-
1
-
-
84941812172
-
The pathology of bronchial asthma
-
Huber HL, Koessler KK., The pathology of bronchial asthma. Arch Intern Med. 1922;30(6):689–760.
-
(1922)
Arch Intern Med
, vol.30
, Issue.6
, pp. 689-760
-
-
Huber, H.L.1
Koessler, K.K.2
-
2
-
-
0345675905
-
Studies in asthma: I. A clinical survey of 1,074 patients with asthma followed for two years
-
Rackemann FM. Studies in asthma:I. A clinical survey of 1,074 patients with asthma followed for two years. J Lab Clin Med. 1927;12(Sept):1185.
-
(1927)
J Lab Clin Med
, vol.12
, Issue.Sept
, pp. 1185
-
-
Rackemann, F.M.1
-
3
-
-
0033606539
-
Non-eosinophilic corticosteroid unresponsive asthma
-
Pavord ID, Brightling CE, Woltmann G, et al. Non-eosinophilic corticosteroid unresponsive asthma. Lancet (London, England). 1999;353(9171):2213–2214.
-
(1999)
Lancet (London, England)
, vol.353
, Issue.9171
, pp. 2213-2214
-
-
Pavord, I.D.1
Brightling, C.E.2
Woltmann, G.3
-
4
-
-
0036795111
-
Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
-
Green RH, Brightling CE, Woltmann G, et al. Analysis of induced sputum in adults with asthma:identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax. 2002;57(10):875–879.
-
(2002)
Thorax
, vol.57
, Issue.10
, pp. 875-879
-
-
Green, R.H.1
Brightling, C.E.2
Woltmann, G.3
-
5
-
-
0036191489
-
Occupational asthma due to low molecular weight agents: eosinophilic and non-eosinophilic variants
-
Anees W, Huggins V, Pavord ID, et al. Occupational asthma due to low molecular weight agents:eosinophilic and non-eosinophilic variants. Thorax. 2002;57(3):231–236.
-
(2002)
Thorax
, vol.57
, Issue.3
, pp. 231-236
-
-
Anees, W.1
Huggins, V.2
Pavord, I.D.3
-
6
-
-
33645101537
-
Inflammatory subtypes in asthma: assessment and identification using induced sputum
-
Simpson JL, Scott R, Boyle MJ, et al. Inflammatory subtypes in asthma:assessment and identification using induced sputum. Respirology (Carlton, Vic.). 2006;11(1):54–61.
-
(2006)
Respirology (Carlton, Vic.)
, vol.11
, Issue.1
, pp. 54-61
-
-
Simpson, J.L.1
Scott, R.2
Boyle, M.J.3
-
7
-
-
0034942124
-
Heterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8
-
Gibson PG, Simpson JL, Saltos N. Heterogeneity of airway inflammation in persistent asthma:evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest. 2001;119(5):1329–1336.
-
(2001)
Chest
, vol.119
, Issue.5
, pp. 1329-1336
-
-
Gibson, P.G.1
Simpson, J.L.2
Saltos, N.3
-
8
-
-
84864022205
-
Stability of inflammatory phenotypes in asthma
-
Green RH, Pavord I. Stability of inflammatory phenotypes in asthma. Thorax. 2012;67(8):665–667.
-
(2012)
Thorax
, vol.67
, Issue.8
, pp. 665-667
-
-
Green, R.H.1
Pavord, I.2
-
9
-
-
77951666051
-
Variability of sputum inflammatory cells in asthmatic patients receiving corticosteroid therapy: a prospective study using multiple samples
-
Al-Samri MT, Benedetti A, Prefontaine D, et al. Variability of sputum inflammatory cells in asthmatic patients receiving corticosteroid therapy:a prospective study using multiple samples. J Allergy Clin Immunol. 2010;125(5):1161-1163.e4.
-
(2010)
J Allergy Clin Immunol
, vol.125
, Issue.5
, pp. 1161
-
-
Al-Samri, M.T.1
Benedetti, A.2
Prefontaine, D.3
-
10
-
-
84905819945
-
Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma
-
Kupczyk M, Dahlen B, Sterk PJ, et al. Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma. Allergy. 2014;69(9):1198–1204.
-
(2014)
Allergy
, vol.69
, Issue.9
, pp. 1198-1204
-
-
Kupczyk, M.1
Dahlen, B.2
Sterk, P.J.3
-
11
-
-
0030048946
-
Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa
-
Bentley AM, Hamid Q, Robinson DS, et al. Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa. Am J Respir Crit Care Med. 1996;153(2):551–556.
-
(1996)
Am J Respir Crit Care Med
, vol.153
, Issue.2
, pp. 551-556
-
-
Bentley, A.M.1
Hamid, Q.2
Robinson, D.S.3
-
12
-
-
0037662045
-
Effect of HFA-flunisolide on peripheral lung inflammation in asthma
-
Hauber HP, Gotfried M, Newman K, et al. Effect of HFA-flunisolide on peripheral lung inflammation in asthma. J Allergy Clin Immunol. 2003;112(1):58–63.
-
(2003)
J Allergy Clin Immunol
, vol.112
, Issue.1
, pp. 58-63
-
-
Hauber, H.P.1
Gotfried, M.2
Newman, K.3
-
13
-
-
79952744099
-
The molecular mechanisms of glucocorticoids-mediated neutrophil survival
-
Saffar AS, Ashdown H, Gounni AS. The molecular mechanisms of glucocorticoids-mediated neutrophil survival. Curr Drug Targets. 2011;12(4):556–562.
-
(2011)
Curr Drug Targets
, vol.12
, Issue.4
, pp. 556-562
-
-
Saffar, A.S.1
Ashdown, H.2
Gounni, A.S.3
-
14
-
-
36749095585
-
-
Berry M, Morgan A, Shaw DE, et al. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax. 2007;62(12):1043–1049.
-
(2007)
-
-
-
15
-
-
67049144615
-
Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies
-
Fahy JV. Eosinophilic and neutrophilic inflammation in asthma:insights from clinical studies. Proc Am Thorac Soc. 2009;6(3):256–259.
-
(2009)
Proc Am Thorac Soc
, vol.6
, Issue.3
, pp. 256-259
-
-
Fahy, J.V.1
-
16
-
-
84858273561
-
A large subgroup of mild-to-moderate asthma is persistently noneosinophilic
-
McGrath KW, Icitovic N, Boushey HA, et al. A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. Am J Respir Crit Care Med. 2012;185(6):612–619.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, Issue.6
, pp. 612-619
-
-
McGrath, K.W.1
Icitovic, N.2
Boushey, H.A.3
-
17
-
-
0037202790
-
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
-
Green RH, Brightling CE, McKenna S, et al. Asthma exacerbations and sputum eosinophil counts:a randomised controlled trial. Lancet (London, England). 2002;360(9347):1715–1721.• Absence of sputum eosinophils is a consistent feature over 12 months’ longitudinal observation of patients with severe asthma, indicating the presence of neutrophilic airway inflammation in asthma.
-
(2002)
Lancet (London, England)
, vol.360
, Issue.9347
, pp. 1715-1721
-
-
Green, R.H.1
Brightling, C.E.2
McKenna, S.3
-
18
-
-
0027216415
-
Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa?
-
Sur S, Crotty TB, Kephart GM, et al. Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? Am Rev Respir Dis. 1993;148(3):713–719.
-
(1993)
Am Rev Respir Dis
, vol.148
, Issue.3
, pp. 713-719
-
-
Sur, S.1
Crotty, T.B.2
Kephart, G.M.3
-
19
-
-
0030859389
-
Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids
-
Wenzel SE, Szefler SJ, Leung DY, et al. Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med. 1997;156(3 Pt 1):737–743.
-
(1997)
Am J Respir Crit Care Med
, vol.156
, Issue.3
, pp. 737-743
-
-
Wenzel, S.E.1
Szefler, S.J.2
Leung, D.Y.3
-
20
-
-
0032698182
-
Neutrophilic inflammation in severe persistent asthma
-
Jatakanon A, Uasuf C, Maziak W, et al. Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med. 1999;160(5 Pt 1):1532–1539.
