Factors that cause trimethoprim resistance in Streptococcus pyogenes

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 4, 2014, Pages 2281-2288

  Bergmann, René ^a   Van Der Linden, Mark ^b   Chhatwal, Gursharan S ^a   Nitsche Schmitz, D Patric ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COTRIMOXAZOLE; DIHYDROFOLATE REDUCTASE; TRIMETHOPRIM;

AGAR DILUTION; AGAR GEL ELECTROPHORESIS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; CLUSTER ANALYSIS; CONTROLLED STUDY; GENE INSERTION SEQUENCE; GENOTYPE; GROUP A STREPTOCOCCAL INFECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; MICROBIAL SENSITIVITY TESTS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM; TRIMETHOPRIM RESISTANCE;

EID: 84896946104     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02282-13     Document Type: Article

References (41)

1. Huovinen P, Sundstrom L, Swedberg G, Skold O. 1995. Trimethoprim and sulfonamide resistance. Antimicrob. Agents Chemother. 39:279-289. http://dx.doi.org/10.1128/AAC.39.2.279.
2. Miovic M, Pizer LI. 1971. Effect of trimethoprim on macromolecular synthesis in Escherichia coli. J. Bacteriol. 106:856-862.
3. Jönsson M, Strom K, Swedberg G. 2003. Mutations and horizontal transmission have contributed to sulfonamide resistance in Streptococcus pyogenes. Microb. Drug Resist. 9:147-153. http://dx.doi.org/10.1089/ 107662903765826732. (Pubitemid 36736232)
4. Swedberg G, Ringertz S, Skold O. 1998. Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomal dihydropteroate synthase. Antimicrob. Agents Chemother. 42:1062-1067. (Pubitemid 28227897)
5. Bushby SR. 1975. Synergy of trimethoprim-sulfamethoxazole. Can. Med. Assoc. J. 112:63-66.
6. Chhatwal GS, Graham RM. 2008. Streptococcal diseases, p 231-241. In Encyclopedia of public health 2008. Academic Press, San Diego, CA.
7. Nitsche-Schmitz DP, Chhatwal GS. 2013. Host-pathogen interactions in streptococcal immune sequelae. Curr. Top. Microbiol. Immunol. 368:155-171. http://dx.doi.org/10.1007/82-2012-296.
8. Bowen AC, Lilliebridge RA, Tong SY, Baird RW, Ward P, McDonald MI, Currie BJ, Carapetis JR. 2012. Is Streptococcus pyogenes resistant or susceptible to trimethoprim-sulfamethoxazole? J. Clin. Microbiol. 50:4067-4072. http://dx.doi.org/10.1128/JCM.02195-12.
9. Tong SY, Andrews RM, Kearns T, Gundjirryirr R, McDonald MI, Currie BJ, Carapetis JR. 2010. Trimethoprim-sulfamethoxazole compared with benzathine penicillin for treatment of impetigo in Aboriginal children: a pilot randomised controlled trial. J. Paediatr. Child Health 46:131-133. http://dx.doi.org/10. 1111/j.1440-1754.2010.01697.x.
10. Bergmann R, Sagar V, Nitsche-Schmitz DP, Chhatwal GS. 2012. First detection of trimethoprim resistance determinant dfrG in Streptococcus pyogenes clinical isolates in India. Antimicrob. Agents Chemother. 56:5424-5425. http://dx.doi.org/10.1128/AAC.01284-12.
11. Huovinen P. 1987. Trimethoprim resistance. Antimicrob. Agents Chemother. 31:1451-1456. http://dx.doi.org/10.1128/AAC.31.10.1451. (Pubitemid 17140791)
12. Pikis A, Donkersloot JA, Rodriguez WJ, Keith JM. 1998. A conservative amino acid mutation in the chromosome-encoded dihydrofolate reductase confers trimethoprim resistance in Streptococcus pneumoniae. J. Infect. Dis. 178:700-706. http://dx.doi.org/10.1086/515371. (Pubitemid 28397217)
13. Bolin JT, Filman DJ, Matthews DA, Hamlin RC, Kraut J. 1982. Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 Å resolution. I. General features and binding of methotrexate. J. Biol. Chem. 257:13650-13662. (Pubitemid 13187127)
14. Filman DJ, Bolin JT, Matthews DA, Kraut J. 1982. Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 Å resolution. II. Environment of bound NADPH and implications for catalysis. J. Biol. Chem. 257:13663-13672. (Pubitemid 13187128)
