-
1
-
-
84960424772
-
Years of potential life lost for brain and CNS tumours relative to other cancers in adults in the United States, 2010
-
Rouse, C., Gittleman, H., Ostrom, Q. T., Kruchko, C. & Barnholtz-Sloan, J. S. Years of potential life lost for brain and CNS tumours relative to other cancers in adults in the United States, 2010. Neuro Oncol. 18, 70-77 (2016).
-
(2016)
Neuro Oncol.
, vol.18
, pp. 70-77
-
-
Rouse, C.1
Gittleman, H.2
Ostrom, Q.T.3
Kruchko, C.4
Barnholtz-Sloan, J.S.5
-
2
-
-
85020249099
-
CBTRUS statistical report: Primary brain and central nervous system tumours diagnosed in the United States in 2008-2012
-
Ostrom, Q. T. et al. CBTRUS statistical report: primary brain and central nervous system tumours diagnosed in the United States in 2008-2012. Neuro Oncol. 17, (Suppl. 4) iv1-iv62 (2015).
-
(2015)
Neuro Oncol.
, vol.17
, pp. iv1-iv62
-
-
Ostrom, Q.T.1
-
3
-
-
84891785971
-
Dose-dense temozolomide for newly diagnosed glioblastoma: A randomised phase III clinical trial
-
Gilbert, M. R. et al. Dose-dense temozolomide for newly diagnosed glioblastoma: a randomised phase III clinical trial. J. Clin. Oncol. 31, 4085-4091 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 4085-4091
-
-
Gilbert, M.R.1
-
4
-
-
84894194756
-
Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma
-
Chinot, O. L. et al. Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N. Engl. J. Med. 370, 709-722 (2014).
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 709-722
-
-
Chinot, O.L.1
-
5
-
-
84894114159
-
A randomised trial of bevacizumab for newly diagnosed glioblastoma
-
Gilbert, M. R. et al. A randomised trial of bevacizumab for newly diagnosed glioblastoma. N. Engl. J. Med. 370, 699-708 (2014).
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 699-708
-
-
Gilbert, M.R.1
-
6
-
-
84977546996
-
Glioblastoma in the Canton of Zurich, Switzerland revisited: 2005 to 2009
-
Gramatzki, D. et al. Glioblastoma in the Canton of Zurich, Switzerland revisited: 2005 to 2009. Cancer 122, 2206-2215 (2016).
-
(2016)
Cancer
, vol.122
, pp. 2206-2215
-
-
Gramatzki, D.1
-
7
-
-
84930453187
-
Cell of origin for malignant gliomas and its implication in therapeutic development
-
Zong, H., Parada, L. F. & Baker, S. J. Cell of origin for malignant gliomas and its implication in therapeutic development. Cold Spring Harb. Perspect. Biol. 29, 7 (2015).
-
(2015)
Cold Spring Harb. Perspect. Biol.
, vol.29
, pp. 7
-
-
Zong, H.1
Parada, L.F.2
Baker, S.J.3
-
8
-
-
84867606428
-
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
-
Sturm, D. et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 22, 425-437 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 425-437
-
-
Sturm, D.1
-
9
-
-
84885074034
-
The somatic genomic landscape of glioblastoma
-
Brennan, C. W. et al. The somatic genomic landscape of glioblastoma. Cell 155, 462-477 (2013).
-
(2013)
Cell
, vol.155
, pp. 462-477
-
-
Brennan, C.W.1
-
10
-
-
84932628860
-
Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas
-
Cancer Genome Atlas Research Network. Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas. N. Engl. J. Med. 372, 2481-2498 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 2481-2498
-
-
-
11
-
-
84929129626
-
Mutational landscape and clonal architecture in grade II and III gliomas
-
Suzuki, H. et al. Mutational landscape and clonal architecture in grade II and III gliomas. Nat. Genet. 47, 458-468 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 458-468
-
-
Suzuki, H.1
-
12
-
-
84955561447
-
Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma
-
Ceccarelli, M. et al. Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma. Cell 164, 550-563 (2016).
-
(2016)
Cell
, vol.164
, pp. 550-563
-
-
Ceccarelli, M.1
-
13
-
-
84862777348
-
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
-
Schwartzentruber, J. et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 482, 226-231 (2012).
-
(2012)
Nature
, vol.482
, pp. 226-231
-
-
Schwartzentruber, J.1
-
14
-
-
84862777410
-
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
-
Wu, G. et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat. Genet. 44, 251-253 (2012).
-
(2012)
Nat. Genet.
, vol.44
, pp. 251-253
-
-
Wu, G.1
-
15
-
-
84880983541
-
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
-
Jones, D. T. et al. Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat. Genet. 45, 927-932 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 927-932
-
-
Jones, D.T.1
-
16
-
-
84878723078
-
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
-
Zhang, J. et al. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat. Genet. 45, 602-612 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 602-612
-
-
Zhang, J.1
-
17
-
-
84899526966
-
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
-
Wu, G. et al. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat. Genet. 46, 444-450 (2014).
-
(2014)
Nat. Genet.
, vol.46
, pp. 444-450
-
-
Wu, G.1
-
18
-
-
84899570180
-
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
-
Buczkowicz, P. et al. Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nat. Genet. 46, 451-456 (2014).
-
(2014)
Nat. Genet.
, vol.46
, pp. 451-456
-
-
Buczkowicz, P.1
-
19
-
-
84896721467
-
C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma
-
Parker, M. et al. C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma. Nature 506, 451-455 (2014).
-
(2014)
Nature
, vol.506
, pp. 451-455
-
-
Parker, M.1
-
20
-
-
84929178049
-
Molecular classification of ependymal tumours across all CNS compartments, histopathological grades, and age groups
-
Pajtler, K. W. et al. Molecular classification of ependymal tumours across all CNS compartments, histopathological grades, and age groups. Cancer Cell 27, 728-743 (2015).
-
(2015)
Cancer Cell
, vol.27
, pp. 728-743
-
-
Pajtler, K.W.1
-
21
-
-
84939973619
-
Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumours with associated molecular prognostic markers
-
Korshunov, A. et al. Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumours with associated molecular prognostic markers. Acta Neuropathol. 129, 669-678 (2015).
-
(2015)
Acta Neuropathol.
, vol.129
, pp. 669-678
-
-
Korshunov, A.1
-
22
-
-
84995675384
-
-
Revised 4th edn (IARC)
-
Louis, D. N., Ohgaki, H., Wiestler, O. D. & Cavenee, W. K. (Eds). WHO Classification of Tumours of the Central Nervous System, Revised 4th edn 10-122 (IARC, 2016).
-
(2016)
WHO Classification of Tumours of the Central Nervous System
, pp. 10-122
-
-
Louis, D.N.1
Ohgaki, H.2
Wiestler, O.D.3
Cavenee, W.K.4
-
23
-
-
34347207046
-
-
4th edn (IARC)
-
Louis, D. N., Ohgaki, H., Wiestler, O. D. & Cavenee, W. K. (Eds). WHO Classification of Tumours of the Central Nervous System, 4th edn 10-80 (IARC, 2007).
-
(2007)
WHO Classification of Tumours of the Central Nervous System
, pp. 10-80
-
-
Louis, D.N.1
Ohgaki, H.2
Wiestler, O.D.3
Cavenee, W.K.4
-
24
-
-
77956227086
-
Interobserver variation of the histopathological diagnosis in clinical trials on glioma: A clinician's perspective
-
van den Bent, M. J. Interobserver variation of the histopathological diagnosis in clinical trials on glioma: a clinician's perspective. Acta Neuropathol. 120, 297-304 (2010).
-
(2010)
Acta Neuropathol.
, vol.120
, pp. 297-304
-
-
Van-Den-Bent, M.J.1
-
25
-
-
84929999099
-
Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma
-
Wiestler, B. et al. Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma. Acta Neuropathol. 128, 561-571 (2014).
-
(2014)
Acta Neuropathol.
, vol.128
, pp. 561-571
-
-
Wiestler, B.1
-
26
-
-
84939952838
-
Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups
-
Weller, M. et al. Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups. Acta Neuropathol. 129, 679-693 (2015).
