Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca2+ response to glucose

Aging

Volumn 6, Issue 3, 2014, Pages 207-214

  Yanagida, Kazuhiro ^a   Maejima, Yuko ^b   Santoso, Putra ^b   Otgon Uul, Zesemdorj ^b   Yang, Yifei ^b   Sakuma, Kazuya ^b   Shimomura, Kenju ^b   Yada, Toshihiko ^b  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Glucotoxicity; Hexosamine pathway; Insulin secretion

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; HEXOSAMINE; INSULIN;

ANIMAL; CALCIUM SIGNALING; CELL CULTURE; DRUG EFFECTS; EXTRACELLULAR FLUID; HYPERGLYCEMIA; METABOLISM; OSMOLARITY; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; RAT; SECRETION (PROCESS); WISTAR RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM SIGNALING; CELLS, CULTURED; EXTRACELLULAR FLUID; GLUCOSE; HEXOSAMINES; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; METABOLIC NETWORKS AND PATHWAYS; OSMOLAR CONCENTRATION; RATS; RATS, WISTAR;

EID: 84897976551     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100647     Document Type: Article

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