Structural comparison of chromosomal and exogenous dihydrofolate reductase from Staphylococcus aureus in complex with the potent inhibitor trimethoprim

Proteins: Structure, Function and Bioinformatics

Volumn 76, Issue 3, 2009, Pages 706-717

  Heaslet, Holly ^a   Harris, Melissa ^a   Fahnoe, Kelly ^a   Sarver, Ronald ^a   Putz, Henry ^a   Chang, Jeanne ^a   Subramanyam, Chakrapani ^a   Barreiro, Gabriela ^a   Miller, J Richard ^a  

^a PFIZER INC   (United States)

Author keywords

Anti bacterial; Dihydrofolate; Reductase; Resistance; Trimethoprim

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; METHOTREXATE; PURINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRAHYDROFOLIC ACID; THYMIDINE PHOSPHATE; TRIMETHOPRIM;

ARTICLE; ENZYME ANALYSIS; ENZYME INHIBITOR COMPLEX; ENZYME STRUCTURE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PRIORITY JOURNAL; PURINE SYNTHESIS; STAPHYLOCOCCUS AUREUS; THERMODYNAMICS;

CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; MUTATION; NADP; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; STAPHYLOCOCCUS AUREUS; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS; TRIMETHOPRIM;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 68049130004     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22383     Document Type: Article

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