Airway inflammation after controlled exposure to diesel exhaust particulates

American Journal of Respiratory and Critical Care Medicine

Volumn 162, Issue 1, 2000, Pages 161-166

  Nightingale, Julia A ^a,b   Maggs, Richard ^a   Cullinan, Paul ^a   Donnelly, Louise E ^a   Rogers, Duncan F ^a   Kinnersley, Robert ^a   Chung, K Fan ^a   Barnes, Peter J ^a   Ashmore, Michael ^a   Newman Taylor, Anthony ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; EXHAUST GAS; EXPOSURE; FEMALE; HOSPITAL ADMISSION; HUMAN; INFLAMMATION; INFLAMMATORY CELL; LUNG FUNCTION; LUNG HOMOGENATE; MALE; OXIDATIVE STRESS; PARTICULATE MATTER; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; SPIROMETRY;

EID: 0033909355     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.162.1.9908092     Document Type: Article

References (47)

1. 1. Pope, C. A., III, D. W. Dockery, and J. Schwartz. 1995. Review of epidemiological evidence of health effects of particulate air pollution. Inhal. Toxicol. 7:1-18.
2. 2. Department of the Environment Expert Panel on Air Quality Standards. 1995. Particles. Her Majesty's Stationery Office, London.
3. 3. Reger, R., J. Hancock, J. Hankinson, F. Hearl, and J. Merchant. 1982. Coal miners exposed to diesel exhaust emissions. Ann. Occup. Hygiene 26:799-815.
4. 2 and respirable particulate on respiratory system. Environ. Res. 42:201-214.
5. 5. Gamble, J., W. Jones, and S. Minshall. 1987. Epidemiological-environmental study of bus garage workers: chronic effects of diesel exhaust on the respiratory system. Environ. Res. 44:6-17.
6. 6. Ulfvarson, U., R. Alexandersson, L. Aringer, E. Svensson, G. Hedenstierna, C. Hogstedt, B. Holmberg, G. Rosén, and M. Sorsa. 1987. Effects of exposure to vehicle exhaust on health. Scand. J. Work Environ. Health 13:505-512.
7. 7. Ulfvarson, U., and R. Alexandersson. 1990. Reduction in adverse effect on pulmonary function after exposure to filtered diesel exhaust. Am. J. Ind. Med. 17:341-347.
8. 8. Ulfvarson, U., R. Alexandersson, M. Dahlqvist, U. Ekholm, and B. Bergström. 1991. Pulmonary function in workers exposed to diesel exhausts: the effect of control measures. Am. J. Ind. Med. 19:283-289.
9. 9. Rudell, B., T. Sandström, U. Hammarström, M. L. Ledin, P. Hörstedt, and N. Stjernberg. 1994. Evaluation of an exposure setup for studying effects of diesel exhaust in humans. Int. Arch. Occup. Environ. Health 66:77-83.
10. 10. Rudell, B., M.-C. Ledin, U. Hammarström, N. Stjernberg, B. Lundbäck, and T. Sandström. 1996. Effects on symptoms and lung function in humans experimentally exposed to diesel exhaust. Occup. Environ. Med. 53:658-662.
11. 11. Salvi, S., A. Blomberg, B. Rudell, F. Kelly, T, Sandström, S. T. Holgate, and A. Frew. 1999. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am. J. Respir. Crit. Care Med. 159:702-709.
12. 12. Richards, R. J. 1997. Small particles, big problems. Biologist 44:249-251.
13. 13. Li, X. Y., D. Brown, S. Smith, W. MacNee, and K. Donaldson. 1999. Short-term inflammatory responses following intratracheal instillation of fine and ultrafine carbon black in rats. Inhal. Toxicol. 11:709-731.
14. 14. Zhang, Q., Y. Kusaka, K. Sato, K. Nakakuki, N. Kohyama, and K. Donaldson. 1998. Differences in the extent of inflammation caused by intratracheal exposure to three ultrafine metals: role of free radicals. J. Toxicol. Environ. Health 53:423-438.