-
(1999)
Am J Respir Crit Care Med
, vol.160
, Issue.5
, pp. 1532-1539
-
-
Jatakanon, A.1
Uasuf, C.2
Maziak, W.3
-
21
-
-
0032875377
-
Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
-
Wenzel SE, Schwartz LB, Langmack EL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med. 1999;160(3):1001–1008.
-
(1999)
Am J Respir Crit Care Med
, vol.160
, Issue.3
, pp. 1001-1008
-
-
Wenzel, S.E.1
Schwartz, L.B.2
Langmack, E.L.3
-
22
-
-
33645116037
-
Low sputum eosinophils predict the lack of response to beclomethasone in symptomatic asthmatic patients
-
Bacci E, Cianchetti S, Bartoli M, et al. Low sputum eosinophils predict the lack of response to beclomethasone in symptomatic asthmatic patients. Chest. 2006;129(3):565–572.
-
(2006)
Chest
, vol.129
, Issue.3
, pp. 565-572
-
-
Bacci, E.1
Cianchetti, S.2
Bartoli, M.3
-
23
-
-
84901761120
-
Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis
-
Moore WC, Hastie AT, Li X, et al. Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. J Allergy Clin Immunol. 2014;133(6):1557–1563.e1555.
-
(2014)
J Allergy Clin Immunol
, vol.133
, Issue.6
, pp. 1557
-
-
Moore, W.C.1
Hastie, A.T.2
Li, X.3
-
24
-
-
84873083832
-
Identification of subtypes of refractory asthma in Korean patients by cluster analysis
-
Jang AS, Kwon HS, Cho YS, et al. Identification of subtypes of refractory asthma in Korean patients by cluster analysis. Lung. 2013;191(1):87–93.
-
(2013)
Lung
, vol.191
, Issue.1
, pp. 87-93
-
-
Jang, A.S.1
Kwon, H.S.2
Cho, Y.S.3
-
25
-
-
84863011547
-
Role of neutrophils in persistent airway obstruction due to refractory asthma
-
Choi JS, Jang AS, Park JS, et al. Role of neutrophils in persistent airway obstruction due to refractory asthma. Respirology (Carlton, Vic.). 2012;17(2):322–329.• Airway neutrophilia is associated with persistent airflow limitations in patients with refractory asthma, whereas eosinophilic inflammation predominates in patients with reversible airway obstruction.
-
(2012)
Respirology (Carlton, Vic.)
, vol.17
, Issue.2
, pp. 322-329
-
-
Choi, J.S.1
Jang, A.S.2
Park, J.S.3
-
26
-
-
70449112851
-
Linkage between smoking and asthma
-
Pietinalho A, Pelkonen A, Rytila P. Linkage between smoking and asthma. Allergy. 2009;64(12):1722–1727.
-
(2009)
Allergy
, vol.64
, Issue.12
, pp. 1722-1727
-
-
Pietinalho, A.1
Pelkonen, A.2
Rytila, P.3
-
27
-
-
0036187872
-
Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma
-
Chalmers GW, Macleod KJ, Little SA, et al. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax. 2002;57(3):226–230.
-
(2002)
Thorax
, vol.57
, Issue.3
, pp. 226-230
-
-
Chalmers, G.W.1
Macleod, K.J.2
Little, S.A.3
-
28
-
-
84900399727
-
Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS): current literature review
-
Papaiwannou A, Zarogoulidis P, Porpodis K, et al. Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS):current literature review. J Thorac Dis. 2014;6(Suppl 1):S146–151.
-
(2014)
J Thorac Dis
, vol.6
, pp. S146-S151
-
-
Papaiwannou, A.1
Zarogoulidis, P.2
Porpodis, K.3
-
29
-
-
68049084752
-
The overlap syndrome of asthma and COPD: what are its features and how important is it?
-
Gibson PG, Simpson JL. The overlap syndrome of asthma and COPD:what are its features and how important is it? Thorax. 2009;64(8):728–735.
-
(2009)
Thorax
, vol.64
, Issue.8
, pp. 728-735
-
-
Gibson, P.G.1
Simpson, J.L.2
-
30
-
-
0032730236
-
Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects
-
Nightingale JA, Rogers DF, Barnes PJ. Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects. Thorax. 1999;54(12):1061–1069.
-
(1999)
Thorax
, vol.54
, Issue.12
, pp. 1061-1069
-
-
Nightingale, J.A.1
Rogers, D.F.2
Barnes, P.J.3
-
31
-
-
0033909355
-
Airway inflammation after controlled exposure to diesel exhaust particulates
-
Nightingale JA, Maggs R, Cullinan P, et al. Airway inflammation after controlled exposure to diesel exhaust particulates. Am J Respir Crit Care Med. 2000;162(1):161–166.
-
(2000)
Am J Respir Crit Care Med
, vol.162
, Issue.1
, pp. 161-166
-
-
Nightingale, J.A.1
Maggs, R.2
Cullinan, P.3
-
32
-
-
33845478528
-
Multiple inflammatory hits and the pathogenesis of severe airway disease
-
Pavord ID, Birring SS, Berry M, et al. Multiple inflammatory hits and the pathogenesis of severe airway disease. Eur Respir J. 2006;27(5):884–888.
-
(2006)
Eur Respir J
, vol.27
, Issue.5
, pp. 884-888
-
-
Pavord, I.D.1
Birring, S.S.2
Berry, M.3
-
33
-
-
14944351482
-
Airway function and markers of airway inflammation in patients with treated hypothyroidism
-
Birring SS, Patel RB, Parker D, et al. Airway function and markers of airway inflammation in patients with treated hypothyroidism. Thorax. 2005;60(3):249–253.
-
(2005)
Thorax
, vol.60
, Issue.3
, pp. 249-253
-
-
Birring, S.S.1
Patel, R.B.2
Parker, D.3
-
34
-
-
0034904034
-
Endotoxin-stimulated innate immunity: a contributing factor for asthma
-
Reed CE, Milton DK. Endotoxin-stimulated innate immunity:a contributing factor for asthma. J Allergy Clin Immunol. 2001;108(2):157–166.
-
(2001)
J Allergy Clin Immunol
, vol.108
, Issue.2
, pp. 157-166
-
-
Reed, C.E.1
Milton, D.K.2
-
35
-
-
0031867516
-
Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects
-
Nightingale JA, Rogers DF, Hart LA, et al. Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects. Thorax. 1998;53(7):563–571.
-
(1998)
Thorax
, vol.53
, Issue.7
, pp. 563-571
-
-
Nightingale, J.A.1
Rogers, D.F.2
Hart, L.A.3
-
36
-
-
0029744374
-
Dose-dependent cigarette smoking-related inflammatory responses in healthy adults
-
Kuschner WG, D’Alessandro A, Wong H, et al. Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. Eur Respir J. 1996;9(10):1989–1994.
-
(1996)
Eur Respir J
, vol.9
, Issue.10
, pp. 1989-1994
-
-
Kuschner, W.G.1
D’Alessandro, A.2
Wong, H.3
-
37
-
-
0027953773
-
Grain dust-induced airflow obstruction and inflammation of the lower respiratory tract
-
Clapp WD, Becker S, Quay J, et al. Grain dust-induced airflow obstruction and inflammation of the lower respiratory tract. Am J Respir Crit Care Med. 1994;150(3):611–617.
-
(1994)
Am J Respir Crit Care Med
, vol.150
, Issue.3
, pp. 611-617
-
-
Clapp, W.D.1
Becker, S.2
Quay, J.3
-
38
-
-
84927950060
-
Occupational exposures, smoking and airway inflammation in refractory asthma
-
Simpson JL, Guest M, Boggess MM, et al. Occupational exposures, smoking and airway inflammation in refractory asthma. BMC Pulm Med. 2014;14:207.
-
(2014)
BMC Pulm Med
, vol.14
, pp. 207
-
-
Simpson, J.L.1
Guest, M.2
Boggess, M.M.3
-
39
-
-
0024571443
-
Ozone-induced changes in pulmonary function and bronchial responsiveness in asthmatics
-
Kreit JW, Gross KB, Moore TB, et al. Ozone-induced changes in pulmonary function and bronchial responsiveness in asthmatics. J Appl Physiol (1985). 1989;66(1):217–222.
