Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: A prospective randomized clinical trial

Journal of Clinical Oncology

Volumn 22, Issue 9, 2004, Pages 1583-1588

  Roa, Wilson ^a   Brasher, P M A ^a   Bauman, G ^a   Anthes, M ^a   Bruera, E ^a   Chan, A ^a   Fisher, B ^a   Fulton, D ^a   Gulavita, S ^a   Hao, C ^a   Husain, S ^a   Murtha, A ^a   Petruk, K ^a   Stewart, D ^a   Tai, P ^a   Urtasun, R ^a   Cairncross, J G ^a   Forsyth, P ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FUNCTIONAL ASSESSMENT; GLIOBLASTOMA; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; QUALITY OF LIFE; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; RANK SUM TEST; ADJUVANT THERAPY; AGE; BRAIN TUMOR; FEMALE; KARNOFSKY PERFORMANCE STATUS; MALE; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; PROSPECTIVE STUDY; RADIATION DOSE FRACTIONATION; SURVIVAL; TREATMENT OUTCOME;

ADRENAL CORTEX HORMONES; AGE FACTORS; AGED; BRAIN NEOPLASMS; DOSE FRACTIONATION; FEMALE; GLIOBLASTOMA; HUMANS; KARNOFSKY PERFORMANCE STATUS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RADIOTHERAPY, ADJUVANT; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 2442659387     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2004.06.082     Document Type: Article

References (15)

1. Halperin EC: Malignant gliomas in older adults with poor prognostic signs. Oncology 9:229-234, 1995
2. Curran WJ, Norton J, Nelson JS, et al: Recursive partitioning analysis of prognostic factors in three radiation therapy oncology group malignant glioma trials. J Natl Cancer Inst 85: 704-710, 1993
3. Whittle IR, Denholm SW, Gregor A: Management of patients aged over 60 years with supratentorial glioma: Lessons from an audit. Surg Neurol 36:106-111, 1991
4. Meckling S, Dold O, Forsyth PAJ, et al: Malignant supratentorial glioma in the elderly: Is RT useful? Neurology 47:901-905, 1996
5. Bauman GS, Fisher BJ, Halperin EC, et al: A prospective study of short-course RT in poor prognosis glioblastoma multiforme. Int J Radiat Oncol Biol Phys 29:835-839, 1994
6. Thomas R, James N, Guerrero D, et al: Hypofractionated RT as palliative treatment in poor prognosis patients with high-grade glioma. Radiother Oncol 33:113-116, 1994
7. Kleinberg L, Slick T, Enger C, et al: Short course accelerated hypofractionated treatment is appropriate for poor prognosis malignant glioma patients. Int J Radiat Oncol Biol Phys 32: 131, 1995 (abstr)
8. Hoegler DB, Davey P: A prospective study of short course RT in elderly patients with malignant glioma. J Neuro-Oncol 33:201-204, 1997
9. Branislav J, Shibamoto Y, Grujicic D, et al: Short-course RT in elderly and frail patients with glioblastoma multiforme: A phase II study. J Neuro-Oncol 44:85-90, 1999
10. Ford JM, Stenning SP, Boote DJ: A short fractionation RT treatment for poor prognosis patients with high-grade glioma. Clin Oncol (R Coll Radiol) 9:20-24, 1997
11. Berk L: An overview of RT trials for the treatment of brain metastases. Oncology 9:1205-1219, 1995
12. Makuch R, Simon R: Sample size requirements for evaluating a conservative therapy. Cancer Treat Rep 62:1037-1040, 1978
13. Jones B, Jarvis P, Lewis JA, et al: Trials to assess equivalence: The importance of rigorous methods. BMJ 313:35-39, 1996
14. Bleehen NM, Stenning SP: A medical research council trial of two RT doses in the treatment of grades 3 and 4 astrocytoma. Br J Cancer 64:769-771, 1991
15. Bernhard J, Cella DF, Coates AS, et al: Missing quality of life data in cancer clinical trials: Serious problems and challenges. Stat Med 17: 517-532, 1998