • Vogelmann, R.1    Nguyen-Tat, M.D.2    Giehl, K.3    Adler, G.4    Wedlich, D.5    Menke, A.6
  • 27
    • 33644534795 scopus 로고    scopus 로고
    • The tumor suppressor smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
    • Deckers M, van Dinther M, Buijs J, et al. The tumor suppressor smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res. 2006;66:2202-2209.
    • (2006) Cancer Res , vol.66 , pp. 2202-2209
    • Deckers, M.1    van Dinther, M.2    Buijs, J.3
  • 28
    • 0030076513 scopus 로고    scopus 로고
    • Histologic growth patterns of metastatic carcinomas of the liver
    • Terayama N, Terada T, Nakanuma Y. Histologic growth patterns of metastatic carcinomas of the liver. Jpn J Clin Oncol. 1996;26:24-29.
    • (1996) Jpn J Clin Oncol , vol.26 , pp. 24-29
    • Terayama, N.1    Terada, T.2    Nakanuma, Y.3
  • 29
    • 20844433863 scopus 로고    scopus 로고
    • Surgical treatment for metastatic malignancies: Nonanatomical resection of liver metastasis: indications and outcomes
    • Yamamoto J, Saiura A, Koga R, et al. Surgical treatment for metastatic malignancies: nonanatomical resection of liver metastasis: indications and outcomes. Int J Clin Oncol. 2005;10:97-102.
    • (2005) Int J Clin Oncol , vol.10 , pp. 97-102
    • Yamamoto, J.1    Saiura, A.2    Koga, R.3
  • 31
    • 0021717053 scopus 로고
    • The bile duct adenoma: A lesion distinct from Meyenburg complex
    • Govindarajan S, Peters RL. The bile duct adenoma: a lesion distinct from Meyenburg complex. Arch Pathol Lab Med. 1984;108:922-924.
    • (1984) Arch Pathol Lab Med , vol.108 , pp. 922-924
    • Govindarajan, S.1    Peters, R.L.2
  • 33
    • 14644394912 scopus 로고    scopus 로고
    • Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver
    • Hornick JL, Lauwers GY, Odze RD. Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. Am J Surg Pathol. 2005;29:381-389.
    • (2005) Am J Surg Pathol , vol.29 , pp. 381-389
    • Hornick, J.L.1    Lauwers, G.Y.2    Odze, R.D.3
  • 34
    • 0030846221 scopus 로고    scopus 로고
    • Can k-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver?: A molecular analysis of 101 liver lesions from 93 patients
    • Hruban RH, Sturm PD, Slebos RJ, et al. Can k-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver?: a molecular analysis of 101 liver lesions from 93 patients. Am J Pathol. 1997;151:943-949.
    • (1997) Am J Pathol , vol.151 , pp. 943-949
    • Hruban, R.H.1    Sturm, P.D.2    Slebos, R.J.3
  • 35
    • 47149112544 scopus 로고    scopus 로고
    • Cholangiocarcinoma: Advances in pathogenesis, diagnosis, and treatment
    • Blechacz B, Gores GJ. Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology. 2008;48:308-321.
    • (2008) Hepatology , vol.48 , pp. 308-321
    • Blechacz, B.1    Gores, G.J.2
  • 36
    • 0035312199 scopus 로고    scopus 로고
    • Differing rates of loss of dpc4 expression and ofp53 overexpression among carcinomas of the proximal and distal bile ducts
    • Argani P, Shaukat A, Kaushal M, et al. Differing rates of loss of dpc4 expression and ofp53 overexpression among carcinomas of the proximal and distal bile ducts. Cancer. 2001;91:1332-1341.
    • (2001) Cancer , vol.91 , pp. 1332-1341
    • Argani, P.1    Shaukat, A.2    Kaushal, M.3
  • 38
    • 45849128125 scopus 로고    scopus 로고
    • Cigarette smoking and subsequent risk of lung cancer in men and women: Analysis of a prospective cohort study
    • Freedman ND, Leitzmann MF, Hollenbeck AR, Schatzkin A, Abnet CC. Cigarette smoking and subsequent risk of lung cancer in men and women: analysis of a prospective cohort study. Lancet Oncol. 2008;9:649-656.