15. 15. Barni-Comparini, I., G. Lungarella, and L. Fonzi. 1982. Response of lung enzyme activities in rabbits following short-term exposure to n-hexane: correlation between morphological and biochemical changes. Agents Actions 12:737-742.
16. 16. Arcoumanis, C., L. N. Barbaris, R. I. Crane, and P. Wisby. 1994. Evaluation of a cyclone-based particulate filtration system for high-speed diesel engines. Proc. Inst. Mech. Eng. (Part D: J. Auto. Eng.) 208:269-279.
17. 17. Reinhold, R. B., and J. Fine. 1971. A technique for quantitative measurement of endotoxin in human plasma. Proc. Soc. Exp. Biol. Med. 137: 334-340.
18. 18. Chai, H., R. S. Farr, L. A. Froelich, D. A. Mathison, J. A. McLean, R. R. Rosenthal, A. L. Sheffer, S. L. Spector, and R. G. Townley. 1975. Standardization of bronchial challenge procedures. J. Allergy Clin. Immu nol. 56:323-327.
19. 19. Horváth, I., L. E. Donnelly, A. Kiss, P. Paredi, S. A. Kharitonov, and P. J. Barnes. 1998. Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress. Thorax 53:668-672.
20. 20. Nightingale, J. A., D. F. Rogers, and P. J. Barnes. 1998. The effect of repeated sputum induction on cell counts in normal volunteers. Thorax 53:87-90.
21. 21. Nightingale, J. A., D. F. Rogers, L. A. Hart, S. A. Kharitonov, K. F. Chung, and P. J. Barnes. 1998. Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects. Thorax 53:563-571.
22. 22. Chinn, S. 1991. Repeatability and method comparison. Thorax 46:454-456.
23. 23. Department of the Environment, Transport and the Regions. 1998. Air pollution in the UK. National Environmental Technology Centre, Abingdon.
24. 24. Airborne Particles Expert Group. 1999. Source apportionment of airborne particulate matter in the United Kingdom. Dep. Environ., Transport and the Regions, London.
25. 25. Watt, M., D. Godden, J. Cherrie, and A. Seaton. 1995. Individual exposure to particulate air pollution and its relevance to thresholds for health effects: a study of traffic wardens. Occup. Environ. Med. 52: 790-792.
26. 26. Bevan, M. A. J., J. C. Proctor, J. Baker-Rogers, and N. D. Warren. 1991. Exposure to carbon monoxide, respirable suspended particulates, and volatile organic compounds while commuting by bicycle. Environ. Sci. Technol. 25:788-791.
27. 27. Guillemin, M. P., H. Herrera, C. K. Huynh, P.-O. Droz, and T. Vu Duc. 1992. Occupational exposure of truck drivers to dust and polynuclear aromatic hydrocarbons: a pilot study in Geneva, Switzerland. Int. Arch. Occup. Environ. Health 63:439-447.
28. 28. BéruBé, K., T. Jones, and B. Williamson. 1997. Electron microscopy of urban airborne particulate matter. Microsc. and Anal. 61:11-13.
29. 29. Hackney, J. D., F. C. Thiede, W. S. Linn, E. E. Pedersen, C. E. Spier, D. C. Law, and D. A. Fischer. 1978. Experimental studies on human health effects of air pollutants: IV. Short-term physiological and clinical effects of nitrogen dioxide exposure. Arch. Environ. Health 33: 176-181.
30. 30. Bourne, H. G. J., and S. Seferian. 1959. Insufficiently polymerized resins, used for wrinkle-proofing clothing, may liberate toxic quantities of formaldehyde. Ind. Med. Surg. 2:232-233.
