Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

Nature Genetics

Volumn 46, Issue 5, 2014, Pages 451-456

  Buczkowicz, Pawel ^a,b   Hoeman, Christine ^c   Rakopoulos, Patricia ^a,b   Pajovic, Sanja ^a   Letourneau, Louis ^d   Dzamba, Misko ^e   Morrison, Andrew ^a   Lewis, Peter ^f   Bouffet, Eric ^a   Bartels, Ute ^a   Zuccaro, Jennifer ^a   Agnihotri, Sameer ^a   Ryall, Scott ^a   Barszczyk, Mark ^a,b   Chornenkyy, Yevgen ^a,b   Bourgey, Mathieu ^d   Bourque, Guillaume ^d   Montpetit, Alexandre ^d   Cordero, Francisco ^c   Castelo Branco, Pedro ^a   Mangerel, Joshua ^a   Tabori, Uri ^a   Ho, King Ching ^a   Huang, Annie ^a   Taylor, Kathryn R ^g   Mackay, Alan ^g   Bendel, Anne E ^h   Nazarian, Javad ⁱ   Fangusaro, Jason R ^j   Karajannis, Matthias A ^k   Zagzag, David ^k   Foreman, Nicholas K ^l   Donson, Andrew ^l   Hegert, Julia V ^m   Smith, Amy ^m   Chan, Jennifer ⁿ   Lafay Cousin, Lucy ⁿ   Dunn, Sandra ^o   Hukin, Juliette ^o   Dunham, Chris ^o   Scheinemann, Katrin ^p   Michaud, Jean ^q   Zelcer, Shayna ^r   Ramsay, David ^r   Cain, Jason ^s   Brennan, Cameron ^t   Souweidane, Mark M ^t   Jones, Chris ^g   Allis, C David ^f   Brudno, Michael ^e,u   Becher, Oren ^c   Hawkins, Cynthia ^a,b   more..

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d MCGILL UNIVERSITY   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f ROCKEFELLER UNIVERSITY   (United States)

^g INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^h CHILDREN S HOSPITALS AND CLINICS OF MINNESOTA   (United States)

ⁱ CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^j CHILDREN'S MEMORIAL HOSPITAL   (United States)

^k NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^l CHILDREN S HOSPITAL   (United States)

^m ARNOLD PALMER HOSPITAL FOR CHILDREN   (United States)

ⁿ UNIVERSITY OF CALGARY   (Canada)

^o BC CHILDREN S HOSPITAL   (Canada)

^p MCMASTER CHILDREN S HOSPITAL   (Canada)

^q CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^r LONDON HEALTH SCIENCES CENTRE   (Canada)

^s MONASH MEDICAL CENTRE   (Australia)

^t MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^u HOSPITAL FOR SICK CHILDREN   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN RECEPTOR; INHIBITOR OF DIFFERENTIATION 1; INHIBITOR OF DIFFERENTIATION 2; SMAD PROTEIN; ACTIVIN; HISTONE H3; MYC PROTEIN;

ARTICLE; CANCER GENETICS; CARCINOGENESIS; CHILD; CLINICAL ARTICLE; DEVICE COMPARISON; FEMALE; GENE DOSAGE; GENE EXPRESSION PROFILING; GENE MUTATION; GENE SEQUENCE; GENOME ANALYSIS; HUMAN; HUMAN CELL; MALE; METHYLATION; NUCLEOTIDE SEQUENCE; PONTINE GLIOMA; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCHOOL CHILD; ACVR1 GENE; BRAIN HISTOLOGY; CANCER GRADING; CELL PROLIFERATION; CHILDHOOD CANCER; CLINICAL FEATURE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE; HUMAN TISSUE; IN VITRO STUDY; INTRACELLULAR SIGNALING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; BRAIN STEM NEOPLASMS; CHILD; DNA COPY NUMBER VARIATIONS; DNA METHYLATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; GLIOMA; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; INHIBITOR OF DIFFERENTIATION PROTEIN 2; PHOSPHORYLATION; SEQUENCE ANALYSIS, DNA; SMAD PROTEINS; ZEBRAFISH;

EID: 84899570180     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2936     Document Type: Article

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