-
(2015)
Acta Neuropathol.
, vol.129
, pp. 679-693
-
-
Weller, M.1
-
27
-
-
84919921568
-
Farewell to oligoastrocytoma: In situ molecular genetics favor classification as either oligodendroglioma or astrocytoma
-
Sahm, F. et al. Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. Acta Neuropathol. 128, 551-559 (2014).
-
(2014)
Acta Neuropathol.
, vol.128
, pp. 551-559
-
-
Sahm, F.1
-
28
-
-
84954364128
-
Gliomatosis cerebri: No evidence for a separate brain tumour entity
-
Herrlinger, U. et al. Gliomatosis cerebri: no evidence for a separate brain tumour entity. Acta Neuropathol. 131, 309-319 (2016).
-
(2016)
Acta Neuropathol.
, vol.131
, pp. 309-319
-
-
Herrlinger, U.1
-
29
-
-
85027948565
-
International Society of Neuropathology-Haarlem consensus guidelines for nervous system tumour classification and grading
-
Louis, D. N. et al. International Society of Neuropathology-Haarlem consensus guidelines for nervous system tumour classification and grading. Brain Pathol. 24, 429-435 (2014).
-
(2014)
Brain Pathol.
, vol.24
, pp. 429-435
-
-
Louis, D.N.1
-
30
-
-
84966687479
-
The 2016 World Health Organization Classification of Tumours of the Central Nervous System: A summary
-
Louis, D. N. et al. The 2016 World Health Organization Classification of Tumours of the Central Nervous System: a summary. Acta Neuropathol. 131, 803-820 (2016).
-
(2016)
Acta Neuropathol.
, vol.131
, pp. 803-820
-
-
Louis, D.N.1
-
31
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons, D. W. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812 (2008).
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
-
32
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan, H. et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360, 765-773 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 765-773
-
-
Yan, H.1
-
33
-
-
56749156414
-
Analysis of the IDH1 codon 132 mutation in brain tumours
-
Balss, J. et al. Analysis of the IDH1 codon 132 mutation in brain tumours. Acta Neuropathol. 116, 597-602 (2008).
-
(2008)
Acta Neuropathol.
, vol.116
, pp. 597-602
-
-
Balss, J.1
-
35
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
-
Xu, W. et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell 19, 17-30 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
-
36
-
-
77952108366
-
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
-
Noushmehr, H. et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17, 510-522 (2010).
-
(2010)
Cancer Cell
, vol.17
, pp. 510-522
-
-
Noushmehr, H.1
-
37
-
-
70449518400
-
Monoclonal antibody specific for IDH1 R132H mutation
-
Capper, D. et al. Monoclonal antibody specific for IDH1 R132H mutation. Acta Neuropathol. 118, 599-601 (2009).
-
(2009)
Acta Neuropathol.
, vol.118
, pp. 599-601
-
-
Capper, D.1
-
38
-
-
84877825900
-
Interlaboratory comparison of IDH mutation detection
-
van den Bent, M. J. et al. Interlaboratory comparison of IDH mutation detection. J. Neurooncol. 112, 173-178 (2013).
-
(2013)
J. Neurooncol.
, vol.112
, pp. 173-178
-
-
Van-Den-Bent, M.J.1
-
39
-
-
84939572877
-
Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities
-
Reuss, D. E. et al. Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities. Acta Neuropathol. 130, 407-417 (2015).
-
(2015)
Acta Neuropathol.
, vol.130
, pp. 407-417
-
-
Reuss, D.E.1
-
40
-
-
84976444914
-
Molecular classification of gliomas
-
Masui, K., Mischel, P. S. & Reifenberger, G. Molecular classification of gliomas. Handb. Clin. Neurol. 134, 97-120 (2016).
-
(2016)
Handb. Clin. Neurol.
, vol.134
, pp. 97-120
-
-
Masui, K.1
Mischel, P.S.2
Reifenberger, G.3
-
41
-
-
84865520089
-
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
-
Sasaki, M. et al. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature 488, 656-659 (2012).
-
(2012)
Nature
, vol.488
, pp. 656-659
-
-
Sasaki, M.1
-
42
-
-
84983095362
-
Emerging roles of ATRX in cancer
-
Watson, L. A., Goldberg, H. & Birubi, N. G. Emerging roles of ATRX in cancer. Epigenomics 7, 1365-1378 (2015).
-
(2015)
Epigenomics
, vol.7
, pp. 1365-1378
-
-
Watson, L.A.1
Goldberg, H.2
Birubi, N.G.3
-
43
-
-
84949035547
-
Integrated genomic characterization of IDH1-mutant glioma malignant progression
-
Bai, H. et al. Integrated genomic characterization of IDH1-mutant glioma malignant progression. Nat. Genet. 48, 59-66 (2016).
-
(2016)
Nat. Genet.
, vol.48
, pp. 59-66
-
-
Bai, H.1
-
44
-
-
84942307003
-
DNA methylation and somatic mutations converge on the cell cycle and define similar evolutionary histories in brain tumours
-
Mazor, T. et al. DNA methylation and somatic mutations converge on the cell cycle and define similar evolutionary histories in brain tumours. Cancer Cell 28, 307-317 (2015).
-
(2015)
Cancer Cell
, vol.28
, pp. 307-317
-
-
Mazor, T.1
-
45
-
-
33749471311
-
Identification of der(1;19)(q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q loss
-
Griffin, C. A. et al. Identification of der(1;19)(q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q loss. J. Neuropathol. Exp. Neurol. 65, 988-994 (2006).
-
(2006)
J. Neuropathol. Exp. Neurol.
, vol.65
, pp. 988-994
-
-
Griffin, C.A.1
-
46
-
-
33750563258
-
A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma
-
Jenkins, R. B. et al. A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma. Cancer Res. 66, 9852-9856 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 9852-9856
-
-
Jenkins, R.B.1
-
47
-
-
84881095932
-
Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss
-
Arita, H. et al. Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss. Acta Neuropathol. 126, 267-276 (2013).
-
(2013)
Acta Neuropathol.
, vol.126
, pp. 267-276
-
-
Arita, H.1
-
48
-
-
80052608062
-
Mutations in CIC and FUBP1 contribute to human oligodendroglioma
-
Bettegowda, C. et al. Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science 333, 1453-1455 (2011).
-
(2011)
Science
, vol.333
, pp. 1453-1455
-
-
Bettegowda, C.1
-
49
-
-
84944392284
-
Allelic loss of 9p21.3 is a prognostic factor in 1p/19q codeleted anaplastic gliomas
-
Alentorn, A. et al. Allelic loss of 9p21.3 is a prognostic factor in 1p/19q codeleted anaplastic gliomas. Neurology 85, 1325-1331 (2015).
-
(2015)
Neurology
, vol.85
, pp. 1325-1331
-
-
Alentorn, A.1
-
50
-
-
84935896707
-
TCF12 is mutated in anaplastic oligodendroglioma
-
Labreche, K. et al. TCF12 is mutated in anaplastic oligodendroglioma. Nat. Commun. 6, 7207 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 7207
-
-
Labreche, K.1
-
51
-
-
84973326510
-
Integrated multi-omics analysis of oligodendroglial tumours identifies three subgroups of 1p/19q co-deleted gliomas
-
Kamoun, A. et al. Integrated multi-omics analysis of oligodendroglial tumours identifies three subgroups of 1p/19q co-deleted gliomas. Nat. Commun. 7, 11263 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 11263
-
-
Kamoun, A.1
-
52
-
-
84929629913
-
Mixed glioma with molecular features of composite oligodendroglioma and astrocytoma: A true "oligoastrocytoma"?
-
Huse, J. T., Diamond, E. L., Wang, L. & Rosenblum, M. K. Mixed glioma with molecular features of composite oligodendroglioma and astrocytoma: a true "oligoastrocytoma"? Acta Neuropathol. 129, 151-153 (2015).
-
(2015)
Acta Neuropathol.
