InflammasomeIL-1Th17 response in allergic lung inflammation

Journal of Molecular Cell Biology

Volumn 4, Issue 1, 2012, Pages 3-10

  Besnard, Anne Gaelle ^a   Togbe, Dieudonnée ^a,b   Couillin, Isabelle ^a   Tan, Zoming ^a   Zheng, Song Guo ^c   Erard, François ^a   Le Bert, Marc ^a   Quesniaux, Valérie ^a   Ryffel, Bernhard ^a,d  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b Centre d'Innovation   (France)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

asthma; IL 1; IL 17; IL 22; NLRP3 inflammasome; Th17 cells

Indexed keywords

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 22; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 4; URIC ACID;

ALLERGIC ASTHMA; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; NONHUMAN; PNEUMONIA; PROTEIN FUNCTION; REVIEW; TH17 CELL; ANIMAL; CELL DIFFERENTIATION; IMMUNOLOGY; METABOLISM; MOUSE; SECRETION; SIGNAL TRANSDUCTION; TH2 CELL;

MUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; INFLAMMASOMES; INTERLEUKIN-1; INTERLEUKIN-17; INTERLEUKIN-1BETA; INTERLEUKINS; MICE; PNEUMONIA; SIGNAL TRANSDUCTION; TH17 CELLS; TH2 CELLS; TOLL-LIKE RECEPTOR 4; URIC ACID;

EID: 84856891935     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjr042     Document Type: Review

References (95)

