Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternate Conformation of NADPH That May Be Linked to Trimethoprim Resistance

Journal of Molecular Biology

Volumn 387, Issue 5, 2009, Pages 1298-1308

  Frey, Kathleen M ^a   Liu, Jieying ^a   Lombardo, Michael N ^a   Bolstad, David B ^a   Wright, Dennis L ^a   Anderson, Amy C ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

DHFR; MRSA; S. aureus; structure based drug design; TMP resistance

Indexed keywords

DIHYDROFOLATE REDUCTASE; LIGAND; NICOTINAMIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRIMETHOPRIM;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; HUMAN; HYDROGEN BOND; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

EID: 63449108992     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.02.045     Document Type: Article

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