Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2

Gastroenterology

Volumn 150, Issue 1, 2016, Pages 181-193.e8

  Koo, Ja Hyun ^a   Lee, Hyo Ju ^a   Kim, Won ^b   Kim, Sang Geon ^a  

^a Seoul National University   (South Korea)

^b Seoul National University Boramae Hospital   (South Korea)

Author keywords

ER Stress; HSC Activation; miR 18a

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; GLUCOSE REGULATED PROTEIN 78; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1; LENTIVIRUS VECTOR; MESSENGER RNA; MICRORNA; MICRORNA 18A; PKR LIKE ENDOPLASMIC RETICULUM KINASE; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; THREONINE; UNCLASSIFIED DRUG; HNRNP A1; PERK KINASE; PROTEIN KINASE R; SMAD2 PROTEIN, MOUSE; TUNICAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CHRONIC HEPATITIS C; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA PROCESSING; STELLATE CELL; UPREGULATION; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL CULTURE; COMPARATIVE STUDY; DISEASE MODEL; GENETICS; LIVER CIRRHOSIS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; RAT; SENSITIVITY AND SPECIFICITY;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; HEPATIC STELLATE CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP A-B; HUMANS; LIVER CIRRHOSIS; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; RATS; SENSITIVITY AND SPECIFICITY; SMAD2 PROTEIN; TUNICAMYCIN; UP-REGULATION;

EID: 84952685001     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.09.039     Document Type: Article

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