Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models

Diabetologia

Volumn 59, Issue 2, 2016, Pages 316-324

  Chen, Fang ^a   Sha, Min ^a   Wang, Yanyang ^a   Wu, Tijun ^a   Shan, Wei ^a   Liu, Jia ^a   Zhou, Wenbo ^a   Zhu, Yunxia ^a   Sun, Yujie ^a   Shi, Yuguang ^b   Bleich, David ^c   Han, Xiao ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Beta cell; Dysfunction; Ets 1; Glucotoxicity; PDX 1

Indexed keywords

ADENOVIRUS VECTOR; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 3BETA; HISTONE H3; HISTONE H4; INSULIN; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PDX 1; GLUCOSE BLOOD LEVEL; HOMEODOMAIN PROTEIN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BIOSYNTHESIS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GLUCOSE TOLERANCE TEST; GLUCOTOXICITY; HISTONE ACETYLATION; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; INSULIN SYNTHESIS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; UPREGULATION; VIRUS RECOMBINANT; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; COMPLICATION; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENETICS; GLUCOSE BLOOD LEVEL; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HYPERGLYCEMIA; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEIN C-ETS-1; RATS; RATS, SPRAGUE-DAWLEY; TRANS-ACTIVATORS;

EID: 84953365618     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3805-3     Document Type: Article

References (41)

1. Henquin JC (2000) Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 49:1751–1760
2. Neutzsky-Wulff AV, Andreassen KV, Hjuler ST et al (2012) Future detection and monitoring of diabetes may entail analysis of both beta-cell function and volume: how markers of beta-cell loss may assist. J Transl Med 10:214
3. Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H (1998) Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 12:1763–1768
4. Jonas JC, Sharma A, Hasenkamp W et al (1999) Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem 274:14112–14121
5. Tokuyama Y, Sturis J, DePaoli AM et al (1995) Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 44:1447–1457
6. Brunner Y, Schvartz D, Priego-Capote F, Coute Y, Sanchez JC (2009) Glucotoxicity and pancreatic proteomics. J Proteomics 71:576–591
7. Poitout V, Amyot J, Semache M, Zarrouki B, Hagman D, Fontes G (2010) Glucolipotoxicity of the pancreatic beta cell. Biochim Biophys Acta 1801:289–298
8. Melloul D (2004) Transcription factors in islet development and physiology: role of PDX-1 in beta-cell function. Ann N Y Acad Sci 1014:28–37
9. Glick E, Leshkowitz D, Walker MD (2000) Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter. J Biol Chem 275:2199–2204
10. Waeber G, Thompson N, Nicod P, Bonny C (1996) Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol 10:1327–1334
11. Watada H, Kajimoto Y, Umayahara Y et al (1996) The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells. Diabetes 45:1478–1488
12. Carty MD, Lillquist JS, Peshavaria M, Stein R, Soeller WC (1997) Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells. J Biol Chem 272:11986–11993
13. Marshak S, Benshushan E, Shoshkes M, Havin L, Cerasi E, Melloul D (2000) Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression. Mol Cell Biol 20:7583–7590
14. Liberzon A, Ridner G, Walker MD (2004) Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1. Nucleic Acids Res 32:54–64
15. Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF (1997) Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 15:106–110
16. Stoffers DA, Ferrer J, Clarke WL, Habener JF (1997) Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet 17:138–139
17. Kawamori D, Kajimoto Y, Kaneto H et al (2003) Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes 52:2896–2904
18. Kitamura T, Nakae J, Kitamura Y et al (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110:1839–1847
19. Issad T, Kuo M (2008) O-GlcNAc modification of transcription factors, glucose sensing and glucotoxicity. Trends Endocrinol Metab 19:380–389
20. Nakae J, Biggs WH 3rd, Kitamura T et al (2002) Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet 32:245–253
21. Kitamura T, Ido Kitamura Y (2007) Role of FoxO proteins in pancreatic beta cells. Endocr J 54:507–515
22. Asada S, Daitoku H, Matsuzaki H et al (2007) Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. Cell Signal 19:519–527
23. Mosley AL, Corbett JA, Ozcan S (2004) Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1. Mol Endocrinol 18:2279–2290
24. Pham TX, Lee J (2012) Dietary regulation of histone acetylases and deacetylases for the prevention of metabolic diseases. Nutrients 4:1868–1886
25. Seeger FH, Chen L, Spyridopoulos I, Altschmied J, Aicher A, Haendeler J (2009) Downregulation of ETS rescues diabetes-induced reduction of endothelial progenitor cells. PLoS One 4:e4529
26. Zhang X, Zhang J, Yang X, Han X (2007) Several transcription factors regulate COX-2 gene expression in pancreatic beta-cells. Mol Biol Rep 34:199–206
27. Han X, Sun Y, Scott S, Bleich D (2001) Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells. Diabetes 50:1047–1055
28. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B (1998) A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A 95:2509–2514
29. Meng ZX, Nie J, Ling JJ et al (2009) Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia 52:125–135
30. Zhang X, Yong W, Lv J et al (2009) Inhibition of forkhead box O1 protects pancreatic beta-cells against dexamethasone-induced dysfunction. Endocrinology 150:4065–4073
31. Lin HY, Yin Y, Zhang JX et al (2012) Identification of direct forkhead box O1 targets involved in palmitate-induced apoptosis in clonal insulin-secreting cells using chromatin immunoprecipitation coupled to DNA selection and ligation. Diabetologia 55:2703–2712
32. Yamasaki S, Yagishita N, Sasaki T et al (2007) Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase ‘Synoviolin’. EMBO J 26:113–122
33. Laybutt DR, Weir GC, Kaneto H et al (2002) Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. Diabetes 51:1793–1804
34. Oshima H, Taketo MM, Oshima M (2006) Destruction of pancreatic beta-cells by transgenic induction of prostaglandin E2 in the islets. J Biol Chem 281:29330–29336
35. Kaneko K, Ueki K, Takahashi N et al (2010) Class IA phosphatidylinositol 3-kinase in pancreatic beta cells controls insulin secretion by multiple mechanisms. Cell Metab 12:619–632
36. Kobberup S, Nyeng P, Juhl K, Hutton J, Jensen J (2007) ETS-family genes in pancreatic development. Dev Dyn 236:3100–3110
37. Picarella DE, Kratz A, Li CB, Ruddle NH, Flavell RA (1992) Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas. Proc Natl Acad Sci U S A 89:10036–10040
38. Mosley AL, Ozcan S (2003) Glucose regulates insulin gene transcription by hyperacetylation of histone h4. J Biol Chem 278:19660–19666
39. Saleh MC, Fatehi-Hassanabad Z, Wang R (2008) Mutated ATP synthase induces oxidative stress and impaired insulin secretion in beta-cells of female BHE/cdb rats. Diabetes Metab Res Rev 24:392–403
40. Kajimoto Y, Matsuoka T, Kaneto H, Watada H, Fujitani Y, Kishimoto M, Sakamoto K, Matsuhisa M, Kawamori R, Yamasaki Y, Hori M (1999) Induction of glycation suppresses glucokinase gene expression in HIT-T15 cells. Diabetologia 42:1417–1424
41. Chen F, Zhu Y, Tang X (2011) Dynamic regulation of PDX-1 and FoxO1 expression by FoxA2 in dexamethasone-induced pancreatic beta-cells dysfunction. Endocrinology 152:1779–1788