-
(1989)
J Appl Physiol (1985)
, vol.66
, Issue.1
, pp. 217-222
-
-
Kreit, J.W.1
Gross, K.B.2
Moore, T.B.3
-
40
-
-
0030016947
-
Greater ozone-induced inflammatory responses in subjects with asthma
-
Scannell C, Chen L, Aris RM, et al. Greater ozone-induced inflammatory responses in subjects with asthma. Am J Respir Crit Care Med. 1996;154(1):24–29.
-
(1996)
Am J Respir Crit Care Med
, vol.154
, Issue.1
, pp. 24-29
-
-
Scannell, C.1
Chen, L.2
Aris, R.M.3
-
41
-
-
0033003542
-
Long-term ambient ozone concentration and the incidence of asthma in nonsmoking adults: the AHSMOG study
-
McDonnell WF, Abbey DE, Nishino N, et al. Long-term ambient ozone concentration and the incidence of asthma in nonsmoking adults:the AHSMOG study. Environ Res. 1999;80(2 Pt 1):110–121.
-
(1999)
Environ Res
, vol.80
, Issue.2
, pp. 110-121
-
-
McDonnell, W.F.1
Abbey, D.E.2
Nishino, N.3
-
42
-
-
0035154920
-
The effect of repeated exposure to particulate air pollution (PM10) on the bone marrow
-
Mukae H, Vincent R, Quinlan K, et al. The effect of repeated exposure to particulate air pollution (PM10) on the bone marrow. Am J Respir Crit Care Med. 2001;163(1):201–209.
-
(2001)
Am J Respir Crit Care Med
, vol.163
, Issue.1
, pp. 201-209
-
-
Mukae, H.1
Vincent, R.2
Quinlan, K.3
-
44
-
-
84903553827
-
Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma
-
Green BJ, Wiriyachaiporn S, Grainge C, et al. Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma. PLoS One. 2014;9(6):e100645.•• Airway colonization with potentially pathogenic microorganisms is associated with more severe airway obstruction and neutrophilic airway inflammation in patients with treatment-resistant severe asthma.
-
(2014)
PLoS One
, vol.9
, Issue.6
, pp. e100645
-
-
Green, B.J.1
Wiriyachaiporn, S.2
Grainge, C.3
-
45
-
-
84959928646
-
Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma
-
Simpson JL, Daly J, Baines KJ, et al. Airway dysbiosis:Haemophilus influenzae and Tropheryma in poorly controlled asthma. Eur Respir J. 2016;47(3):792–800.
-
(2016)
Eur Respir J
, vol.47
, Issue.3
, pp. 792-800
-
-
Simpson, J.L.1
Daly, J.2
Baines, K.J.3
-
46
-
-
0032612216
-
The role of viral and atypical bacterial pathogens in asthma pathogenesis
-
Johnston SL. The role of viral and atypical bacterial pathogens in asthma pathogenesis. Pediatr Pulmonol Suppl. 1999;18:141–143.
-
(1999)
Pediatr Pulmonol Suppl
, vol.18
, pp. 141-143
-
-
Johnston, S.L.1
-
48
-
-
84960387678
-
Reduced antiviral interferon production in poorly controlled asthma is associated with neutrophilic inflammation and high-dose inhaled corticosteroids
-
Simpson JL, Carroll M, Yang IA, et al. Reduced antiviral interferon production in poorly controlled asthma is associated with neutrophilic inflammation and high-dose inhaled corticosteroids. Chest. 2016;149(3):704–713.
-
(2016)
Chest
, vol.149
, Issue.3
, pp. 704-713
-
-
Simpson, J.L.1
Carroll, M.2
Yang, I.A.3
-
49
-
-
23644456321
-
ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation
-
Boldogh I, Bacsi A, Choudhury BK, et al. ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation. J Clin Invest. 2005;115(8):2169–2179.
-
(2005)
J Clin Invest
, vol.115
, Issue.8
, pp. 2169-2179
-
-
Boldogh, I.1
Bacsi, A.2
Choudhury, B.K.3
-
50
-
-
33745425236
-
The course of allergen-induced leukocyte infiltration in human and experimental asthma
-
Lommatzsch M, Julius P, Kuepper M, et al. The course of allergen-induced leukocyte infiltration in human and experimental asthma. J Allergy Clin Immunol. 2006;118(1):91–97.
-
(2006)
J Allergy Clin Immunol
, vol.118
, Issue.1
, pp. 91-97
-
-
Lommatzsch, M.1
Julius, P.2
Kuepper, M.3
-
51
-
-
0033933005
-
Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production
-
Kauffman HF, Tomee JF, van de Riet MA, et al. Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production. J Allergy Clin Immunol. 2000;105(6 Pt 1):1185–1193.
-
(2000)
J Allergy Clin Immunol
, vol.105
, Issue.6
, pp. 1185-1193
-
-
Kauffman, H.F.1
Tomee, J.F.2
van de Riet, M.A.3
-
52
-
-
84880146024
-
Barrier responses of human bronchial epithelial cells to grass pollen exposure
-
Blume C, Swindle EJ, Dennison P, et al. Barrier responses of human bronchial epithelial cells to grass pollen exposure. Eur Respir J. 2013;42(1):87–97.
-
(2013)
Eur Respir J
, vol.42
, Issue.1
, pp. 87-97
-
-
Blume, C.1
Swindle, E.J.2
Dennison, P.3
-
53
-
-
84963820194
-
Facilitation of allergic sensitization and allergic airway inflammation by pollen-induced Innate neutrophil recruitment
-
Hosoki K, Aguilera-Aguirre L, Brasier AR, et al. Facilitation of allergic sensitization and allergic airway inflammation by pollen-induced Innate neutrophil recruitment. Am J Respir Cell Mol Biol. 2016;54(1):81–90.
-
(2016)
Am J Respir Cell Mol Biol
, vol.54
, Issue.1
, pp. 81-90
-
-
Hosoki, K.1
Aguilera-Aguirre, L.2
Brasier, A.R.3
-
54
-
-
59049100417
-
Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
-
Trompette A, Divanovic S, Visintin A, et al. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Am J Respir Cell Mol Biol. 2009;457(7229):585–588.
-
(2009)
Am J Respir Cell Mol Biol
, vol.457
, Issue.7229
, pp. 585-588
-
-
Trompette, A.1
Divanovic, S.2
Visintin, A.3
-
55
-
-
64149087970
-
House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
-
Hammad H, Chieppa M, Perros F, et al. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat Med. 2009;15(4):410–416.
-
(2009)
Nat Med
, vol.15
, Issue.4
, pp. 410-416
-
-
Hammad, H.1
Chieppa, M.2
Perros, F.3
-
56
-
-
84871973839
-
Asthmatic airway neutrophilia after allergen challenge is associated with the glutathione S-transferase M1 genotype
-
Hoskins A, Reiss S, Wu P, et al. Asthmatic airway neutrophilia after allergen challenge is associated with the glutathione S-transferase M1 genotype. Am J Respir Crit Care Med. 2013;187(1):34–41.
-
(2013)
Am J Respir Crit Care Med
, vol.187
, Issue.1
, pp. 34-41
-
-
Hoskins, A.1
Reiss, S.2
Wu, P.3
-
57
-
-
84863845758
-
Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response
-
Telenga ED, Tideman SW, Kerstjens HA, et al. Obesity in asthma:more neutrophilic inflammation as a possible explanation for a reduced treatment response. Allergy. 2012;67(8):1060–1068.
-
(2012)
Allergy
, vol.67
, Issue.8
, pp. 1060-1068
-
-
Telenga, E.D.1
Tideman, S.W.2
Kerstjens, H.A.3
-
59
-
-
80053091650
-
Airway inflammation is augmented by obesity and fatty acids in asthma
-
Scott HA, Gibson PG, Garg ML, et al. Airway inflammation is augmented by obesity and fatty acids in asthma. Eur Respir J. 2011;38(3):594–602.
