메뉴 건너뛰기




Volumn 116, Issue 7, 2010, Pages 1035-1044

Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; TUMOR ANTIGEN;

EID: 77956535599     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-01-043737     Document Type: Review
Times cited : (252)

References (167)
  • 1
    • 68049118980 scopus 로고    scopus 로고
    • Loss of mismatched HLA in leukemia after stem-cell transplantation
    • Vago L, Perna SK, Zanussi M, et al. Loss of mismatched HLA in leukemia after stem-cell transplantation. N Engl J Med. 2009;361(5):478-488.
    • (2009) N Engl J Med , vol.361 , Issue.5 , pp. 478-488
    • Vago, L.1    Perna, S.K.2    Zanussi, M.3
  • 2
    • 0024834988 scopus 로고
    • Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity
    • Gross G, Waks T, Eshhar Z. Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc Natl Acad Sci U S A. 1989;86(24):10024-10028.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , Issue.24 , pp. 10024-10028
    • Gross, G.1    Waks, T.2    Eshhar, Z.3
  • 3
    • 0027471898 scopus 로고
    • Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors
    • DOI 10.1073/pnas.90.2.720
    • Eshhar Z,Waks T, Gross G, et al. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci U S A. 1993;90(2):720-724. (Pubitemid 23028937)
    • (1993) Proceedings of the National Academy of Sciences of the United States of America , vol.90 , Issue.2 , pp. 720-724
    • Eshhar, Z.1    Waks, T.2    Gross, G.3    Schindler, D.G.4
  • 4
    • 10844296758 scopus 로고    scopus 로고
    • Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells
    • DOI 10.1158/0008-5472.CAN-04-0454
    • Kahlon KS, Brown C, Cooper LJ, et al. Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells. Cancer Res. 2004;64(24):9160-9166. (Pubitemid 39665531)
    • (2004) Cancer Research , vol.64 , Issue.24 , pp. 9160-9166
    • Kahlon, K.S.1    Brown, C.2    Cooper, L.J.N.3    Raubitschek, A.4    Forman, S.J.5    Jensen, M.C.6
  • 5
    • 3042551216 scopus 로고    scopus 로고
    • Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
    • DOI 10.1038/sj.leu.2403302
    • Imai C, Mihara K, Andreansky M, et al. Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia. 2004;18(4):676-684. (Pubitemid 38500185)
    • (2004) Leukemia , vol.18 , Issue.4 , pp. 676-684
    • Imai, C.1    Mihara, K.2    Andreansky, M.3    Nicholson, I.C.4    Pui, C.-H.5    Geiger, T.L.6    Campana, D.7
  • 6
    • 76749120309 scopus 로고    scopus 로고
    • A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity
    • Zhao Y, Wang QJ, Yang S, et al. A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity. J Immunol. 2009;183(9):5563- 5574.
    • (2009) J Immunol , vol.183 , Issue.9 , pp. 5563-5574
    • Zhao, Y.1    Wang, Q.J.2    Yang, S.3
  • 8
    • 0034526330 scopus 로고    scopus 로고
    • Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors
    • Yun CO, Nolan KF, Beecham EJ, et al. Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors. Neoplasia. 2000;2(5):449-459.
    • (2000) Neoplasia , vol.2 , Issue.5 , pp. 449-459
    • Yun, C.O.1    Nolan, K.F.2    Beecham, E.J.3
  • 9
    • 0041677653 scopus 로고    scopus 로고
    • Immune response manipulation: Recombinant immunoreceptors endow T-cells with predefined specificity
    • DOI 10.2174/1381612033454289
    • Abken H, Hombach A, Heuser C. Immune response manipulation: recombinant immunoreceptors endow T-cells with predefined specificity. Curr Pharm Des. 2003;9(24):1992-2001. (Pubitemid 37010105)
    • (2003) Current Pharmaceutical Design , vol.9 , Issue.24 , pp. 1992-2001
    • Abken, H.1    Hombach, A.2    Heuser, C.3
  • 10
    • 71549119185 scopus 로고    scopus 로고
    • Recognition and killing of brain tumor stem-like initiating cells by CD8+ cytolytic T cells
    • Brown CE, Starr R, Martinez C, et al. Recognition and killing of brain tumor stem-like initiating cells by CD8+ cytolytic T cells. Cancer Res. 2009;69(23):8886-8893.
    • (2009) Cancer Res , vol.69 , Issue.23 , pp. 8886-8893
    • Brown, C.E.1    Starr, R.2    Martinez, C.3
  • 11
    • 0242331180 scopus 로고    scopus 로고
    • Chimeric t-cell receptors for the targeting of cancer cells
    • DOI 10.1159/000072465
    • Rossig C, Brenner MK. Chimeric T-cell receptors for the targeting of cancer cells. Acta Haematol. 2003;110(2-3):154-159. (Pubitemid 37340194)
    • (2003) Acta Haematologica , vol.110 , Issue.2-3 , pp. 154-159
    • Rossig, C.1    Brenner, M.K.2
  • 12
    • 0037242741 scopus 로고    scopus 로고
    • Genetic engineering of T cell specificity for immunotherapy of cancer
    • DOI 10.1016/S0198-8859(02)00730-9, PII S0198885902007309
    • Willemsen RA, Debets R, Chames P, et al. Genetic engineering of T cell specificity for immunotherapy of cancer. Hum Immunol. 2003;64(1):56-68. (Pubitemid 36109813)
    • (2003) Human Immunology , vol.64 , Issue.1 , pp. 56-68
    • Willemsen, R.A.1    Debets, R.2    Chames, P.3    Bolhuis, R.L.H.4
  • 13
    • 4744376594 scopus 로고    scopus 로고
    • Targeting of tumor cells by lymphocytes engineered to express chimeric receptor genes
    • Baxevanis CN, Papamichail M. Targeting of tumor cells by lymphocytes engineered to express chimeric receptor genes. Cancer Immunol Immunother. 2004;53(10):893-903.
    • (2004) Cancer Immunol Immunother , vol.53 , Issue.10 , pp. 893-903
    • Baxevanis, C.N.1    Papamichail, M.2
  • 14
    • 3042772669 scopus 로고    scopus 로고
    • Genetic modification of T lymphocytes for adoptive immunotherapy
    • DOI 10.1016/j.ymthe.2004.04.014, PII S1525001604001510
    • Rossig C, Brenner MK. Genetic modification of T lymphocytes for adoptive immunotherapy. Mol Ther. 2004;10(1):5-18. (Pubitemid 38878144)
    • (2004) Molecular Therapy , vol.10 , Issue.1 , pp. 5-18
    • Rossig, C.1    Brenner, M.K.2
  • 15
    • 4644280313 scopus 로고    scopus 로고
    • Novel strategies for cancer therapy: The potential of genetically modified T lymphocytes
    • Riviere I, Sadelain M, Brentjens RJ. Novel strategies for cancer therapy: the potential of genetically modified T lymphocytes. Curr Hematol Rep. 2004;3(4):290-297.
    • (2004) Curr Hematol Rep , vol.3 , Issue.4 , pp. 290-297
    • Riviere, I.1    Sadelain, M.2    Brentjens, R.J.3
  • 17
    • 28544448646 scopus 로고    scopus 로고
    • Supernatural T cells: Genetic modification of T cells for cancer therapy
    • Kershaw MH, Teng MW, Smyth MJ, et al. Supernatural T cells: genetic modification of T cells for cancer therapy. Nat Rev Immunol. 2005;5(12):928-940.
    • (2005) Nat Rev Immunol , vol.5 , Issue.12 , pp. 928-940
    • Kershaw, M.H.1    Teng, M.W.2    Smyth, M.J.3
  • 18
    • 22944467854 scopus 로고    scopus 로고
    • Current status of genetic modification of T cells for cancer treatment
    • DOI 10.1080/14653240510027217
    • Dotti G, Heslop HE. Current status of genetic modification of T cells for cancer treatment. Cytotherapy. 2005;7(3):262-272. (Pubitemid 41051369)
    • (2005) Cytotherapy , vol.7 , Issue.3 , pp. 262-272
    • Dotti, G.1    Heslop, H.E.2
  • 20
    • 33644747233 scopus 로고    scopus 로고
    • Improving T cell therapy for cancer
    • Foster AE, Rooney CM. Improving T cell therapy for cancer. Expert Opin Biol Ther. 2006;6(3):215-229.
