Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus

Journal of the American Chemical Society

Volumn 137, Issue 28, 2015, Pages 8983-8990

  Keshipeddy, Santosh ^a   Reeve, Stephanie M ^a   Anderson, Amy C ^a   Wright, Dennis L ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; ENZYMES; THERMOMECHANICAL PULPING PROCESS;

ANTIBACTERIAL EFFECTS; ASYMMETRIC CONJUGATE ADDITION; BACTERIAL STRAINS; CHEMICAL EQUATIONS; DIHYDROFOLATE REDUCTASE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; POTENT INHIBITION; RESISTANT MUTANTS;

ENZYME INHIBITION;

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ANTIINFECTIVE AGENT;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENANTIOMER; ENZYME INHIBITION; ISOMERIZATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POINT MUTATION; RACEMIC MIXTURE; SONOGASHIRA REACTION; STAPHYLOCOCCUS AUREUS; STEREOCHEMISTRY; SUZUKI REACTION; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIOLOGY; MOLECULAR MODEL; STAPHYLOCOCCAL INFECTIONS; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FOLIC ACID ANTAGONISTS; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MODELS, MOLECULAR; POINT MUTATION; STAPHYLOCOCCAL INFECTIONS; STEREOISOMERISM; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84937697847     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b01442     Document Type: Article

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