CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1

European Journal of Pharmacology

Volumn 668, Issue 3, 2011, Pages 443-449

  Braber, Saskia ^a   Overbeek, Saskia A ^a   Koelink, Pim J ^a   Henricks, Paul A J ^a   Zaman, Guido J R ^b   Garssen, Johan ^a,c   Kraneveld, Aletta D ^a   Folkerts, Gert ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b MERCK RESEARCH LABORATORIES   (United States)

^c DANONE RESEARCH   (Netherlands)

Author keywords

COPD; CXCR2; Lung inflammation; N Ac PGP; Neutrophils

Indexed keywords

1 (2 BROMOPHENYL) 3 (2 HYDROXY 4 NITROPHENYL)UREA; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; CXCL1 CHEMOKINE; MYELOPEROXIDASE; N ACETYLPROLYLGLYCYLPROLINE; SB 332235; TRIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG MECHANISM; ENZYME INHIBITION; HOMOGENATE; IMMUNOHISTOLOGY; IN VIVO STUDY; INNATE IMMUNITY; LEUKOCYTE ACTIVATION; LEUKOCYTE MIGRATION; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CXCL1; CHEMOTAXIS, LEUKOCYTE; LUNG; MALE; MICE; MICE, INBRED C57BL; NEUTROPHIL INFILTRATION; NEUTROPHILS; OLIGOPEPTIDES; PEROXIDASE; PHENYLUREA COMPOUNDS; RECEPTORS, INTERLEUKIN-8B;

EID: 80052030404     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.03.025     Document Type: Article

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