    • (2008) Lancet Oncol , vol.9 , pp. 649-656
    • Freedman, N.D.1    Leitzmann, M.F.2    Hollenbeck, A.R.3    Schatzkin, A.4    Abnet, C.C.5
  • 39
    • 62249120674 scopus 로고    scopus 로고
    • Metastatic pancreatic cancer to the lung: A potential mimicker of primary bronchioalveolar carcinoma of the lung
    • Karanjawala ZE, Hruban RH, Iacobuzio-Donahue CA. Metastatic pancreatic cancer to the lung: a potential mimicker of primary bronchioalveolar carcinoma of the lung. Mod Pathol. 2008;21:307A.
    • (2008) Mod Pathol , vol.21
    • Karanjawala, Z.E.1    Hruban, R.H.2    Iacobuzio-Donahue, C.A.3
  • 40
    • 34247468088 scopus 로고    scopus 로고
    • From Krukenbergto today: The ever present problems posed by metastatic tumors in the ovary: part II
    • Young RH. From Krukenbergto today: the ever present problems posed by metastatic tumors in the ovary: part II. Adv Anat Pathol. 2007;14:149-177.
    • (2007) Adv Anat Pathol , vol.14 , pp. 149-177
    • Young, R.H.1
  • 41
    • 0012816611 scopus 로고    scopus 로고
    • Primary and metastatic mucinous adenocarcinomas in the ovaries: Incidence in routine practice with a new approach to improve intraoperative diagnosis
    • Seidman JD, Kurman RJ, Ronnett BM. Primary and metastatic mucinous adenocarcinomas in the ovaries: incidence in routine practice with a new approach to improve intraoperative diagnosis. Am J Surg Pathol. 2003;27:985-993.
    • (2003) Am J Surg Pathol , vol.27 , pp. 985-993
    • Seidman, J.D.1    Kurman, R.J.2    Ronnett, B.M.3
  • 42
    • 0036783713 scopus 로고    scopus 로고
    • Cytokeratins 7 and 20, dpc4, and muc5ac in the distinction of metastatic mucinous carcinomas in the ovary from primary ovarian mucinous tumors: Dpc4 assists in identifying metastatic pancreatic carcinomas
    • Ji H, Isacson C, Seidman JD, Kurman RJ, Ronnett BM. Cytokeratins 7 and 20, dpc4, and muc5ac in the distinction of metastatic mucinous carcinomas in the ovary from primary ovarian mucinous tumors: dpc4 assists in identifying metastatic pancreatic carcinomas. Int J Gynecol Pathol. 2002;21:391-400.
    • (2002) Int J Gynecol Pathol , vol.21 , pp. 391-400
    • Ji, H.1    Isacson, C.2    Seidman, J.D.3    Kurman, R.J.4    Ronnett, B.M.5
  • 43
    • 11244324803 scopus 로고    scopus 로고
    • Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differ entiating primary ovarian mucinous tumors from metastatic pancreatic mucinous carcinomas in the ovary
    • Cao D, Ji H, Ronnett BM. Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differ entiating primary ovarian mucinous tumors from metastatic pancreatic mucinous carcinomas in the ovary. Int J Gynecol Pathol. 2005;24:67-72.
    • (2005) Int J Gynecol Pathol , vol.24 , pp. 67-72
    • Cao, D.1    Ji, H.2    Ronnett, B.M.3
  • 44
    • 10744229498 scopus 로고    scopus 로고
    • Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss
    • Iacobuzio-Donahue CA, van der Heijden MS, Baumgartner MR, et al. Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss. Cancer Res. 2004;64:871-875.
    • (2004) Cancer Res , vol.64 , pp. 871-875
    • Iacobuzio-Donahue, C.A.1    van der Heijden, M.S.2    Baumgartner, M.R.3
  • 45
    • 33748057487 scopus 로고    scopus 로고
    • Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays
    • Calhoun ES, Hucl T, Gallmeier E, et al. Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays. Cancer Res. 2006;66:7920-7928.
