EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss

Clinical Cancer Research

Volumn 20, Issue 4, 2014, Pages 972-984

  Sampson, John H ^a,b   Choi, Bryan D ^a,b   Sanchez Perez, Luis ^a,b   Suryadevara, Carter M ^a   Snyder, David J ^a   Flores, Catherine T ^a   Schmittling, Robert J ^a   Nair, Smita K ^a   Reap, Elizabeth A ^a   Norberg, Pamela K ^a   Herndon Ii, James E ^c   Kuan, Chien Tsun ^a   Morgan, Richard A ^d   Rosenberg, Steven A ^d   Johnson, Laura A ^a,b,e  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE CANCER INSTITUTE   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CHIMERIC ANTIGEN RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 8; EPIDERMAL GROWTH FACTOR RECEPTOR 8 CHIMERIC ANTIGEN RECEPTOR; EPITOPE; GAMMA INTERFERON; GROWTH FACTOR RECEPTOR; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN TUMOR; CANCER IMMUNOTHERAPY; CELL THERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG RECHALLENGE; GLIOBLASTOMA; GLIOMA; IMMUNOCOMPETENCE; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN TARGETING; RECEPTOR BLOCKING; T LYMPHOCYTE; TREATMENT OUTCOME; TUMOR IMMUNITY; TUMOR RESISTANCE; TUMOR XENOGRAFT;

ADOPTIVE TRANSFER; ANIMALS; ASTROCYTOMA; BRAIN NEOPLASMS; CELL LINE, TUMOR; HUMANS; MICE; NEOPLASM TRANSPLANTATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ANTIGEN, T-CELL; SINGLE-CHAIN ANTIBODIES; T-LYMPHOCYTES;

EID: 84896734231     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-0709     Document Type: Article

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