Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects

Thorax

Volumn 54, Issue 12, 1999, Pages 1061-1069

  Nightingale, Julia A ^a   Rogers, Duncan F ^a   Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Exhaled nitric oxide; Nitrite; Ozone

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 8; METHACHOLINE; NITRIC OXIDE; OZONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; ASTHMA; BREATH ANALYSIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; EXERCISE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG FUNCTION; MALE; NEUTROPHIL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPIROMETRY; SPUTUM;

EID: 0032730236     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.54.12.1061     Document Type: Article

References (43)

1. Moncada S, Higgs A, The L-arginine-nitric oxide pathway. N Engl J Med 1993;329:2002 12.
2. Anggård E. Nitric oxide: Mediator, murderer, and medicine. Lancet 1994;343:1199-206.
3. Kiechle FL, Malinski T. Nitric oxide: Biochemistry pathophysiology, and detection. Am J Clin Pathol 1993;100:567-75.
4. Lowenstein CJ, Dinerman JL, Snyder SH. Nitric oxide: A physiologic messenger. Ann Intern Med 1994;120:227-37.
5. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992;6:3051-64.
6. Pendino KJ, Laskin JD, Shuler RL, et al. Enhanced production of nitric oxide by rat alveolar macrophages after inhalation of a pulmonary irritant is associated with increased expression of nitric oxide synthase. J Immunol 1993;151:7196-205.
7. Punjabi CJ, Laskin JD, Pendino KJ, et al. Production of nitric oxide by rat type II pneumocytes: Increased expression of inducible nitric oxide synthase following inhalation of a pulmonary irritant. Am J Respir Cell Mol Biol 1994;11:165-72.
8. Laskin DL, Pendino KJ, Punjabi CJ, et al. Pulmonary and hepatic effects of inhaled ozone in rats. Environ Health Perspect 1994;102(Suppl 10):61-4.
9. Haddad E-B, Liu SII, Sahnon M, et al. Expression of inducible nitric oxide synthase mRNA in Brown Norway rats exposed to ozone: Effect of dexamethasone. Eur J Pharmacol Environ Toxicol Pharmacol Section 1995;293:287-90.
10. Royall JA, Kooy NW, Beckman JS, Peroxynitrite and other nitric oxide-derived oxidants. In: Zapol WM, Bloch KD. Nitric Oxide and the Lung. New York: Marcel Dekker, 1996;223-46.
11. Hunt J, Byrns RE, Ignarro LJ, et al. Condensed expirate nitrite as a home marker for acute asthma. Lancet 1995;346:1235-6.
12. McDonnell WF, Horstman DH, Hazucha MJ, et al. Pulmonary effects of ozone exposure during exercise: Dose-response characteristics. J Appl Physiol 1983;54:1345-52.
13. Kreit JW, Gross KB, Moore TB, et al. Ozone induced changes in pulmonary function and bronchial responsiveness in asthmatics. Appl Physiol 1989;66:217-22.
14. Aris RM, Christian D, Hearne PQ, et al. Ozone-induced airway inflammation in human subjects as determined by airway lavage and biopsy. Am Rev Respir Dis 1993;148:1363-72.
15. Basha MA, Gross KB, Gwizdala CJ, et al. Bronchoalveolar lavage neurophilia in asthmatic and healthy volunteers after controlled exposure to ozone and filtered purified air. Chest 1994;106:1757-65.
16. Fahy JV, Wong HH, Liu JT, et al. Analysis of induced sputum after air and ozone exposures in healthy subjects. Environ Res 1995;70:77-83.
17. Scannell C, Chen L, Aris RM, et al. Greater ozone-induced inflammatory responses in subjects with asthma. Am J Respir Crit Care 1996;154:24-9.
18. 1 and FVC do not correlate with measures of inflammation. Am J Respir Crit Care Med 1996;153;904-9.
19. Barnes PJ, Chung KF, Page CP. Inflammatory mediators of asthma: An update. Pharmacol Rev 1998;50:515-96.
20. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987;136:225-44.
21. Chai H, Farr RS, Froelich LA, et al. Standardization of bronchial challenge procedures. J Allergy Clin Immunol 1975;56:323-7.
22. Kharitonov SA, Alving K, Barnes PJ. Exhaled and nasal nitric oxide measurements: Recommendations. Eur Respir J 1997;10:1683-93.
23. Horvath I, Donnelly LE, Kiss A, et al. Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. Am J Respir Crit Care Med 1998;158:1042-6.
24. Misko TP, Shilling RJ, Salvemini D, et al. A fluurometric assay for the measurement of nitrite in biological samples. Anal Biochem 1993;214:11-6.
25. Nightingale JA, Rogers DF, Barnes PJ. The effect of repeated sputum induction on cell counts in normal volunteers. Thorax 1998;53:87-90.
26. Nightingale JA, Rogers DF, Hart LA, et al. Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects. Thorax 1998;53:563-71.
27. Kharitonov SA. Exhaled Nitric Oxide in Inflammatory Lung Diseases. PhD thesis, University of London, 1997.
28. DOH Advisory Group on the Medical Aspects of Air Pollution Episodes. First Report: Ozone. London: HMSO, 1991.
29. Kharitonov SA, Barnes PJ. Nitric oxide in exhaled air is a new marker of airway inflammation. Mon Arch Chest Dis 1996;51:533-7.
30. Kharitonov SA, Yates D, Robbins RA, et al. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994;343:133-5.
31. Alving K, Weitzberg F, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993;6:1368 70.
32. Pendino KJ, Gardner CR, Shuler RL, et al. Inhibition of ozone-induced nitric oxide synthase expression in the lung by endotoxin. Am J Respir Cell Mol Biol 1996;14:516-25.
33. Casimir CM, Teahan CG. The respiratory burst of neutrophils and its deficiency. In: Hellewell PG, Williams TJ, eds. Immunopharmacology of Neutrophils. London: Academic Press, 1994:27-54.
34. Fukuyama N, Ichimori K, Su Z, et al. Peroxynitrite formation from activated human leukocytes. Biochem Biophys Res Commun 1996;224:414-9.
35. 1. Chest 1995;107:621-8.
36. Holtzman MJ, Cunningham JH, Sheller JR, et al. Effect of ozone on bronchial reactivity in atopic and nonatopic subjects. Am Rev Respir Dis 1979;120:1059-67.
37. 3-induced change in bronchial reactivity to methacholine and airway inflammation in humans. J Appl Physiol 1986;60:1321-6.
38. Hiltermann TJN, Stolk J, Hiemstra PS, et al. Effect of ozone exposure on maximal airway narrowing in non-asthmatic and asthmatic subjects. Clin Sci 1995;89:619-24.
39. Claman DM, Boushey HA, Liu J, et al. Analysis of induced sputum to examine the effects of prednisone on airway inflammation in asthmatic subjects. J Allergy Clin Immunol 1994;94:861-9.
40. Ward R, Woltmann G, Wardlaw AJ, et al. Between-observer repeatability of sputum differential cell counts. Influence of cell viability and squamous cell contamination. Clin Exp Allergy 1990;29:248-52.
41. Holz O, Richter K, Jörres RA, et al. Changes in sputum composition between two inductions performed on consecutive days. Thorax 1998;53:83-6.
42. Torres A, Utell MJ, Morow PE, et al. Airway inflammation in smokers and nonsmokers with varying responses to ozone. Am J Respir Crit Care Med 1997;156:728-36.
43. Devlin RB, McDonnell WF, Mann R, et al. Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. Am J Respir Cell Mol Biol 1991;4:72-81.