    • (2006) Cancer Res , vol.66 , pp. 7920-7928
    • Calhoun, E.S.1    Hucl, T.2    Gallmeier, E.3
  • 46
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (mts1) gene in pancreatic adenocarcinoma
    • Caldas C, Hahn SA, da Costa LT, et al. Frequent somatic mutations and homozygous deletions of the p16 (mts1) gene in pancreatic adenocarcinoma. Nat Genet. 1994;8:27-32.
    • (1994) Nat Genet , vol.8 , pp. 27-32
    • Caldas, C.1    Hahn, S.A.2    da Costa, L.T.3
  • 47
    • 0030593038 scopus 로고    scopus 로고
    • Dpc4, acandidate tumor suppressor gene at human chromosome 18q21.1
    • Hahn SA, Schutte M, Hoque AT, et al. Dpc4, acandidate tumor suppressor gene at human chromosome 18q21.1. Science. 1996;271:350-353.
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.3
  • 48
    • 0028308492 scopus 로고
    • P53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions
    • Redston MS, Caldas C, Seymour AB, et al. P53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Res. 1994;54:3025-3033.
    • (1994) Cancer Res , vol.54 , pp. 3025-3033
    • Redston, M.S.1    Caldas, C.2    Seymour, A.B.3
  • 49
    • 0032100617 scopus 로고    scopus 로고
    • Alterations in pancreatic, biliary, and breast carcinomas support mkk4 as a genetically targeted tumor suppressor gene
    • Su GH, Hilgers W, Shekher MC, et al. Alterations in pancreatic, biliary, and breast carcinomas support mkk4 as a genetically targeted tumor suppressor gene. Cancer Res. 1998;58:2339-2342.
    • (1998) Cancer Res , vol.58 , pp. 2339-2342
    • Su, G.H.1    Hilgers, W.2    Shekher, M.C.3
  • 50
    • 12644253827 scopus 로고    scopus 로고
    • Germline brca2 gene mutations in patients with apparently sporadic pancreatic carcinomas
    • Goggins M, Schutte M, Lu J, et al. Germline brca2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res. 1996;56:5360-5364.
    • (1996) Cancer Res , vol.56 , pp. 5360-5364
    • Goggins, M.1    Schutte, M.2    Lu, J.3
  • 52
    • 0036841802 scopus 로고    scopus 로고
    • Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia
    • van Heek NT, Meeker AK, Kern SE, et al. Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am J Pathol. 2002;161:1541-1547.
    • (2002) Am J Pathol , vol.161 , pp. 1541-1547
    • van Heek, N.T.1    Meeker, A.K.2    Kern, S.E.3
  • 53
    • 2942643922 scopus 로고    scopus 로고
    • High-resolution characterization of the pancreatic adenocarcinoma genome
    • Aguirre AJ, Brennan C, Bailey G, et al. High-resolution characterization of the pancreatic adenocarcinoma genome. Proc Natl Acad Sci U S A. 2004;101:9067-9072.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 9067-9072
    • Aguirre, A.J.1    Brennan, C.2    Bailey, G.3
  • 54
    • 23244467697 scopus 로고    scopus 로고
    • Genome-wide aberrations in pancreatic adenocarcinoma
    • Nowak NJ, Gaile D, Conroy JM, et al. Genome-wide aberrations in pancreatic adenocarcinoma. Cancer Genet Cytogenet. 2005;161:36-50.
    • (2005) Cancer Genet Cytogenet , vol.161 , pp. 36-50
    • Nowak, N.J.1    Gaile, D.2    Conroy, J.M.3
  • 55
    • 22044450542 scopus 로고    scopus 로고
    • Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer
    • Bashyam MD, Bair R, Kim YH, et al. Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer. Neoplasia. 2005;7:556-562.
    • (2005) Neoplasia , vol.7 , pp. 556-562
    • Bashyam, M.D.1    Bair, R.2    Kim, Y.H.3
  • 56
    • 6944222706 scopus 로고    scopus 로고
    • High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer
    • Mahlamaki EH, Kauraniemi P, Monni O, Wolf M, Hautaniemi S, Kallioniemi A. High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer. Neoplasia. 2004;6:432-439.