-
(2011)
Eur Respir J
, vol.38
, Issue.3
, pp. 594-602
-
-
Scott, H.A.1
Gibson, P.G.2
Garg, M.L.3
-
60
-
-
84901424065
-
Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity
-
Huh JY, Park YJ, Ham M, et al. Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. Mol Cells. 2014;37(5):365–371.
-
(2014)
Mol Cells
, vol.37
, Issue.5
, pp. 365-371
-
-
Huh, J.Y.1
Park, Y.J.2
Ham, M.3
-
61
-
-
84882238835
-
Eosinophils in the spotlight: eosinophilic airway inflammation in nonallergic asthma
-
Brusselle GG, Maes T, Bracke KR. Eosinophils in the spotlight:eosinophilic airway inflammation in nonallergic asthma. Nat Med. 2013;19(8):977–979.
-
(2013)
Nat Med
, vol.19
, Issue.8
, pp. 977-979
-
-
Brusselle, G.G.1
Maes, T.2
Bracke, K.R.3
-
62
-
-
0036310908
-
Non-eosinophilic asthma: importance and possible mechanisms
-
Douwes J, Gibson P, Pekkanen J, et al. Non-eosinophilic asthma:importance and possible mechanisms. Thorax. 2002;57(7):643–648.
-
(2002)
Thorax
, vol.57
, Issue.7
, pp. 643-648
-
-
Douwes, J.1
Gibson, P.2
Pekkanen, J.3
-
63
-
-
33947588653
-
Innate immune activation in neutrophilic asthma and bronchiectasis
-
Simpson JL, Grissell TV, Douwes J, et al. Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax. 2007;62(3):211–218.
-
(2007)
Thorax
, vol.62
, Issue.3
, pp. 211-218
-
-
Simpson, J.L.1
Grissell, T.V.2
Douwes, J.3
-
64
-
-
33744787332
-
Diesel exhaust enhances virus- and poly(I:C)-induced Toll-like receptor 3 expression and signaling in respiratory epithelial cells
-
Ciencewicki J, Brighton L, Wu WD, et al. Diesel exhaust enhances virus- and poly(I:C)-induced Toll-like receptor 3 expression and signaling in respiratory epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2006;290(6):L1154–1163.
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.290
, Issue.6
, pp. L1154-L1163
-
-
Ciencewicki, J.1
Brighton, L.2
Wu, W.D.3
-
65
-
-
79957933703
-
Cigarette smoke suppresses TLR-7 stimulation in response to virus infection in plasmacytoid dendritic cells
-
Castro SM, Chakraborty K, Guerrero-Plata A. Cigarette smoke suppresses TLR-7 stimulation in response to virus infection in plasmacytoid dendritic cells. Toxicol In Vitro. 2011;25(5):1106–1113.
-
(2011)
Toxicol In Vitro
, vol.25
, Issue.5
, pp. 1106-1113
-
-
Castro, S.M.1
Chakraborty, K.2
Guerrero-Plata, A.3
-
66
-
-
78349268377
-
Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor
-
Mortaz E, Adcock IM, Ito K, et al. Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor. Eur Respir J. 2010;36(5):1143–1154.
-
(2010)
Eur Respir J
, vol.36
, Issue.5
, pp. 1143-1154
-
-
Mortaz, E.1
Adcock, I.M.2
Ito, K.3
-
67
-
-
77956354815
-
Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone
-
Hernandez ML, Lay JC, Harris B, et al. Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone. J Allergy Clin Immunol. 2010;126(3):537-44.e1.
-
(2010)
J Allergy Clin Immunol
, vol.126
, Issue.3
, pp. 537
-
-
Hernandez, M.L.1
Lay, J.C.2
Harris, B.3
-
68
-
-
33746689785
-
The role of Toll-like receptors and related receptors of the innate immune system in asthma
-
Yang IA, Fong KM, Holgate ST, et al. The role of Toll-like receptors and related receptors of the innate immune system in asthma. Curr Opin Allergy Clin Immunol. 2006;6(1):23–28.
-
(2006)
Curr Opin Allergy Clin Immunol
, vol.6
, Issue.1
, pp. 23-28
-
-
Yang, I.A.1
Fong, K.M.2
Holgate, S.T.3
-
70
-
-
39449123817
-
Differences in airway cytokine profile in severe asthma compared to moderate asthma
-
Shannon J, Ernst P, Yamauchi Y, et al. Differences in airway cytokine profile in severe asthma compared to moderate asthma. Chest. 2008;133(2):420–426.
-
(2008)
Chest
, vol.133
, Issue.2
, pp. 420-426
-
-
Shannon, J.1
Ernst, P.2
Yamauchi, Y.3
-
71
-
-
0033958901
-
Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo
-
Hoshino H, Laan M, Sjostrand M, et al. Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo. J Allergy Clin Immunol. 2000;105(1 Pt 1):143–149.
-
(2000)
J Allergy Clin Immunol
, vol.105
, Issue.1
, pp. 143-149
-
-
Hoshino, H.1
Laan, M.2
Sjostrand, M.3
-
72
-
-
34249059942
-
Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia
-
Michel ML, Keller AC, Paget C, et al. Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia. J Exp Med. 2007;204(5):995–1001.
-
(2007)
J Exp Med
, vol.204
, Issue.5
, pp. 995-1001
-
-
Michel, M.L.1
Keller, A.C.2
Paget, C.3
-
73
-
-
77957736967
-
gammadelta T cells protect against lung fibrosis via IL-22
-
Simonian PL, Wehrmann F, Roark CL, et al. gammadelta T cells protect against lung fibrosis via IL-22. J Exp Med. 2010;207(10):2239–2253.
-
(2010)
J Exp Med
, vol.207
, Issue.10
, pp. 2239-2253
-
-
Simonian, P.L.1
Wehrmann, F.2
Roark, C.L.3
-
74
-
-
84880029974
-
IL-17-producing peripheral blood CD177+ neutrophils increase in allergic asthmatic subjects
-
Ramirez-Velazquez C, Castillo EC, Guido-Bayardo L, et al. IL-17-producing peripheral blood CD177+ neutrophils increase in allergic asthmatic subjects. Allergy Asthma Clin Immunol. 2013;9(1):23.
-
(2013)
Allergy Asthma Clin Immunol
, vol.9
, Issue.1
, pp. 23
-
-
Ramirez-Velazquez, C.1
Castillo, E.C.2
Guido-Bayardo, L.3
-
75
-
-
75649148842
-
Evidence for a cross-talk between human neutrophils and Th17 cells
-
Pelletier M, Maggi L, Micheletti A, et al. Evidence for a cross-talk between human neutrophils and Th17 cells. Blood. 2010;115(2):335–343.• The first evidence that upon activation, human neutrophils, and TH17 cells can directly recruit each other.
-
(2010)
Blood
, vol.115
, Issue.2
, pp. 335-343
-
-
Pelletier, M.1
Maggi, L.2
Micheletti, A.3
-
76
-
-
33751180809
-
IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?
-
Bullens DM, Truyen E, Coteur L, et al. IL-17 mRNA in sputum of asthmatic patients:linking T cell driven inflammation and granulocytic influx? Respir Res. 2006;7:135.• Neutrophils mature monocyte-derived dendritic cells to induce T-cell proliferation and polarization toward the Th1 cell phenotype.
-
(2006)
Respir Res
, vol.7
, pp. 135
-
-
Bullens, D.M.1
Truyen, E.2
Coteur, L.3
-
77
-
-
18244389671
-
Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN
-
van Gisbergen KP, Sanchez-Hernandez M, Geijtenbeek TB, et al. Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN. J Exp Med. 2005;201(8):1281–1292.
-
(2005)
J Exp Med
, vol.201
, Issue.8
, pp. 1281-1292
-
-
van Gisbergen, K.P.1
Sanchez-Hernandez, M.2
Geijtenbeek, T.B.3
-
78
-
-
0037059509
-
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
-
Finotto S, Neurath MF, Glickman JN, et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science (New York, N.Y.). 2002;295(5553):336–338.
-
(2002)
Science (New York, N.Y.)