, vol.129
, pp. 151-153
-
-
Huse, J.T.1
Diamond, E.L.2
Wang, L.3
Rosenblum, M.K.4
-
53
-
-
84929706306
-
Glioblastoma: Pathology, molecular mechanisms and markers
-
Aldape, K., Zadeh, G., Mansouri, S., Reifenberger, G. & von Deimling, A. Glioblastoma: pathology, molecular mechanisms and markers. Acta Neuropathol. 129, 829-848 (2015).
-
(2015)
Acta Neuropathol.
, vol.129
, pp. 829-848
-
-
Aldape, K.1
Zadeh, G.2
Mansouri, S.3
Reifenberger, G.4
Von Deimling, A.5
-
54
-
-
84876680857
-
Epithelioid GBMs show a high percentage of BRAF V600E mutation
-
Kleinschmidt-De Masters, B. K., Aisner, D. L., Birks, D. K. & Foreman, N. K. Epithelioid GBMs show a high percentage of BRAF V600E mutation. Am. J. Surg. Pathol. 37, 685-698 (2013).
-
(2013)
Am. J. Surg. Pathol.
, vol.37
, pp. 685-698
-
-
Kleinschmidt-De-Masters, B.K.1
Aisner, D.L.2
Birks, D.K.3
Foreman, N.K.4
-
55
-
-
73649123907
-
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterised by abnormalities in PDGFRA, IDH1, EGFR, and NF1
-
Verhaak, R. G. et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterised by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17, 98-110 (2010).
-
(2010)
Cancer Cell
, vol.17
, pp. 98-110
-
-
Verhaak, R.G.1
-
56
-
-
84883656941
-
Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma
-
Bhat, K. P. et al. Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma. Cancer Cell. 24, 331-346 (2013).
-
(2013)
Cancer Cell.
, vol.24
, pp. 331-346
-
-
Bhat, K.P.1
-
57
-
-
84902668801
-
Single-cell RNA-seq highlights intratumoural heterogeneity in primary glioblastoma
-
Patel, A. P. et al. Single-cell RNA-seq highlights intratumoural heterogeneity in primary glioblastoma. Science 344, 1396-1401 (2014).
-
(2014)
Science
, vol.344
, pp. 1396-1401
-
-
Patel, A.P.1
-
58
-
-
84941359544
-
Patients with proneural glioblastoma may derive overall survival benefit from the addition of bevacizumab to first-line radiotherapy and temozolomide: Retrospective analysis of the AVAglio trial
-
Sandmann, T. et al. Patients with proneural glioblastoma may derive overall survival benefit from the addition of bevacizumab to first-line radiotherapy and temozolomide: retrospective analysis of the AVAglio trial. J. Clin. Oncol. 33, 2735-2744 (2015).
-
(2015)
J. Clin. Oncol.
, vol.33
, pp. 2735-2744
-
-
Sandmann, T.1
-
59
-
-
79960388615
-
BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma
-
Hawkins, C. et al. BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma. Clin. Cancer Res. 17, 4790-4798 (2011).
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 4790-4798
-
-
Hawkins, C.1
-
60
-
-
33847053161
-
ARF/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas
-
ARF/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas. Oncogene 26, 1088-1097 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 1088-1097
-
-
Weber, R.G.1
-
61
-
-
79954441895
-
Analysis of BRAF V600E mutation in 1,320 nervous system tumours reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
-
Schindler, G. et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumours reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol. 121, 397-405 (2011).
-
(2011)
Acta Neuropathol.
, vol.121
, pp. 397-405
-
-
Schindler, G.1
-
62
-
-
84898540842
-
BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression
-
Koelsche, C. et al. BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression. Brain Pathol. 24, 221-229 (2014).
-
(2014)
Brain Pathol.
, vol.24
, pp. 221-229
-
-
Koelsche, C.1
-
63
-
-
84945278496
-
Epithelioid glioblastomas and anaplastic epithelioid pleomorphic xanthoastrocytomas - Same entity or first cousins?
-
Alexandrescu, S. et al. Epithelioid glioblastomas and anaplastic epithelioid pleomorphic xanthoastrocytomas - same entity or first cousins? Brain Pathol. 26, 215-223 (2016).
-
(2016)
Brain Pathol.
, vol.26
, pp. 215-223
-
-
Alexandrescu, S.1
-
64
-
-
10044259616
-
Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: Biallelic inactivation of TSC1 or TSC2 leads to mTOR activation
-
Chan, J. A. et al. Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. J. Neuropathol. Exp. Neurol. 63, 1236-1242 (2004).
-
(2004)
J. Neuropathol. Exp. Neurol.
, vol.63
, pp. 1236-1242
-
-
Chan, J.A.1
-
65
-
-
84939244139
-
Molecular analysis of pediatric oligodendrogliomas highlights genetic differences with adult counterparts and other pediatric gliomas
-
Nauen, D. et al. Molecular analysis of pediatric oligodendrogliomas highlights genetic differences with adult counterparts and other pediatric gliomas. Brain Pathol. 26, 206-214 (2016).
-
(2016)
Brain Pathol.
, vol.26
, pp. 206-214
-
-
Nauen, D.1
-
66
-
-
84955315769
-
Genetic alterations in uncommon low-grade neuroepithelial tumours: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology
-
Qaddoumi, I. et al. Genetic alterations in uncommon low-grade neuroepithelial tumours: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology. Acta Neuropathol. 131, 833-845 (2016).
-
(2016)
Acta Neuropathol.
, vol.131
, pp. 833-845
-
-
Qaddoumi, I.1
-
67
-
-
84959547851
-
MYB-QKI rearrangements in angiocentric glioma drive tumourigenicity through a tripartite mechanism
-
Bandopadhayay, P. et al. MYB-QKI rearrangements in angiocentric glioma drive tumourigenicity through a tripartite mechanism. Nat. Genet. 48, 273-282 (2016).
-
(2016)
Nat. Genet.
, vol.48
, pp. 273-282
-
-
Bandopadhayay, P.1
-
68
-
-
84887617868
-
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
-
Bender, S. et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell 24, 660-672 (2013).
-
(2013)
Cancer Cell
, vol.24
, pp. 660-672
-
-
Bender, S.1
-
69
-
-
84877785024
-
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
-
Lewis, P. W. et al. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 340, 857-861 (2013).
-
(2013)
Science
, vol.340
, pp. 857-861
-
-
Lewis, P.W.1
-
70
-
-
84961291627
-
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
-
Hashizume, R. et al. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat. Med. 20, 1394-1396 (2014).
-
(2014)
Nat. Med.
, vol.20
, pp. 1394-1396
-
-
Hashizume, R.1
-
71
-
-
84930764914
-
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
-
Grasso, C. S. et al. Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nat. Med. 21, 555-559 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 555-559
-
-
Grasso, C.S.1
-
72
-
-
84947617209
-
Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes
-
Castel, D. et al. Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. Acta Neuropathol. 130, 815-827 (2015).
-
(2015)
Acta Neuropathol.
, vol.130
, pp. 815-827
-
-
Castel, D.1
-
73
-
-
84896739200
-
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
-
Mack, S. C. et al. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature 506, 445-450 (2014).
-
(2014)
Nature
, vol.506
, pp. 445-450
-
-
Mack, S.C.1
-
74
-
-
84904902698
-
EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma
-
Weller, M. et al. EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma. Lancet Oncol. 15, e395-403 (2014).
-
(2014)
Lancet Oncol.
, vol.15
, pp. e395-403
-
-
Weller, M.1
-
75
-
-
84863091424
-
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: The NOA-08 randomised, phase 3 trial
-
Wick, W. et al. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol. 13, 707-715 (2012).
-
(2012)
Lancet Oncol.
, vol.13
, pp. 707-715
-
-
Wick, W.1
-
76
-
-
84865558322
-
Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: The Nordic randomised, phase 3 trial
-
Malmstrøm, A. et al. Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial. Lancet Oncol. 13, 916-926 (2012).
-
(2012)
Lancet Oncol.