    • (2004) Neoplasia , vol.6 , pp. 432-439
    • Mahlamaki, E.H.1    Kauraniemi, P.2    Monni, O.3    Wolf, M.4    Hautaniemi, S.5    Kallioniemi, A.6
  • 57
    • 2342569751 scopus 로고    scopus 로고
    • Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines
    • Heidenblad M, Schoenmakers EF, Jonson T, et al. Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines. Cancer Res. 2004;64:3052-3059.
    • (2004) Cancer Res , vol.64 , pp. 3052-3059
    • Heidenblad, M.1    Schoenmakers, E.F.2    Jonson, T.3
  • 58
    • 14944343419 scopus 로고    scopus 로고
    • Microarray analyses reveal strong influence of DNA copy number alterations on the transcriptional patterns in pancreatic cancer: Implications for the interpretation of genomic amplifications
    • Heidenblad M, Lindgren D, Veltman JA, et al. Microarray analyses reveal strong influence of DNA copy number alterations on the transcriptional patterns in pancreatic cancer: implications for the interpretation of genomic amplifications. Oncogene. 2005;24:1794-1801.
    • (2005) Oncogene , vol.24 , pp. 1794-1801
    • Heidenblad, M.1    Lindgren, D.2    Veltman, J.A.3
  • 59
    • 0028875562 scopus 로고
    • Allelotype of pancreatic adenocarcinoma using xenograft enrichment
    • Hahn SA, Seymour AB, Hoque AT, et al. Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res. 1995;55:4670-4675.
    • (1995) Cancer Res , vol.55 , pp. 4670-4675
    • Hahn, S.A.1    Seymour, A.B.2    Hoque, A.T.3
  • 60
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells. Cancer Res. 2007;67:1030-1037.
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 61
    • 9144241047 scopus 로고    scopus 로고
    • Highlyexpressed genes in pancreatic ductal adenocarcinomas: A comprehensive characterization and comparison of the transcription profiles obtained from three major technologies
    • Iacobuzio-Donahue CA, Ashfaq R, Maitra A, et al. Highlyexpressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res. 2003;63:8614-8622.
    • (2003) Cancer Res , vol.63 , pp. 8614-8622
    • Iacobuzio-Donahue, C.A.1    Ashfaq, R.2    Maitra, A.3
  • 62
    • 28844481452 scopus 로고    scopus 로고
    • The kras oncogene: Past, present, and future
    • Kranenburg O. The kras oncogene: past, present, and future. Biochim Biophys Acta. 2005;1756:81-82.
    • (2005) Biochim Biophys Acta , vol.1756 , pp. 81-82
    • Kranenburg, O.1
  • 64
    • 0027733796 scopus 로고
    • K-ras oncogene activation in adenocarcinoma of the human pancreas: Astudyof82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization
    • Hruban RH, van Mansfeld AD, Offerhaus GJ, et al. K-ras oncogene activation in adenocarcinoma of the human pancreas: astudyof82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol. 1993;143:545-554.
    • (1993) Am J Pathol , vol.143 , pp. 545-554
    • Hruban, R.H.1    van Mansfeld, A.D.2    Offerhaus, G.J.3
  • 65
    • 0030988302 scopus 로고    scopus 로고
    • P16 and k-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
    • Moskaluk CA, Hruban RH, Kern SE. P16 and k-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res. 1997;57:2140-2143.
    • (1997) Cancer Res , vol.57 , pp. 2140-2143
    • Moskaluk, C.A.1    Hruban, R.H.2    Kern, S.E.3
  • 66
    • 0344061528 scopus 로고    scopus 로고
    • The k-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium
    • Luttges J, Schlehe B, Menke MA, Vogel I, Henne-Bruns D, Kloppel G. The k-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium. Cancer. 1999;85:1703-1710.
    • (1999) Cancer , vol.85 , pp. 1703-1710
    • Luttges, J.1    Schlehe, B.2    Menke, M.A.3    Vogel, I.4    Henne-Bruns, D.5    Kloppel, G.6
  • 68
    • 0031047115 scopus 로고    scopus 로고
    • Molecular pathology of primary and metastatic ductal pancreatic lesions: Analyses of mutations and expression of the p53, mdm-2, and p21/waf-1 genes in sporadic and familial lesions
    • Ruggeri BA, Huang L, Berger D, et al. Molecular pathology of primary and metastatic ductal pancreatic lesions: analyses of mutations and expression of the p53, mdm-2, and p21/waf-1 genes in sporadic and familial lesions. Cancer. 1997;79:700-716.