    • (2006) Expert Opin Biol Ther , vol.6 , Issue.3 , pp. 215-229
    • Foster, A.E.1    Rooney, C.M.2
  • 21
    • 34247582928 scopus 로고    scopus 로고
    • Chimeric T-cell receptors: New challenges for targeted immunotherapy in hematologic malignancies
    • Biagi E, Marin V, Giordano Attianese GM, et al. Chimeric T-cell receptors: new challenges for targeted immunotherapy in hematologic malignancies. Haematologica. 2007;92(3):381-388.
    • (2007) Haematologica , vol.92 , Issue.3 , pp. 381-388
    • Biagi, E.1    Marin, V.2    Giordano Attianese, G.M.3
  • 22
    • 36849028631 scopus 로고    scopus 로고
    • Genetic therapies against HIV
    • Rossi JJ, June CH, Kohn DB. Genetic therapies against HIV. Nat Biotechnol. 2007;25(12):1444-1454.
    • (2007) Nat Biotechnol , vol.25 , Issue.12 , pp. 1444-1454
    • Rossi, J.J.1    June, C.H.2    Kohn, D.B.3
  • 23
    • 61849185275 scopus 로고    scopus 로고
    • Genetic engineering of T cells for adoptive immunotherapy
    • Varela-Rohena A, Carpenito C, Perez EE, et al. Genetic engineering of T cells for adoptive immunotherapy. Immunol Res. 2008;42(1-3):166-181.
    • (2008) Immunol Res , vol.42 , Issue.1-3 , pp. 166-181
    • Varela-Rohena, A.1    Carpenito, C.2    Perez, E.E.3
  • 24
    • 38449095735 scopus 로고    scopus 로고
    • The T-body approach: Redirecting T cells with antibody specificity
    • Eshhar Z. The T-body approach: redirecting T cells with antibody specificity. Hand Exp Pharmacol. 2008;181:329-342.
    • (2008) Hand Exp Pharmacol , vol.181 , pp. 329-342
    • Eshhar, Z.1
  • 25
    • 67649101753 scopus 로고    scopus 로고
    • Retargeting T-cells against cancer by gene-transfer of tumor-reactive receptors
    • Marcu-Malina V, van Dorp S, Kuball J. Retargeting T-cells against cancer by gene-transfer of tumor-reactive receptors. Expert Opin Biol Ther. 2009;9(5):579-591.
    • (2009) Expert Opin Biol Ther , vol.9 , Issue.5 , pp. 579-591
    • Marcu-Malina, V.1    Van Dorp, S.2    Kuball, J.3
  • 26
    • 70349342731 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: The next generation of gene-engineered immune cells
    • Berry LJ, Moeller M, Darcy PK. Adoptive immunotherapy for cancer: the next generation of gene-engineered immune cells. Tissue Antigens. 2009;74(4):277-289.
    • (2009) Tissue Antigens , vol.74 , Issue.4 , pp. 277-289
    • Berry, L.J.1    Moeller, M.2    Darcy, P.K.3
  • 27
    • 65249101637 scopus 로고    scopus 로고
    • The promise and potential pitfalls of chimeric antigen receptors
    • Sadelain M, Brentjens R, Riviere I. The promise and potential pitfalls of chimeric antigen receptors. Curr Opin Immunol. 2009;21(2):215-223.
    • (2009) Curr Opin Immunol , vol.21 , Issue.2 , pp. 215-223
    • Sadelain, M.1    Brentjens, R.2    Riviere, I.3
  • 28
    • 70349438847 scopus 로고    scopus 로고
    • Engineering lymphocyte subsets: Tools, trials and tribulations
    • June CH, Blazar BR, Riley JL. Engineering lymphocyte subsets: tools, trials and tribulations. Nat Rev Immunol. 2009;9(10):704-716.
    • (2009) Nat Rev Immunol , vol.9 , Issue.10 , pp. 704-716
    • June, C.H.1    Blazar, B.R.2    Riley, J.L.3
  • 29
    • 70449123840 scopus 로고    scopus 로고
    • Fifteen years of gene therapy based on chimeric antigen receptors: "are we nearly there yet?"
    • Dotti G, Savoldo B, Brenner M. Fifteen years of gene therapy based on chimeric antigen receptors: "are we nearly there yet?" Hum Gene Ther. 2009;20(11):1229-1239.
    • (2009) Hum Gene Ther , vol.20 , Issue.11 , pp. 1229-1239
    • Dotti, G.1    Savoldo, B.2    Brenner, M.3
  • 30
    • 70350686498 scopus 로고    scopus 로고
    • Treatment of lymphoma with adoptively transferred T cells
    • Till BG, Press OW. Treatment of lymphoma with adoptively transferred T cells. Expert Opin Biol Ther. 2009;9(11):1407-1425.
    • (2009) Expert Opin Biol Ther , vol.9 , Issue.11 , pp. 1407-1425
    • Till, B.G.1    Press, O.W.2
  • 31
    • 73449132930 scopus 로고    scopus 로고
    • Immunotherapy of human cancers using gene modified T lymphocytes
    • Vera JF, Brenner MK, Dotti G. Immunotherapy of human cancers using gene modified T lymphocytes. Curr Gene Ther. 2009;9(5):396-408.
    • (2009) Curr Gene Ther , vol.9 , Issue.5 , pp. 396-408
    • Vera, J.F.1    Brenner, M.K.2    Dotti, G.3
  • 32
    • 77951259293 scopus 로고    scopus 로고
    • Adoptive T cell therapy of cancer
    • Brenner MK, Heslop HE. Adoptive T cell therapy of cancer. Curr Opin Immunol. 2010;22(2):251-257.
    • (2010) Curr Opin Immunol , vol.22 , Issue.2 , pp. 251-257
    • Brenner, M.K.1    Heslop, H.E.2
  • 33
    • 77952484156 scopus 로고    scopus 로고
    • Genetic redirection of T cells for cancer therapy
    • Westwood JA, Kershaw MH. Genetic redirection of T cells for cancer therapy. J Leukoc Biol. 2010;87(5):791-803.
    • (2010) J Leukoc Biol , vol.87 , Issue.5 , pp. 791-803
    • Westwood, J.A.1    Kershaw, M.H.2
  • 34
    • 33749624177 scopus 로고    scopus 로고
    • Cancer regression in patients after transfer of genetically engineered lymphocytes
    • Morgan RA, Dudley ME, Wunderlich JR, et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science. 2006;314(5796):126-129.
    • (2006) Science , vol.314 , Issue.5796 , pp. 126-129
    • Morgan, R.A.1    Dudley, M.E.2    Wunderlich, J.R.3
  • 36
    • 70350726110 scopus 로고    scopus 로고
    • Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo
    • Milone MC, Fish JD, Carpenito C, et al. Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. Mol Ther. 2009;17(8):1453-1464.
    • (2009) Mol Ther , vol.17 , Issue.8 , pp. 1453-1464
    • Milone, M.C.1    Fish, J.D.2    Carpenito, C.3
  • 37
    • 70349439277 scopus 로고    scopus 로고
    • Immunotherapy of metastatic melanoma using genetically engineered GD2-specific T cells
    • Yvon E, Del Vecchio M, Savoldo B, et al. Immunotherapy of metastatic melanoma using genetically engineered GD2-specific T cells. Clin Cancer Res. 2009;15(18):5852-5860.
    • (2009) Clin Cancer Res , vol.15 , Issue.18 , pp. 5852-5860
    • Yvon, E.1    Del Vecchio, M.2    Savoldo, B.3
  • 38
    • 33845294816 scopus 로고    scopus 로고
    • CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells
    • Kowolik CM, Topp MS, Gonzalez S, et al. CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells. Cancer Res. 2006;66(22):10995-11004.