15. Matthews DA, Bolin JT, Burridge JM, Filman DJ, Volz KW, Kaufman BT, Beddell CR, Champness JN, Stammers DK, Kraut J. 1985. Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim. J. Biol. Chem. 260:381-391. (Pubitemid 15164062)
16. Matthews DA, Bolin JT, Burridge JM, Filman DJ, Volz KW, Kraut J. 1985. Dihydrofolate reductase. The stereochemistry of inhibitor selectivity. J. Biol. Chem. 260:392-399. (Pubitemid 15164063)
17. Adrian PV, Klugman KP. 1997. Mutations in the dihydrofolate reductase gene of trimethoprim-resistant isolates of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 41:2406-2413. (Pubitemid 27467548)
18. Brochet M, Couve E, Zouine M, Poyart C, Glaser P. 2008. A naturally occurring gene amplification leading to sulfonamide and trimethoprim resistance in Streptococcus agalactiae. J. Bacteriol. 190:672-680. http://dx.doi.org/10. 1128/JB.01357-07. (Pubitemid 351360083)
19. Brook I. 2001. Failure of penicillin to eradicate group A beta-hemolytic streptococci tonsillitis: causes and management. J. Otolaryngol. 30:324-329. http://dx.doi.org/10.2310/7070.2001.19359. (Pubitemid 34272973)
20. Kaplan EL, Johnson DR. 2001. Unexplained reduced microbiological efficacy of intramuscular benzathine penicillin G and of oral penicillin V in eradication of group a streptococci from children with acute pharyngitis. Pediatrics 108:1180-1186. http://dx.doi.org/10.1542/peds.108.5.1180. (Pubitemid 33021196)
21. Macy E, Ngor E. 4 April 2013. Recommendations for the management of beta-lactam intolerance. Clin. Rev. Allergy Immunol. http://dx.doi.org/10.1007/ s12016-013-8369-8.
22. Coenen S, Adriaenssens N, Versporten A, Muller A, Minalu G, Faes C, Vankerckhoven V, Aerts M, Hens N, Molenberghs G, Goossens H, ESAC Project Group. 2011. European Surveillance of Antimicrobial Consumption (ESAC): outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in Europe (1997-2009). J. Antimicrob. Chemother. 66(Suppl 6):vi57-vi70. http://dx.doi.org/10.1093/jac/dkr458.
23. McClean P, Hughes C, Tunney M, Goossens H, Jans B, European Surveillance of Antimicrobial Consumption Nursing Home Project G. 2011. Antimicrobial prescribing in European nursing homes. J. Antimicrob. Chemother. 66:1609-1616. http://dx.doi.org/10.1093/jac/dkr183.
24. Bapna JS, Tekur U, Gitanjali B, Shashindran CH, Pradhan SC, Thulasimani M, Tomson G. 1992. Drug utilization at primary health care level in southern India. Eur. J. Clin. Pharmacol. 43:413-415. http://dx.doi.org/10.1007/ BF02220618.
25. Devi U, Borah PK, Mahanta J. 2011. The prevalence and antimicrobial susceptibility patterns of beta-hemolytic streptococci colonizing the throats of schoolchildren in Assam, India. J. Infect. Dev. Ctries. 5:804-808. http://dx.doi.org/10.3855/jidc.1465.
26. Jain A, Shukla VK, Tiwari V, Kumar R. 2008. Antibiotic resistance pattern of group-A beta-hemolytic streptococci isolated from north Indian children. Indian J. Med. Sci. 62:392-396. http://dx.doi.org/10.4103/0019-5359.44018.
27. Sagar V, Bergmann R, Nerlich A, McMillan DJ, Nitsche Schmitz DP, Chhatwal GS. 2012. Variability in the distribution of genes encoding virulence factors and putative extracellular proteins of Streptococcus pyogenes in India, a region with high streptococcal disease burden, and implication for development of a regional multisubunit vaccine. Clin. Vaccine Immunol. 19:1818-1825. http://dx.doi.org/10.1128/CVI.00112-12.
28. Haggar A, Nerlich A, Kumar R, Abraham VJ, Brahmadathan KN, Ray P, Dhanda V, Joshua JM, Mehra N, Bergmann R, Chhatwal GS, Norrby-Teglund A. 2012. Clinical and microbiologic characteristics of invasive Streptococcus pyogenes infections in north and south India. J. Clin. Microbiol. 50:1626-1631. http://dx.doi.org/10.1128/JCM.06697-11.