    • (1997) Cancer , vol.79 , pp. 700-716
    • Ruggeri, B.A.1    Huang, L.2    Berger, D.3
  • 69
    • 0030048977 scopus 로고    scopus 로고
    • P53, ki-ras, and DNA ploidy in human pancreatic ductal adenocarcinomas
    • Weyrer K, Feichtinger H, Haun M, et al. P53, ki-ras, and DNA ploidy in human pancreatic ductal adenocarcinomas. Lab Invest. 1996;74:279-289.
    • (1996) Lab Invest , vol.74 , pp. 279-289
    • Weyrer, K.1    Feichtinger, H.2    Haun, M.3
  • 70
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • Zavadil J, Bottinger EP. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene. 2005;24:5764-5774.
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 71
    • 0034032009 scopus 로고    scopus 로고
    • Loss of expression of dpc4 in pancreatic intraepithelial neoplasia: Evidence that dpc4 inactivation occurs late in neoplastic progression
    • Wilentz RE, Iacobuzio-Donahue CA, Argani P, et al. Loss of expression of dpc4 in pancreatic intraepithelial neoplasia: evidence that dpc4 inactivation occurs late in neoplastic progression. Cancer Res. 2000;60:2002-2006.
    • (2000) Cancer Res , vol.60 , pp. 2002-2006
    • Wilentz, R.E.1    Iacobuzio-Donahue, C.A.2    Argani, P.3
  • 72
    • 0035671396 scopus 로고    scopus 로고
    • The smad4 protein and prognosis of pancreatic ductal adenocarcinoma
    • Tascilar M, Skinner HG, Rosty C, et al. The smad4 protein and prognosis of pancreatic ductal adenocarcinoma. Clin Cancer Res. 2001;7:4115-4121.
    • (2001) Clin Cancer Res , vol.7 , pp. 4115-4121
    • Tascilar, M.1    Skinner, H.G.2    Rosty, C.3
  • 73
    • 0036894028 scopus 로고    scopus 로고
    • Dpc4/smad4 expression and outcome in pancreatic ductal adenocarcinoma
    • Biankin AV, Morey AL, Lee CS, et al. Dpc4/smad4 expression and outcome in pancreatic ductal adenocarcinoma. J Clin Oncol. 2002;20:4531-4542.
    • (2002) J Clin Oncol , vol.20 , pp. 4531-4542
    • Biankin, A.V.1    Morey, A.L.2    Lee, C.S.3
  • 74
    • 0028558986 scopus 로고
    • Role of sapk/erk kinase-1 in the stress-activated pathway regulating transcription factor c-jun
    • Sanchez I, Hughes RT, Mayer BJ, et al. Role of sapk/erk kinase-1 in the stress-activated pathway regulating transcription factor c-jun. Nature. 1994;372:794-798.
    • (1994) Nature , vol.372 , pp. 794-798
    • Sanchez, I.1    Hughes, R.T.2    Mayer, B.J.3
  • 75
    • 19944429290 scopus 로고    scopus 로고
    • Map2k4/mkk4 expression in pancreatic cancer: Genetic validation of immunohistochemistry and relationship to disease course
    • Xin W, Yun KJ, Ricci F, et al. Map2k4/mkk4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course. Clin Cancer Res. 2004;10:8516-8520.
    • (2004) Clin Cancer Res , vol.10 , pp. 8516-8520
    • Xin, W.1    Yun, K.J.2    Ricci, F.3
  • 76
    • 0037112512 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase 4 (mkk4) acts as a metastasis suppressor gene in human ovarian carcinoma
    • Yamada SD, Hickson JA, Hrobowski Y, et al. Mitogen-activated protein kinase kinase 4 (mkk4) acts as a metastasis suppressor gene in human ovarian carcinoma. Cancer Res. 2002;62:6717-6723.
