Effects of NorA inhibitors on in vitro antibacterial activities and postantibiotic effects of levofloxacin, ciprofloxacin, and norfloxacin in genetically related strains of Staphylococcus aureus

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 2, 1999, Pages 335-340

  Aeschlimann, Jeffrey R ^a,b   Dresser, Linda D ^a,b   Kaatz, Glenn W ^b   Rybak, Michael J ^a,b  

^a DETROIT RECEIVING HOSPITAL   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; CYCLOSPORIN; DILTIAZEM; GENE PRODUCT; LANSOPRAZOLE; LEVOFLOXACIN; NORFLOXACIN; OMEPRAZOLE; PROTEIN NORA; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RESERPINE; UNCLASSIFIED DRUG; VERAPAMIL;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG TRANSPORT; GENE MUTATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

EID: 0033040998     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.2.335     Document Type: Article

References (27)

1. Barnes, K. M., B. Dickstein, G. B. Cutler, T. Fojo, and S. E. Bates. 1996. Steroid transport, accumulation, and antagonism of p-glycoprotein in multidrug-resistant cells. Biochemistry 35:4820-4827.
2. Blaser, J., B. B. Stone, M. C. Groner, and S. H. Zinner. 1987. Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance. Antimicrob. Agents Chemother. 31:1054-1060.
3. Cambau, E., and L. Gutman. 1993. Mechanisms of resistance to quinolones. Drugs 45(Suppl. 3):15-23.
4. Craig, W. A., and S. Gudmundsson. 1996. Postantibiotic effect, p. 296-329. In V. Lorian (ed.), Antibiotics in laboratory medicine, 4th ed. The Williams and Wilkins Co., Baltimore, Md.
5. Dudley, M. N., H. D. Mandler, D. Gilbert, J. Ericson, K. H. Mayer, and S. H. Zinner. 1987. Pharmacokinetics and pharmacodynamics of intravenous ciprofloxacin. Am. J. Med. 82(Suppl. 4A):363-368.
6. Ferrero, L., B. Cameron, and J. Crouzet. 1995. Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus. Antimicrob. Agents Chemother. 39:1554-1558.
7. Fisher, G. A., B. L. Lum, J. Hausdorff, and B. I. Sikic. 1996. Pharmacological considerations in the modulation of multidrug resistance. Eur. J. Cancer 32A:1082-1088.
8. Ford, J. M. 1996. Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers. Eur. J. Cancer 32A: 991-1001.
9. Fraimow, H. S., and M. Esposito. 1996. Effects of omeprazole (Om) and lansoprazole (Lan) on fluoroquinolone (FQ) and aminoglycoside (AG) activity in Staphylococcus aureus (SA), abstr. C36. In Program and abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
10. Gottfredsson, M., H. Erlendsdottir, A. Gudmundsson, and S. Gudmundsson. 1995. Different patterns of bacterial DNA synthesis during the postantibiotic effect. Antimicrob. Agents Chemother. 39:1314-1319.
11. Kaatz, G. W., and S. M. Seo. 1997. Mechanisms of fluoroquinolone resistance in genetically related strains of Staphylococcus aureus. Antimicrob. Agents Chemother. 41:2733-2737.
12. Kaatz, G. W., and S. M. Seo. 1995. Inducible NorA-mediated multidrug resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 39: 2650-2655.
13. Kaatz, G. W., S. M. Seo, and C. A. Ruble. 1993. Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 37:1086-1094.
14. Kaatz, G. W., S. M. Seo, and C. A. Ruble. 1991. Mechanisms of fluoroquinolone resistance in Staphylococcus aureus. J. Infect. Dis. 163:1080-1086.
15. Markham, P. N., and A. A. Neyfakh. 1996. Inhibition of the multidrug transporter NorA prevents emergence of norfloxacin resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 40:2673-2674.
16. Nakanishi, N., S. Yoshida, H. Wakebe, M. Inoue, T. Yamaguchi, and S. Mitsuhashi. 1991. Mechanisms of clinical resistance to fluoroquinolones in Staphylococcus aureus. Antimicrob. Agents Chemother. 35:2562-2576.
17. National Committee for Clinical Laboratory Standards. 1993. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 3rd ed. Approved standard M7-A3. National Committee for Clinical Laboratory Standards, Villanova, Pa.
18. Neyfakh, A. A. 1992. The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein. Antimicrob. Agents Chemother. 36:484-485.
19. Neyfakh, A. A., C. M. Borsch, and G. W. Kaatz. 1993. Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter. Antimicrob. Agents Chemother. 37:128-129.
20. Ng, E. Y., M. Trucksis, and D. C. Hooper. 1994. Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome. Antimicrob. Agents Chemother. 38:1343-1355.
21. Piddock, L. J. V., and R. Wise. 1987. Induction of the SOS response in Escherichia coli by 4-quinolone antimicrobial agents. FEMS Microbiol. Lett. 41:918-932.
22. Salles, E., and M. Defrais. 1984. Signal induction of recA protein in E. coli. Mulat. Res. 131:53-59.
23. Sonneveld, P. 1996. Reversal of multidrug resistance in acute myeloid leukemia and other haematological malignancies. Eur. J. Cancer 32A:1062-1069.
24. Takenouchi, T., F. Tabata, Y. Iwata, H. Hanzawa, M. Sugawara, and S. Ohya. 1996. Hydrophilicity of quinolones is not an exclusive factor for decreased activity in efflux-mediated resistant mutants of Staphylococcus aureus. Antimicrob. Agents Chemother. 40:1835-1842.
25. Tanaka, M., Y. X. Zhang, H. Ishida, et al. 1995. Mechanisms of 4-quinolone resistance in quinolone-resistant and methicillin-resistant Staphylococcus aureus. J. Med. Microbiol. 42:214-219.
26. Wiedemann, B., and P. Heisig. 1994. Mechanisms of quinolone resistance. Infection 22(Suppl. 2):73-79.
27. Yoshida, S., T. Kojima, M. Inoue, and S. Mitsuhashi. 1991. Uptake of sparfloxacin and norfloxacin by clinical isolates of Staphylococcus aureus. Antimicrob. Agents Chemother. 35:368-370.