Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates

ACS Infectious Diseases

Volumn 2, Issue 2, 2016, Pages 149-156

  Lombardo, Michael N ^a   G Dayanandan, Narendran ^a   Wright, Dennis L ^a   Anderson, Amy C ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

antifolate; DfrA1; Enterobacteriaceae; resistance; trimethoprim

Indexed keywords

AMINOGLYCOSIDE DERIVATIVE; BACTERIAL ENZYME; CARBAPENEM DERIVATIVE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE TYPE 1; FOLIC ACID ANTAGONIST; PENICILLINASE; QUINOLONE DERIVATIVE; TRIMETHOPRIM; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERICIDAL ACTIVITY; CRYSTAL STRUCTURE; DRUG POTENCY; ENZYME INHIBITION; ENZYME INHIBITION ASSAY; ESCHERICHIA COLI; GENETIC CODE; IC50; INTEGRON; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; STAPHYLOCOCCUS AUREUS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; TRIMETHOPRIM RESISTANCE; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; HUMANS; INTEGRONS; KLEBSIELLA PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM; TRIMETHOPRIM RESISTANCE;

EID: 84969262374     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.5b00129     Document Type: Article

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