Palmitate-induced impairment of glucose-stimulated insulin secretion precedes mitochondrial dysfunction in mouse pancreatic islets

Biochemical Journal

Volumn 473, Issue 4, 2016, Pages 487-496

  Barlow, Jonathan ^a   Jensen, Verena Hirschberg ^a   Jastroch, Martin ^b   Affourtit, Charles ^a  

^a UNIVERSITY OF PLYMOUTH   (United Kingdom)

^b Garching   (Germany)

Author keywords

Glucolipotoxicity; Mitochondria; Obesity; Oxidative phosphorylation; Pancreatic cells; Type 2 diabetes.

Indexed keywords

GLUCOSE; INSULIN; PALMITIC ACID; PALMITOLEIC ACID; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; FEMALE; INSULIN RELEASE; LIPID OXIDATION; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CELL LINE; DRUG EFFECTS; MITOCHONDRION; PANCREAS ISLET; PHYSIOLOGY; SECRETION (PROCESS);

ANIMALS; CELL LINE; FEMALE; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; PALMITIC ACID;

EID: 84958554946     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20151080     Document Type: Article

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