31. 31. Cernansky, N. P. 1983. Diesel exhaust odor and irritants: a review. J. Air Pollut. Cont. Assoc. 33:97-104.
32. 10) in vivo and in vitro. Thorax 51:1216-1222.
33. 33. Blomberg, A., C. Sainsbury, B. Rudell, A. J. Frew, S. T. Holgate, T. Sandström, and F. J. Kelly. 1998. Nasal cavity lining fluid ascorbic acid concentration increases in healthy human volunteers following short term exposure to diesel exhaust. Free Radic. Res. 28:59-67.
34. 34. Tenhunen, R., H. S. Marver, and R. Schmid. 1968. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc. Nat. Acad. Sci. U.S.A. 61:748-755.
35. 35. Choi, A. M. K., and J. Alam. 1996. Heme oxygenase-1: function, regulation, and implication of a novel stress-induced protein in oxidant-induced lung injury. Am. J. Respir. Cell Mol. Biol. 15:9-19.
36. 36. Camhi, S. L., P. Lee, and A. M. K. Choi. 1995. The oxidative stress response. New Horiz. 3:170-182.
37. 37. Stocker, R., Y. Yamamoto, A. F. McDonagh, A. N. Glazer, and B. N. Ames. 1987. Bilirubin is an antioxidant of possible physiological importance. Science 235:1043-1046.
38. 38. Vogt, B. A., J. Alam, A. J. Croatt, G. M. Vercellotti, and K. A. Nath. 1995. Acquired resistance to acute oxidative stress: possible role of heme oxygenase and ferritin. Lab. Invest. 72:474-183.
39. 39. Zayasu, K., K. Sekizawa, S. Okinaga, M. Yamaya, T. Ohrui, and H. Sasaki. 1997. Increased carbon monoxide in exhaled air of asthmatic patients. Am. J. Respir. Crit. Care Med 156:1140-1143.
40. 40. Zetterquist, W., J. O. N. Lundberg, E. Weitzberg, P. Wennerholm, S. L. Nordvall, and K. Alving. 1999. Comparison of exhaled carbon monoxide and nitric oxide in asthmatics and atopies. Eur. Respir. J. 14(Suppl. 30):171s.
41. 41. Rudell, B., T. Sandström, N. Stjernberg, and B. Kolmodin-Hedman. 1990. Controlled diesel exhaust exposure in an exposure chamber: pulmonary effects investigated with bronchoalveolar lavage. J. Aerosol Sci. 21(Suppl. 1):S411-S414.
42. 42. Bayram, H., J. L. Devalia, R. J. Sapsford, T. Ohtoshi, Y. Miyabara, M. Sagai, and R. J. Davies. 1998. The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am. J. Respir. Cell Mol Biol. 18:441-448.
43. 43. Ohtoshi, T., H. Takizawa, H. Okazaki, S. Kawasaki, N. Takeuchi, K. Ohta, and K. Ito. 1998. Diesel exhaust particles stimulate human airway epithelial cells to produce cytokines relevant to airway inflammation in vitro. J. Allergy Clin. Immunol. 101:778-785.
44. 44. Steerenberg, P. A., J. A. J. Zonnenberg, J. A. M. A. Dormans, P. N. T. Joon, I. M. Wouters, L. van Bree, P. T. J. Scheepers, and H. Van Loveren. 1998. Diesel exhaust particles induced release of interleukin 6 and 8 by (primed) human bronchial epithelial cells (BEAS 2B) in vitro. Exp. Lung Res. 24:85-100.
45. 45. Pavord, I. D., M. M. Pizzichini, E. Pizzichini, and F. E. Hargreave. 1997. The use of induced sputum to investigate airway inflammation. Thorax 52:498-501.
46. 46. Diaz-Sanchez, D., A. Tsien, A. Casillas, A. R. Dotson, and A. Saxon. 1996. Enhanced nasal cytokine production in human beings after in vivo challenge with diesel exhaust particles. J. Allergy Clin. Immunol. 98:114-123.
47. 47. Bloemen, P. G. M., P. A. J. Henricks, and F. P. Nijkamp. 1997. Cell adhesion molecules and asthma. Clin. Exp. Allergy 27:128-141.