The downregulation of Bcl-2 expression is necessary for theophylline-induced apoptosis of eosinophil

Cellular Immunology

Volumn 203, Issue 2, 2000, Pages 95-102

  Chung, Il Yup ^b   Nam Kung, Eun Kyung ^a   Lee, Nam Min ^a   Chang, Hun Soo ^b   Kim, Do Jin ^a   Kim, Yong Hoon ^a   Park, Choon Sik ^a  

^a Soonchunhyang University College of Medicine   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Apoptosis; Bcl 2; Eosinophils; Phosphodiesterase inhibitor; Theophylline

Indexed keywords

INTERLEUKIN 5; PROTEIN BCL 2; THEOPHYLLINE;

ALLERGIC REACTION; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CHROMOSOME BREAKAGE; DRUG INDUCED DISEASE; EFFECTOR CELL; EOSINOPHIL; HUMAN; HUMAN CELL; IN VITRO STUDY; MEDIATOR RELEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION;

EID: 0034253389     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1006/cimm.2000.1678     Document Type: Article

References (35)

1. Eosinophilic inflammation in asthma
2. The eosinophil and bronchial asthma: Current understanding
3. Eosinophils express interleukin 5 and granulocyte-macrophage colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics
4. IL-5 is the predominant eosinophil-active cytokine in the antigen-induced pulmonary late-phase reaction
5. Granulocyte macrophage colony-stimulating factor is the main cytokine enhancing survival of eosinophils in asthmatic airways
6. Induction of apoptosis in human eosinophils by anti-Fas antibody treatment in vitro
7. Fas-mediated apoptosis in cultured human eosinophils
8. Expression and function of the Fas receptor on human blood and tissue eosinophils
9. Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: Implications for the regulation of apoptosis in neutrophils
10. Analysis of the survival of mature human eosinophils: Interleukin- 5 prevents apoptosis in mature human eosinophils
11. Analysis of the structure, transcripts, and protein products of bcl- 2, the gene involved in human follicular lymphoma
12. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
13. Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines
14. bcl-2 Protooncogene expression in normal and neoplastic human myeloid cells
15. + T lymphocytes in acute infectious mononucleosis supporting their susceptibility to programmed cell death
16. Bcl- 2 and the regulation of programmed cell death
17. Human eosinophils express bcl-2 family proteins: Modulation of Mcl-1 expression by IFN-gamma
18. Apoptosis, proliferation, and expression of Bcl-2, Fas, and Fas ligand in bronchial biopsies from asthmatics
19. Expression of Bcl-2 and its homologues in human eosinophils: Modulation by interleukin- 5
20. Role for Bcl-xL in delayed eosinophil apoptosis mediated by granulocyte-macrophage colony-stimulating factor and interleukin- 5
21. Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition
22. Modulation of cytokine-induced eosinophil infiltration by phosphodiesterase inhibitors
23. Theophylline - An immunomodulatory role in asthma?
24. The effect of theophylline and enprofylline on allergen-induced bronchoconstriction
25. Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: Interaction with the beta adrenoceptor agonist albuterol
26. Eosinophil apoptosis caused by theophylline, glucocorticoids, and macrolides after stimulation with IL- 5
27. Effects of intracellular cyclic AMP modulators on human eosinophil survival, degranulation and CD 11b expression
28. Interleukin-5 downregulates tumor necrosis factor-induced eotaxin messenger RNA expression in eosinophils: Induction of eotaxin mRNA by TNF and IL- 5 in eosinophils
29. Inhibition of programmed eosinophil death: A key pathogenic event for eosinophilia?
30. Theophylline, a new inducer of apoptosis in B-CLL: Role of cyclic nucleotides
31. Immunoblot analysis of cellular expression of Bcl-2 family proteins, Bcl-2, Bax, Bcl-X and Mcl- 1, in human peripheral blood and lymphoid tissues
32. Phosphodiesterase inhibitors: New opportunities for the treatment of asthma
33. Cyclic AMP-elevating agents prolong or inhibit eosinophil survival depending on prior exposure to GM-CSF
34. Selective differentiation and proliferation of hematopoietic cells induced by recombinant human interleukins
35. IL-5 but not interferon-gamma (IFN-gamma) inhibits eosinophil apoptosis by up-regulation of bcl- 2 expression