Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway

Diabetologia

Volumn 55, Issue 1, 2012, Pages 141-153

  Lombardi, Angela ^a,b   Ulianich, L ^b   Treglia, A S ^a   Nigro, C ^b   Parrillo, L ^b   Lofrumento, D D ^a   Nicolardi, G ^a   Garbi, C ^b   Beguinot, F ^b   Miele, C ^b   Di Jeso, B ^a  

^a UNIVERSITY OF SALENTO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Beta cells; Dedifferentiation; ER stress; ERK1 2

Indexed keywords

4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 6; CELL MARKER; CHAPERONE; GLUCOSAMINE; GLUCOSE; GLUCOSE REGULATED PROTEIN 78; GLUCOSE TRANSPORTER 2; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEXOSAMINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDX 1; TUNICAMYCIN; X BOX BINDING PROTEIN 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; ATF6 GENE; BIP GENE; CARBOHYDRATE SYNTHESIS; CARBOHYDRATE TRANSPORT; CELL DIFFERENTIATION; CELL VIABILITY; CHOP GENE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE; GLUT2 GENE; INS1 GENE; INSULIN RELEASE; INSULIN RESPONSE; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN UNFOLDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; XBP1 GENE;

EID: 84856729420     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2315-1     Document Type: Article

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