    • (2002) Cancer Res , vol.62 , pp. 6717-6723
    • Yamada, S.D.1    Hickson, J.A.2    Hrobowski, Y.3
  • 77
    • 33646814635 scopus 로고    scopus 로고
    • Targeted deletion of mkk4 in cancer cells: A detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss
    • Cunningham SC, Gallmeier E, Hucl T, et al. Targeted deletion of mkk4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss. Cancer Res. 2006;66:5560-5564.
    • (2006) Cancer Res , vol.66 , pp. 5560-5564
    • Cunningham, S.C.1    Gallmeier, E.2    Hucl, T.3
  • 78
    • 33646816786 scopus 로고    scopus 로고
    • Theoretical proposal: Allele dosage of map2k4/mkk4 could rationalize frequent 17p loss in diverse human cancers
    • Cunningham SC, Gallmeier E, Hucl T, et al. Theoretical proposal: allele dosage of map2k4/mkk4 could rationalize frequent 17p loss in diverse human cancers. Cell Cycle. 2006;5:1090-1093.
    • (2006) Cell Cycle , vol.5 , pp. 1090-1093
    • Cunningham, S.C.1    Gallmeier, E.2    Hucl, T.3
  • 79
    • 20344396123 scopus 로고    scopus 로고
    • Eph receptor signalling casts a wide net on cell behaviour
    • Pasquale EB. Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol. 2005;6:462-475.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 462-475
    • Pasquale, E.B.1
  • 80
    • 0037378465 scopus 로고    scopus 로고
    • Differential regulation of epha2 in normal and malignant cells
    • Walker-Daniels J, Hess AR, Hendrix MJ, Kinch MS. Differential regulation of epha2 in normal and malignant cells. Am J Pathol. 2003;162:1037-1042.
    • (2003) Am J Pathol , vol.162 , pp. 1037-1042
    • Walker-Daniels, J.1    Hess, A.R.2    Hendrix, M.J.3    Kinch, M.S.4
  • 81
    • 1442308345 scopus 로고    scopus 로고
    • Epha2: A determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma
    • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. Epha2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma. Oncogene. 2004;23:1448-1456.
    • (2004) Oncogene , vol.23 , pp. 1448-1456
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 82
    • 3142677219 scopus 로고    scopus 로고
    • Ligation of epha2 by ephrin a1-fc inhibits pancreatic adenocarcinoma cellular invasiveness
    • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. Ligation of epha2 by ephrin a1-fc inhibits pancreatic adenocarcinoma cellular invasiveness. Biochem Biophys Res Commun. 2004;320:1096-1102.
    • (2004) Biochem Biophys Res Commun , vol.320 , pp. 1096-1102
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 83
    • 33846651832 scopus 로고    scopus 로고
    • Patterns of epha2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic status
    • Mudali SV, Fu B, Lakkur SS, Luo M, Embuscado EE, Iacobuzio-Donahue CA. Patterns of epha2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic status. Clin Exp Metastasis. 2006;23:357-365.
    • (2006) Clin Exp Metastasis , vol.23 , pp. 357-365
    • Mudali, S.V.1    Fu, B.2    Lakkur, S.S.3    Luo, M.4    Embuscado, E.E.5    Iacobuzio-Donahue, C.A.6
  • 84
    • 0037093097 scopus 로고    scopus 로고
    • Antibody targeting of the epha2 tyrosine kinase inhibits malignant cell behavior
    • Carles-Kinch K, Kilpatrick KE, Stewart JC, Kinch MS. Antibody targeting of the epha2 tyrosine kinase inhibits malignant cell behavior. Cancer Res. 2002;62:2840-2847.
    • (2002) Cancer Res , vol.62 , pp. 2840-2847
    • Carles-Kinch, K.1    Kilpatrick, K.E.2    Stewart, J.C.3    Kinch, M.S.4
  • 85
    • 4544317212 scopus 로고    scopus 로고
    • Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis
    • Missiaglia E, Blaveri E, Terris B, et al. Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis. Int J Cancer. 2004;112:100-112.
    • (2004) Int J Cancer , vol.112 , pp. 100-112
    • Missiaglia, E.1    Blaveri, E.2    Terris, B.3
  • 86
    • 0036468914 scopus 로고    scopus 로고
    • Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression
    • Ryu B, Jones J, Blades NJ, et al. Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression. Cancer Res. 2002;62:819-826.