    • (2006) Cancer Res , vol.66 , Issue.22 , pp. 10995-11004
    • Kowolik, C.M.1    Topp, M.S.2    Gonzalez, S.3
  • 39
    • 77955510549 scopus 로고    scopus 로고
    • Anti-transgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor re-directed T cells in humans
    • published online ahead of print March 18, 2010. doi:10.1016/j.bbmt.2010. 03.014
    • Jensen MC, Popplewell L, Cooper LJ, et al. Anti-transgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor re-directed T cells in humans [published online ahead of print March 18, 2010]. Biol Blood Marrow Transplant. doi:10.1016/j.bbmt.2010.03.014.
    • Biol Blood Marrow Transplant
    • Jensen, M.C.1    Popplewell, L.2    Cooper, L.J.3
  • 40
    • 50549096284 scopus 로고    scopus 로고
    • Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
    • Till BG, Jensen MC, Wang J, et al. Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood. 2008;112(6):2261-2271.
    • (2008) Blood , vol.112 , Issue.6 , pp. 2261-2271
    • Till, B.G.1    Jensen, M.C.2    Wang, J.3
  • 41
    • 55549145071 scopus 로고    scopus 로고
    • Virus-specific T cells engineered to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma
    • Pule MA, Savoldo B, Myers GD, et al. Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med. 2008;14(11):1264-1270.
    • (2008) Nat Med , vol.14 , Issue.11 , pp. 1264-1270
    • Pule, M.A.1    Savoldo, B.2    Myers, G.D.3
  • 42
    • 33947265424 scopus 로고    scopus 로고
    • Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma
    • Park JR, Digiusto DL, Slovak M, et al. Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. Mol Ther. 2007;15(4):825-833.
    • (2007) Mol Ther , vol.15 , Issue.4 , pp. 825-833
    • Park, J.R.1    Digiusto, D.L.2    Slovak, M.3
  • 43
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
    • Morgan RA, Yang JC, Kitano M, et al. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther. 2010;18(4):843-851.
    • (2010) Mol Ther , vol.18 , Issue.4 , pp. 843-851
    • Morgan, R.A.1    Yang, J.C.2    Kitano, M.3
  • 45
    • 0347994955 scopus 로고    scopus 로고
    • Activation of resting human primary T cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain
    • Finney HM, Akbar AN, Lawson AD. Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J Immunol. 2004;172(1):104-113.
    • (2004) J Immunol , vol.172 , Issue.1 , pp. 104-113
    • Finney, H.M.1    Akbar, A.N.2    Lawson, A.D.3
  • 46
    • 27744566329 scopus 로고    scopus 로고
    • A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells
    • DOI 10.1016/j.ymthe.2005.04.016, PII S1525001605001863
    • Pule MA, Straathof KC, Dotti G, et al. A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Mol Ther. 2005;12(5):933-941. (Pubitemid 41614489)
    • (2005) Molecular Therapy , vol.12 , Issue.5 , pp. 933-941
    • Pule, M.A.1    Straathof, K.C.2    Dotti, G.3    Heslop, H.E.4    Rooney, C.M.5    Brenner, M.K.6
  • 47
    • 0032531091 scopus 로고    scopus 로고
    • Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product
    • Finney HM, Lawson AD, Bebbington CR, et al. Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J Immunol. 1998;161(6):2791-2797.
    • (1998) J Immunol , vol.161 , Issue.6 , pp. 2791-2797
    • Finney, H.M.1    Lawson, A.D.2    Bebbington, C.R.3
  • 48
    • 0035576250 scopus 로고    scopus 로고
    • Tumor-specific T cell activation by recombinant immunoreceptors: CD3zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3zeta signaling receptor molecule
    • Hombach A, Wieczarkowiecz A, Marquardt T, et al. Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule. J Immunol. 2001;167(11):6123-6131. (Pubitemid 33081538)
    • (2001) Journal of Immunology , vol.167 , Issue.11 , pp. 6123-6131
    • Hombach, A.1    Wieczarkowiecz, A.2    Marquardt, T.3    Heuser, C.4    Usai, L.5    Pohl, C.6    Seliger, B.7    Abken, H.8
  • 49
    • 0037111240 scopus 로고    scopus 로고
    • Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation
    • Haynes NM, Trapani JA, Teng MW, et al. Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation. J Immunol. 2002;169(10):5780-5786.
    • (2002) J Immunol , vol.169 , Issue.10 , pp. 5780-5786
    • Haynes, N.M.1    Trapani, J.A.2    Teng, M.W.3
  • 50
    • 0035186913 scopus 로고    scopus 로고
    • A phage display selected Fab fragment with MHC class i-restricted specificity for MAGE-A1 allows for retargeting of primary human T lymphocytes
    • DOI 10.1038/sj.gt.3301570
    • Willemsen RA, Debets R, Hart E, et al. A phage display selected fab fragment with MHC class I-restricted specificity for MAGE-A1 allows for retargeting of primary human T lymphocytes. Gene Ther. 2001;8(21):1601-1608. (Pubitemid 33085581)
    • (2001) Gene Therapy , vol.8 , Issue.21 , pp. 1601-1608
    • Willemsen, R.A.1    Debets, R.2    Hart, E.3    Hoogenboom, H.R.4    Bolhuis, R.L.H.5    Chames, P.6
  • 52
    • 10344265510 scopus 로고    scopus 로고
    • T cell activation by antibody-like immunoreceptors: Increase in affinity of the single-chain fragment domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity
    • Chmielewski M, Hombach A, Heuser C, et al. T cell activation by antibody-like immunoreceptors: increase in affinity of the single-chain fragment domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity. J Immunol. 2004;173(12):7647-7653. (Pubitemid 39628207)
    • (2004) Journal of Immunology , vol.173 , Issue.12 , pp. 7647-7653
    • Chmielewski, M.1    Hombach, A.2    Heuser, C.3    Adams, G.P.4    Abken, H.5
  • 53
    • 33845256434 scopus 로고    scopus 로고
    • T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells
    • DOI 10.1182/blood-2006-04-017061
    • Vera J, Savoldo B, Vigouroux S, et al. T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells. Blood. 2006;108(12):3890-3897. (Pubitemid 44864573)
    • (2006) Blood , vol.108 , Issue.12 , pp. 3890-3897
    • Vera, J.1    Savoldo, B.2    Vigouroux, S.3    Biagi, E.4    Pule, M.5    Rossig, C.6    Wu, J.7    Heslop, H.E.8    Rooney, C.M.9    Brenner, M.K.10    Dotti, G.11
  • 54
    • 0033385052 scopus 로고    scopus 로고
    • Bypassing immunization: Optimized design of "designer T cells" against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA
    • Nolan KF, Yun CO, Akamatsu Y, et al. Bypassing immunization: optimized design of "designer T cells" against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA. Clin Cancer Res. 1999;5(12):3928-3941.
    • (1999) Clin Cancer Res , vol.5 , Issue.12 , pp. 3928-3941
    • Nolan, K.F.1    Yun, C.O.2    Akamatsu, Y.3
  • 55
    • 0033857630 scopus 로고    scopus 로고
    • An entirely humanized CD3 zeta-chain signaling receptor that directs peripheral blood t cells to specific lysis of carcinoembryonic antigen-positive tumor cells
    • Hombach A, Schneider C, Sent D, et al. An entirely humanized CD3 zeta-chain signaling receptor that directs peripheral blood t cells to specific lysis of carcinoembryonic antigen-positive tumor cells. Int J Cancer. 2000;88(1):115-120.
    • (2000) Int J Cancer , vol.88 , Issue.1 , pp. 115-120
    • Hombach, A.1    Schneider, C.2    Sent, D.3
  • 57
    • 73949092897 scopus 로고    scopus 로고
    • Noninvasive detection of therapeutic cytolytic T cells with 18F-FHBG PET in a patient with glioma
    • Yaghoubi SS, Jensen MC, Satyamurthy N, et al. Noninvasive detection of therapeutic cytolytic T cells with 18F-FHBG PET in a patient with glioma. Nat Clin Pract Oncol. 2009;6(1):53-58.
    • (2009) Nat Clin Pract Oncol , vol.6 , Issue.1 , pp. 53-58
    • Yaghoubi, S.S.1    Jensen, M.C.2    Satyamurthy, N.3
  • 59
    • 62549120345 scopus 로고    scopus 로고
    • PET imaging of T cells derived from umbilical cord blood
    • Singh H, Najjar AM, Olivares S, et al. PET imaging of T cells derived from umbilical cord blood. Leukemia. 2009;23(3):620-622.