, vol.295
, Issue.5553
, pp. 336-338
-
-
Finotto, S.1
Neurath, M.F.2
Glickman, J.N.3
-
79
-
-
33845604366
-
Interferon-gamma as a possible target in chronic asthma
-
Kumar RK, Webb DC, Herbert C, et al. Interferon-gamma as a possible target in chronic asthma. Inflamm Allergy Drug Targets. 2006;5(4):253–256.
-
(2006)
Inflamm Allergy Drug Targets
, vol.5
, Issue.4
, pp. 253-256
-
-
Kumar, R.K.1
Webb, D.C.2
Herbert, C.3
-
80
-
-
84904435841
-
The complex relationship between inflammation and lung function in severe asthma
-
Manni ML, Trudeau JB, Scheller EV, et al. The complex relationship between inflammation and lung function in severe asthma. Mucosal Immunol. 2014;7(5):1186–1198.
-
(2014)
Mucosal Immunol
, vol.7
, Issue.5
, pp. 1186-1198
-
-
Manni, M.L.1
Trudeau, J.B.2
Scheller, E.V.3
-
81
-
-
84939224355
-
High IFN-gamma and low SLPI mark severe asthma in mice and humans
-
Raundhal M, Morse C, Khare A, et al. High IFN-gamma and low SLPI mark severe asthma in mice and humans. J Clin Invest. 2015;125(8):3037–3050.
-
(2015)
J Clin Invest
, vol.125
, Issue.8
, pp. 3037-3050
-
-
Raundhal, M.1
Morse, C.2
Khare, A.3
-
82
-
-
84856891935
-
Inflammasome-IL-1-Th17 response in allergic lung inflammation
-
Besnard AG, Togbe D, Couillin I, et al. Inflammasome-IL-1-Th17 response in allergic lung inflammation. J Mol Cell Biol. 2012;4(1):3–10.
-
(2012)
J Mol Cell Biol
, vol.4
, Issue.1
, pp. 3-10
-
-
Besnard, A.G.1
Togbe, D.2
Couillin, I.3
-
83
-
-
84877102781
-
Beyond pattern recognition: NOD-like receptors in dendritic cells
-
Krishnaswamy JK, Chu T, Eisenbarth SC. Beyond pattern recognition:NOD-like receptors in dendritic cells. Trends Immunol. 2013;34(5):224–233.
-
(2013)
Trends Immunol
, vol.34
, Issue.5
, pp. 224-233
-
-
Krishnaswamy, J.K.1
Chu, T.2
Eisenbarth, S.C.3
-
84
-
-
84897434287
-
Elevated expression of the NLRP3 inflammasome in neutrophilic asthma
-
Simpson JL, Phipps S, Baines KJ, et al. Elevated expression of the NLRP3 inflammasome in neutrophilic asthma. Eur Respir J. 2014;43(4):1067–1076.
-
(2014)
Eur Respir J
, vol.43
, Issue.4
, pp. 1067-1076
-
-
Simpson, J.L.1
Phipps, S.2
Baines, K.J.3
-
85
-
-
34948900275
-
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
-
Vogl T, Tenbrock K, Ludwig S, et al. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med. 2007;13(9):1042–1049.
-
(2007)
Nat Med
, vol.13
, Issue.9
, pp. 1042-1049
-
-
Vogl, T.1
Tenbrock, K.2
Ludwig, S.3
-
86
-
-
0037443667
-
Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion
-
Ryckman C, Vandal K, Rouleau P, et al. Proinflammatory activities of S100:proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion. J Immunol. 2003;170(6):3233–3242.
-
(2003)
J Immunol
, vol.170
, Issue.6
, pp. 3233-3242
-
-
Ryckman, C.1
Vandal, K.2
Rouleau, P.3
-
87
-
-
84866650842
-
The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway
-
Yano J, Kolls JK, Happel KI, et al. The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway. Plos One. 2012;7(9):e46311.
-
(2012)
Plos One
, vol.7
, Issue.9
, pp. e46311
-
-
Yano, J.1
Kolls, J.K.2
Happel, K.I.3
-
88
-
-
84902191417
-
Human S100A9 potentiates IL-8 production in response to GM-CSF or fMLP via activation of a different set of transcription factors in neutrophils
-
Simard JC, Noel C, Tessier PA, et al. Human S100A9 potentiates IL-8 production in response to GM-CSF or fMLP via activation of a different set of transcription factors in neutrophils. FEBS Lett. 2014;588(13):2141–2146.
-
(2014)
FEBS Lett
, vol.588
, Issue.13
, pp. 2141-2146
-
-
Simard, J.C.1
Noel, C.2
Tessier, P.A.3
-
89
-
-
84893822649
-
S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-kappaB(1.)
-
Simard JC, Cesaro A, Chapeton-Montes J, et al. S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-kappaB(1.). PLoS One. 2013;8(8):e72138.
-
(2013)
PLoS One
, vol.8
, Issue.8
, pp. e72138
-
-
Simard, J.C.1
Cesaro, A.2
Chapeton-Montes, J.3
-
90
-
-
84964282095
-
Role of inflammasome activation in development and exacerbation of asthma
-
Lee TH, Song HJ, Park CS. Role of inflammasome activation in development and exacerbation of asthma. Asia Pac Allergy. 2014;4(4):187–196.
-
(2014)
Asia Pac Allergy
, vol.4
, Issue.4
, pp. 187-196
-
-
Lee, T.H.1
Song, H.J.2
Park, C.S.3
-
91
-
-
84884533825
-
Elevation of S100 calcium binding protein A9 in sputum of neutrophilic inflammation in severe uncontrolled asthma
-
Lee TH, Jang AS, Park JS, et al. Elevation of S100 calcium binding protein A9 in sputum of neutrophilic inflammation in severe uncontrolled asthma. Ann Allergy Asthma Immunol. 2013;111(4):268-275.e1.•• The first observation on relation of S100A9 with uncontrolled severe asthma and neutrophilic inflammation of the airway.
-
(2013)
Ann Allergy Asthma Immunol
, vol.111
, Issue.4
, pp. 268
-
-
Lee, T.H.1
Jang, A.S.2
Park, J.S.3
-
92
-
-
0035575705
-
Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells
-
Sugawara S, Uehara A, Nochi T, et al. Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells. J Immunol. 2001;167(11):6568–6575.
-
(2001)
J Immunol
, vol.167
, Issue.11
, pp. 6568-6575
-
-
Sugawara, S.1
Uehara, A.2
Nochi, T.3
-
93
-
-
1542287347
-
Neutrophil extracellular traps kill bacteria
-
Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science (New York, N.Y.). 2004;303(5663):1532–1535.
-
(2004)
Science (New York, N.Y.)
, vol.303
, Issue.5663
, pp. 1532-1535
-
-
Brinkmann, V.1
Reichard, U.2
Goosmann, C.3
-
94
-
-
84897434505
-
Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes
-
Baines KJ, Simpson JL, Wood LG, et al. Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes. J Allergy Clin Immunol. 2014;133(4):997–1007.
-
(2014)
J Allergy Clin Immunol
, vol.133
, Issue.4
, pp. 997-1007
-
-
Baines, K.J.1
Simpson, J.L.2
Wood, L.G.3
-
95
-
-
84920369993
-
Identification of novel immune phenotypes for allergic and nonallergic childhood asthma
-
Raedler D, Ballenberger N, Klucker E, et al. Identification of novel immune phenotypes for allergic and nonallergic childhood asthma. J Allergy Clin Immunol. 2015;135(1):81–91.
-
(2015)
J Allergy Clin Immunol
, vol.135
, Issue.1
, pp. 81-91
-
-
Raedler, D.1
Ballenberger, N.2
Klucker, E.3
-
96
-
-
0037504020
-
Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair
-
Wenzel SE, Balzar S, Cundall M, et al. Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9:association with asthma severity, neutrophilic inflammation, and wound repair. J Allergy Clin Immunol. 2003;111(6):1345–1352.
-
(2003)
J Allergy Clin Immunol
, vol.111
, Issue.6
, pp. 1345-1352
-
-
Wenzel, S.E.1
Balzar, S.2
Cundall, M.3
-
97
-
-
0345734195
-
Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids
-
Cundall M, Sun Y, Miranda C, et al. Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids. J Allergy Clin Immunol. 2003;112(6):1064–1071.