, vol.13
, pp. 916-926
-
-
Malmstrøm, A.1
-
77
-
-
84873345824
-
Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: Long-term follow-up of EORTC brain tumour group study 26951
-
van den Bent, M. J. et al. Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumour group study 26951. J. Clin. Oncol. 31, 344-350 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 344-350
-
-
Van-Den-Bent, M.J.1
-
78
-
-
84873338121
-
Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: Long-term results of RTOG 9402
-
Cairncross, G. et al. Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402. J. Clin. Oncol. 31, 337-343 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 337-343
-
-
Cairncross, G.1
-
79
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp, R. et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352, 987-996 (2005).
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 987-996
-
-
Stupp, R.1
-
80
-
-
84904070681
-
MGMT testing - The challenges for biomarker-based glioma treatment
-
Wick, W. et al. MGMT testing - the challenges for biomarker-based glioma treatment. Nat. Rev. Neurol. 10, 372-385 (2014).
-
(2014)
Nat. Rev. Neurol.
, vol.10
, pp. 372-385
-
-
Wick, W.1
-
81
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
Hegi, M. E. et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N. Engl. J. Med. 352, 997-1003 (2005).
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 997-1003
-
-
Hegi, M.E.1
-
82
-
-
84888229904
-
Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation
-
Wick, W. et al. Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation. Neurology 81, 1515-1522 (2013).
-
(2013)
Neurology
, vol.81
, pp. 1515-1522
-
-
Wick, W.1
-
83
-
-
35649001325
-
Intratumoural homogeneity of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas
-
Grasbon-Frodl, E. et al. Intratumoural homogeneity of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas. Int. J. Cancer 121, 2458-2464 (2007).
-
(2007)
Int. J. Cancer
, vol.121
, pp. 2458-2464
-
-
Grasbon-Frodl, E.1
-
84
-
-
79958072588
-
Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas
-
Felsberg, J. et al. Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas. Int. J. Cancer 129, 659-670 (2011).
-
(2011)
Int. J. Cancer
, vol.129
, pp. 659-670
-
-
Felsberg, J.1
-
85
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068 (2008).
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
86
-
-
78650294541
-
Distinct patterns of 1p and 19q alterations identify subtypes of human gliomas that have different prognoses
-
Vogazianou, A. P. et al. Distinct patterns of 1p and 19q alterations identify subtypes of human gliomas that have different prognoses. Neuro Oncol. 12, 664-678 (2010).
-
(2010)
Neuro Oncol.
, vol.12
, pp. 664-678
-
-
Vogazianou, A.P.1
-
87
-
-
84954338858
-
BRAF inhibitors in BRAF-V600 mutated primary neuroepithelial brain tumours
-
Preusser, M., Bienkowski, M. & Birner, P. BRAF inhibitors in BRAF-V600 mutated primary neuroepithelial brain tumours. Expert Opin. Investig. Drugs 25, 7-14 (2016).
-
(2016)
Expert Opin. Investig. Drugs
, vol.25
, pp. 7-14
-
-
Preusser, M.1
Bienkowski, M.2
Birner, P.3
-
88
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
Rohle, D. et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 340, 626-630 (2013).
-
(2013)
Science
, vol.340
, pp. 626-630
-
-
Rohle, D.1
-
89
-
-
84906557615
-
A vaccine targeting mutant IDH1 induces antitumour immunity
-
Schumacher, T. et al. A vaccine targeting mutant IDH1 induces antitumour immunity. Nature 512, 324-327 (2014).
-
(2014)
Nature
, vol.512
, pp. 324-327
-
-
Schumacher, T.1
-
90
-
-
78149254368
-
Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
-
Sampson, J. H. et al. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J. Clin. Oncol. 28, 4722-4729 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 4722-4729
-
-
Sampson, J.H.1
-
91
-
-
84934981297
-
A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: The ACT III study
-
Schuster, J. et al. A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study. Neuro Oncol. 17, 854-861 (2015).
-
(2015)
Neuro Oncol.
, vol.17
, pp. 854-861
-
-
Schuster, J.1
-
92
-
-
84964318484
-
ABT-414, an antibody-drug conjugate targeting a tumor-selective EGFR epitope
-
Phillips, A. C. et al. ABT-414, an antibody-drug conjugate targeting a tumor-selective EGFR epitope. Mol. Cancer Ther. 15, 661-669 (2016).
-
(2016)
Mol. Cancer Ther.
, vol.15
, pp. 661-669
-
-
Phillips, A.C.1
-
93
-
-
84942163319
-
Preclinical test of dacomitinib, an irreversible EGFR inhibitor, confirms its effectiveness for glioblastoma
-
Zahonero, C. et al. Preclinical test of dacomitinib, an irreversible EGFR inhibitor, confirms its effectiveness for glioblastoma. Mol. Cancer Ther. 14, 1548-1558 (2015).
-
(2015)
Mol. Cancer Ther.
, vol.14
, pp. 1548-1558
-
-
Zahonero, C.1
-
94
-
-
84947485465
-
ReACT: Overall survival from a randomised phase II study of rindopepimut (CDX-110) plus bevacizumab in relapsed glioblastoma
-
abstr 2009
-
Reardon, D. A. et al. ReACT: overall survival from a randomised phase II study of rindopepimut (CDX-110) plus bevacizumab in relapsed glioblastoma. J. Clin. Oncol. 33 (Suppl.), abstr 2009 (2015).
-
(2015)
J. Clin. Oncol.
, vol.33
-
-
Reardon, D.A.1
-
95
-
-
84865805666
-
Transforming fusions of FGFR and TACC genes in human glioblastoma
-
Singh, D. et al. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science 337, 1231-1235 (2012).
-
(2012)
Science
, vol.337
, pp. 1231-1235
-
-
Singh, D.1
-
96
-
-
84929114925
-
Detection, characterization, and inhibition of FGFR-TACC fusions in IDH wild-type glioma
-
Di Stefano, A. L. et al. Detection, characterization, and inhibition of FGFR-TACC fusions in IDH wild-type glioma. Clin. Cancer Res. 21, 3307-3317 (2015).
-
(2015)
Clin. Cancer Res.
, vol.21
, pp. 3307-3317
-
-
Di-Stefano, A.L.1
-
97
-
-
84979671297
-
Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study
-
Worst, B. C. et al. Next-generation personalised medicine for high-risk paediatric cancer patients - the INFORM pilot study. Eur. J. Cancer 65, 91-101 (2016).
-
(2016)
Eur. J. Cancer
, vol.65
, pp. 91-101
-
-
Worst, B.C.1
-
99
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02465060 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
100
-
-
84960077443
-
Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: A report of the prospective randomised EORTC Brain Tumour Group 26951 phase III trial
-
Dubbink, H. J. et al. Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomised EORTC Brain Tumour Group 26951 phase III trial. Neuro Oncol. 18, 388-400 (2016).
-
(2016)
Neuro Oncol.
, vol.18
, pp. 388-400
-
-
Dubbink, H.J.1
-
101
-
-
84960108414
-
Targeted next-generation sequencing panel (GlioSeq) provides comprehensive genetic profiling of central nervous system tumours
-
Nikiforova, M. N. et al. Targeted next-generation sequencing panel (GlioSeq) provides comprehensive genetic profiling of central nervous system tumours. Neuro Oncol. 18, 379-387 (2016).
-
(2016)
Neuro Oncol.
, vol.18
, pp. 379-387
-
-
Nikiforova, M.N.1
-
102
-
-
84949991007
-
Next-generation sequencing in routine brain tumour diagnostics enables an integrated diagnosis and identifies actionable targets
-
Sahm, F. et al. Next-generation sequencing in routine brain tumour diagnostics enables an integrated diagnosis and identifies actionable targets. Acta Neuropathol. 131, 903-910 (2016).
-
(2016)
Acta Neuropathol.
, vol.131
, pp. 903-910
-
-
Sahm, F.1
-
103
-
-
84964354713
-
Molecular diagnostics of gliomas using next generation sequencing of a glioma-tailored gene panel
-
Zacher, A. et al. Molecular diagnostics of gliomas using next generation sequencing of a glioma-tailored gene panel. Brain Pathol. http://dx.doi.org/10.1111/bpa.12367 (2016).
-
(2016)
Brain Pathol.
