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Volumn 4, Issue 3, 2016, Pages 259-268

CAR T cells targeting Podoplanin reduce orthotopic glioblastomas in mouse brains

Author keywords

[No Author keywords available]

Indexed keywords

CALCEIN; CD137 ANTIGEN; CD28 ANTIGEN; CHIMERIC ANTIGEN RECEPTOR; PODOPLANIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; HYBRID PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; PDPN PROTEIN, HUMAN;

EID: 84962034350     PISSN: 23266066     EISSN: 23266074     Source Type: Journal    
DOI: 10.1158/2326-6066.CIR-15-0060     Document Type: Article
Times cited : (82)

References (46)
  • 2
    • 77955877130 scopus 로고    scopus 로고
    • Immunotherapy approaches for malignant glioma from 2007 to 2009
    • Johnson LA, Sampson JH. Immunotherapy approaches for malignant glioma from 2007 to 2009. Curr Neurol Neurosci Rep 2010;10:259-66.
    • (2010) Curr Neurol Neurosci Rep , vol.10 , pp. 259-266
    • Johnson, L.A.1    Sampson, J.H.2
  • 3
    • 0027471898 scopus 로고
    • Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma-subunit or zeta-subunit of the immunoglobulin and T-cell receptors
    • Eshhar Z, Waks T, Gross G, Schindler DG. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma-subunit or zeta-subunit of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci U S A 1993;90:720-4.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 720-724
    • Eshhar, Z.1    Waks, T.2    Gross, G.3    Schindler, D.G.4
  • 4
    • 84877091854 scopus 로고    scopus 로고
    • LOH in the HLA class I region at 6p21 is associated with shorter survival in newly diagnosed adult glioblastoma
    • Yeung JT, Hamilton RL, Ohnishi K, Ikeura M, Potter DM, Nikiforova MN, et al. LOH in the HLA class I region at 6p21 is associated with shorter survival in newly diagnosed adult glioblastoma. Clin Cancer Res 2013;19:1816-26.
    • (2013) Clin Cancer Res , vol.19 , pp. 1816-1826
    • Yeung, J.T.1    Hamilton, R.L.2    Ohnishi, K.3    Ikeura, M.4    Potter, D.M.5    Nikiforova, M.N.6
  • 5
    • 84877669593 scopus 로고    scopus 로고
    • The basic principles of chimeric antigen receptor design
    • Sadelain M, Brentjens R, Riviere I. The basic principles of chimeric antigen receptor design. Cancer Discov 2013;3:388-98.
    • (2013) Cancer Discov , vol.3 , pp. 388-398
    • Sadelain, M.1    Brentjens, R.2    Riviere, I.3
  • 7
    • 0036137615 scopus 로고    scopus 로고
    • Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCR zeta/CD28 receptor
    • Maher J, Brentjens RJ, Gunset G, Riviere I, Sadelain M. Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCR zeta/CD28 receptor. Nat Biotechnol 2002;20:70-5.
    • (2002) Nat Biotechnol , vol.20 , pp. 70-75
    • Maher, J.1    Brentjens, R.J.2    Gunset, G.3    Riviere, I.4    Sadelain, M.5
  • 8
    • 0347994955 scopus 로고    scopus 로고
    • Activation of resting human primary T cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain
    • Finney HM, Akbar AN, Lawson ADG. Activation of resting human primary T cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J Immunol 2004;172:104-13.
    • (2004) J Immunol , vol.172 , pp. 104-113
    • Finney, H.M.1    Akbar, A.N.2    Lawson, A.D.G.3
  • 9
    • 33750061330 scopus 로고    scopus 로고
    • Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells
    • Loskog A, Giandomenico V, Rossig C, Pule M, Dotti G, Brenner MK. Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells. Leukemia 2006;20:1819-28.
    • (2006) Leukemia , vol.20 , pp. 1819-1828
    • Loskog, A.1    Giandomenico, V.2    Rossig, C.3    Pule, M.4    Dotti, G.5    Brenner, M.K.6
  • 10
    • 62549097817 scopus 로고    scopus 로고
    • Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
    • Carpenito C, Milone MC, Hassan R, Simonet JC, Lakhal M, Suhoski MM, et al. Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains. Proc Natl Acad Sci U S A 2009;106:3360-5.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 3360-3365