-
(2003)
J Allergy Clin Immunol
, vol.112
, Issue.6
, pp. 1064-1071
-
-
Cundall, M.1
Sun, Y.2
Miranda, C.3
-
98
-
-
79956351574
-
concentrations in severe asthma and its relationship with FEV1
-
Morjaria JB, Babu KS, Vijayanand P, et al. concentrations in severe asthma and its relationship with FEV1. Thorax. 2011;66(6):537.
-
(2011)
Thorax
, vol.66
, Issue.6
, pp. 537
-
-
Morjaria, J.B.1
Babu, K.S.2
Vijayanand, P.3
-
99
-
-
70450213353
-
Oncostatin M (OSM) is increased in asthma with incompletely reversible airflow obstruction
-
Simpson JL, Baines KJ, Boyle MJ, et al. Oncostatin M (OSM) is increased in asthma with incompletely reversible airflow obstruction. Exp Lung Res. 2009;35(9):781–794.
-
(2009)
Exp Lung Res
, vol.35
, Issue.9
, pp. 781-794
-
-
Simpson, J.L.1
Baines, K.J.2
Boyle, M.J.3
-
100
-
-
0025982378
-
Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium
-
Amitani R, Wilson R, Rutman A, et al. Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium. Am J Respir Cell Mol Biol. 1991;4(1):26–32.
-
(1991)
Am J Respir Cell Mol Biol
, vol.4
, Issue.1
, pp. 26-32
-
-
Amitani, R.1
Wilson, R.2
Rutman, A.3
-
101
-
-
0029878790
-
Bronchial elastic fibers in normal subjects and asthmatic patients
-
Bousquet J, Lacoste JY, Chanez P, et al. Bronchial elastic fibers in normal subjects and asthmatic patients. Am J Respir Crit Care Med. 1996;153(5):1648–1654.
-
(1996)
Am J Respir Crit Care Med
, vol.153
, Issue.5
, pp. 1648-1654
-
-
Bousquet, J.1
Lacoste, J.Y.2
Chanez, P.3
-
102
-
-
0041663868
-
Specific allergens enhance elastase release in stimulated neutrophils from asthmatic patients
-
Monteseirin J, Bonilla I, Camacho MJ, et al. Specific allergens enhance elastase release in stimulated neutrophils from asthmatic patients. Int Arch Allergy Immunol. 2003;131(3):174–181.
-
(2003)
Int Arch Allergy Immunol
, vol.131
, Issue.3
, pp. 174-181
-
-
Monteseirin, J.1
Bonilla, I.2
Camacho, M.J.3
-
103
-
-
0037264075
-
Increased matrix metalloproteinase-9 with elastolysis in nocturnal asthma
-
Pham DN, Chu HW, Martin RJ, et al. Increased matrix metalloproteinase-9 with elastolysis in nocturnal asthma. Ann Allergy Asthma Immunol. 2003;90(1):72–78.
-
(2003)
Ann Allergy Asthma Immunol
, vol.90
, Issue.1
, pp. 72-78
-
-
Pham, D.N.1
Chu, H.W.2
Martin, R.J.3
-
104
-
-
24144482766
-
Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma
-
Simpson JL, Scott RJ, Boyle MJ, et al. Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma. Am J Respir Crit Care Med. 2005;172(5):559–565.
-
(2005)
Am J Respir Crit Care Med
, vol.172
, Issue.5
, pp. 559-565
-
-
Simpson, J.L.1
Scott, R.J.2
Boyle, M.J.3
-
105
-
-
10444279215
-
High-resolution CT findings in patients with near-fatal asthma: comparison of patients with mild-to-severe asthma and normal control subjects and changes in airway abnormalities following steroid treatment
-
Lee YM, Park JS, Hwang JH, et al. High-resolution CT findings in patients with near-fatal asthma:comparison of patients with mild-to-severe asthma and normal control subjects and changes in airway abnormalities following steroid treatment. Chest. 2004;126(6):1840–1848.
-
(2004)
Chest
, vol.126
, Issue.6
, pp. 1840-1848
-
-
Lee, Y.M.1
Park, J.S.2
Hwang, J.H.3
-
106
-
-
84862794930
-
Air trapping is a major determinant of persistent airway obstruction in asthmatics
-
Park SW, Park JS, Jeong SH, et al. Air trapping is a major determinant of persistent airway obstruction in asthmatics. Respir Med. 2012;106(6):786–793.
-
(2012)
Respir Med
, vol.106
, Issue.6
, pp. 786-793
-
-
Park, S.W.1
Park, J.S.2
Jeong, S.H.3
-
107
-
-
30844442805
-
Differences in radiological/HRCT findings in eosinophilic bronchitis and asthma: implication for bronchial responsiveness
-
Park SW, Park JS, Lee YM, et al. Differences in radiological/HRCT findings in eosinophilic bronchitis and asthma:implication for bronchial responsiveness. Thorax. 2006;61(1):41–47.
-
(2006)
Thorax
, vol.61
, Issue.1
, pp. 41-47
-
-
Park, S.W.1
Park, J.S.2
Lee, Y.M.3
-
108
-
-
0035447569
-
Factors associated with persistent airflow limitation in severe asthma
-
Ten Brinke A, Zwinderman AH, Sterk PJ, et al. Factors associated with persistent airflow limitation in severe asthma. Am J Respir Crit Care Med. 2001;164(5):744–748.
-
(2001)
Am J Respir Crit Care Med
, vol.164
, Issue.5
, pp. 744-748
-
-
Ten Brinke, A.1
Zwinderman, A.H.2
Sterk, P.J.3
-
109
-
-
37549004387
-
Association between neutrophilic airway inflammation and airflow limitation in adults with asthma
-
Shaw DE, Berry MA, Hargadon B, et al. Association between neutrophilic airway inflammation and airflow limitation in adults with asthma. Chest. 2007;132(6):1871–1875.
-
(2007)
Chest
, vol.132
, Issue.6
, pp. 1871-1875
-
-
Shaw, D.E.1
Berry, M.A.2
Hargadon, B.3
-
110
-
-
65449163128
-
Neutrophilic asthma has different radiographic features to COPD and smokers
-
Simpson JL, Milne DG, Gibson PG. Neutrophilic asthma has different radiographic features to COPD and smokers. Respir Med. 2009;103(6):881–887.
-
(2009)
Respir Med
, vol.103
, Issue.6
, pp. 881-887
-
-
Simpson, J.L.1
Milne, D.G.2
Gibson, P.G.3
-
111
-
-
58249121587
-
A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis
-
Busacker A, Newell JD, Jr., Keefe T, et al. A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis. Chest. 2009;135(1):48–56.• A high level of neutrophils in the airway is a risk factor associated with air trapping in patients with severe asthma.
-
(2009)
Chest
, vol.135
, Issue.1
, pp. 48-56
-
-
Busacker, A.1
Newell, J.D.2
Keefe, T.3
-
112
-
-
77956796272
-
Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes
-
Gupta S, Siddiqui S, Haldar P, et al. Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes. Thorax. 2010;65(9):775–781.
-
(2010)
Thorax
, vol.65
, Issue.9
, pp. 775-781
-
-
Gupta, S.1
Siddiqui, S.2
Haldar, P.3
-
113
-
-
84907424177
-
Mepolizumab treatment in patients with severe eosinophilic asthma
-
Ortega HG, Liu MC, Pavord ID, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. 2014;371(13):1198–1207.
-
(2014)
N Engl J Med
, vol.371
, Issue.13
, pp. 1198-1207
-
-
Ortega, H.G.1
Liu, M.C.2
Pavord, I.D.3
-
114
-
-
81455155725
-
Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study
-
Castro M, Mathur S, Hargreave F, et al. Reslizumab for poorly controlled, eosinophilic asthma:a randomized, placebo-controlled study. Am J Respir Crit Care Med. 2011;184(10):1125–1132.
-
(2011)
Am J Respir Crit Care Med
, vol.184
, Issue.10
, pp. 1125-1132
-
-
Castro, M.1
Mathur, S.2
Hargreave, F.3
-
115
-
-
77952733788
-
MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function
-
Kolbeck R, Kozhich A, Koike M, et al. MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol. 2010;125(6):1344–1353.e1342.