    • (2009) Leukemia , vol.23 , Issue.3 , pp. 620-622
    • Singh, H.1    Najjar, A.M.2    Olivares, S.3
  • 61
    • 33645514987 scopus 로고    scopus 로고
    • Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy
    • Serrano LM, Pfeiffer T, Olivares S, et al. Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy. Blood. 2006;107(7):2643-2652.
    • (2006) Blood , vol.107 , Issue.7 , pp. 2643-2652
    • Serrano, L.M.1    Pfeiffer, T.2    Olivares, S.3
  • 64
    • 4143074668 scopus 로고    scopus 로고
    • Human gammadelta T cells as mediators of chimaeric-receptor redirected anti-tumour immunity
    • DOI 10.1111/j.1365-2141.2004.05077.x
    • Rischer M, Pscherer S, Duwe S, et al. Human gammadelta T cells as mediators of chimaeric-receptor redirected anti-tumour immunity. Br J Haematol. 2004;126(4):583-592. (Pubitemid 39093102)
    • (2004) British Journal of Haematology , vol.126 , Issue.4 , pp. 583-592
    • Rischer, M.1    Pscherer, S.2    Duwe, S.3    Vormoor, J.4    Jurgens, H.5    Rossig, C.6
  • 65
    • 14844322786 scopus 로고    scopus 로고
    • Highly efficient redirected anti-tumor activity of human lymphocytes transduced with a completely human chimeric immune receptor
    • DOI 10.1002/jgm.647
    • Turatti F, Figini M, Alberti P, et al. Highly efficient redirected anti-tumor activity of human lymphocytes transduced with a completely human chimeric immune receptor. J Gene Med. 2005;7(2):158-170. (Pubitemid 40348020)
    • (2005) Journal of Gene Medicine , vol.7 , Issue.2 , pp. 158-170
    • Turatti, F.1    Figini, M.2    Alberti, P.3    Willemsen, R.A.4    Canevari, S.5    Mezzanzanica, D.6
  • 68
    • 68449088813 scopus 로고    scopus 로고
    • Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor
    • Kochenderfer JN, Feldman SA, Zhao Y, et al. Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor. J Immunother. 2009;32(7):689-702.
    • (2009) J Immunother , vol.32 , Issue.7 , pp. 689-702
    • Kochenderfer, J.N.1    Feldman, S.A.2    Zhao, Y.3
  • 69
    • 63649112916 scopus 로고    scopus 로고
    • Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy
    • Hollyman D, Stefanski J, Przybylowski M, et al. Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy. J Immunother. 2009;32(2):169-180.
    • (2009) J Immunother , vol.32 , Issue.2 , pp. 169-180
    • Hollyman, D.1    Stefanski, J.2    Przybylowski, M.3
  • 71
    • 39849086801 scopus 로고    scopus 로고
    • Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies
    • Huang X, Guo H, Kang J, et al. Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies. Mol Ther. 2008;16(3):580-589.
    • (2008) Mol Ther , vol.16 , Issue.3 , pp. 580-589
    • Huang, X.1    Guo, H.2    Kang, J.3
  • 72
    • 0037441593 scopus 로고    scopus 로고
    • T-cell clones can be rendered specific for CD19: Toward the selective augmentation of the graft-versus-B-lineage leukemia effect
    • Cooper LJ, Topp MS, Serrano LM, et al. T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B- lineage leukemia effect. Blood. 2003;101(4):1637-1644.
    • (2003) Blood , vol.101 , Issue.4 , pp. 1637-1644
    • Cooper, L.J.1    Topp, M.S.2    Serrano, L.M.3
  • 73
    • 0033655529 scopus 로고    scopus 로고
    • Human T lymphocyte genetic modification with naked DNA
    • Jensen MC, Clarke P, Tan G, et al. Human T lymphocyte genetic modification with naked DNA. Mol Ther. 2000;1(1):49-55.
    • (2000) Mol Ther , vol.1 , Issue.1 , pp. 49-55
    • Jensen, M.C.1    Clarke, P.2    Tan, G.3
  • 74
    • 42349088534 scopus 로고    scopus 로고
    • Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system
    • Singh H, Manuri PR, Olivares S, et al. Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system. Cancer Res. 2008;68(8):2961-2971.
    • (2008) Cancer Res , vol.68 , Issue.8 , pp. 2961-2971
    • Singh, H.1    Manuri, P.R.2    Olivares, S.3
  • 75
    • 70349320475 scopus 로고    scopus 로고
    • Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system
    • Xue X, Huang X, Nodland SE, et al. Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system. Blood. 2009;114(7):1319-1330.
    • (2009) Blood , vol.114 , Issue.7 , pp. 1319-1330
    • Xue, X.1    Huang, X.2    Nodland, S.E.3
  • 76
    • 77950953208 scopus 로고    scopus 로고
    • PiggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies
    • Manuri PV, Wilson MH, Maiti SN, et al. piggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies. Hum Gene Ther. 2010;21(4):427-437.
    • (2010) Hum Gene Ther , vol.21 , Issue.4 , pp. 427-437
    • Manuri, P.V.1    Wilson, M.H.2    Maiti, S.N.3
  • 77
    • 70349696650 scopus 로고    scopus 로고
    • Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes
    • Nakazawa Y, Huye LE, Dotti G, et al. Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes. J Immunother. 2009;32(8):826-836.
    • (2009) J Immunother , vol.32 , Issue.8 , pp. 826-836
    • Nakazawa, Y.1    Huye, L.E.2    Dotti, G.3
  • 78
    • 0030662074 scopus 로고    scopus 로고
    • Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells
    • Ivics Z, Hackett PB, Plasterk RH, et al. Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell. 1997;91(4):501-510.
    • (1997) Cell , vol.91 , Issue.4 , pp. 501-510
    • Ivics, Z.1    Hackett, P.B.2    Plasterk, R.H.3
  • 79
    • 25144492340 scopus 로고    scopus 로고
    • Sleeping beauty transposon-mediated gene therapy for prolonged expression
    • 0
    • Hackett PB, Ekker SC, Largaespada DA, et al. Sleeping beauty transposon-mediated gene therapy for prolonged expression. Adv Genet. 2005;54(0):189-232.
    • (2005) Adv Genet , vol.54 , pp. 189-232
    • Hackett, P.B.1    Ekker, S.C.2    Largaespada, D.A.3
  • 80
    • 33745500648 scopus 로고    scopus 로고
    • Sleeping Beauty transposon system-future trend in T-cell-based gene therapies?
    • Frommolt R, Rohrbach F, Theobald M. Sleeping Beauty transposon system-future trend in T-cell-based gene therapies? Future Oncol. 2006;2(3):345-349.
    • (2006) Future Oncol , vol.2 , Issue.3 , pp. 345-349
    • Frommolt, R.1    Rohrbach, F.2    Theobald, M.3
  • 81
    • 33744827138 scopus 로고    scopus 로고
    • Structure-based prediction of insertion-site preferences of transposons into chromosomes
    • Geurts AM, Hackett CS, Bell JB, et al. Structure-based prediction of insertion-site preferences of transposons into chromosomes. Nucleic Acids Res. 2006;34(9):2803-2811.
    • (2006) Nucleic Acids Res , vol.34 , Issue.9 , pp. 2803-2811
    • Geurts, A.M.1    Hackett, C.S.2    Bell, J.B.3
  • 82
    • 33748526535 scopus 로고    scopus 로고
    • Stable gene transfer to human CD34(+) hematopoietic cells using the Sleeping Beauty transposon
    • Hollis RP, Nightingale SJ, Wang X, et al. Stable gene transfer to human CD34(+) hematopoietic cells using the Sleeping Beauty transposon. Exp Hematol. 2006;34(10):1333-1343.
    • (2006) Exp Hematol , vol.34 , Issue.10 , pp. 1333-1343
    • Hollis, R.P.1    Nightingale, S.J.2    Wang, X.3
  • 83
    • 36248983231 scopus 로고    scopus 로고
    • Efficient and stable transgene expression in human embryonic stem cells using transposon-mediated gene transfer
    • Wilber A, Linehan JL, Tian X, et al. Efficient and stable transgene expression in human embryonic stem cells using transposon-mediated gene transfer. Stem Cells. 2007;25(11):2919-2927.
