Protein design algorithms predict viable resistance to an experimental antifolate

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 3, 2015, Pages 749-754

  Reevea, Stephanie M ^a   Gainzab, Pablo ^b   Freya, Kathleen M ^a,c   Georgievb, Ivelin ^b,d   Donaldb, Bruce R ^b   Andersona, Amy C ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Antifolate; DHFR; Drug resistance; MRSA; Protein design

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; FOLIC ACID ANTAGONIST; PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRIMETHOPRIM;

ALGORITHM; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENZYME ANALYSIS; ENZYME INHIBITION ASSAY; ENZYME KINETICS; ENZYME PURIFICATION; HYDROGEN BOND; IN VITRO STUDY; LIGAND BINDING; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; STAPHYLOCOCCUS AUREUS; STEREOSPECIFICITY; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; ENZYMOLOGY; GENETICS;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

ALGORITHMS; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; STAPHYLOCOCCUS AUREUS; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84922243002     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1411548112     Document Type: Article

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