-
(2010)
J Allergy Clin Immunol
, vol.125
, Issue.6
, pp. 1344
-
-
Kolbeck, R.1
Kozhich, A.2
Koike, M.3
-
116
-
-
77953039047
-
A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma
-
Corren J, Busse W, Meltzer EO, et al. A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma. Am J Respir Crit Care Med. 2010;181(8):788–796.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, Issue.8
, pp. 788-796
-
-
Corren, J.1
Busse, W.2
Meltzer, E.O.3
-
117
-
-
84941182925
-
Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial
-
Brightling CE, Chanez P, Leigh R, et al. Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma:a randomised, double-blind, placebo-controlled, phase 2b trial. Lancet Respir Med. 2015;3(9):692–701.
-
(2015)
Lancet Respir Med
, vol.3
, Issue.9
, pp. 692-701
-
-
Brightling, C.E.1
Chanez, P.2
Leigh, R.3
-
118
-
-
84897379012
-
Efficacy and safety of an anti-IL-13 mAb in patients with severe asthma: a randomized trial
-
De Boever EH, Ashman C, Cahn AP, et al. Efficacy and safety of an anti-IL-13 mAb in patients with severe asthma:a randomized trial. J Allergy Clin Immunol. 2014;133(4):989–996.
-
(2014)
J Allergy Clin Immunol
, vol.133
, Issue.4
, pp. 989-996
-
-
De Boever, E.H.1
Ashman, C.2
Cahn, A.P.3
-
119
-
-
0030984157
-
Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition
-
Yasui K, Hu B, Nakazawa T, et al. Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition. J Clin Invest. 1997;100(7):1677–1684.
-
(1997)
J Clin Invest
, vol.100
, Issue.7
, pp. 1677-1684
-
-
Yasui, K.1
Hu, B.2
Nakazawa, T.3
-
120
-
-
0034253389
-
The downregulation of Bcl-2 expression is necessary for theophylline-induced apoptosis of eosinophil
-
Chung IY, Nam-Kung EK, Lee NM, et al. The downregulation of Bcl-2 expression is necessary for theophylline-induced apoptosis of eosinophil. Cell Immunol. 2000;203(2):95–102.
-
(2000)
Cell Immunol
, vol.203
, Issue.2
, pp. 95-102
-
-
Chung, I.Y.1
Nam-Kung, E.K.2
Lee, N.M.3
-
121
-
-
0023845877
-
Polymorphonuclear leukocyte inhibition by therapeutic concentrations of theophylline is mediated by cyclic-3ʹ,5ʹ-adenosine monophosphate
-
Nielson CP, Crowley JJ, Morgan ME, et al. Polymorphonuclear leukocyte inhibition by therapeutic concentrations of theophylline is mediated by cyclic-3ʹ,5ʹ-adenosine monophosphate. Am Rev Respir Dis. 1988;137(1):25–30.
-
(1988)
Am Rev Respir Dis
, vol.137
, Issue.1
, pp. 25-30
-
-
Nielson, C.P.1
Crowley, J.J.2
Morgan, M.E.3
-
122
-
-
0033859791
-
Effects of theophylline on human eosinophil functions: comparative study with neutrophil functions
-
Yasui K, Agematsu K, Shinozaki K, et al. Effects of theophylline on human eosinophil functions:comparative study with neutrophil functions. J Leukoc Biol. 2000;68(2):194–200.
-
(2000)
J Leukoc Biol
, vol.68
, Issue.2
, pp. 194-200
-
-
Yasui, K.1
Agematsu, K.2
Shinozaki, K.3
-
123
-
-
0029941523
-
Theophylline: potential antiinflammatory effects in nocturnal asthma
-
Kraft M, Torvik JA, Trudeau JB, et al. Theophylline:potential antiinflammatory effects in nocturnal asthma. J Allergy Clin Immunol. 1996;97(6):1242–1246.
-
(1996)
J Allergy Clin Immunol
, vol.97
, Issue.6
, pp. 1242-1246
-
-
Kraft, M.1
Torvik, J.A.2
Trudeau, J.B.3
-
124
-
-
0037092557
-
Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease
-
Culpitt SV, de Matos C, Russell RE, et al. Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2002;165(10):1371–1376.
-
(2002)
Am J Respir Crit Care Med
, vol.165
, Issue.10
, pp. 1371-1376
-
-
Culpitt, S.V.1
de Matos, C.2
Russell, R.E.3
-
125
-
-
0029793188
-
Theophylline’s effect on neutrophil function and the late asthmatic response
-
Kraft M, Pak J, Borish L, et al. Theophylline’s effect on neutrophil function and the late asthmatic response. J Allergy Clin Immunol. 1996;98(2):251–257.
-
(1996)
J Allergy Clin Immunol
, vol.98
, Issue.2
, pp. 251-257
-
-
Kraft, M.1
Pak, J.2
Borish, L.3
-
126
-
-
27144535903
-
Formoterol attenuates neutrophilic airway inflammation in asthma
-
Maneechotesuwan K, Essilfie-Quaye S, Meah S, et al. Formoterol attenuates neutrophilic airway inflammation in asthma. Chest. 2005;128(4):1936–1942.
-
(2005)
Chest
, vol.128
, Issue.4
, pp. 1936-1942
-
-
Maneechotesuwan, K.1
Essilfie-Quaye, S.2
Meah, S.3
-
127
-
-
0037975664
-
Possible anti-inflammatory effect of salmeterol against interleukin-8 and neutrophil activation in asthma in vivo
-
Reid DW, Ward C, Wang N, et al. Possible anti-inflammatory effect of salmeterol against interleukin-8 and neutrophil activation in asthma in vivo. Eur Respir J. 2003;21(6):994–999.
-
(2003)
Eur Respir J
, vol.21
, Issue.6
, pp. 994-999
-
-
Reid, D.W.1
Ward, C.2
Wang, N.3
-
128
-
-
84902137136
-
Cysteinyl leukotriene receptor-1 antagonists as modulators of innate immune cell function
-
Theron AJ, Steel HC, Tintinger GR, et al. Cysteinyl leukotriene receptor-1 antagonists as modulators of innate immune cell function. J Immunol Res Ther. 2014;608930:2014.
-
(2014)
J Immunol Res Ther
, pp. 2014
-
-
Theron, A.J.1
Steel, H.C.2
Tintinger, G.R.3
-
129
-
-
84860995531
-
Montelukast effects on inflammation in allergic rhinitis: a double blind placebo controlled pilot study
-
Braido F, Riccio AM, Rogkakou A, et al. Montelukast effects on inflammation in allergic rhinitis:a double blind placebo controlled pilot study. Eur Ann Allergy Clin Immunol. 2012;44(2):48–53.
-
(2012)
Eur Ann Allergy Clin Immunol
, vol.44
, Issue.2
, pp. 48-53
-
-
Braido, F.1
Riccio, A.M.2
Rogkakou, A.3
-
130
-
-
38348998987
-
Clarithromycin targets neutrophilic airway inflammation in refractory asthma
-
Simpson JL, Powell H, Boyle MJ, et al. Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med. 2008;177(2):148–155.
-
(2008)
Am J Respir Crit Care Med
, vol.177
, Issue.2
, pp. 148-155
-
-
Simpson, J.L.1
Powell, H.2
Boyle, M.J.3
-
132
-
-
84875219719
-
Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial
-
Brusselle GG, Vanderstichele C, Jordens P, et al. Azithromycin for prevention of exacerbations in severe asthma (AZISAST):a multicentre randomised double-blind placebo-controlled trial. Thorax. 2013;68(4):322–329.
-
(2013)
Thorax
, vol.68
, Issue.4
, pp. 322-329
-
-
Brusselle, G.G.1
Vanderstichele, C.2
Jordens, P.3
-
133
-
-
77957788255
-
Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase
-
Maneechotesuwan K, Ekjiratrakul W, Kasetsinsombat K, et al. Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase. J Allergy Clin Immunol. 2010;126(4):754–762.e751.