    • (2007) Stem Cells , vol.25 , Issue.11 , pp. 2919-2927
    • Wilber, A.1    Linehan, J.L.2    Tian, X.3
  • 84
    • 70349779189 scopus 로고    scopus 로고
    • Efficient stable gene transfer into human cells by the Sleeping Beauty transposon vectors
    • Izsvak Z, Chuah MK, Vandendriessche T, et al. Efficient stable gene transfer into human cells by the Sleeping Beauty transposon vectors. Methods. 2009;49(3):287-297.
    • (2009) Methods , vol.49 , Issue.3 , pp. 287-297
    • Izsvak, Z.1    Chuah, M.K.2    Vandendriessche, T.3
  • 85
    • 50549098264 scopus 로고    scopus 로고
    • Sleeping beauty vector system moves toward human trials in the United States
    • Williams DA. Sleeping beauty vector system moves toward human trials in the United States. Mol Ther. 2008;16(9):1515-1516.
    • (2008) Mol Ther , vol.16 , Issue.9 , pp. 1515-1516
    • Williams, D.A.1
  • 86
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • Dudley ME, Wunderlich JR, Robbins PF, et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science. 2002;298(5594):850-854.
    • (2002) Science , vol.298 , Issue.5594 , pp. 850-854
    • Dudley, M.E.1    Wunderlich, J.R.2    Robbins, P.F.3
  • 89
    • 62749185585 scopus 로고    scopus 로고
    • Fludarabine modulates immune response and extends in vivo survival of adoptively transferred CD8 T cells in patients with metastatic melanoma
    • Wallen H, Thompson JA, Reilly JZ, et al. Fludarabine modulates immune response and extends in vivo survival of adoptively transferred CD8 T cells in patients with metastatic melanoma. PLoS ONE. 2009;4(3):e4749.
    • (2009) PLoS ONE , vol.4 , Issue.3
    • Wallen, H.1    Thompson, J.A.2    Reilly, J.Z.3
  • 90
    • 74349084455 scopus 로고    scopus 로고
    • Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells
    • Wrzesinski C, Paulos CM, Kaiser A, et al. Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells. J Immunother. 2010;33(1):1-7.
    • (2010) J Immunother , vol.33 , Issue.1 , pp. 1-7
    • Wrzesinski, C.1    Paulos, C.M.2    Kaiser, A.3
  • 92
    • 0036905078 scopus 로고    scopus 로고
    • Dual-specific T cells combine proliferation and antitumor activity
    • DOI 10.1038/nbt756
    • Kershaw MH, Westwood JA, Hwu P. Dual-specific T cells combine proliferation and antitumor activity. Nat Biotechnol. 2002;20(12):1221-1227. (Pubitemid 35462486)
    • (2002) Nature Biotechnology , vol.20 , Issue.12 , pp. 1221-1227
    • Kershaw, M.H.1    Westwood, J.A.2    Hwu, P.3
  • 94
    • 0037085804 scopus 로고    scopus 로고
    • Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: Potential for improved immunotherapy
    • DOI 10.1182/blood.V99.6.2009
    • Rossig C, Bollard CM, Nuchtern JG, et al. Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy. Blood. 2002;99(6):2009-2016. (Pubitemid 34525482)
    • (2002) Blood , vol.99 , Issue.6 , pp. 2009-2016
    • Rossig, C.1    Bollard, C.M.2    Nuchtern, J.G.3    Rooney, C.M.4    Brenner, M.K.5
  • 97
    • 36248957577 scopus 로고    scopus 로고
    • + memory T cells
    • DOI 10.1002/eji.200737585
    • Carrio R, Rolle CE, Malek TR. Non-redundant role for IL-7R signaling for the survival of CD8+ memory T cells. Eur J Immunol. 2007;37(11):3078-3088. (Pubitemid 350131287)
    • (2007) European Journal of Immunology , vol.37 , Issue.11 , pp. 3078-3088
    • Carrio, R.1    Rolle, C.E.2    Malek, T.R.3
  • 98
    • 11144241310 scopus 로고    scopus 로고
    • Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy
    • Powell DJ, Jr., Dudley ME, Robbins PF, et al. Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy. Blood. 2005;105(1):241-250.
    • (2005) Blood , vol.105 , Issue.1 , pp. 241-250
    • Powell Jr., D.J.1    Dudley, M.E.2    Robbins, P.F.3
  • 99
    • 77956548515 scopus 로고    scopus 로고
    • Long Live T Cells
    • Cooper LJ. Long Live T Cells. Blood. 2005;105(1):8-9.
    • (2005) Blood , vol.105 , Issue.1 , pp. 8-9
    • Cooper, L.J.1
  • 100
    • 33746046073 scopus 로고    scopus 로고
    • IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells
    • Rosenberg SA, Sportes C, Ahmadzadeh M, et al. IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells. J Immunother. 2006;29(3):313-319.
    • (2006) J Immunother , vol.29 , Issue.3 , pp. 313-319
    • Rosenberg, S.A.1    Sportes, C.2    Ahmadzadeh, M.3
  • 101
    • 46949105036 scopus 로고    scopus 로고
    • Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
    • Sportes C, Hakim FT, Memon SA, et al. Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J Exp Med. 2008;205(7):1701-1714.
    • (2008) J Exp Med , vol.205 , Issue.7 , pp. 1701-1714
    • Sportes, C.1    Hakim, F.T.2    Memon, S.A.3
  • 102
    • 67650467728 scopus 로고    scopus 로고
    • Modulating T-cell homeostasis with IL-7: Preclinical and clinical studies
    • Capitini CM, Chisti AA, Mackall CL. Modulating T-cell homeostasis with IL-7: preclinical and clinical studies. J Intern Med. 2009;266(2):141-153.
    • (2009) J Intern Med , vol.266 , Issue.2 , pp. 141-153
    • Capitini, C.M.1    Chisti, A.A.2    Mackall, C.L.3
  • 103
    • 67349252824 scopus 로고    scopus 로고
    • Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7
    • Vera JF, Hoyos V, Savoldo B, et al. Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7. Mol Ther. 2009;17(5):880-888.
    • (2009) Mol Ther , vol.17 , Issue.5 , pp. 880-888
    • Vera, J.F.1    Hoyos, V.2    Savoldo, B.3
  • 104
    • 77956525453 scopus 로고    scopus 로고
    • IL-7 as a Membrane-Bound Molecule for the Costimulation of Tumor-Specific T Cells
    • Hurton L, Singh H, Olivares S, et al. IL-7 as a Membrane-Bound Molecule for the Costimulation of Tumor-Specific T Cells. Blood (ASH Annual Meeting Abstracts). 2009;114(22):3035.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , Issue.22 , pp. 3035
    • Hurton, L.1    Singh, H.2    Olivares, S.3
  • 105
    • 48949115595 scopus 로고    scopus 로고
    • Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera
    • Sogo T, Kawahara M, Tsumoto K, et al. Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera. J Immunol Methods. 2008;337(1):16-23.
    • (2008) J Immunol Methods , vol.337 , Issue.1 , pp. 16-23
    • Sogo, T.1    Kawahara, M.2    Tsumoto, K.3
  • 106
    • 60749101528 scopus 로고    scopus 로고
    • Expression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cis
    • Rowley JMA, Hung CF, Wu TC. Expression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cis. Eur J Immunol. 2009;39(2):491-506.
    • (2009) Eur J Immunol , vol.39 , Issue.2 , pp. 491-506
    • Rowley, J.M.A.1    Hung, C.F.2    Wu, T.C.3
  • 107
    • 77951746241 scopus 로고    scopus 로고
    • IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice
    • Markley JC, Sadelain M. IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice. Blood. 2010;115(17):3508-3519.
    • (2010) Blood , vol.115 , Issue.17 , pp. 3508-3519
    • Markley, J.C.1    Sadelain, M.2
  • 108
    • 0035575701 scopus 로고    scopus 로고
    • Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activity
    • Liu K, Rosenberg SA. Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activity. J Immunol. 2001;167(11):6356-6365. (Pubitemid 33081567)
    • (2001) Journal of Immunology , vol.167 , Issue.11 , pp. 6356-6365
    • Liu, K.1    Rosenberg, S.A.2
  • 109
    • 34250023777 scopus 로고    scopus 로고
    • Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene
    • Hsu C, Jones SA, Cohen CJ, et al. Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene. Blood. 2007;109(12):5168-5177.
