MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates

Cell Chemical Biology

Volumn 23, Issue 12, 2016, Pages 1458-1467

  Reeve, Stephanie M ^a   Scocchera, Eric W ^a   G Dayanadan, Narendran ^a   Keshipeddy, Santosh ^a   Krucinska, Jolanta ^a   Hajian, Behnoush ^a   Ferreira, Jacob ^a   Nailor, Michael ^a,b   Aeschlimann, Jeffrey ^a,c   Wright, Dennis L ^a   Anderson, Amy C ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b HARTFORD HOSPITAL   (United States)

^c University of Connecticut   (United States)

Author keywords

antibiotics; antifolate; drug discovery; drug resistance; MRSA; trimethoprim

Indexed keywords

ANTIBIOTIC AGENT; CIPROFLOXACIN; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; LEVOFLOXACIN; LINEZOLID; SULFAMETHOXAZOLE; TRIMETHOPRIM; UCP1039; UCP1164; UCP1172; UCP1173; UCP1175; UCP1191; UCP1205; UCP1206; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; CLONAL VARIATION; CONTROLLED STUDY; DRUG ACTIVITY; GENETIC RESISTANCE; GENETIC VARIABILITY; HETEROZYGOTE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; NONHUMAN; PRIORITY JOURNAL; UNITED STATES; WHOLE GENOME SEQUENCING;

EID: 85006862918     PISSN: 24519456     EISSN: 24519448     Source Type: Journal    
DOI: 10.1016/j.chembiol.2016.11.007     Document Type: Article

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