1. Acosta-Rodriguez, E.V., Napolitani, G., Lanzavecchia, A., et al. (2007). Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8, 942-949. (Pubitemid 47300008)
2. Akira, S., Uematsu, S., and Takeuchi, O. (2006). Pathogen recognition and innate immunity. Cell 124, 783-801. (Pubitemid 43261452)
3. Andersson, U., and Tracey, K.J. (2011). HMGB1 is a therapeutic target for sterile inflammation and infection. Annu. Rev. Immunol. 29, 139-162.
4. Aujla, S.J., Chan, Y.R., Zheng, M., et al. (2008). IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med. 14, 275-281. (Pubitemid 351347908)
5. Besnard, A.G., Guillou, N., Tschopp, J., et al. (2011a). NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant. Allergy 66, 1047-1057.
6. Besnard, A.G., Sabat, R., Dumoutier, L., et al. (2011b). Dual role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. Am. J. Respir. Crit. Care Med. 183, 1153-1163.
7. Besnard, A.G., Togbe, D., Guillou, N., et al. (2011c). IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur. J. Immunol. 41, 1675-1686.
8. Bettelli, E., Korn, T., and Kuchroo, V.K. (2007a). Th17: The third member of the effector T cell trilogy. Curr. Opin. Immunol. 19, 652-657. (Pubitemid 350236805)
9. Bettelli, E., Oukka, M., and Kuchroo, V.K. (2007b). TH-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 8, 345-350. (Pubitemid 46745409)
10. Bettelli, E., Korn, T., Oukka, M., et al. (2008). Induction and effector functions of TH17 cells. Nature 453, 1051-1057. (Pubitemid 351871737)
11. Beutler, B., Jiang, Z., Georgel, P., et al. (2006). Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu. Rev. Immunol. 24, 353-389.
12. Bullens, D.M., Truyen, E., Coteur, L., et al. (2006). IL-17 mRNA in sputum of asthmatic patients: Linking T cell driven inflammation and granulocytic influx? Respir. Res. 7, 135.
13. Chamaillard, M., Hashimoto, M., Horie, Y., et al. (2003). An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat. Immunol. 4, 702-707. (Pubitemid 36874448)
14. Chung, Y., Chang, S.H., Martinez, G.J., et al. (2009). Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30, 576-587.
15. Conti, H.R., Shen, F., Nayyar, N., et al. (2009). Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. 206, 299-311.
16. Couillin, I., Maillet, I., Vargaftig, B.B., et al. (2004). Arthropod-derived histamine-binding protein prevents murine allergic asthma. J. Immunol. 173, 3281-3286. (Pubitemid 39142036)
17. Dumoutier, L., Louahed, J., and Renauld, J.C. (2000a). Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J. Immunol. 164, 1814-1819. (Pubitemid 30108734)
18. Dumoutier, L., Van Roost, E., Colau, D., et al. (2000b). Human interleukin-10- related T cell-derived inducible factor: Molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc. Natl Acad. Sci. USA 97, 10144-10149.
19. Dumoutier, L., Lejeune, D., Colau, D., et al. (2001). Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cellderived inducible factor/IL-22. J. Immunol. 166, 7090-7095. (Pubitemid 32525578)
20. Eisenbarth, S.C., Piggott, D.A., Huleatt, J.W., et al. (2002). Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196, 1645-1651. (Pubitemid 36026476)
21. Ferretti, S., Bonneau, O., Dubois, G.R., et al. (2003). IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J. Immunol. 170, 2106-2112. (Pubitemid 36197433)
22. Gasse, P., Mary, C., Guenon, I., et al. (2007). IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J. Clin. Invest. 117, 3786-3799. (Pubitemid 350224089)
23. Gasse, P., Riteau, N., Charron, S., et al. (2009). Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am. J. Respir. Crit. Care Med. 179, 903-913.
24. Gasse, P., Riteau, N., Vacher, R., et al. (2011). IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis. PLoS One 6, e23185.
25. Hammad, H., and Lambrecht, B.N. (2008). Dendritic cells and epithelial cells: Linking innate and adaptive immunity in asthma. Nat. Rev. Immunol. 8, 193-204. (Pubitemid 351323293)
26. Hammad, H., Chieppa, M., Perros, F., et al. (2009). House dust mite allergen induces asthma via toll-like receptor 4 triggering of airway structural cells. Nat. Med. 15, 410-416.
27. Hoffman, H.M., and Wanderer, A.A. (2010). Inflammasome and IL-1beta-mediated disorders. Curr. Allergy Asthma Rep. 10, 229-235.
28. Hoshino, H., Laan, M., Sjostrand, M., et al. (2000). Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo. J. Allergy Clin. Immunol. 105, 143-149. (Pubitemid 30059114)
29. Huh, J.R., Leung, M.W., Huang, P., et al. (2011). Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORgammat activity. Nature 472, 486-490.
30. Idzko, M., Hammad, H., van Nimwegen, M., et al. (2007). Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat. Med. 13, 913-919. (Pubitemid 47222044)
31. Ivanov, S., Palmberg, L., Venge, P., et al. (2005). Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust. Respir. Res. 6, 44.
32. Kennedy, S.M., Christiani, D.C., Eisen, E.A., et al. (1987). Cotton dust and endotoxin exposure-response relationships in cotton textile workers. Am. Rev. Respir. Dis. 135, 194-200. (Pubitemid 17223913)