    • (2007) Blood , vol.109 , Issue.12 , pp. 5168-5177
    • Hsu, C.1    Jones, S.A.2    Cohen, C.J.3
  • 110
    • 77954590000 scopus 로고    scopus 로고
    • Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
    • Hoyos V, Savoldo B, Quintarelli C, et al. Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety. Leukemia. 2010;24(6):1160-1170.
    • (2010) Leukemia , vol.24 , Issue.6 , pp. 1160-1170
    • Hoyos, V.1    Savoldo, B.2    Quintarelli, C.3
  • 113
    • 38149117105 scopus 로고    scopus 로고
    • Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates
    • Berger C, Jensen MC, Lansdorp PM, et al. Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. J Clin Invest. 2008;118(1):294-305.
    • (2008) J Clin Invest , vol.118 , Issue.1 , pp. 294-305
    • Berger, C.1    Jensen, M.C.2    Lansdorp, P.M.3
  • 114
    • 70350458112 scopus 로고    scopus 로고
    • Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity
    • Hinrichs CS, Borman ZA, Cassard L, et al. Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity. Proc Natl Acad Sci U S A. 2009;106(41):17469-17474.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.41 , pp. 17469-17474
    • Hinrichs, C.S.1    Borman, Z.A.2    Cassard, L.3
  • 115
    • 38449118049 scopus 로고    scopus 로고
    • Tumor-derived chemokine MCP-1/CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cells
    • Brown CE, Vishwanath RP, Aguilar B, et al. Tumor-derived chemokine MCP-1/CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cells. J Immunol. 2007;179(5):3332-3341.
    • (2007) J Immunol , vol.179 , Issue.5 , pp. 3332-3341
    • Brown, C.E.1    Vishwanath, R.P.2    Aguilar, B.3
  • 116
    • 54049137681 scopus 로고    scopus 로고
    • Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow
    • Palendira U, Chinn R, Raza W, et al. Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow. Blood. 2008;112(8):3293-3302.
    • (2008) Blood , vol.112 , Issue.8 , pp. 3293-3302
    • Palendira, U.1    Chinn, R.2    Raza, W.3
  • 118
    • 67650638846 scopus 로고    scopus 로고
    • T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model
    • Di Stasi A, DeAngelis B, Rooney CM, et al. T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model. Blood. 2009;113(25):6392-6402.
    • (2009) Blood , vol.113 , Issue.25 , pp. 6392-6402
    • Di Stasi, A.1    DeAngelis, B.2    Rooney, C.M.3
  • 120
    • 33750061330 scopus 로고    scopus 로고
    • Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells
    • Loskog A, Giandomenico V, Rossig C, et al. Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells. Leukemia. 2006;20(10):1819-1828.
    • (2006) Leukemia , vol.20 , Issue.10 , pp. 1819-1828
    • Loskog, A.1    Giandomenico, V.2    Rossig, C.3
  • 121
    • 33750699642 scopus 로고    scopus 로고
    • A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
    • Kershaw MH, Westwood JA, Parker LL, et al. A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res. 2006;12(20 Pt 1):6106-6115.
    • (2006) Clin Cancer Res , vol.12 , Issue.20 PART 1 , pp. 6106-6115
    • Kershaw, M.H.1    Westwood, J.A.2    Parker, L.L.3
  • 122
    • 33746102229 scopus 로고    scopus 로고
    • Comparison of common gamma-chain cytokines, interleukin-2, interleukin-7, and interleukin-15 for the in vitro generation of human tumor-reactive T lymphocytes for adoptive cell transfer therapy
    • Liu S, Riley J, Rosenberg S, et al. Comparison of common gamma-chain cytokines, interleukin-2, interleukin-7, and interleukin-15 for the in vitro generation of human tumor-reactive T lymphocytes for adoptive cell transfer therapy. J Immunother. 2006;29(3):284-293.
    • (2006) J Immunother , vol.29 , Issue.3 , pp. 284-293
    • Liu, S.1    Riley, J.2    Rosenberg, S.3
  • 123
    • 67649876115 scopus 로고    scopus 로고
    • New insights into the regulation of T cells by gamma(c) family cytokines
    • Rochman Y, Spolski R, Leonard WJ. New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol. 2009;9(7):480-490.
    • (2009) Nat Rev Immunol , vol.9 , Issue.7 , pp. 480-490
    • Rochman, Y.1    Spolski, R.2    Leonard, W.J.3
  • 124
    • 0037348324 scopus 로고    scopus 로고
    • Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15
    • Brentjens RJ, Latouche JB, Santos E, et al. Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15. Nat Med. 2003;9(3):279-286.
    • (2003) Nat Med , vol.9 , Issue.3 , pp. 279-286
    • Brentjens, R.J.1    Latouche, J.B.2    Santos, E.3
  • 125
    • 70149115961 scopus 로고    scopus 로고
    • A panel of artificial APCs expressing prevalent HLA alleles permits generation of cytotoxic T cells specific for both dominant and subdominant viral epitopes for adoptive therapy
    • Hasan AN, Kollen WJ, Trivedi D, et al. A panel of artificial APCs expressing prevalent HLA alleles permits generation of cytotoxic T cells specific for both dominant and subdominant viral epitopes for adoptive therapy. J Immunol. 2009;183(4):2837-2850.
    • (2009) J Immunol , vol.183 , Issue.4 , pp. 2837-2850
    • Hasan, A.N.1    Kollen, W.J.2    Trivedi, D.3
  • 126
    • 33750043473 scopus 로고    scopus 로고
    • Characterization of an artificial antigen-presenting cell to propagate cytolytic CD19-specific T cells
    • Numbenjapon T, Serrano LM, Singh H, et al. Characterization of an artificial antigen-presenting cell to propagate cytolytic CD19-specific T cells. Leukemia. 2006;20(10):1889-1892.
    • (2006) Leukemia , vol.20 , Issue.10 , pp. 1889-1892
    • Numbenjapon, T.1    Serrano, L.M.2    Singh, H.3
  • 127
    • 34247212403 scopus 로고    scopus 로고
    • Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules
    • Suhoski MM, Golovina TN, Aqui NA, et al. Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules. Mol Ther. 2007;15(5):981-988.
    • (2007) Mol Ther , vol.15 , Issue.5 , pp. 981-988
    • Suhoski, M.M.1    Golovina, T.N.2    Aqui, N.A.3
  • 128
    • 34250180927 scopus 로고    scopus 로고
    • Long-lived antitumor CD8+ lymphocytes for adoptive therapy generated using an artificial antigen-presenting cell
    • Butler MO, Lee JS, Ansen S, et al. Long-lived antitumor CD8+ lymphocytes for adoptive therapy generated using an artificial antigen-presenting cell. Clin Cancer Res. 2007;13(6):1857-1867.
    • (2007) Clin Cancer Res , vol.13 , Issue.6 , pp. 1857-1867
    • Butler, M.O.1    Lee, J.S.2    Ansen, S.3
  • 129
    • 22044456688 scopus 로고    scopus 로고
    • Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells
    • Imai C, Iwamoto S, Campana D. Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells. Blood. 2005;106(1):376-383.
    • (2005) Blood , vol.106 , Issue.1 , pp. 376-383
    • Imai, C.1    Iwamoto, S.2    Campana, D.3
  • 130
    • 23944488287 scopus 로고    scopus 로고
    • Chimeric NK-receptor-bearing T cells mediate antitumor immunotherapy
    • Zhang T, Lemoi BA, Sentman CL. Chimeric NK-receptor-bearing T cells mediate antitumor immunotherapy. Blood. 2005;106(5):1544-1551.
    • (2005) Blood , vol.106 , Issue.5 , pp. 1544-1551
    • Zhang, T.1    Lemoi, B.A.2    Sentman, C.L.3
  • 131
    • 37349039692 scopus 로고    scopus 로고
    • Expression of a CD20-specific chimeric antigen receptor enhances cytotoxic activity of NK cells and overcomes NK-resistance of lymphoma and leukemia cells
    • Muller T, Uherek C, Maki G, et al. Expression of a CD20-specific chimeric antigen receptor enhances cytotoxic activity of NK cells and overcomes NK-resistance of lymphoma and leukemia cells. Cancer Immunol Immunother. 2008;57(3):411-423.