    • (2002) Cancer Res , vol.62 , pp. 819-826
    • Ryu, B.1    Jones, J.2    Blades, N.J.3
  • 87
    • 6944230881 scopus 로고    scopus 로고
    • Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays
    • Grutzmann R, Pilarsky C, Ammerpohl O, et al. Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. Neoplasia. 2004;6:611-622.
    • (2004) Neoplasia , vol.6 , pp. 611-622
    • Grutzmann, R.1    Pilarsky, C.2    Ammerpohl, O.3
  • 88
    • 0037019181 scopus 로고    scopus 로고
    • Expression profiling of microdissected pancreatic adenocarcinomas
    • Crnogorac-Jurcevic T, Efthimiou E, Nielsen T, et al. Expression profiling of microdissected pancreatic adenocarcinomas. Oncogene. 2002;21:4587-4594.
    • (2002) Oncogene , vol.21 , pp. 4587-4594
    • Crnogorac-Jurcevic, T.1    Efthimiou, E.2    Nielsen, T.3
  • 89
    • 0038179900 scopus 로고    scopus 로고
    • Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer
    • Logsdon CD, Simeone DM, Binkley C, et al. Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res. 2003;63:2649-2657.
    • (2003) Cancer Res , vol.63 , pp. 2649-2657
    • Logsdon, C.D.1    Simeone, D.M.2    Binkley, C.3
  • 91
    • 33748136848 scopus 로고    scopus 로고
    • The max-interacting transcription factor network
    • Hurlin PJ, Huang J. The max-interacting transcription factor network. Semin Cancer Biol. 2006;16:265-274.
    • (2006) Semin Cancer Biol , vol.16 , pp. 265-274
    • Hurlin, P.J.1    Huang, J.2
  • 93
    • 31144478127 scopus 로고    scopus 로고
    • Mxi1 is induced by hypoxia in a hif-1-dependent manner and protects cells from c-myc-induced apoptosis
    • Corn PG, Ricci MS, Scata KA, et al. Mxi1 is induced by hypoxia in a hif-1-dependent manner and protects cells from c-myc-induced apoptosis. Cancer Biol Ther. 2005;4:1285-1294.
    • (2005) Cancer Biol Ther , vol.4 , pp. 1285-1294
    • Corn, P.G.1    Ricci, M.S.2    Scata, K.A.3
  • 94
    • 0036229486 scopus 로고    scopus 로고
    • C-myc activation in primary and metastatic ductal adenocarcinoma of the pancreas: Incidence, mechanisms, and clinical significance
    • Schleger C, Verbeke C, Hildenbrand R, Zentgraf H, Bleyl U. C-myc activation in primary and metastatic ductal adenocarcinoma of the pancreas: incidence, mechanisms, and clinical significance. Mod Pathol. 2002;15:462-469.
    • (2002) Mod Pathol , vol.15 , pp. 462-469
    • Schleger, C.1    Verbeke, C.2    Hildenbrand, R.3    Zentgraf, H.4    Bleyl, U.5
  • 95
    • 4644266467 scopus 로고    scopus 로고
    • Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity
    • Loukopoulos P, Kanetaka K, Takamura M, Shibata T, Sakamoto M, Hirohashi S. Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. Pancreas. 2004;29:193-203.
    • (2004) Pancreas , vol.29 , pp. 193-203
    • Loukopoulos, P.1    Kanetaka, K.2    Takamura, M.3    Shibata, T.4    Sakamoto, M.5    Hirohashi, S.6
  • 96
    • 35848931900 scopus 로고    scopus 로고
    • Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel quantitative model of metastasis in nod/scid/gammacnull (nog) mice
    • Suemizu H, Monnai M, Ohnishi Y, Ito M, Tamaoki N, Nakamura M. Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel quantitative model of metastasis in nod/scid/gammacnull (nog) mice. Int J Oncol. 2007;31:741-751.
