The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response

Food and Chemical Toxicology

Volumn 100, Issue , 2017, Pages 161-167

  Zhang, Qiang ^b   Cui, Qi ^a   Hou, Yongyong ^a   Wang, Huihui ^a   Xu, Yuanyuan ^a   Pi, Jingbo ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b EMORY UNIVERSITY   (United States)

Author keywords

Adaptive antioxidant response; Glucose stimulated insulin secretion; Glucotoxicity; Lipotoxicity; Pancreatic cells

Indexed keywords

GLUCOSE; GLUTATHIONE; GLUTATHIONE DISULFIDE; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; ANTIOXIDANT; INSULIN; LIPID; MESSENGER RNA; SWEETENING AGENT;

ADAPTIVE ANTIOXIDANT RESPONSE; ARTICLE; BIOACCUMULATION; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; CELL LEVEL; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISORDERS OF CARBOHYDRATE METABOLISM; GLUCOSE STIMULATED INSULIN SECRETION; GLUCOTOXICITY; HUMAN; HUMAN CELL; IMPAIRMENT OF GLUCOSE STIMULATED INSULIN SECRETION; INSULIN RELEASE; LIPOTOXICITY; MOLECULAR DYNAMICS; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; GENETICS; HYPERGLYCEMIA; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION (PROCESS); WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; GLUCOSE; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; LIPIDS; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SWEETENING AGENTS;

EID: 85007359098     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2016.12.016     Document Type: Article

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