    • (2008) Cancer Immunol Immunother , vol.57 , Issue.3 , pp. 411-423
    • Muller, T.1    Uherek, C.2    Maki, G.3
  • 132
    • 51549100478 scopus 로고    scopus 로고
    • Adoptive transfer of gene-modified primary NK cells can specifically inhibit tumor progression in vivo
    • Pegram HJ, Jackson JT, Smyth MJ, et al. Adoptive transfer of gene-modified primary NK cells can specifically inhibit tumor progression in vivo. J Immunol. 2008;181(5):3449-3455.
    • (2008) J Immunol , vol.181 , Issue.5 , pp. 3449-3455
    • Pegram, H.J.1    Jackson, J.T.2    Smyth, M.J.3
  • 133
    • 67549118956 scopus 로고    scopus 로고
    • Transfection with mRNA for CD19 specific chimeric antigen receptor restores NK cell mediated killing of CLL cells
    • Boissel L, Betancur M, Wels WS, et al. Transfection with mRNA for CD19 specific chimeric antigen receptor restores NK cell mediated killing of CLL cells. Leuk Res. 2009;33(9):1255-1259.
    • (2009) Leuk Res , vol.33 , Issue.9 , pp. 1255-1259
    • Boissel, L.1    Betancur, M.2    Wels, W.S.3
  • 134
    • 68049128101 scopus 로고    scopus 로고
    • Persuading natural killer cells to eliminate bad B cells
    • Cooper LJ. Persuading natural killer cells to eliminate bad B cells. Clin Cancer Res. 2009;15(15):4790-4791.
    • (2009) Clin Cancer Res , vol.15 , Issue.15 , pp. 4790-4791
    • Cooper, L.J.1
  • 135
    • 65949111530 scopus 로고    scopus 로고
    • Expansion of highly cytotoxic human natural killer cells for cancer cell therapy
    • Fujisaki H, Kakuda H, Shimasaki N, et al. Expansion of highly cytotoxic human natural killer cells for cancer cell therapy. Cancer Res. 2009;69(9):4010-4017.
    • (2009) Cancer Res , vol.69 , Issue.9 , pp. 4010-4017
    • Fujisaki, H.1    Kakuda, H.2    Shimasaki, N.3
  • 136
    • 77956499229 scopus 로고    scopus 로고
    • Sustained ex vivo expansion of human peripheral blood NK cells using artificial APCs bearing membrane-bound IL-21
    • Abstract 3030
    • Denman CJ, Kopp LM, Senyukov V, et al. Sustained ex vivo expansion of human peripheral blood NK cells using artificial APCs bearing membrane-bound IL-21. Blood (ASH Annual Meeting Abstracts). 2009;114(11):Abstract 3030.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , Issue.11
    • Denman, C.J.1    Kopp, L.M.2    Senyukov, V.3
  • 137
    • 0037105453 scopus 로고    scopus 로고
    • Natural killer cell receptors: New biology and insights into the graft-versus-leukemia effect
    • Farag SS, Fehniger TA, Ruggeri L, et al. Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect. Blood. 2002;100(6):1935-1947.
    • (2002) Blood , vol.100 , Issue.6 , pp. 1935-1947
    • Farag, S.S.1    Fehniger, T.A.2    Ruggeri, L.3
  • 138
    • 0037086131 scopus 로고    scopus 로고
    • Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    • Ruggeri L, Capanni M, Urbani E, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science. 2002;295(5562):2097-2100.
    • (2002) Science , vol.295 , Issue.5562 , pp. 2097-2100
    • Ruggeri, L.1    Capanni, M.2    Urbani, E.3
  • 139
    • 57949103408 scopus 로고    scopus 로고
    • Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy
    • Kondo M, Sakuta K, Noguchi A, et al. Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy. Cytotherapy. 2008;10(8):842-856.
    • (2008) Cytotherapy , vol.10 , Issue.8 , pp. 842-856
    • Kondo, M.1    Sakuta, K.2    Noguchi, A.3
  • 140
    • 61749100637 scopus 로고    scopus 로고
    • Harnessing endogenous miR-181a to segregate transgenic antigen receptor expression in developing versus post-thymic T cells in murine hematopoietic chimeras
    • Papapetrou EP, Kovalovsky D, Beloeil L, et al. Harnessing endogenous miR-181a to segregate transgenic antigen receptor expression in developing versus post-thymic T cells in murine hematopoietic chimeras. J Clin Invest. 2009;119(1):157-168.
    • (2009) J Clin Invest , vol.119 , Issue.1 , pp. 157-168
    • Papapetrou, E.P.1    Kovalovsky, D.2    Beloeil, L.3
  • 141
    • 15444378447 scopus 로고    scopus 로고
    • Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells
    • Yang L, Baltimore D. Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells. Proc Natl Acad Sci U S A. 2005;102(12):4518-4523.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.12 , pp. 4518-4523
    • Yang, L.1    Baltimore, D.2
  • 142
    • 20844439271 scopus 로고    scopus 로고
    • Fulminant experimental autoimmune encephalomyelitis induced by retrovirally mediated TCR gene transfer
    • Stolzer AL, Sadelain M, Sant'Angelo DB. Fulminant experimental autoimmune encephalomyelitis induced by retrovirally mediated TCR gene transfer. Eur J Immunol. 2005;35(6):1822-1830.
    • (2005) Eur J Immunol , vol.35 , Issue.6 , pp. 1822-1830
    • Stolzer, A.L.1    Sadelain, M.2    Sant'Angelo, D.B.3
  • 143
    • 36549043268 scopus 로고    scopus 로고
    • Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors
    • van Lent AU, Nagasawa M, van Loenen MM, et al. Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors. J Immunol. 2007;179(8):4959-4968.
    • (2007) J Immunol , vol.179 , Issue.8 , pp. 4959-4968
    • Van Lent, A.U.1    Nagasawa, M.2    Van Loenen, M.M.3
  • 144
    • 41849106141 scopus 로고    scopus 로고
    • Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors
    • Zakrzewski JL, Suh D, Markley JC, et al. Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors. Nat Biotechnol. 2008;26(4):453-461.
    • (2008) Nat Biotechnol , vol.26 , Issue.4 , pp. 453-461
    • Zakrzewski, J.L.1    Suh, D.2    Markley, J.C.3
  • 145
    • 51349090473 scopus 로고    scopus 로고
    • Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
    • Hacein-Bey-Abina S, Garrigue A, Wang GP, et al. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest. 2008;118(9):3132-3142.
    • (2008) J Clin Invest , vol.118 , Issue.9 , pp. 3132-3142
    • Hacein-Bey-Abina, S.1    Garrigue, A.2    Wang, G.P.3
  • 146
    • 0344511772 scopus 로고    scopus 로고
    • Safety of retroviral gene marking with a truncated NGF receptor
    • Bonini C, Grez M, Traversari C, et al. Safety of retroviral gene marking with a truncated NGF receptor. Nat Med. 2003;9(4):367-369.
    • (2003) Nat Med , vol.9 , Issue.4 , pp. 367-369
    • Bonini, C.1    Grez, M.2    Traversari, C.3
  • 147
    • 77956499908 scopus 로고    scopus 로고
    • A high throughput microelectroporation device to introduce a chimeric antigen receptor to redirect the specificity of human T cells
    • [published online ahead of print June 24, 2010]. doi: 10.1007/s10544-010-9440-3
    • Choi Y, Yuen C, Maiti SN, et al. A high throughput microelectroporation device to introduce a chimeric antigen receptor to redirect the specificity of human T cells [published online ahead of print June 24, 2010]. Biomed Microdevices. doi: 10.1007/s10544-010-9440-3.
    • Biomed Microdevices
    • Choi, Y.1    Yuen, C.2    Maiti, S.N.3
  • 148
    • 77950525914 scopus 로고    scopus 로고
    • A transposon and transposase system for human application
    • Hackett PB, Largaespada DA, Cooper LJ. A transposon and transposase system for human application. Mol Ther. 2010;18(4):674-683.