-
-
Zacher, A.1
-
104
-
-
84963977862
-
Sensitivity analysis of the MGMT-STP27 model and impact of genetic and epigenetic context to predict the MGMT methylation status in gliomas and other tumours
-
Bady, P., Delorenzi, M. & Hegi, M. E. Sensitivity analysis of the MGMT-STP27 model and impact of genetic and epigenetic context to predict the MGMT methylation status in gliomas and other tumours. J. Mol. Diagn. 18, 350-361 (2016).
-
(2016)
J. Mol. Diagn.
, vol.18
, pp. 350-361
-
-
Bady, P.1
Delorenzi, M.2
Hegi, M.E.3
-
105
-
-
84896371874
-
Detection of circulating tumour DNA in early- and late-stage human malignancies
-
Bettegowda, C. et al. Detection of circulating tumour DNA in early- and late-stage human malignancies. Sci. Transl. Med. 6, 224ra24 (2014).
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 224ra24
-
-
Bettegowda, C.1
-
106
-
-
84946719441
-
Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma
-
De Mattos-Arruda, L. et al. Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma. Nat. Commun. 6, 8839 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 8839
-
-
De-Mattos-Arruda, L.1
-
107
-
-
84938632046
-
Detection of tumour-derived DNA in cerebrospinal fluid of patients with primary tumours of the brain and spinal cord
-
Wang, Y. et al. Detection of tumour-derived DNA in cerebrospinal fluid of patients with primary tumours of the brain and spinal cord. Proc. Natl Acad. Sci. USA 112, 9704-9709 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 9704-9709
-
-
Wang, Y.1
-
108
-
-
84940730294
-
A differentially expressed set of microRNAs in cerebro-spinal fluid (CSF) can diagnose CNS malignancies
-
Drusco, A. et al. A differentially expressed set of microRNAs in cerebro-spinal fluid (CSF) can diagnose CNS malignancies. Oncotarget 6, 20829-20839 (2015).
-
(2015)
Oncotarget
, vol.6
, pp. 20829-20839
-
-
Drusco, A.1
-
109
-
-
84944463325
-
Exosomal levels of miRNA-21 from cerebrospinal fluids associated with poor prognosis and tumor recurrence of glioma patients
-
Shi, R. et al. Exosomal levels of miRNA-21 from cerebrospinal fluids associated with poor prognosis and tumor recurrence of glioma patients. Oncotarget 6, 26971-26981 (2015).
-
(2015)
Oncotarget
, vol.6
, pp. 26971-26981
-
-
Shi, R.1
-
110
-
-
56749109572
-
Ependymomas of the adult: Molecular biology and treatment
-
Rudà, R., Gilbert, M. & Soffietti, R. Ependymomas of the adult: molecular biology and treatment. Curr. Opin. Neurol. 21, 754-761 (2008).
-
(2008)
Curr. Opin. Neurol.
, vol.21
, pp. 754-761
-
-
Rudà, R.1
Gilbert, M.2
Soffietti, R.3
-
111
-
-
33645986455
-
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: A randomised controlled multicentre phase III trial
-
Stummer, W. et al. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol. 7, 392-401 (2006).
-
(2006)
Lancet Oncol.
, vol.7
, pp. 392-401
-
-
Stummer, W.1
-
112
-
-
84860392329
-
Intraoperative MRI guidance and extent of resection in glioma surgery: A randomised, controlled trial
-
Senft, C. et al. Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial. Lancet Oncol. 12, 997-1003 (2011).
-
(2011)
Lancet Oncol.
, vol.12
, pp. 997-1003
-
-
Senft, C.1
-
113
-
-
0037262954
-
Debulking or biopsy of malignant glioma in elderly people - A randomised study
-
Vuorinen, V., Hinkka, S., Farkkila, M. & Jaaskelainen, J. Debulking or biopsy of malignant glioma in elderly people - a randomised study. Acta Neurochir. (Wien) 145, 5-10 (2003).
-
(2003)
Acta Neurochir. (Wien)
, vol.145
, pp. 5-10
-
-
Vuorinen, V.1
Hinkka, S.2
Farkkila, M.3
Jaaskelainen, J.4
-
114
-
-
24944439786
-
Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: The EORTC 22845 randomised trial
-
van den Bent, M. J. et al. Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial. Lancet 366, 985-990 (2005).
-
(2005)
Lancet
, vol.366
, pp. 985-990
-
-
Van-Den-Bent, M.J.1
-
115
-
-
79961129343
-
Validation of EORTC prognostic factors for adults with low-grade glioma: A report using intergroup 86-72-51
-
Daniels, T. B. et al. Validation of EORTC prognostic factors for adults with low-grade glioma: a report using intergroup 86-72-51. Int. J. Radiat. Oncol. Biol. Phys. 81, 218-224 (2011).
-
(2011)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.81
, pp. 218-224
-
-
Daniels, T.B.1
-
116
-
-
0037089635
-
Prognostic factors for survival in adult patients with cerebral low-grade glioma
-
Pignatti, F. et al. Prognostic factors for survival in adult patients with cerebral low-grade glioma. J. Clin. Oncol. 20, 2076-2084 (2002).
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 2076-2084
-
-
Pignatti, F.1
-
117
-
-
84963804957
-
Radiation plus procarbazine, CCNU, and vincristine in low-grade glioma
-
Buckner, J. C. et al. Radiation plus procarbazine, CCNU, and vincristine in low-grade glioma. N. Engl. J. Med. 374, 1344-1355 (2016).
-
(2016)
N. Engl. J. Med.
, vol.374
, pp. 1344-1355
-
-
Buckner, J.C.1
-
118
-
-
84995596353
-
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): A randomised, open-label, phase 3 intergroup study
-
Baumert, B. G. et al. Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study. Lancet Oncol. 17, 1521-1532 (2016).
-
(2016)
Lancet Oncol.
, vol.17
, pp. 1521-1532
-
-
Baumert, B.G.1
-
119
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT00887146 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
120
-
-
84899760157
-
Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH
-
Cairncross, J. G. et al. Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH. J. Clin. Oncol. 32, 783-790 (2014).
-
(2014)
J. Clin. Oncol.
, vol.32
, pp. 783-790
-
-
Cairncross, J.G.1
-
121
-
-
84886445555
-
MGMT-STP27 methylation status as predictive marker for response to PCV in anaplastic oligodendrogliomas and oligoastrocytomas. A report from EORTC study 26951
-
van den Bent, M. J. et al. MGMT-STP27 methylation status as predictive marker for response to PCV in anaplastic oligodendrogliomas and oligoastrocytomas. A report from EORTC study 26951. Clin. Cancer Res. 19, 5513-5522 (2013).
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 5513-5522
-
-
Van-Den-Bent, M.J.1
-
122
-
-
84983744916
-
Results of the interim analysis of the EORTC randomized phase III CATNON trial on concurrent and adjuvant temozolomide in anaplastic glioma without 1p/19q co-deletion, an intergroup trial [abstract]
-
van den Bent, M. J. et al. Results of the interim analysis of the EORTC randomized phase III CATNON trial on concurrent and adjuvant temozolomide in anaplastic glioma without 1p/19q co-deletion, an intergroup trial [abstract]. J. Clin. Oncol. 34, LBA2000 (2016).
-
(2016)
J. Clin. Oncol.
, vol.34
, pp. LBA2000
-
-
Van-Den-Bent, M.J.1
-
123
-
-
84875502202
-
Optimal management of elderly patients with glioblastoma
-
Laperriere, N. et al. Optimal management of elderly patients with glioblastoma. Cancer Treat. Rev. 39, 350-357 (2013).
-
(2013)
Cancer Treat. Rev.
, vol.39
, pp. 350-357
-
-
Laperriere, N.1
-
124
-
-
2442659387
-
Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: A prospective randomised clinical trial
-
Roa, W. et al. Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomised clinical trial. J. Clin. Oncol. 22, 1583-1588 (2004).
