Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations

Journal of Medicinal Chemistry

Volumn 59, Issue 13, 2016, Pages 6493-6500

  Reeve, Stephanie M ^a   Scocchera, Eric ^a   Ferreira, Jacob J ^a   G Dayanandan, Narendran ^a   Keshipeddy, Santosh ^a   Wright, Dennis L ^a   Anderson, Amy C ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; TRIMETHOPRIM; ANTIINFECTIVE AGENT; FOLIC ACID;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL MUTATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME INHIBITION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MUTATION RATE; NONHUMAN; SINGLE NUCLEOTIDE POLYMORPHISM; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FOLIC ACID; FOLIC ACID ANTAGONISTS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIMETHOPRIM;

EID: 84978512269     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00688     Document Type: Article

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