    • Carpenito, C.1    Milone, M.C.2    Hassan, R.3    Simonet, J.C.4    Lakhal, M.5    Suhoski, M.M.6
  • 11
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptormodified T cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptormodified T cells in chronic lymphoid leukemia. N Engl J Med 2011;365:725-33.
    • (2011) N Engl J Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 12
    • 78549278144 scopus 로고    scopus 로고
    • Eradication of B-lineage cells and regression of lymphomain apatient treated with autologous Tcells genetically engineered to recognize CD19
    • Kochenderfer JN, Wilson WH, Janik JE, Dudley ME, Stetler-Stevenson M, Feldman SA, et al. Eradication of B-lineage cells and regression of lymphomain apatient treated with autologous Tcells genetically engineered to recognize CD19. Blood 2010;116:4099-102.
    • (2010) Blood , vol.116 , pp. 4099-4102
    • Kochenderfer, J.N.1    Wilson, W.H.2    Janik, J.E.3    Dudley, M.E.4    Stetler-Stevenson, M.5    Feldman, S.A.6
  • 13
    • 55549145071 scopus 로고    scopus 로고
    • Virusspecific T cells engineeredto coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma
    • Pule MA, Savoldo B, Myers GD, Rossig C, Russell HV, Dotti G, et al. Virusspecific T cells engineeredto coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med 2008;14:1264-70.
    • (2008) Nat Med , vol.14 , pp. 1264-1270
    • Pule, M.A.1    Savoldo, B.2    Myers, G.D.3    Rossig, C.4    Russell, H.V.5    Dotti, G.6
  • 14
    • 78449281478 scopus 로고    scopus 로고
    • Retrovirally engineered T-cell-based immunotherapy targeting type III variant epidermal growth factor receptor, a glioma-associated antigen
    • Ohno M, Natsume A, Ichiro Iwami K, Iwamizu H, Noritake K, Ito D, et al. Retrovirally engineered T-cell-based immunotherapy targeting type III variant epidermal growth factor receptor, a glioma-associated antigen. Cancer Sci 2010;101:2518-24.
    • (2010) Cancer Sci , vol.101 , pp. 2518-2524
    • Ohno, M.1    Natsume, A.2    Ichiro Iwami, K.3    Iwamizu, H.4    Noritake, K.5    Ito, D.6
  • 15
    • 74549196076 scopus 로고    scopus 로고
    • HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors
    • Ahmed N, Salsman VS, Kew Y, Shaffer D, Powell S, Zhang YJ, et al. HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors. Clin Cancer Res 2010;16:474-85.
    • (2010) Clin Cancer Res , vol.16 , pp. 474-485
    • Ahmed, N.1    Salsman, V.S.2    Kew, Y.3    Shaffer, D.4    Powell, S.5    Zhang, Y.J.6
  • 16
    • 84868576774 scopus 로고    scopus 로고
    • Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells
    • Kong S, Sengupta S, Tyler B, Bais AJ, Ma Q, Doucette S, et al. Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells. Clin Cancer Res 2012;18:5949-60.
    • (2012) Clin Cancer Res , vol.18 , pp. 5949-5960
    • Kong, S.1    Sengupta, S.2    Tyler, B.3    Bais, A.J.4    Ma, Q.5    Doucette, S.6
  • 21
    • 14644406264 scopus 로고    scopus 로고
    • Upregulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors
    • Schacht V, Dadras SS, Johnson LA, Jackson DG, Hong YK, Detmar M. Upregulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 2005;166:913-21.
    • (2005) Am J Pathol , vol.166 , pp. 913-921
    • Schacht, V.1    Dadras, S.S.2    Johnson, L.A.3    Jackson, D.G.4    Hong, Y.K.5    Detmar, M.6
  • 22
    • 12344270308 scopus 로고    scopus 로고
    • Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma
    • Chu AY, Litzky LA, Pasha TL, Acs G, Zhang PJ. Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol 2005;18:105-10.
    • (2005) Mod Pathol , vol.18 , pp. 105-110
    • Chu, A.Y.1    Litzky, L.A.2    Pasha, T.L.3    Acs, G.4    Zhang, P.J.5
  • 23
    • 0036227312 scopus 로고    scopus 로고
    • Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas
    • Kahn HJ, Bailey D, Marks A. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol 2002;15:434-40.
    • (2002) Mod Pathol , vol.15 , pp. 434-440
    • Kahn, H.J.1    Bailey, D.2    Marks, A.3
  • 24
    • 9144265869 scopus 로고    scopus 로고
    • Aggrus: A diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors
    • Kato Y, Sasagawa I, Kaneko M, Osawa M, Fujita N, Tsuruo T. Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors. Oncogene 2004;23:8552-6.
    • (2004) Oncogene , vol.23 , pp. 8552-8556
    • Kato, Y.1    Sasagawa, I.2    Kaneko, M.3    Osawa, M.4    Fujita, N.5    Tsuruo, T.6
  • 25
    • 33646259475 scopus 로고    scopus 로고
    • Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression
    • Mishima K, Kato Y, Kaneko MK, Nishikawa R, Hirose T, Matsutani M. Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression. Acta Neuropathol 2006;111:483-8.
    • (2006) Acta Neuropathol , vol.111 , pp. 483-488
    • Mishima, K.1    Kato, Y.2    Kaneko, M.K.3    Nishikawa, R.4    Hirose, T.5    Matsutani, M.6
  • 26
    • 36949020661 scopus 로고    scopus 로고
    • Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2
    • Kato Y, Kaneko MK, Kunita A, Ito H, Kameyama A, Ogasawara S, et al. Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2. Cancer Sci 2008;99:54-61.
    • (2008) Cancer Sci , vol.99 , pp. 54-61
    • Kato, Y.1    Kaneko, M.K.2    Kunita, A.3    Ito, H.4    Kameyama, A.5    Ogasawara, S.6
  • 27
    • 33751539322 scopus 로고    scopus 로고
    • Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition
    • Martin-Villar E, Megias D, Castel S, Yurrita MM, Vilaro S, Quintanilla M. Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. J Cell Sci 2006;119(Pt 21):4541-53.
    • (2006) J Cell Sci , vol.119 , pp. 4541-4553
    • Martin-Villar, E.1    Megias, D.2    Castel, S.3    Yurrita, M.M.4    Vilaro, S.5    Quintanilla, M.6
  • 28
    • 84867231671 scopus 로고    scopus 로고
    • Immunohistochemical analysis-based proteomic subclassification of newly diagnosed glioblastomas
    • Motomura K, Natsume A, Watanabe R, Ito I, Kato Y, Momota H, et al. Immunohistochemical analysis-based proteomic subclassification of newly diagnosed glioblastomas. Cancer Sci 2012;103:1871-9.
    • (2012) Cancer Sci , vol.103 , pp. 1871-1879
    • Motomura, K.1    Natsume, A.2    Watanabe, R.3    Ito, I.4    Kato, Y.5    Momota, H.6
  • 29
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010;17:98-110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6
  • 30
    • 33748772794 scopus 로고    scopus 로고
    • Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregationstimulating domain
    • Kato Y, Kaneko MK, Kuno A, Uchiyama N, Amano K, Chiba Y, et al. Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregationstimulating domain. Biochem Biophys Res Commun 2006;349:1301-7.
    • (2006) Biochem Biophys Res Commun , vol.349 , pp. 1301-1307
    • Kato, Y.1    Kaneko, M.K.2    Kuno, A.3    Uchiyama, N.4    Amano, K.5    Chiba, Y.6
  • 31
    • 84874941321 scopus 로고    scopus 로고
    • Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors
    • Chandramohan V, Bao XH, Kaneko MK, Kato Y, Keir ST, Szafranski SE, et al. Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors. Int J Cancer 2013;132:2339-48.
    • (2013) Int J Cancer , vol.132 , pp. 2339-2348
    • Chandramohan, V.1    Bao, X.H.2    Kaneko, M.K.3    Kato, Y.4    Keir, S.T.5    Szafranski, S.E.6
  • 32
    • 69049120195 scopus 로고    scopus 로고
    • Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signaling
    • Yuki K, Natsume A, Yokoyama H, Kondo Y, Ohno M, Kato T, et al. Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signaling. Cancer Lett 2009;284:71-9.
    • (2009) Cancer Lett , vol.284 , pp. 71-79
    • Yuki, K.1    Natsume, A.2    Yokoyama, H.3    Kondo, Y.4    Ohno, M.5    Kato, T.6
  • 33
    • 76249090489 scopus 로고    scopus 로고
    • BioGPS: An extensible and customizable portal for querying and organizing gene annotation resources
    • Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, et al. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol 2009;10:R130.
    • (2009) Genome Biol , vol.10 , pp. R130
    • Wu, C.1    Orozco, C.2    Boyer, J.3    Leglise, M.4    Goodale, J.5    Batalov, S.6
  • 35
    • 80052723350 scopus 로고    scopus 로고
    • O-6-Methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma
    • Watanabe R, Nakasu Y, Tashiro H, Mitsuya K, Ito I, Nakasu S, et al. O-6-Methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma. Brain Tumor Pathol 2011;28:127-35.
    • (2011) Brain Tumor Pathol , vol.28 , pp. 127-135
    • Watanabe, R.1    Nakasu, Y.2    Tashiro, H.3    Mitsuya, K.4    Ito, I.5    Nakasu, S.6
  • 36
    • 84991035101 scopus 로고    scopus 로고
    • Expressionof miR-17-92 enhances anti-tumoractivity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts
    • Ohno M, Ohkuri T, Kosaka A, Tanahashi K, June CH, Natsume A, et al. Expressionof miR-17-92 enhances anti-tumoractivity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts. J Immunother Cancer 2013;1:21.
    • (2013) J Immunother Cancer , vol.1 , pp. 21
    • Ohno, M.1    Ohkuri, T.2    Kosaka, A.3    Tanahashi, K.4    June, C.H.5    Natsume, A.6
  • 38
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252-64.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 39
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4onboth effector and regulatory Tcell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs KS, Quezada SA, Chambers CA, Korman AJ, Allison JP. Blockade of CTLA-4onboth effector and regulatory Tcell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med 2009;206:1717-25.
    • (2009) J Exp Med , vol.206 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 40
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong HD, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002;8:793-800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.D.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 41
    • 44349150012 scopus 로고    scopus 로고
    • Inhibitory B7-family molecules in the tumour microenvironment
    • Zou W, Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nat Rev Immunol 2008;8:467-77.
    • (2008) Nat Rev Immunol , vol.8 , pp. 467-477
    • Zou, W.1    Chen, L.2
  • 42
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000;192:1027-34.
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3    Bourque, K.4    Chernova, T.5    Nishimura, H.6
  • 44
    • 84886397930 scopus 로고    scopus 로고
    • Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells
    • John LB, Devaud C, Duong CP, Yong CS, Beavis PA, Haynes NM, et al. Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells. Clin Cancer Res 2013;19:5636-46.
    • (2013) Clin Cancer Res , vol.19 , pp. 5636-5646
    • John, L.B.1    Devaud, C.2    Duong, C.P.3    Yong, C.S.4    Beavis, P.A.5    Haynes, N.M.6
  • 45
    • 21344464959 scopus 로고    scopus 로고
    • D2-40, a novel monoclonal antibody against the M2A antigen as a marker to distinguish hemangioblastomas from renal cell carcinomas
    • Roy S, Chu A, Trojanowski JQ, Zhang PJ. D2-40, a novel monoclonal antibody against the M2A antigen as a marker to distinguish hemangioblastomas from renal cell carcinomas. Acta Neuropathol 2005;109:497-502.
    • (2005) Acta Neuropathol , vol.109 , pp. 497-502
    • Roy, S.1    Chu, A.2    Trojanowski, J.Q.3    Zhang, P.J.4
  • 46
    • 84905455049 scopus 로고    scopus 로고
    • A cancer-specific monoclonal antibody recognizes the aberrantly glycosylated podoplanin
    • Electronic
    • Kato Y, Kaneko MK. A cancer-specific monoclonal antibody recognizes the aberrantly glycosylated podoplanin. Sci Rep 2014;4(2045-2322 (Electronic)):5924.
    • (2014) Sci Rep , vol.4 , Issue.2045-2322 , pp. 5924
    • Kato, Y.1    Kaneko, M.K.2


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