    • (2010) Mol Ther , vol.18 , Issue.4 , pp. 674-683
    • Hackett, P.B.1    Largaespada, D.A.2    Cooper, L.J.3
  • 149
    • 33646440024 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: First clinical experience
    • Lamers CH, Sleijfer S, Vulto AG, et al. Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol. 2006;24(13):e20-e22.
    • (2006) J Clin Oncol , vol.24 , Issue.13
    • Lamers, C.H.1    Sleijfer, S.2    Vulto, A.G.3
  • 150
    • 77950993215 scopus 로고    scopus 로고
    • Derivation of human T-lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation
    • Micklethwaite KP, Savoldo B, Hanley PJ, et al. Derivation of human T-lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation. Blood. 2010;115(13):2695-2703.
    • (2010) Blood , vol.115 , Issue.13 , pp. 2695-2703
    • Micklethwaite, K.P.1    Savoldo, B.2    Hanley, P.J.3
  • 151
    • 77950480974 scopus 로고    scopus 로고
    • Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: Case report of an unforeseen adverse event in a phase I clinical trial
    • Brentjens R, Yeh R, Bernal Y, Riviere I, Sadelain M. Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial. Mol Ther. 2010;18(4):666-668.
    • (2010) Mol Ther , vol.18 , Issue.4 , pp. 666-668
    • Brentjens, R.1    Yeh, R.2    Bernal, Y.3    Riviere, I.4    Sadelain, M.5
  • 152
    • 65349157330 scopus 로고    scopus 로고
    • Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): A non-randomised phase I-II study
    • Ciceri F, Bonini C, Stanghellini MT, et al. Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study. Lancet Oncol. 2009;10(5):489-500.
    • (2009) Lancet Oncol , vol.10 , Issue.5 , pp. 489-500
    • Ciceri, F.1    Bonini, C.2    Stanghellini, M.T.3
  • 153
    • 0037441766 scopus 로고    scopus 로고
    • Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation
    • Marktel S, Magnani Z, Ciceri F, et al. Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation. Blood. 2003;101(4):1290-1298.
    • (2003) Blood , vol.101 , Issue.4 , pp. 1290-1298
    • Marktel, S.1    Magnani, Z.2    Ciceri, F.3
  • 154
    • 33644750264 scopus 로고    scopus 로고
    • Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation
    • Berger C, Flowers ME, Warren EH, et al. Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation. Blood. 2006;107(6):2294-2302.
    • (2006) Blood , vol.107 , Issue.6 , pp. 2294-2302
    • Berger, C.1    Flowers, M.E.2    Warren, E.H.3
  • 155
    • 34249748406 scopus 로고    scopus 로고
    • The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies
    • Traversari C, Marktel S, Magnani Z, et al. The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies. Blood. 2007;109(11):4708-4715.
    • (2007) Blood , vol.109 , Issue.11 , pp. 4708-4715
    • Traversari, C.1    Marktel, S.2    Magnani, Z.3
  • 156
    • 70449090022 scopus 로고    scopus 로고
    • Transgene expression levels determine the immunogenicity of transduced hematopoietic grafts in partially myeloablated mice
    • Eixarch H, Gomez A, Kadar E, et al. Transgene expression levels determine the immunogenicity of transduced hematopoietic grafts in partially myeloablated mice. Mol Ther. 2009;17(11):1904-1909.
    • (2009) Mol Ther , vol.17 , Issue.11 , pp. 1904-1909
    • Eixarch, H.1    Gomez, A.2    Kadar, E.3
  • 157
    • 34247194881 scopus 로고    scopus 로고
    • Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy
    • Sato T, Neschadim A, Konrad M, et al. Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy. Mol Ther. 2007;15(5):962-970.
    • (2007) Mol Ther , vol.15 , Issue.5 , pp. 962-970
    • Sato, T.1    Neschadim, A.2    Konrad, M.3
  • 158
    • 0035282726 scopus 로고    scopus 로고
    • A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease
    • Thomis DC, Marktel S, Bonini C, et al. A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease. Blood. 2001;97(5):1249-1257.
    • (2001) Blood , vol.97 , Issue.5 , pp. 1249-1257
    • Thomis, D.C.1    Marktel, S.2    Bonini, C.3
  • 159
    • 19344365874 scopus 로고    scopus 로고
    • An inducible caspase 9 safety switch for T-cell therapy
    • Straathof KC, Pule MA, Yotnda P, et al. An inducible caspase 9 safety switch for T-cell therapy. Blood. 2005;105(11):4247-4254.
    • (2005) Blood , vol.105 , Issue.11 , pp. 4247-4254
    • Straathof, K.C.1    Pule, M.A.2    Yotnda, P.3
  • 160
    • 70349090562 scopus 로고    scopus 로고
    • Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy
    • Griffioen M, van Egmond EH, Kester MG, et al. Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy. Haematologica. 2009;94(9):1316-1320.
    • (2009) Haematologica , vol.94 , Issue.9 , pp. 1316-1320
    • Griffioen, M.1    Van Egmond, E.H.2    Kester, M.G.3
  • 161
    • 0034054579 scopus 로고    scopus 로고
    • Genetic modification of human T cells with CD20: A strategy to purify and lyse transduced cells with anti-CD20 antibodies
    • Introna M, Barbui AM, Bambacioni F, et al. Genetic modification of human T cells with CD20: a strategy to purify and lyse transduced cells with anti-CD20 antibodies. Hum Gene Ther. 2000;11(4):611-620.
    • (2000) Hum Gene Ther , vol.11 , Issue.4 , pp. 611-620
    • Introna, M.1    Barbui, A.M.2    Bambacioni, F.3
  • 162
    • 76249116978 scopus 로고    scopus 로고
    • Antibody mediated B cell depletion prior to adoptive immunotherapy with T cells expressing CD20-specific chimeric T cell receptors facilitates eradication of leukemia in immunocompetent mice
    • James SE, Orgun NN, Tedder TF, et al. Antibody mediated B cell depletion prior to adoptive immunotherapy with T cells expressing CD20-specific chimeric T cell receptors facilitates eradication of leukemia in immunocompetent mice. Blood. 2009;114:5454-5463.
    • (2009) Blood , vol.114 , pp. 5454-5463
    • James, S.E.1    Orgun, N.N.2    Tedder, T.F.3
  • 163
    • 34047271156 scopus 로고    scopus 로고
    • Combining adoptive cellular and immunocytokine therapies to improve treatment of B-lineage malignancy
    • Singh H, Serrano LM, Pfeiffer T, et al. Combining adoptive cellular and immunocytokine therapies to improve treatment of B-lineage malignancy. Cancer Res. 2007;67(6):2872-2880.
    • (2007) Cancer Res , vol.67 , Issue.6 , pp. 2872-2880
    • Singh, H.1    Serrano, L.M.2    Pfeiffer, T.3
  • 164
    • 70350625443 scopus 로고    scopus 로고
    • Gene therapy deserves a fresh chance
    • Editorial
    • Editorial. Gene therapy deserves a fresh chance. Nature. 2009;461(7268):1173.
    • (2009) Nature , vol.461 , Issue.7268 , pp. 1173
  • 165
    • 70449105734 scopus 로고    scopus 로고
    • Risk in clinical research: Size matters
    • Lowenstein PR. Risk in clinical research: size matters. Mol Ther. 2009;17(11):1833-1834.
    • (2009) Mol Ther , vol.17 , Issue.11 , pp. 1833-1834
    • Lowenstein, P.R.1
  • 166
    • 77950501752 scopus 로고    scopus 로고
    • Safer CARS
    • editorial
    • Heslop HE. Safer CARS [editorial]. Mol Ther. 2010;18(4):661-662.
    • (2010) Mol Ther , vol.18 , Issue.4 , pp. 661-662
    • Heslop, H.E.1
  • 167
    • 33749514632 scopus 로고    scopus 로고
    • Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals
    • Leen AM, Myers GD, Sili U, et al. Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat Med. 2006;12(10):1160-1166.
    • (2006) Nat Med , vol.12 , Issue.10 , pp. 1160-1166
    • Leen, A.M.1    Myers, G.D.2    Sili, U.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.