Hepatitis C Virus-Induced Reactive Oxygen Species Raise Hepatic Iron Level in Mice by Reducing Hepcidin Transcription

Gastroenterology

Volumn 134, Issue 1, 2008, Pages 226-238

  Nishina, Sohji ^a   Hino, Keisuke ^a   Korenaga, Masaaki ^a   Vecchi, Chiara ^c   Pietrangelo, Antonello ^c   Mizukami, Yoichi ^a   Furutani, Takakazu ^a   Sakai, Aya ^a   Okuda, Michiari ^a   Hidaka, Isao ^a   Okita, Kiwamu ^b   Sakaida, Isao ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Social Insurance Alliance Shimonoseki Kohsei Hospital   (Japan)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CD71 ANTIGEN; CYTOKINE; FERRITIN; FERROPORTIN; HEPCIDIN; IRON; IRON REGULATORY FACTOR; LIPOPOLYSACCHARIDE; POLYPROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; DUODENUM; GENETIC TRANSCRIPTION; HEPATITIS; HEPATITIS C VIRUS; IN VITRO STUDY; IN VIVO STUDY; IRON BLOOD LEVEL; IRON OVERLOAD; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; SPLEEN; TRANSGENIC MOUSE;

EID: 37349065804     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.10.011     Document Type: Article

References (34)

1. Farinati F., Cardin R., De Maria N., et al. Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis. J Hepatol 22 (1995) 449-456
2. Di Bisceglie A.M., Axiotis C.A., Hoofnagle J.H., et al. Measurements of iron status in patients with chronic hepatitis. Gastroenterology 102 (1992) 2108-2113
3. Fenton H.J.H. Oxidation of tartaric acid in presence of iron. J Chem Soc 65 (1894) 899-910
4. Okuda M., Li K., Beard M.R., et al. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 122 (2002) 366-375
5. Furutani T., Hino K., Okuda M., et al. Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein. Gastroenterology 130 (2006) 2087-2098
6. Kato J., Kobune M., Nakamura T., et al. Normalization of elevated hepatic 8-hydroxy-2'-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet. Cancer Res 61 (2001) 8697-8702
7. Nemeth E., Rivera S., Gabayan V., et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113 (2004) 1271-1276
8. Park C.H., Valore E.V., Waring A.J., et al. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276 (2001) 7806-7810
9. Beard M.R., Abell G., Honda M., et al. An infectious molecular clone of a Japanese genotype 1b hepatitis C virus. Hepatology 30 (1999) 316-324
10. Lerat H., Honda M., Beard M.R., et al. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 122 (2002) 352-365
11. Pigeon C., Ilyin G., Courselaud B., et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276 (2001) 7811-7819
12. Harrison-Findik D.D., Schafer D., Klein E., et al. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem 281 (2006) 22974-22982
13. Hentze M.W., Muckenthaler M.U., and Andrews N.C. Balancing acts: molecular control of mammalian iron metabolism. Cell 117 (2004) 285-297
14. Nemeth E., Tuttle M.S., Powelson J., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 (2004) 2090-2093
15. Chua A.C., Olynyk J.K., Leedman P.J., et al. Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis. Blood 104 (2004) 1519-1525
16. Hentze M.W., and Kuhn L.C. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci U S A 93 (1996) 8175-8182
17. Boyd D., Vecoli C., Belcher D.M., et al. Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones. J Biol Chem 260 (1985) 11755-11761
18. Theurl I., Ludwiczek S., Eller P., et al. Pathways for the regulation of body iron homeostasis in response to experimental iron overload. J Hepatol 43 (2005) 711-719
19. Courselaud B., Pigeon C., Inoue Y., et al. C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J Biol Chem 277 (2002) 41163-41170
20. Ron D., and Habener J.F. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 6 (1992) 439-453
21. Bek M.F., Bayer M., Muller B., et al. Expression and function of C/EBP homology protein (GADD153) in podocytes. Am J Pathol 168 (2006) 20-32
22. Shan Y., Lambrecht R.W., and Bonkovsky H.L. Association of hepatitis C virus infection with serum iron status: analysis of data from the third National Health and Nutrition Examination Survey. Clin Infect Dis 40 (2005) 834-841
23. Kulaksiz H., Gehrke S.G., Janetzko A., et al. Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia. Gut 53 (2004) 735-743
24. Kemna E., Pickkers P., Nemeth E., et al. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 106 (2005) 1864-1866
25. Bonkovsky H.L., Banner B.F., and Rothman A.L. Iron and chronic viral hepatitis. Hepatology 25 (1997) 759-768
26. Brunt E.M. Pathology of hepatic iron overload. Semin Liver Dis 25 (2005) 392-401
27. Fiel M.I., Schiano T.D., Guido M., et al. Increased hepatic iron deposition resulting from treatment of chronic hepatitis C with ribavirin. Am J Clin Pathol 113 (2000) 35-39
28. Pietrangelo A. Hereditary hemochromatosis-a new look at an old disease. N Engl J Med 350 (2004) 2383-2397
29. Thorstensen K., Trinder D., Zak O., et al. Uptake of iron from N-terminal half-transferrin by isolated rat hepatocytes. Evidence of transferrin-receptor-independent iron uptake. Eur J Biochem 232 (1995) 129-133
30. Pietrangelo A., Dierssen U., Valli L., et al. STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology 132 (2007) 294-300
31. Wang R.H., Li C., Xu X., et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2 (2005) 399-409
32. Babitt J.L., Huang F.W., Wrighting D.M., et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 38 (2006) 531-539
33. Van Lenten B.J., Prieve J., Navab M., et al. Lipid-induced changes in intracellular iron homeostasis in vitro and in vivo. J Clin Invest 95 (1995) 2104-2110
34. Migita K., Abiru S., Maeda Y., et al. Serum levels of interleukin-6 and its soluble receptors in patients with hepatitis C virus infection. Hum Immunol 67 (2006) 27-32