Effect of free iron on collagen synthesis, cell proliferation and MMP-2 expression in rat hepatic stellate cells

Biochemical Pharmacology

Volumn 64, Issue 7, 2002, Pages 1139-1145

  Gardi, Concetta ^a   Arezzini, Beatrice ^a   Fortino, Vittoria ^a   Comporti, Mario ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

Collagen metabolism; Hepatic stellate cells; Iron chelates; Iron overload; Liver fibrosis; Metalloproteases

Indexed keywords

COLLAGEN; GELATINASE A; IRON;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; IRON THERAPY; LIPID PEROXIDATION; LIVER; LIVER CELL; LIVER FIBROSIS; NONHUMAN; PATHOLOGY; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STELLATE CELL;

ACTINS; ANIMALS; CELL DIVISION; COLLAGEN; FERRIC COMPOUNDS; GENE EXPRESSION; HEPATOCYTES; IRON; MALONDIALDEHYDE; MATRIX METALLOPROTEINASE 2; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036775797     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01257-1     Document Type: Article

References (33)

1. Pietrangelo A. Metals, oxidative stress, and hepatic fibrogenesis. Semin. Liver Dis. 16:1996;13-29.
2. Weintraub L.R., Goral A., Grasso J., Franzblau C., Sullivan A., Sullivan S. Collagen biosynthesis in iron overload. Ann. N.Y. Acad. Sci. 526:1988;179-184.
3. Tavill A.S., Sharma B.K., Bacon B.R. Iron and the liver: genetic hemochromatosis and other hepatic iron overload disorders. Prog. Liver Dis. 9:1990;281-305.
4. Pietrangelo A., Gualdi R., Casalgrandi G., Montosi G., Ventura E. Molecular and cellular aspects of iron-induced hepatic cirrhosis in rodents. J. Clin. Invest. 95:1995;1824-1831.
5. Tsukamoto H., Horne W., Kamimura S., Niemela O., Parkkila S., Yla-Herttuala S., Brittenham G.M. Experimental liver cirrhosis induced by alcohol and iron. J. Clin. Invest. 96:1995;620-630.
6. Olynyk J., Hall P., Reed W., Williams P., Kerr R., Mackinnon M. A long-term study of the interaction between iron and alcohol in an animal model of iron overload. J. Hepatol. 22:1995;671-676.
7. Kawada N. The hepatic perisinusoidal stellate cell. Histol. Histopathol. 12:1997;1069-1080.
8. Pinzani M., Gentilini P. Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis. Semin. Liver Dis. 19:1999;397-410.
9. Gardi C., Calzoni P., Ferrali M., Comporti M. Iron mobilization from crocidolite as enhancer of collagen content in rat lung fibroblasts. Biochem. Pharmacol. 53:1997;1659-1665.
10. Woessner J.F. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 5:1991;2145-2154.
11. Benyon R.C., Iredale J.P., Goddard S., Winwood P.J., Arthur M.J.P. Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver. Gastroenterology. 110:1996;821-831.
12. Milani S., Herbst H., Schuppan D., Grappone C., Pellegrini G., Pinzani M., Casini A., Calabrò A., Ciancio G., Stefanini F., Burroughs A.K., Surrenti C. Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am. J. Pathol. 144:1994;528-537.
13. Arthur M.J.P., Stanley A., Iredale J.P., Rafferty J.A., Hembry R.M., Friedman S.L. Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes: analysis of gene expression, protein synthesis and proteinase activity. Biochem. J. 287:1992;701-707.
14. Theret N., Lehti K., Musso O., Clement B. MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells. Hepatology. 30:1999;462-468.
15. Arthur M.J.P., Friedman S.L., Roll F.J., Bissel D.M. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. J. Clin. Invest. 84:1989;1076-1085.
16. Arthur M.J.P. Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis. Am. J. Physiol. 279:2000;G245-G249.
17. De Bleser P, Geerts A, van Eyken P, Vrijsen R, Lazou J, Desmet V, Wisse E. Tenascin synthesis in cultured rat liver fat-storing cells. In: Wisse E, Knook D, McCusker R, editors. Cells of the hepatic sinusoid. Rijswijk, The Netherlands: Kupffer Cell Foundation, 1991. p. 218-21.
18. Taylor C.M., Blanchard B., Zava D.T. A simple method to determine whole cell uptake of radiolabelled oestrogen and progesterone and their subcellular localization in breast cancer cell lines in monolayer culture. J. Steroid Biochem. 20:1984;1083-1088.
19. Boscoboinik D., Szewczyk A., Hensey C., Azzi A. Inhibition of cell proliferation by α-tocopherol. Role of protein kinase C. J. Biol. Chem. 266:1991;6188-6194.
20. Peterkofsky B., Diegelmann R. Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins. Biochemistry. 10:1971;988-993.
21. Diegelmann R., Peterkofsky B. Inhibition of collagen secretion from bone and cultured fibroblasts by microtubular disruptive drugs. Proc. Natl. Acad. Sci. U.S.A. 69:1972;892-896.
22. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. In: Packer L, Glazer AN, editors. Methods Enzymol 1990;186:407-21.
23. Kleiner D.E., Stetler-Stevenson W.G. Quantitative zymography: detection of picogram quantities of gelatinases. Anal. Biochem. 218:1994;325-329.
24. Pietrangelo A., Gualdi R., Casalgrandi G., Geerts A., De Bleser P., Montosi G., Ventura E. Enhanced hepatic collagen type I mRNA expression into fat-storing cells in a rodent model of hemochromatosis. Hepatology. 19:1994;714-721.
25. Bacon B.R., Britton R.S. The pathology of hepatic iron overload: a free radical-mediated process? Hepatology. 11:1990;127-137.
26. Carthew P., Dorman B.M., Edwards R.E., Francis J.E., Smith A.G. A unique rodent model for both the cardiotoxic and hepatotoxic effects of prolonged iron overload. Lab. Invest. 69:1993;217-222.
27. Poli G., Parola M. Oxidative damage and fibrogenesis. Free Radic. Biol. Med. 22:1997;287-305.
28. 1 (I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis? Hepatology. 19:1994;1262-1271.
29. Montosi G., Garuti C., Martinelli S., Pietrangelo A. Hepatic stellate cells are not subjected to oxidant stress during iron-induced fibrogenesis in rodents. Hepatology. 27:1998;1611-1622.
30. Svegliati Baroni G., D'Ambrosio L., Ferretti G., Casini A., Di Sario A., Salzano R., Ridolfi F., Saccomanno S., Jezequel A.M., Benedetti A. Fibrogenic effect of oxidative stress on rat hepatic stellate cells. Hepatology. 27:1998;720-726.
31. Hutton J.J., Tappel A.L., Udenfriend S. Cofactor and substrate requirements of collagen proline hydroxylase. Arch. Biochem. Biophys. 118:1967;231-240.
32. Weintraub L.R., Goral A., Grasso J., Franzblau C., Sullivan A., Sullivan S. Pathogenesis of hepatic fibrosis in experimental iron overload. Br. J. Haematol. 59:1985;321-331.
33. Arthur M.J.P. Fibrosis and altered matrix degradation. Digestion. 59:1998;376-380.