A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance

Journal of Molecular Biology

Volumn 266, Issue 1, 1997, Pages 23-30

  Dale, Glenn E ^a   Broger, Clemens ^a   D' Arcy, Allan ^a   Hartman, Peter G ^a   DeHoogt, Ronald ^a   Jolidon, Synèse ^a   Kompis, Ivan ^a   Labhardt, Alexander M ^a   Langen, Hanno ^a   Locher, Hans ^a   Page, Malcolm G P ^a   Stüber, Dietrich ^a   Then, Rudolf L ^a   Wipf, Beat ^a   Oefner, Christian ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

DHFR; NMR; S. aureus; TMP resistance; X ray structure

Indexed keywords

DIHYDROFOLATE REDUCTASE; METHOTREXATE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHENYLALANINE; TRIMETHOPRIM; TYROSINE;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; DRUG DESIGN; ENZYME ACTIVE SITE; HYDROGEN BOND; NONHUMAN; PLASMID; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; X RAY CRYSTALLOGRAPHY;

EID: 0031566958     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0770     Document Type: Article

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