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 1583-1588
-
-
Roa, W.1
-
125
-
-
84980416915
-
A phase III randomised controlled trial of short-course radiotherapy with or without concomitant and adjuvant temozolomide in elderly patients with glioblastoma (CCTG CE.6, EORTC 26062-22061, TROG 08.02, NCT00482677)
-
LBA2
-
Perry, J. R. et al. A phase III randomised controlled trial of short-course radiotherapy with or without concomitant and adjuvant temozolomide in elderly patients with glioblastoma (CCTG CE.6, EORTC 26062-22061, TROG 08.02, NCT00482677). J. Clin. Oncol. 34, LBA2 (2016).
-
(2016)
J. Clin. Oncol.
, vol.34
-
-
Perry, J.R.1
-
126
-
-
84966589269
-
Complete resection of contrast-enhancing tumour volume is associated with improved survival in recurrent glioblastoma-results from the DIRECTOR trial
-
Suchorska, B. et al. Complete resection of contrast-enhancing tumour volume is associated with improved survival in recurrent glioblastoma-results from the DIRECTOR trial. Neuro Oncol. 18, 549-556 (2016).
-
(2016)
Neuro Oncol.
, vol.18
, pp. 549-556
-
-
Suchorska, B.1
-
128
-
-
84887116872
-
Phase III randomised trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma
-
Batchelor, T. T. et al. Phase III randomised trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. J. Clin. Oncol. 31, 3212-3218 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 3212-3218
-
-
Batchelor, T.T.1
-
129
-
-
77949891455
-
Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma
-
Wick, W. et al. Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J. Clin. Oncol. 28, 1168-1174 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 1168-1174
-
-
Wick, W.1
-
130
-
-
77951648272
-
Phase II trial of continuous dose-intense temozolomide in recurrent malignant glioma: RESCUE study
-
Perry, J. R. et al. Phase II trial of continuous dose-intense temozolomide in recurrent malignant glioma: RESCUE study. J. Clin. Oncol. 28, 2051-2057 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 2051-2057
-
-
Perry, J.R.1
-
131
-
-
84937939301
-
MGMT promoter methylation is a strong prognostic biomarker for benefit from dose-intensified temozolomide rechallenge in progressive glioblastoma: The DIRECTOR trial
-
Weller, M. et al. MGMT promoter methylation is a strong prognostic biomarker for benefit from dose-intensified temozolomide rechallenge in progressive glioblastoma: the DIRECTOR trial. Clin. Cancer Res. 21, 2057-2064 (2015).
-
(2015)
Clin. Cancer Res.
, vol.21
, pp. 2057-2064
-
-
Weller, M.1
-
132
-
-
70350461699
-
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
-
Friedman, H. S. et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J. Clin. Oncol. 27, 4733-4740 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 4733-4740
-
-
Friedman, H.S.1
-
133
-
-
59949083263
-
Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumour progression in recurrent glioblastoma
-
Kreisl, T. N. et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumour progression in recurrent glioblastoma. J. Clin. Oncol. 27, 740-745 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 740-745
-
-
Kreisl, T.N.1
-
134
-
-
84970982109
-
Phase III trial exploring the combination of bevacizumab and lomustine in patients with first recurrence of a glioblastoma: The EORTC 26101 trial [abstract LB-05]
-
Wick, W. et al. Phase III trial exploring the combination of bevacizumab and lomustine in patients with first recurrence of a glioblastoma: the EORTC 26101 trial [abstract LB-05]. Neuro Oncol. 17 (Suppl. 5), v1 (2015).
-
(2015)
Neuro Oncol.
, vol.17
, pp. v1
-
-
Wick, W.1
-
135
-
-
84950157098
-
Maintenance therapy with tumour-treating fields plus temozolomide versus temozolomide alone for glioblastoma: A randomised clinical trial
-
Stupp, R. et al. Maintenance therapy with tumour-treating fields plus temozolomide versus temozolomide alone for glioblastoma: a randomised clinical trial. JAMA 314, 2535-2543 (2015).
-
(2015)
JAMA
, vol.314
, pp. 2535-2543
-
-
Stupp, R.1
-
136
-
-
84960081834
-
TTFields: Where does all the skepticism come from?
-
Wick, W. TTFields: where does all the skepticism come from? Neuro Oncol. 18, 303-305 (2016).
-
(2016)
Neuro Oncol.
, vol.18
, pp. 303-305
-
-
Wick, W.1
-
137
-
-
84892373020
-
Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma
-
Johnson, B. E. et al. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science 343, 189-193 (2014).
-
(2014)
Science
, vol.343
, pp. 189-193
-
-
Johnson, B.E.1
-
138
-
-
9244241576
-
Identification of human brain tumour initiating cells
-
Singh, S. K. et al. Identification of human brain tumour initiating cells. Nature 432, 396-401 (2004).
-
(2004)
Nature
, vol.432
, pp. 396-401
-
-
Singh, S.K.1
-
139
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
Bao, S. et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444, 756-760 (2006).
-
(2006)
Nature
, vol.444
, pp. 756-760
-
-
Bao, S.1
-
140
-
-
84865203983
-
A restricted cell population propagates glioblastoma growth after chemotherapy
-
Chen, J. et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488, 522-526 (2012).
-
(2012)
Nature
, vol.488
, pp. 522-526
-
-
Chen, J.1
-
141
-
-
84933530651
-
Cancer stem cells in glioblastoma
-
Lathia, J. D., Mack, S. C., Mulkearns-Hubert, E. E., Valentim, C. L. & Rich, J. N. Cancer stem cells in glioblastoma. Genes Dev. 29, 1203-1217 (2015).
-
(2015)
Genes Dev.
, vol.29
, pp. 1203-1217
-
-
Lathia, J.D.1
Mack, S.C.2
Mulkearns-Hubert, E.E.3
Valentim, C.L.4
Rich, J.N.5
-
142
-
-
84959164500
-
MLL5 orchestrates a cancer self-renewal state by repressing the histone variant H3.3 and globally reorganizing chromatin
-
Gallo, M. et al. MLL5 orchestrates a cancer self-renewal state by repressing the histone variant H3.3 and globally reorganizing chromatin. Cancer Cell 28, 715-729 (2015).
-
(2015)
Cancer Cell
, vol.28
, pp. 715-729
-
-
Gallo, M.1
-
143
-
-
84896107633
-
Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumour growth
-
Pietras, A. et al. Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumour growth. Cell Stem Cell 14, 357-369 (2014).
-
(2014)
Cell Stem Cell
, vol.14
, pp. 357-369
-
-
Pietras, A.1
-
144
-
-
84905856772
-
Targeting self-renewal in high-grade brain tumours leads to loss of brain tumour stem cells and prolonged survival
-
Zhu, Z. et al. Targeting self-renewal in high-grade brain tumours leads to loss of brain tumour stem cells and prolonged survival. Cell Stem Cell 15, 185-198 (2014).
-
(2014)
Cell Stem Cell
, vol.15
, pp. 185-198
-
-
Zhu, Z.1
-
145
-
-
84991211970
-
Molecular and clinical effects of Notch inhibition in glioma patients: A phase 0/I trial
-
Xu, R. et al. Molecular and clinical effects of Notch inhibition in glioma patients: a phase 0/I trial. Clin. Cancer Res. 22, 4786-4796 (2016).
-
(2016)
Clin. Cancer Res.
, vol.22
, pp. 4786-4796
-
-
Xu, R.1
-
146
-
-
85014088728
-
Targeting glioma-initiating cells in GBM: ABTC-0904, a randomized phase 0/II study targeting the Sonic Hedgehog-signaling pathway
-
Sloan, A. E. et al. Targeting glioma-initiating cells in GBM: ABTC-0904, a randomized phase 0/II study targeting the Sonic Hedgehog-signaling pathway. J. Clin. Oncol. 32, (2014).
-
(2014)
J. Clin. Oncol.
, vol.32
-
-
Sloan, A.E.1
-
147
-
-
84939992139
-
Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment
-
van Thuijl, H. F. et al. Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment. Acta Neuropathol. 129, 597-607 (2015).
-
(2015)
Acta Neuropathol.
, vol.129
, pp. 597-607
-
-
Van Thuijl, H.F.1
-
148
-
-
78650014447
-
Loss of ATM/Chk2/p53 pathway components accelerates tumour development and contributes to radiation resistance in gliomas
-
Squatrito, M. et al. Loss of ATM/Chk2/p53 pathway components accelerates tumour development and contributes to radiation resistance in gliomas. Cancer Cell 18, 619-629 (2010).
