Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt

Nature Communications

Volumn 7, Issue , 2016, Pages

  Han, Chang Yeob ^a   Koo, Ja Hyun ^a   Kim, Sung Hoon ^b   Gardenghi, Sara ^c   Rivella, Stefano ^c   Strnad, Pavel ^d   Hwang, Se Jin ^b   Kim, Sang Geon ^a  

^a Seoul National University   (South Korea)

^b Hanyang University   (South Korea)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; COLLAGEN TYPE 1; FERRITIN; FERROPORTIN; GELATINASE A; GELATINASE B; HEPCIDIN; LACTATE DEHYDROGENASE; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE B; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; CATION TRANSPORT PROTEIN; METAL TRANSPORTING PROTEIN 1;

BIOASSAY; CELLS AND CELL COMPONENTS; GENE; GENE EXPRESSION; GENE TRANSFER; GENETIC ANALYSIS; INDUCED RESPONSE; INHIBITION; INJURY; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT LIGATION; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; DRUG PROTEIN BINDING; FIBROGENESIS; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATORY CELL; IRON STORAGE; LIVER CELL; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STELLATE CELL; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG EFFECT; EXPERIMENTAL LIVER CIRRHOSIS; GENE KNOCKDOWN; GENETICS; HEPATIC STELLATE CELL; LIVER CIRRHOSIS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ANIMALIA; MUS;

ANIMALS; CATION TRANSPORT PROTEINS; GENE KNOCKDOWN TECHNIQUES; HEPATIC STELLATE CELLS; HEPCIDINS; HUMANS; LIVER CIRRHOSIS; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 85006999095     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13817     Document Type: Article

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