Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus

Acta Crystallographica Section D: Biological Crystallography

Volumn 65, Issue 8, 2009, Pages 751-757

  Oefner, Christian ^a,b   Parisi, Sandro ^a   Schulz, Henk ^a,c   Lociuro, Sergio ^a   Dale, Glenn E ^a  

^a Arpida Ltd   (Switzerland)

^b Polyphor Ltd   (Switzerland)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Dihydrofolate reductase; Iclaprim; Staphylococcus aureus

Indexed keywords

ANTIINFECTIVE AGENT; DIHYDROFOLATE REDUCTASE; ENZYME INHIBITOR; ICLAPRIM; MULTIENZYME COMPLEX; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PYRIMIDINE DERIVATIVE; TRIMETHOPRIM;

ARTICLE; CHEMISTRY; CRYSTALLIZATION; ENZYMOLOGY; GENETICS; ISOMERISM; METABOLISM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PENICILLIN RESISTANCE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ISOMERISM; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MULTIENZYME COMPLEXES; MUTANT PROTEINS; NADP; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM;

POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 68349125102     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444909013936     Document Type: Article

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