33. Kolls, J.K., and Linden, A. (2004). Interleukin-17 family members and inflammation. Immunity 21, 467-476. (Pubitemid 39370503)
34. Kool, M., Soullie, T., van Nimwegen, M., et al. (2008). Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J. Exp. Med. 205, 869-882. (Pubitemid 351549884)
35. Kool, M., Willart, M.A., van Nimwegen, M., et al. (2011). An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity 34, 527-540.
36. Korn, T., Bettelli, E., Gao, W., et al. (2007a). IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448, 484-487. (Pubitemid 47123515)
37. Korn, T., Oukka, M., Kuchroo, V., et al. (2007b). Th17 cells: Effector T cells with inflammatory properties. Semin. Immunol. 19, 362-371. (Pubitemid 351274046)
38. Korn, T., Bettelli, E., Oukka, M., et al. (2009). IL-17 and Th17 cells. Annu. Rev. Immunol. 27, 485-517.
39. Kouzaki, H., O'Grady, S.M., Lawrence, C.B., et al. (2009). Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2. J. Immunol. 183, 1427-1434.
40. Laan, M., Cui, Z.H., Hoshino, H., et al. (1999). Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J. Immunol. 162, 2347-2352. (Pubitemid 29288861)
41. Laan, M., Prause, O., Miyamoto, M., et al. (2003). A role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF-alpha. Eur. Respir. J. 21, 387-393. (Pubitemid 36336194)
42. Lajoie, S., Lewkowich, I.P., Suzuki, Y., et al. (2010). Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nat. Immunol. 11, 928-935.
43. Lambrecht, B.N., and Hammad, H. (2003). Taking our breath away: Dendritic cells in the pathogenesis of asthma. Nat. Rev. Immunol. 3, 994-1003. (Pubitemid 37521541)
44. Lee, W.W., Kang, S.W., Choi, J., et al. (2010). Regulating human Th17 cells via differential expression of IL-1 receptor. Blood 115, 530-540.
45. Lefort, J., Motreff, L., and Vargaftig, B.B. (2001). Airway administration of Escherichia coli endotoxin to mice induces glucocorticosteroid-resistant bronchoconstriction and vasopermeation. Am. J. Respir. Cell Mol. Biol. 24, 345-351. (Pubitemid 32228384)
46. Liang, S.C., Tan, X.Y., Luxenberg, D.P., et al. (2006). Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203, 2271-2279. (Pubitemid 44498362)
47. Ma, H.L., Liang, S., Li, J., et al. (2008). IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J. Clin. Invest. 118, 597-607. (Pubitemid 351206549)
48. Magalhaes, J.G., Fritz, J.H., Le Bourhis, L., et al. (2008). Nod2-dependent Th2 polarization of antigen-specific immunity. J. Immunol. 181, 7925-7935.
49. Maillet, I., Schnyder-Candrian, S., Couillin, I., et al. (2011). Allergic lung inflammation is mediated by soluble tumor necrosis factor (TNF) and attenuated by dominant-negative TNF biologics. Am. J. Respir. Cell Mol. Biol. 45, 731-739.
50. Martin, B., Hirota, K., Cua, D.J., et al. (2009). Interleukin-17- producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity 31, 321-330.
51. Martinon, F., Petrilli, V., Mayor, A., et al. (2006). Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241. (Pubitemid 43372104)
52. Michel, O., Kips, J., Duchateau, J., et al. (1996). Severity of asthma is related to endotoxin in house dust. Am. J. Respir. Crit. Care Med. 154, 1641-1646. (Pubitemid 26424928)
53. Michel, M.L., Keller, A.C., Paget, C., et al. (2007). Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia. J. Exp. Med. 204, 995-1001. (Pubitemid 46798144)
54. Molet, S., Hamid, Q., Davoine, F., et al. (2001). IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J. Allergy Clin. Immunol. 108, 430-438. (Pubitemid 32881066)
55. Munoz, M., Heimesaat, M.M., Danker, K., et al. (2009). Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. J. Exp. Med. 206, 3047-3059.
56. Nakae, S., Komiyama, Y., Nambu, A., et al. (2002). Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17, 375-387. (Pubitemid 35279557)
57. Nakae, S., Komiyama, Y., Yokoyama, H., et al. (2003). IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response. Int. Immunol. 15, 483-490. (Pubitemid 36432401)
58. Nanno, M., Shiohara, T., Yamamoto, H., et al. (2007). gammadelta T cells: Firefighters or fire boosters in the front lines of inflammatory responses. Immunol. Rev. 215, 103-113. (Pubitemid 46212233)
59. Phipps, S., Lam, C.E., Kaiko, G.E., et al. (2009). Toll/IL-1 signaling is critical for house dust mite-specific helper T cell type 2 and type 17 [corrected] responses. Am. J. Respir. Crit. Care Med. 179, 883-893.
60. Quesniaux, V., Ryffel, B., and Di Padova, F. (2009). TH17 Cells: Role in Inflammation and Autoimmune Disease. Switzerland: Birkhäuser Verlag AG.
61. Quintana, F.J., Basso, A.S., Iglesias, A.H., et al. (2008). Control of Treg and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453, 65-71. (Pubitemid 351630328)
62. Radaeva, S., Sun, R., Pan, H.N., et al. (2004). Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39, 1332-1342. (Pubitemid 38569055)
63. Riteau, N., Gasse, P., Fauconnier, L., et al. (2010). Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am. J. Respir. Crit. Care Med. 182, 774-783.
