Nr2e1 Deficiency Augments Palmitate-Induced Oxidative Stress in Beta Cells

Oxidative Medicine and Cellular Longevity

Volumn 2016, Issue , 2016, Pages

  Shi, Xiaoli ^a   Deng, Haohua ^a   Dai, Zhe ^a   Xu, Yancheng ^a   Xiong, Xiaokan ^a   Ma, Pei ^a   Cheng, Jing ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CELLS; INSULIN; PALMITIC ACID; PHYSIOLOGY; STEM CELLS;

ANTIOXIDANT ENZYME; BETA CELL FUNCTIONS; CELL-CYCLE ARREST; EXPRESSION LEVELS; INSULIN SECRETION; MOLECULAR LEVELS; NUCLEAR RECEPTORS; PROTECTIVE EFFECTS;

CYTOLOGY;

CELL NUCLEUS RECEPTOR; INSULIN; NUCLEAR RECEPTOR SUBFAMILY 2 GROUP E MEMBER 1 PROTEIN; PALMITIC ACID; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIOXIDANT; CELL RECEPTOR; NR2E1 PROTEIN, MOUSE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; G1 PHASE CELL CYCLE CHECKPOINT; INSULIN RELEASE; LIPOTOXICITY; MIN6 CELL LINE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; ANIMAL; CELL LINE; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY;

ANIMALS; ANTIOXIDANTS; CELL LINE; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INSULIN-SECRETING CELLS; MICE; OXIDATIVE STRESS; PALMITIC ACID; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RESTING PHASE, CELL CYCLE;

EID: 84948798601     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2016/9648769     Document Type: Article

References (29)

1. G. C. Weir and S. Bonner-Weir, "Islet β cell mass in diabetes and how it relates to function, birth, and death," Annals of the New York Academy of Sciences, vol. 1281, no. 1, pp. 92-105, 2013.
2. V. Poitout and R. P. Robertson, "Minireview: secondary β-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity," Endocrinology, vol. 143, no. 2, pp. 339-342, 2002.
3. J. L. Leahy, "Pathogenesis of type 2 diabetes mellitus," Archives of Medical Research, vol. 36, no. 3, pp. 197-209, 2005.
4. G. M. Steil, N. Trivedi, J.-C. Jonas et al., "Adaptation of betacell mass to substrate oversupply: enhanced function with normal gene expression," The American Journal of Physiology-Endocrinology and Metabolism, vol. 280, no. 5, pp. E788-E796, 2001.
5. T. L. Jetton, J. Lausier, K. LaRock et al., "Mechanisms of compensatory β-cell growth in insulin-resistant rats: roles of Akt kinase," Diabetes, vol. 54, no. 8, pp. 2294-2304, 2005.
6. Y. Q. Liu, T. L. Jetton, and J. L. Leahy, "β-cell adaptation to insulin resistance. Increased pyruvate carboxylase and malatepyruvate shuttle activity in islets of nondiabetic zucker fatty rats," The Journal of Biological Chemistry, vol. 277, no. 42, pp. 39163-39168, 2002.
7. R. T. Yu, M. McKeown, R. M. Evans, and K. Umesono, "Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx," Nature, vol. 370, no. 6488, pp. 375-379, 1994.
8. A. P. Monaghan, D. Bock, P. Gass et al., "Defective limbic system in mice lacking the tailless gene," Nature, vol. 390, no. 6659, pp. 515-517, 1997.
9. K. A. Young, M. L. Berry, C. L. Mahaffey et al., "Fierce: A new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent," Behavioural Brain Research, vol. 132, no. 2, pp. 145-158, 2002.
10. Y. Shi, D. C. Lie, P. Taupin et al., "Expression and function of orphan nuclear receptor TLX in adult neural stemcells," Nature, vol. 427, no. 6969, pp. 78-83, 2004.
11. C.-L. Zhang, Y. Zou, R. T. Yu, F. H. Gage, and R. M. Evans, "Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1," Genes and Development, vol. 20, no. 10, pp. 1308-1320, 2006.
12. Q. Qu, G. Sun, W. Li et al., "Orphan nuclear receptor TLX activates Wnt/β-catenin signalling to stimulate neural stem cell proliferation and self-renewal," Nature Cell Biology, vol. 12, no. 1, pp. 31-40, 2010.
13. R. Sehgal, N. Sheibani, S. J. Rhodes, and T. L. Belecky Adams, "BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression," Developmental Biology, vol. 332, no. 2, pp. 429-443, 2009.
14. G. Sun, K. Alzayady, R. Stewart et al., "Histone demethylase LSD1 regulates neural stem cell proliferation," Molecular and Cellular Biology, vol. 30, no. 8, pp. 1997-2005, 2010.
15. G. Sun, R.T. Yu, R.M. Evans, and Y. Shi, "Orphannuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation," Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 39, pp. 15282-15287, 2007.
16. D. Wu, S. Yu, L. Jia et al., "Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21WAF1/CIP1) and SIRT1 genes," Journal of Pathology, vol. 236, no. 1, pp. 103-115, 2015.
17. H. Ishihara, T. Asano, K. Tsukuda et al., "Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets," Diabetologia, vol. 36, no. 11, pp. 1139-1145, 1993.
18. J.-I. Miyazaki, K. Araki, E. Yamato et al., "Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms," Endocrinology, vol. 127, no. 1, pp. 126-132, 1990.
19. E. Pepin, A. Higa, C. Schuster-Klein et al., "Deletion of apoptosis signal-regulating kinase1 (ASK1) protects pancreatic beta-cells from stress-induced death but not from glucose homeostasis alterations under pro-inflammatory conditions," PLoS ONE, vol. 9, no. 11, Article ID e112714, 2014.
20. R. B. Sharma and L. C. Alonso, "Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well?" Current Diabetes Reports, vol. 14, no. 6, article 492, 2014.
21. A. Uemura, S. Kusuhara, S. J. Wiegand, R. T. Yu, and S.-I. Nishikawa, "Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes," The Journal of Clinical Investigation, vol. 116, no. 2, pp. 369-377, 2006.
22. W. Li, G. Sun, S. Yang, Q. Qu, K. Nakashima, and Y. Shi, "Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain," Molecular Endocrinology, vol. 22, no. 1, pp. 56-64, 2008.
23. C.-L. Zhang, Y. Zou, W. He, F. H. Gage, and R. M. Evans, "A role for adult TLX-positive neural stem cells in learning and behaviour," Nature, vol. 451, no. 7181, pp. 1004-1007, 2008.
24. N. Ni, D. Zhang, Q. Xie et al., "Effects of let-7b and TLX on the proliferation and differentiation of retinal progenitor cells in vitro," Scientific Reports, vol. 4, article 6671, 2014.
25. B. B. Lowell and G. I. Shulman, "Mitochondrial dysfunction and type 2 diabetes," Science, vol. 307, no. 5708, pp. 384-387, 2005.
26. K. Grankvist, S. L. Marklund, and I. B. Taljedal, "Cu Znsuperoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse," Biochemical Journal, vol. 199, no. 2, pp. 393-398, 1981.
27. M. Tiedge, S. Lortz, R. Monday, and S. Lenzen, "Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species," Diabetes, vol. 47, no. 10, pp. 1578-1585, 1998.
28. H.-A. Seo and I.-K. Lee, "The role of Nrf2: adipocyte differentiation, obesity, and insulin resistance," Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 184598, 7 pages, 2013.
29. B. N. Das, Y.-W. Kim, and Y.-S. Keum, "Mechanisms of Nrf2/keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates," Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 839409, 7 pages, 2013.