Hepcidin knockout mice fed with iron-rich diet develop chronic liver injury and liver fibrosis due to lysosomal iron overload

Journal of Hepatology

Volumn 61, Issue 3, 2014, Pages 633-641

  Lunova, Mariia ^a   Goehring, Claudia ^a   Kuscuoglu, Deniz ^e   Mueller, Katrin ^a   Chen, Yu ^a   Walther, Paul ^b   Deschemin, Jean Christophe ^c   Vaulont, Sophie ^c   Haybaeck, Johannes ^d   Lackner, Carolin ^d   Trautwein, Christian ^e   Strnad, Pavel ^a,e  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c INSTITUT COCHIN   (France)

^d MEDICAL UNIVERSITY OF GRAZ   (Austria)

^e UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Autophagy; Hemochromatosis; Inflammation

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; CATHEPSIN B; CD45 ANTIGEN; CHAPERONIN 60; CHLORDANE; COLLAGEN; CYTOCHROME C; FERRITIN; FERROPORTIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLYCOPROTEIN P 15095; HEAT SHOCK COGNATE PROTEIN 70; HEPCIDIN; HISTONE DEACETYLASE 2; HYDROXYPROLINE; IRON; IRON COMPLEX; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; LYSOZYME; LYSOZYME 2; MACROPHAGE ELASTASE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROHIBITIN; PROTEIN P62; RANTES; UNCLASSIFIED DRUG; IRON INTAKE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOFLUORESCENCE; BODY WEIGHT; CELL ACTIVATION; CELL FRACTIONATION; CHRONIC LIVER DISEASE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FERRITIN BLOOD LEVEL; HEPATITIS; HEPATOMEGALY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IRON BLOOD LEVEL; IRON INTAKE; IRON OVERLOAD; KNOCKOUT MOUSE; LIVER CELL; LIVER FIBROSIS; LIVER HISTOLOGY; LIVER LYSOSOME; LIVER WEIGHT; MOUSE; NICK END LABELING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; STELLATE CELL; ZONATION; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; ENZYMOLOGY; GENETICS; HOMEOSTASIS; LIVER; LIVER CIRRHOSIS; LUNG INJURY; LYSOSOME; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TIME;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; HEPATIC STELLATE CELLS; HEPCIDINS; HOMEOSTASIS; IRON; IRON, DIETARY; LIVER; LIVER CIRRHOSIS; LUNG INJURY; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TIME FACTORS;

EID: 84906307881     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.04.034     Document Type: Article

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