-
(2010)
J Allergy Clin Immunol
, vol.126
, Issue.4
, pp. 754
-
-
Maneechotesuwan, K.1
Ekjiratrakul, W.2
Kasetsinsombat, K.3
-
134
-
-
84887115924
-
Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials
-
Franciosi LG, Diamant Z, Banner KH, et al. Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease:findings from four clinical trials. Lancet Respir Med. 2013;1(9):714–727.
-
(2013)
Lancet Respir Med
, vol.1
, Issue.9
, pp. 714-727
-
-
Franciosi, L.G.1
Diamant, Z.2
Banner, K.H.3
-
136
-
-
0032508533
-
Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
-
Laufs U, Liao JK. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem. 1998;273(37):24266–24271.
-
(1998)
J Biol Chem
, vol.273
, Issue.37
, pp. 24266-24271
-
-
Laufs, U.1
Liao, J.K.2
-
137
-
-
1442302282
-
Simvastatin enhances the regeneration of endothelial cells via VEGF secretion in injured arteries
-
Matsuno H, Takei M, Hayashi H, et al. Simvastatin enhances the regeneration of endothelial cells via VEGF secretion in injured arteries. J Cardiovasc Pharmacol. 2004;43(3):333–340.
-
(2004)
J Cardiovasc Pharmacol
, vol.43
, Issue.3
, pp. 333-340
-
-
Matsuno, H.1
Takei, M.2
Hayashi, H.3
-
138
-
-
85016765389
-
-
Davies H, Olson L, Gibson P. Methotrexate as a steroid sparing agent for asthma in adults. Cochrane Database of Systematic Reviews 1998:published online 26 July 1998, DOI:10.1002/14651858.CD000391
-
(1998)
-
-
-
139
-
-
77953105482
-
The preclinical pharmacology of roflumilast–a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
-
Hatzelmann A, Morcillo EJ, Lungarella G, et al. The preclinical pharmacology of roflumilast–a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2010;23(4):235–256.
-
(2010)
Pulm Pharmacol Ther
, vol.23
, Issue.4
, pp. 235-256
-
-
Hatzelmann, A.1
Morcillo, E.J.2
Lungarella, G.3
-
140
-
-
19444363467
-
PDE4 inhibitors as new anti-inflammatory drugs: effects on cell trafficking and cell adhesion molecules expression
-
Sanz MJ, Cortijo J, Morcillo EJ. PDE4 inhibitors as new anti-inflammatory drugs:effects on cell trafficking and cell adhesion molecules expression. Pharmacol Ther. 2005;106(3):269–297.
-
(2005)
Pharmacol Ther
, vol.106
, Issue.3
, pp. 269-297
-
-
Sanz, M.J.1
Cortijo, J.2
Morcillo, E.J.3
-
141
-
-
84862519263
-
Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial
-
Nair P, Gaga M, Zervas E, et al. Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils:a randomized, placebo-controlled clinical trial. Clin Exp Allergy. 2012;42(7):1097–1103.
-
(2012)
Clin Exp Allergy
, vol.42
, Issue.7
, pp. 1097-1103
-
-
Nair, P.1
Gaga, M.2
Zervas, E.3
-
142
-
-
84890290253
-
Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist
-
Leaker BR, Barnes PJ, O’Connor B. Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist. Respir Res. 2013;14:137.
-
(2013)
Respir Res
, vol.14
, pp. 137
-
-
Leaker, B.R.1
Barnes, P.J.2
O’Connor, B.3
-
143
-
-
84874931119
-
Vitamin E, gamma-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers
-
Hernandez ML, Wagner JG, Kala A, et al. Vitamin E, gamma-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers. Free Radic Biol Med. 2013;60:56–62.
-
(2013)
Free Radic Biol Med
, vol.60
, pp. 56-62
-
-
Hernandez, M.L.1
Wagner, J.G.2
Kala, A.3
-
144
-
-
84890026323
-
Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma
-
Busse WW, Holgate S, Kerwin E, et al. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am J Respir Crit Care Med. 2013;188(11):1294–1302.
-
(2013)
Am J Respir Crit Care Med
, vol.188
, Issue.11
, pp. 1294-1302
-
-
Busse, W.W.1
Holgate, S.2
Kerwin, E.3
-
145
-
-
32644490529
-
Evidence of a role of tumor necrosis factor alpha in refractory asthma
-
Berry MA, Hargadon B, Shelley M, et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med. 2006;354(7):697–708.• The TNF-α antagonist etanercept is associated with significant improvement in airway responsiveness and airflow obstruction in patients with severe asthma.
-
(2006)
N Engl J Med
, vol.354
, Issue.7
, pp. 697-708
-
-
Berry, M.A.1
Hargadon, B.2
Shelley, M.3
-
146
-
-
84920862197
-
Anti-TNF inhibits the airways neutrophilic inflammation induced by inhaled endotoxin in human
-
Michel O, Dinh PH, Doyen V, et al. Anti-TNF inhibits the airways neutrophilic inflammation induced by inhaled endotoxin in human. BMC Pharmacol Toxicol. 2014;15:60.
-
(2014)
BMC Pharmacol Toxicol
, vol.15
, pp. 60
-
-
Michel, O.1
Dinh, P.H.2
Doyen, V.3
-
147
-
-
84922370441
-
IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers
-
Hernandez ML, Mills K, Almond M, et al. IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers. J Allergy Clin Immunol. 2015;135(2):379–385.•• An IL-1 receptor antagonist (anakinra) significantly reduced LPS-induced IL-1β, IL-6, and IL-8 levels in conjunction with inhaled LPS, with concomitant attenuation of airway neutrophilic inflammation in a model of inhaled LPS challenge.
-
(2015)
J Allergy Clin Immunol
, vol.135
, Issue.2
, pp. 379-385
-
-
Hernandez, M.L.1
Mills, K.2
Almond, M.3
-
148
-
-
84885359620
-
Statin use and asthma control in patients with severe asthma
-
Zeki AA, Oldham J, Wilson M, et al. Statin use and asthma control in patients with severe asthma. BMJ Open. 2013;3:8.
-
(2013)
BMJ Open
, vol.3
, pp. 8
-
-
Zeki, A.A.1
Oldham, J.2
Wilson, M.3
-
149
-
-
35348972883
-
Statin use reduces decline in lung function: VA normative aging study
-
Alexeeff SE, Litonjua AA, Sparrow D, et al. Statin use reduces decline in lung function:VA normative aging study. Am J Respir Crit Care Med. 2007;176(8):742–747.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, Issue.8
, pp. 742-747
-
-
Alexeeff, S.E.1
Litonjua, A.A.2
Sparrow, D.3
-
150
-
-
84926313464
-
Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma
-
Thomson NC, Charron CE, Chaudhuri R, et al. Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma. Pulm Pharmacol Ther. 2015;31:1–8.
-
(2015)
Pulm Pharmacol Ther
, vol.31
, pp. 1-8
-
-
Thomson, N.C.1
Charron, C.E.2
Chaudhuri, R.3
-
151
-
-
0025268469
-
Long-term methotrexate treatment in corticosteroid-dependent asthma
-
Mullarkey MF, Lammert JK, Blumenstein BA. Long-term methotrexate treatment in corticosteroid-dependent asthma. Ann Intern Med. 1990;112(8):577–581.
-
(1990)
Ann Intern Med
, vol.112
, Issue.8
, pp. 577-581
-
-
Mullarkey, M.F.1
Lammert, J.K.2
Blumenstein, B.A.3
-
152
-
-
80052030404
-
CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1
-
Braber S, Overbeek SA, Koelink PJ, et al. CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1. Eur J Pharmacol. 2011;668(3):443–449.
-
(2011)
Eur J Pharmacol
, vol.668
, Issue.3
, pp. 443-449
-
-
Braber, S.1
Overbeek, S.A.2
Koelink, P.J.3
-
153
-
-
62549084077
-
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
-
Wenzel SE, Barnes PJ, Bleecker ER, et al. A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med. 2009;179(7):549–558.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, Issue.7
, pp. 549-558
-
-
Wenzel, S.E.1
Barnes, P.J.2
Bleecker, E.R.3
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