29. Facklam R, Beall B, Efstratiou A, Fischetti V, Johnson D, Kaplan E, Kriz P, Lovgren M, Martin D, Schwartz B, Totolian A, Bessen D, Hollingshead S, Rubin F, Scott J, Tyrrell G. 1999. emm typing and validation of provisional M types for group A streptococci. Emerg. Infect. Dis. 5:247-253. http://dx.doi.org/10. 3201/eid0502.990209. (Pubitemid 29200623)
30. Bertsch D, Uruty A, Anderegg J, Lacroix C, Perreten V, Meile L. 2013. Tn6198, a novel transposon containing the trimethoprim resistance gene dfrG embedded into a Tn916 element in Listeria monocytogenes. J. Antimicrob. Chemother. 68:986-991. http://dx.doi.org/10.1093/jac/dks531.
31. Coque TM, Singh KV, Weinstock GM, Murray BE. 1999. Characterization of dihydrofolate reductase genes from trimethoprim-susceptible and trimethoprim-resistant strains of Enterococcus faecalis. Antimicrob. Agents Chemother. 43:141-147. http://dx.doi.org/10.1093/jac/43.1.141. (Pubitemid 29069213)
32. Lopez M, Kadlec K, Schwarz S, Torres C. 2012. First detection of the staphylococcal trimethoprim resistance gene dfrK and the dfrK-carrying transposon Tn559 in enterococci. Microb. Drug Resist. 18:13-18. http://dx.doi.org/10.1089/mdr.2011.0073.
33. Rouch DA, Messerotti LJ, Loo LS, Jackson CA, Skurray RA. 1989. Trimethoprim resistance transposon Tn4003 from Staphylococcus aureus encodes genes for a dihydrofolate reductase and thymidylate synthetase flanked by three copies of IS257. Mol. Microbiol. 3:161-175. http://dx.doi.org/10.1111/j.1365- 2958.1989.tb01805.x. (Pubitemid 19241060)
34. Dale GE, Langen H, Page MG, Then RL, Stuber D. 1995. Cloning and characterization of a novel, plasmid-encoded trimethoprim-resistant dihydrofolate reductase from Staphylococcus haemolyticus MUR313. Antimicrob. Agents Chemother. 39:1920-1924. http://dx.doi.org/10.1128/AAC.39.9.1920.
35. Charpentier E, Courvalin P. 1997. Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293. Antimicrob. Agents Chemother. 41:1134-1136. (Pubitemid 27194198)
36. Perreten V, Kadlec K, Schwarz S, Gronlund Andersson U, Finn M, Greko C, Moodley A, Kania SA, Frank LA, Bemis DA, Franco A, Iurescia M, Battisti A, Duim B, Wagenaar JA, van Duijkeren E, Weese JS, Fitzgerald JR, Rossano A, Guardabassi L. 2010. Clonal spread of methicillin-resistant Staphylococcus pseudintermedius in Europe and North America: an international multicentre study. J. Antimicrob. Chemother. 65:1145-1154. http://dx.doi.org/10.1093/jac/dkq078.
37. Kadlec K, Schwarz S. 2009. Identification of a novel trimethoprim resistance gene, dfrK, in a methicillin-resistant Staphylococcus aureus ST398 strain and its physical linkage to the tetracycline resistance gene tet(L). Antimicrob. Agents Chemother. 53:776-778. http://dx.doi.org/10.1128/AAC.01128- 08.
38. Kadlec K, Fessler AT, Couto N, Pomba CF, Schwarz S. 2012. Unusual small plasmids carrying the novel resistance genes dfrK or apmA isolated from methicillin-resistant or -susceptible staphylococci. J. Antimicrob. Chemother. 67:2342-2345. http://dx.doi.org/10.1093/jac/dks235.
39. Tanimoto K, Ike Y. 2002. Analysis of the conjugal transfer system of the pheromone-independent highly transferable Enterococcus plasmid pMG1: identification of a tra gene (traA) up-regulated during conjugation. J. Bacteriol. 184:5800-5804. http://dx.doi.org/10.1128/JB.184.20.5800-5804.2002.
40. Sekiguchi J, Tharavichitkul P, Miyoshi-Akiyama T, Chupia V, Fujino T, Araake M, Irie A, Morita K, Kuratsuji T, Kirikae T. 2005. Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454). Antimicrob. Agents Chemother. 49:3948-3951. http://dx.doi.org/10.1128/AAC.49.9.3948-3951. 2005. (Pubitemid 41233057)
41. Cattoir V, Huynh TM, Bourdon N, Auzou M, Leclercq R. 2009. Trimethoprim resistance genes in vancomycin-resistant Enterococcus faecium clinical isolates from France. Int. J. Antimicrob. Agents 34:390-392. http://dx.doi.org/10.1016/j. ijantimicag.2009.06.013.