    • (2007) Int J Oncol , vol.31 , pp. 741-751
    • Suemizu, H.1    Monnai, M.2    Ohnishi, Y.3    Ito, M.4    Tamaoki, N.5    Nakamura, M.6
  • 97
    • 0035571602 scopus 로고    scopus 로고
    • Transcriptional profiling of cell lines derived from an orthotopic pancreatic tumor model reveals metastasis-associated genes
    • Tarbe N, Evtimova V, Burtscher H, Jarsch M, Alves F, Weidle UH. Transcriptional profiling of cell lines derived from an orthotopic pancreatic tumor model reveals metastasis-associated genes. Anticancer Res. 2001;21:3221-3228.
    • (2001) Anticancer Res , vol.21 , pp. 3221-3228
    • Tarbe, N.1    Evtimova, V.2    Burtscher, H.3    Jarsch, M.4    Alves, F.5    Weidle, U.H.6
  • 98
    • 36148988790 scopus 로고    scopus 로고
    • Gene expression profiling of liver metastases and tumour invasion in pancreatic cancer using an orthotopic scid mouse model
    • Niedergethmann M, Alves F, Neff JK, et al. Gene expression profiling of liver metastases and tumour invasion in pancreatic cancer using an orthotopic scid mouse model. Br J Cancer. 2007;97:1432-1440.
    • (2007) Br J Cancer , vol.97 , pp. 1432-1440
    • Niedergethmann, M.1    Alves, F.2    Neff, J.K.3
  • 99
    • 0036345182 scopus 로고    scopus 로고
    • A new liver metastatic and peritoneal dissemination model established from the same human pancreatic cancer cell line: Analysis using cdna macroarray
    • Nomura H, Nishimori H, Yasoshima T, et al. A new liver metastatic and peritoneal dissemination model established from the same human pancreatic cancer cell line: analysis using cdna macroarray. Clin Exp Metastasis. 2002;19:391-399.
    • (2002) Clin Exp Metastasis , vol.19 , pp. 391-399
    • Nomura, H.1    Nishimori, H.2    Yasoshima, T.3
  • 100
    • 0030681247 scopus 로고    scopus 로고
    • Notochord to endoderm signaling is required for pancreas development
    • Kim SK, Hebrok M, Melton DA. Notochord to endoderm signaling is required for pancreas development. Development. 1997;124:4243-4252.
    • (1997) Development , vol.124 , pp. 4243-4252
    • Kim, S.K.1    Hebrok, M.2    Melton, D.A.3
  • 101
    • 2642589990 scopus 로고    scopus 로고
    • Notochord repression of endodermal sonic hedgehog permits pancreas development
    • Hebrok M, Kim SK, Melton DA. Notochord repression of endodermal sonic hedgehog permits pancreas development. Genes Dev. 1998;12:1705-1713.
    • (1998) Genes Dev , vol.12 , pp. 1705-1713
    • Hebrok, M.1    Kim, S.K.2    Melton, D.A.3
  • 102
    • 33747827890 scopus 로고    scopus 로고
    • Hedgehog signal transduction: Signal integration and cross talk in development and cancer
    • Riobo NA, Lu K, Emerson CP Jr. Hedgehog signal transduction: signal integration and cross talk in development and cancer. Cell Cycle. 2006;5:1612-1615.
    • (2006) Cell Cycle , vol.5 , pp. 1612-1615
    • Riobo, N.A.1    Lu, K.2    Emerson Jr., C.P.3
  • 103
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature. 2004;432:324-331.
    • (2004) Nature , vol.432 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 104
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 2003;425:846-851.
    • (2003) Nature , vol.425 , pp. 846-851
    • Berman, D.M.1    Karhadkar, S.S.2    Maitra, A.3
  • 105
    • 0242270878 scopus 로고    scopus 로고
    • Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    • Thayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 2003;425:851-856.
    • (2003) Nature , vol.425 , pp. 851-856
    • Thayer, S.P.1    di Magliano, M.P.2    Heiser, P.W.3
  • 106
    • 33947254016 scopus 로고    scopus 로고
    • Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
    • Feldmann G, Dhara S, Fendrich V, et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res. 2007;67:2187-2196.
    • (2007) Cancer Res , vol.67 , pp. 2187-2196
    • Feldmann, G.1    Dhara, S.2    Fendrich, V.3


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