Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes

Acta Neuropathologica

Volumn 130, Issue 6, 2015, Pages 815-827

  Castel, David ^a,b   Philippe, Cathy ^a   Calmon, Raphaël ^c   Le Dret, Ludivine ^a   Truffaux, Nathalène ^a   Boddaert, Nathalie ^c   Pagès, Mélanie ^f   Taylor, Kathryn R ^d   Saulnier, Patrick ^b   Lacroix, Ludovic ^b   Mackay, Alan ^d   Jones, Chris ^d   Sainte Rose, Christian ^e   Blauwblomme, Thomas ^e   Andreiuolo, Felipe ^f   Puget, Stephanie ^e   Grill, Jacques ^a,b   Varlet, Pascale ^f   Debily, Marie Anne ^a,g  

^a CNRS   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c Pitié Salpêtrière Hospital   (France)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^e HÔPITAL NECKER ENFANTS MALADES   (France)

^f CENTRE HOSPITALIER SAINTE ANNE   (France)

^g UNIVERSITÉ D EVRY VAL D ESSONNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H1; HISTONE H1H3B K27M; HISTONE H3; HISTONE H3F3A K27M; HOMEODOMAIN PROTEIN; HOXD8 PROTEIN; IRX4 PROTEIN; ISOLEUCINE; LYSINE; PROTEIN P53; PRRX1 PROTEIN; TLX2 PROTEIN; UNCLASSIFIED DRUG; H3 HISTONE FAMILY MEMBER 3A, HUMAN; HIST1H3B PROTEIN, HUMAN; HISTONE;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; ASTROCYTE; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER SURVIVAL; CELL ADHESION; CELL DIFFERENTIATION; CELL VACUOLE; CHILD; CODON; CONTRAST ENHANCEMENT; CROSS REACTION; DIRECT SEQUENCING; FEMALE; GENE; GENE DOSAGE; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE SEQUENCE; GLIOBLASTOMA; HISTONE METHYLATION; HUMAN; HUMAN TISSUE; IMMUNOCHEMISTRY; IMMUNODETECTION; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSERVATIONAL STUDY; OVERALL SURVIVAL; PHENOTYPE; PONTINE GLIOMA; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SOMATIC MUTATION; STEREOTACTIC BIOPSY; TUMOR BIOPSY; TUMOR RECURRENCE; UPREGULATION; WILD TYPE; BRAIN STEM NEOPLASMS; COHORT ANALYSIS; GENETICS; GLIOMA; HELA CELL LINE; METABOLISM; MUTATION; NERVE CELL; OLIGODENDROGLIA; PATHOLOGY; PONS; PRESCHOOL CHILD; PROGNOSIS; RADIATION RESPONSE; SURGERY;

ASTROCYTES; BRAIN STEM NEOPLASMS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; GLIOMA; HELA CELLS; HISTONES; HUMANS; MALE; MUTATION; NEURONS; OLIGODENDROGLIA; PHENOTYPE; PONS; PROGNOSIS;

EID: 84947617209     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1478-0     Document Type: Article

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