-
(2010)
Cancer Cell
, vol.18
, pp. 619-629
-
-
Squatrito, M.1
-
149
-
-
84898022873
-
In vivo radiation response of proneural glioma characterised by protective p53 transcriptional program and proneural-mesenchymal shift
-
Halliday, J. et al. In vivo radiation response of proneural glioma characterised by protective p53 transcriptional program and proneural-mesenchymal shift. Proc. Natl Acad. Sci. USA 111, 5248-5253 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 5248-5253
-
-
Halliday, J.1
-
150
-
-
84949293502
-
Brain tumour cells interconnect to a functional and resistant network
-
Osswald, M. et al. Brain tumour cells interconnect to a functional and resistant network. Nature 528, 93-98 (2015).
-
(2015)
Nature
, vol.528
, pp. 93-98
-
-
Osswald, M.1
-
151
-
-
78049510428
-
Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
-
Krueger, D. A. et al. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N. Engl. J. Med. 363, 1801-1811 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 1801-1811
-
-
Krueger, D.A.1
-
152
-
-
84872088946
-
Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): A multicentre, randomised, placebo-controlled phase 3 trial
-
Franz, D. N. et al. Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial. Lancet 381, 125-132 (2013).
-
(2013)
Lancet
, vol.381
, pp. 125-132
-
-
Franz, D.N.1
-
153
-
-
84885059781
-
Salvage therapy with BRAF inhibitors for recurrent pleomorphic xanthoastrocytoma: A retrospective case series
-
Chamberlain, M. C. Salvage therapy with BRAF inhibitors for recurrent pleomorphic xanthoastrocytoma: a retrospective case series. J. Neurooncol. 114, 237-240 (2013).
-
(2013)
J. Neurooncol.
, vol.114
, pp. 237-240
-
-
Chamberlain, M.C.1
-
154
-
-
84963593691
-
Successful treatment of a progressive BRAF V600E-mutated anaplastic pleomorphic xanthoastrocytoma with vemurafenib monotherapy
-
Lee, E. Q., Ruland, S., Le Boeuf, N. R., Wen, P. Y. & Santagata, S. Successful treatment of a progressive BRAF V600E-mutated anaplastic pleomorphic xanthoastrocytoma with vemurafenib monotherapy. J. Clin. Oncol. 34, e87-89 (2016).
-
(2016)
J. Clin. Oncol.
, vol.34
, pp. e87-89
-
-
Lee, E.Q.1
Ruland, S.2
Le-Boeuf, N.R.3
Wen, P.Y.4
Santagata, S.5
-
155
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01748149 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
156
-
-
85084273119
-
The first study of dabrafenib in pediatric patients with BRAF V600-mutant relapsed or refractory low-grade gliomas
-
abstr LBA19-PR
-
Kieran, M. W. et al. The first study of dabrafenib in pediatric patients with BRAF V600-mutant relapsed or refractory low-grade gliomas. Ann. Oncol. 27 (Suppl. 6), abstr LBA19-PR (2016).
-
(2016)
Ann. Oncol.
, vol.27
-
-
Kieran, M.W.1
-
157
-
-
84876040346
-
Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas
-
Sievert, A. J. et al. Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas. Proc. Natl Acad. Sci. USA 110, 5957-5962 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 5957-5962
-
-
Sievert, A.J.1
-
158
-
-
84921596103
-
Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas
-
Karajannis, M. A. et al. Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas. Neuro Oncol. 16, 1408-1416 (2014).
-
(2014)
Neuro Oncol.
, vol.16
, pp. 1408-1416
-
-
Karajannis, M.A.1
-
159
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01089101 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
160
-
-
84899485468
-
Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy
-
Robinson, G. W., Orr, B. A. & Gajjar, A. Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy. BMC Cancer 14, 258 (2014).
-
(2014)
BMC Cancer
, vol.14
, pp. 258
-
-
Robinson, G.W.1
Orr, B.A.2
Gajjar, A.3
-
161
-
-
23944453425
-
Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study
-
Galanis, E. et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J. Clin. Oncol. 23, 5294-5304 (2005).
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 5294-5304
-
-
Galanis, E.1
-
162
-
-
84991211405
-
Phase II study of radiotherapy and temsirolimus versus radiochemotherapy with temozolomide in patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation (EORTC 26082)
-
Wick, W. et al. Phase II study of radiotherapy and temsirolimus versus radiochemotherapy with temozolomide in patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation (EORTC 26082). Clin. Cancer Res. 22, 4797-4806 (2016).
-
(2016)
Clin. Cancer Res.
, vol.22
, pp. 4797-4806
-
-
Wick, W.1
-
163
-
-
62449150719
-
Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034
-
Van den Bent, M. J. et al. Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034. J. Clin. Oncol. 27, 1268-1274 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 1268-1274
-
-
Van-Den-Bent, M.J.1
-
164
-
-
84908563697
-
Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): A multicentre, randomised, open-label, phase 3 trial
-
Stupp, R. et al. Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 15, 1100-1108 (2014).
-
(2014)
Lancet Oncol.
, vol.15
, pp. 1100-1108
-
-
Stupp, R.1
-
165
-
-
84870065591
-
Epidermal growth factor receptor: A re-emerging target in glioblastoma
-
Hegi, M. E., Rajakannu, P. & Weller, M. Epidermal growth factor receptor: a re-emerging target in glioblastoma. Curr. Opin. Neurol. 25, 774-779 (2012).
-
(2012)
Curr. Opin. Neurol.
, vol.25
, pp. 774-779
-
-
Hegi, M.E.1
Rajakannu, P.2
Weller, M.3
-
166
-
-
84992103934
-
Efficacy of a novel antibody-drug conjugate (ADC), ABT-414, as monotherapy in epidermal growth factor receptor (EGFR) amplified, recurrent glioblastoma (GBM)
-
Van den Bent, M. J. et al. Efficacy of a novel antibody-drug conjugate (ADC), ABT-414, as monotherapy in epidermal growth factor receptor (EGFR) amplified, recurrent glioblastoma (GBM). J. Clin. Oncol. 34, 2542 (2016).
-
(2016)
J. Clin. Oncol.
, vol.34
, pp. 2542
-
-
Van-Den-Bent, M.J.1
-
167
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02073994 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
168
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02481154 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
169
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02381886 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
170
-
-
84944896282
-
EGFR mutation promotes glioblastoma through epigenome and transcription factor network remodeling
-
Liu, F. et al. EGFR mutation promotes glioblastoma through epigenome and transcription factor network remodeling. Mol. Cell. 60, 307-318 (2015).
-
(2015)
Mol. Cell.
, vol.60
, pp. 307-318
-
-
Liu, F.1
-
171
-
-
84861760527
-
Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors
-
Vivanco, I. et al. Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors. Cancer Discov. 2, 458-471 (2012).
-
(2012)
Cancer Discov.
, vol.2
, pp. 458-471
-
-
Vivanco, I.1
-
172
-
-
83455176258
-
Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma
-
Snuderl, M. et al. Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. Cancer Cell 20, 810-817 (2011).
-
(2011)
Cancer Cell
, vol.20
, pp. 810-817
-
-
Snuderl, M.1
-
173
-
-
84942252588
-
Toward precision medicine in glioblastoma: The promise and the challenges
-
Prados, M. D. et al. Toward precision medicine in glioblastoma: the promise and the challenges. Neuro Oncol. 17, 1051-1063 (2015).
-
(2015)
Neuro Oncol.
, vol.17
, pp. 1051-1063
-
-
Prados, M.D.1
-
174
-
-
84962269800
-
Immunosuppressive mechanisms in glioblastoma
-
Nduom, E. K., Weller, M. & Heimberger, A. B. Immunosuppressive mechanisms in glioblastoma. Neuro Oncol. 17, vii9-vii14 (2015).
-
(2015)
Neuro Oncol.