64. Schmitz, N., Kurrer, M., and Kopf, M. (2003). The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model. Eur. J. Immunol. 33, 991-1000. (Pubitemid 36546687)
65. Schnyder-Candrian, S., Quesniaux, V.F., Di Padova, F., et al. (2005). Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome. J. Immunol. 175, 262-269. (Pubitemid 40884327)
66. Schnyder-Candrian, S., Togbe, D., Couillin, I., et al. (2006). Interleukin-17 is a negative regulator of established allergic asthma. J. Exp. Med. 203, 2715-2725. (Pubitemid 44833347)
67. Schwartz, D.A., Thorne, P.S., Yagla, S.J., et al. (1995). The role of endotoxin in grain dust-induced lung disease. Am. J. Respir. Crit. Care Med. 152, 603-608.
68. Siegemund, S., Schutze, N., Schulz, S., et al. (2009). Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis. Int. Immunol. 21, 555-565.
69. Simonian, P.L., Wehrmann, F., Roark, C.L., et al. (2010). gammadelta T cells protect against lung fibrosis via IL-22. J. Exp. Med. 207, 2239-2253.
70. Sonnenberg, G.F., Nair, M.G., Kirn, T.J., et al. (2010). Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. J. Exp. Med. 207, 1293-1305.
71. Stockinger, B., and Veldhoen, M. (2007). Differentiation and function of Th17 T cells. Curr. Opin. Immunol. 19, 281-286. (Pubitemid 46687011)
72. Sugimoto, K., Ogawa, A., Mizoguchi, E., et al. (2008). IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118, 534-544. (Pubitemid 351206544)
73. Sutton, C., Brereton, C., Keogh, B., et al. (2006). A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203, 1685-1691. (Pubitemid 44036274)
74. Sutton, C.E., Lalor, S.J., Sweeney, C.M., et al. (2009). Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 31, 331-341.
75. Takahashi, K., Hirose, K., Kawashima, S., et al. (2011). IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation. J. Allergy Clin. Immunol. 128, 1067-1076.
76. Togbe, D., Aurore, G., Noulin, N., et al. (2006a). Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways. Lab. Invest. 86, 1126-1135. (Pubitemid 44624149)
77. Togbe, D., Schnyder-Candrian, S., Schnyder, B., et al. (2006b). TLR4 gene dosage contributes to endotoxin-induced acute respiratory inflammation. J. Leukoc. Biol. 80, 451-457. (Pubitemid 44835777)
78. Trompette, A., Divanovic, S., Visintin, A., et al. (2009). Allergenicity resulting from functional mimicry of a toll-like receptor complex protein. Nature 457, 585-588.
79. Tschopp, J., Martinon, F., and Burns, K. (2003). NALPs: A novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol. 4, 95-104. (Pubitemid 36172693)
80. Veldhoen, M., Hirota, K., Westendorf, A.M., et al. (2008). The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453, 106-109. (Pubitemid 351630329)
81. Wakashin, H., Hirose, K., Maezawa, Y., et al. (2008). IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. Am. J. Respir. Crit. Care Med. 178, 1023-1032.
82. Wills-Karp, M. (1999). Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17, 255-281. (Pubitemid 29241125)
83. Wilson, N.J., Boniface, K., Chan, J.R., et al. (2007). Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat. Immunol. 8, 950-957. (Pubitemid 47300009)
84. Wolk, K., Kunz, S., Witte, E., et al. (2004). IL-22 increases the innate immunity of tissues. Immunity 21, 241-254. (Pubitemid 39094053)
85. Wolk, K., Witte, E., Wallace, E., et al. (2006). IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: A potential role in psoriasis. Eur. J. Immunol. 36, 1309-1323.
86. Wolk, K., Haugen, H.S., Xu, W., et al. (2009a). IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not. J. Mol. Med. 87, 523-536.
87. Wolk, K., Witte, E., Warszawska, K., et al. (2009b). The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: A novel immunological cascade with potential relevance in psoriasis. Eur. J. Immunol. 39, 3570-3581.
88. Xie, M.H., Aggarwal, S., Ho, W.H., et al. (2000). Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J. Biol. Chem. 275, 31335-31339.
89. Xu, M., Morishima, N., Mizoguchi, I., et al. (2011). Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production. Eur. J. Immunol. 41, 2828-2839.
90. Yang, L., Anderson, D.E., Baecher-Allan, C., et al. (2008). IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 454, 350-352.
91. Zeisel, M.B., Druet, V.A., Sibilia, J., et al. (2005). Cross talk between MyD88 and focal adhesion kinase pathways. J. Immunol. 174, 7393-7397. (Pubitemid 40705710)
92. Zenewicz, L.A., Yancopoulos, G.D., Valenzuela, D.M., et al. (2007). Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27, 647-659. (Pubitemid 47615503)
93. Zenewicz, L.A., Yancopoulos, G.D., Valenzuela, D.M., et al. (2008). Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29, 947-957.
94. Zheng, Y., Danilenko, D.M., Valdez, P., et al. (2007). Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445, 648-651. (Pubitemid 46232884)
95. Zheng, Y., Valdez, P.A., Danilenko, D.M., et al. (2008). Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med. 14, 282-289. (Pubitemid 351347912)