, vol.17
, pp. vii9-vii14
-
-
Nduom, E.K.1
Weller, M.2
Heimberger, A.B.3
-
175
-
-
84982121622
-
Vascular, glial, and lymphatic immune gateways of the central nervous system
-
Engelhardt, B. et al. Vascular, glial, and lymphatic immune gateways of the central nervous system. Acta Neuropathol. 132, 317-338 (2016).
-
(2016)
Acta Neuropathol.
, vol.132
, pp. 317-338
-
-
Engelhardt, B.1
-
176
-
-
84911890607
-
Immunotherapy advances for glioblastoma
-
Reardon, D. A. et al. Immunotherapy advances for glioblastoma. Neuro Oncol. 16, 1441-1458 (2014).
-
(2014)
Neuro Oncol.
, vol.16
, pp. 1441-1458
-
-
Reardon, D.A.1
-
177
-
-
85019444570
-
ACT IV: An international, double-blind, phase 3 trial of rindopepimut in newly diagnosed, EGFRvIII-expressing glioblastoma
-
Weller, M. et al. ACT IV: An international, double-blind, phase 3 trial of rindopepimut in newly diagnosed, EGFRvIII-expressing glioblastoma. Neuro Oncol. 18, (Suppl. 6): vi17-vi18 (2016).
-
(2016)
Neuro Oncol.
, vol.18
, pp. vi17-vi18
-
-
Weller, M.1
-
178
-
-
84925045090
-
Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients
-
Mitchell, D. A. et al. Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients. Nature 519, 366-369 (2015).
-
(2015)
Nature
, vol.519
, pp. 366-369
-
-
Mitchell, D.A.1
-
179
-
-
84975204817
-
A randomised double blind placebo-controlled phase 2 trial of dendritic cell (DC) vaccine ICT-107 following standard treatment in newly diagnosed patients with GBM
-
Wen, P. et al. A randomised double blind placebo-controlled phase 2 trial of dendritic cell (DC) vaccine ICT-107 following standard treatment in newly diagnosed patients with GBM. Neuro Oncol. 16, v8-v22 (2014).
-
(2014)
Neuro Oncol.
, vol.16
, pp. v8-v22
-
-
Wen, P.1
-
180
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02546102 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
181
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT00045968 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
182
-
-
84941025149
-
Prospects of immune checkpoint modulators in the treatment of glioblastoma
-
Preusser, M., Lim, M., Hafler, D. A., Reardon, D. A. & Sampson, J. H. Prospects of immune checkpoint modulators in the treatment of glioblastoma. Nat. Rev. Neurol. 11, 504-514 (2015).
-
(2015)
Nat. Rev. Neurol.
, vol.11
, pp. 504-514
-
-
Preusser, M.1
Lim, M.2
Hafler, D.A.3
Reardon, D.A.4
Sampson, J.H.5
-
183
-
-
84874605864
-
Phase III randomised clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
-
Ribas, A. et al. Phase III randomised clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J. Clin. Oncol. 31, 616-622 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 616-622
-
-
Ribas, A.1
-
184
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok, J. D. et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369, 122-133 (2013).
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 122-133
-
-
Wolchok, J.D.1
-
185
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
Brahmer, J. et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N. Engl. J. Med. 373, 123-135 (2015).
-
(2015)
N. Engl. J. Med.
, vol.373
, pp. 123-135
-
-
Brahmer, J.1
-
186
-
-
84924901863
-
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial
-
Rizvi, N. A. et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol. 16, 257-265 (2015).
-
(2015)
Lancet Oncol.
, vol.16
, pp. 257-265
-
-
Rizvi, N.A.1
-
187
-
-
84962032646
-
Glioblastoma eradication following immune checkpoint blockade in an orthotopic, immunocompetent model
-
Reardon, D. A. et al. Glioblastoma eradication following immune checkpoint blockade in an orthotopic, immunocompetent model. Cancer Immunol. Res. 4, 124-135 (2016).
-
(2016)
Cancer Immunol. Res.
, vol.4
, pp. 124-135
-
-
Reardon, D.A.1
-
188
-
-
84976467739
-
Immune checkpoint inhibition for hypermutant glioblastoma multiforme resulting from germline biallelic mismatch repair deficiency
-
Bouffet, E. et al. Immune checkpoint inhibition for hypermutant glioblastoma multiforme resulting from germline biallelic mismatch repair deficiency. J. Clin. Oncol. 34, 2206-2211 (2016).
-
(2016)
J. Clin. Oncol.
, vol.34
, pp. 2206-2211
-
-
Bouffet, E.1
-
189
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02017717 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
190
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02667587 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
191
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02617589 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
192
-
-
77956535599
-
Redirecting T-cell specificity by introducing a tumour-specific chimeric antigen receptor
-
Jena, B., Dotti, G. & Cooper, L. J. Redirecting T-cell specificity by introducing a tumour-specific chimeric antigen receptor. Blood 116, 1035-1044 (2010).
-
(2010)
Blood
, vol.116
, pp. 1035-1044
-
-
Jena, B.1
Dotti, G.2
Cooper, L.J.3
-
193
-
-
84896335556
-
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
-
Davila, M. L. et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci. Transl. Med. 6, 224ra25 (2014).
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 224ra25
-
-
Davila, M.L.1
-
194
-
-
84873991752
-
Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
-
Morgan, R. A. et al. Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J. Immunother. 36, 133-151 (2013).
-
(2013)
J. Immunother.
, vol.36
, pp. 133-151
-
-
Morgan, R.A.1
-
195
-
-
84896734231
-
EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss
-
Sampson, J. H. et al. EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss. Clin. Cancer Res. 20, 972-984 (2014).
-
(2014)
Clin. Cancer Res.
, vol.20
, pp. 972-984
-
-
Sampson, J.H.1
-
196
-
-
84962034350
-
CAR T cells targeting podoplanin reduce orthotopic glioblastomas in mouse brains
-
Shiina, S. et al. CAR T cells targeting podoplanin reduce orthotopic glioblastomas in mouse brains. Cancer Immunol. Res. 4, 259-268 (2016).
-
(2016)
Cancer Immunol. Res.
, vol.4
, pp. 259-268
-
-
Shiina, S.1
-
197
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01454596 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
198
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01109095 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
199
-
-
84933513655
-
Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor-modified T cells for the immunotherapy of HER2-positive sarcoma
-
Ahmed, N. et al. Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor-modified T cells for the immunotherapy of HER2-positive sarcoma. J. Clin. Oncol. 33, 1688-1696 (2015).
-
(2015)
J. Clin. Oncol.
, vol.33
, pp. 1688-1696
-
-
Ahmed, N.1
-
200
-
-
84959262585
-
Research methods to change clinical practice for patients with rare cancers
-
Billingham, L., Malottki, K. & Steven, N. Research methods to change clinical practice for patients with rare cancers. Lancet Oncol. 17, e70-80 (2016).
-
(2016)
Lancet Oncol.
, vol.17
, pp. e70-80
-
-
Billingham, L.1
Malottki, K.2
Steven, N.3
-
201
-
-
84860487114
-
Phase 2 trial design in neuro-oncology revisited: A report from the RANO group
-
Galanis, E. et al. Phase 2 trial design in neuro-oncology revisited: a report from the RANO group. Lancet Oncol. 13, e196-204 (2012).
-
(2012)
Lancet Oncol.
, vol.13
, pp. e196-204
-
-
Galanis, E.1
-
202
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02343406 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
203
-
-
37249013214
-
-
US National Institutes of Health. (2016)
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02573324 (2016).
-
ClinicalTrials.gov
-
-
-
204
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01112527 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
205
-
-
37249013214
-
-
US National Institutes of Health
-
US National Institutes of Health. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01975701 (2016).
-
(2016)
ClinicalTrials.gov
-
-
-
206
-
-
84877278637
-
Implementing personalised cancer genomics in clinical trials
-
Simon, R. & Roychowdhury, S. Implementing personalised cancer genomics in clinical trials. Nat. Rev. Drug Discov. 12, 358-369 (2013).
-
(2013)
Nat. Rev. Drug Discov.
, vol.12
, pp. 358-369
-
-
Simon, R.1
Roychowdhury, S.2
|