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Volumn 28, Issue 1, 2017, Pages 3-18

Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease

Author keywords

diabetes; exosome; miRNA; nanoparticle; obesity

Indexed keywords

ADIPOSE TISSUE; CELL COMMUNICATION; CELL INTERACTION; EXOSOME; HOMEOSTASIS; HUMAN; INTRACELLULAR SIGNALING; METABOLIC DISORDER; MICROENVIRONMENT; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; PANCREAS; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SKELETAL MUSCLE; TARGET CELL; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; PHYSIOLOGY;

EID: 85005870107     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2016.10.003     Document Type: Review
Times cited : (288)

References (125)
  • 1
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: Exosomes, microvesicles, and friends
    • 1 Raposo, G., Stoorvogel, W., Extracellular vesicles: Exosomes, microvesicles, and friends. J. Cell Biol. 200 (2013), 373–383.
    • (2013) J. Cell Biol. , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 2
    • 0020804037 scopus 로고
    • Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
    • 2 Harding, C., et al. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J. Cell Biol. 97 (1983), 329–339.
    • (1983) J. Cell Biol. , vol.97 , pp. 329-339
    • Harding, C.1
  • 3
    • 0020956787 scopus 로고
    • Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor
    • 3 Pan, B.T., Johnstone, R.M., Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 33 (1983), 967–978.
    • (1983) Cell , vol.33 , pp. 967-978
    • Pan, B.T.1    Johnstone, R.M.2
  • 4
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • 4 Valadi, H., et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9 (2007), 654–659.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 654-659
    • Valadi, H.1
  • 5
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • 5 Skog, J., et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 10 (2008), 1470–1476.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 1470-1476
    • Skog, J.1
  • 6
    • 84947723880 scopus 로고    scopus 로고
    • Tumour exosome integrins determine organotropic metastasis
    • 6 Hoshino, A., et al. Tumour exosome integrins determine organotropic metastasis. Nature 527 (2015), 329–335.
    • (2015) Nature , vol.527 , pp. 329-335
    • Hoshino, A.1
  • 7
    • 84862908547 scopus 로고    scopus 로고
    • Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes
    • 7 Montecalvo, A., et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 119 (2012), 756–766.
    • (2012) Blood , vol.119 , pp. 756-766
    • Montecalvo, A.1
  • 8
    • 85028828913 scopus 로고    scopus 로고
    • Exosomes: mechanisms of uptake
    • 8 McKelvey, K.J., et al. Exosomes: mechanisms of uptake. J. Circ. Biomarkers, 4, 2015, 1.
    • (2015) J. Circ. Biomarkers , vol.4 , pp. 1
    • McKelvey, K.J.1
  • 9
    • 84867383019 scopus 로고    scopus 로고
    • Microvesicles/exosomes as potential novel biomarkers of metabolic diseases
    • 9 Müller, G., Microvesicles/exosomes as potential novel biomarkers of metabolic diseases. Diabetes Metab. Syndr. Obes. Targets Ther. 5 (2012), 247–282.
    • (2012) Diabetes Metab. Syndr. Obes. Targets Ther. , vol.5 , pp. 247-282
    • Müller, G.1
  • 10
    • 84864539550 scopus 로고    scopus 로고
    • Exosomes and the emerging field of exosome-based gene therapy
    • 10 O'Loughlin, A.J., et al. Exosomes and the emerging field of exosome-based gene therapy. Curr. Gene Ther. 12 (2012), 262–274.
    • (2012) Curr. Gene Ther. , vol.12 , pp. 262-274
    • O'Loughlin, A.J.1
  • 11
    • 84871702725 scopus 로고    scopus 로고
    • Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation
    • 11 Kalra, H., et al. Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol., 10, 2012, e1001450.
    • (2012) PLoS Biol. , vol.10 , pp. e1001450
    • Kalra, H.1
  • 12
    • 84959288708 scopus 로고    scopus 로고
    • ExoCarta: a web-based compendium of exosomal cargo
    • 12 Keerthikumar, S., et al. ExoCarta: a web-based compendium of exosomal cargo. J. Mol. Biol. 428 (2016), 688–692.
    • (2016) J. Mol. Biol. , vol.428 , pp. 688-692
    • Keerthikumar, S.1
  • 13
    • 84878629272 scopus 로고    scopus 로고
    • Proteomics, transcriptomics and lipidomics of exosomes and ectosomes
    • 13 Choi, D-S., et al. Proteomics, transcriptomics and lipidomics of exosomes and ectosomes. Proteomics 13 (2013), 1554–1571.
    • (2013) Proteomics , vol.13 , pp. 1554-1571
    • Choi, D.-S.1
  • 14
    • 84888042782 scopus 로고    scopus 로고
    • Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma
    • 14 Kalra, H., et al. Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma. Proteomics 13 (2013), 3354–3364.
    • (2013) Proteomics , vol.13 , pp. 3354-3364
    • Kalra, H.1
  • 15
    • 77956404647 scopus 로고    scopus 로고
    • Exosomes: extracellular organelles important in intercellular communication
    • 15 Mathivanan, S., et al. Exosomes: extracellular organelles important in intercellular communication. J. Proteomics 73 (2010), 1907–1920.
    • (2010) J. Proteomics , vol.73 , pp. 1907-1920
    • Mathivanan, S.1
  • 16
    • 42749085108 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants
    • 16 Thery, C., et al. Isolation and characterization of exosomes from cell culture supernatants. Curr. Protoc. Cell Biol. 3 (2006), 1–29.
    • (2006) Curr. Protoc. Cell Biol. , vol.3 , pp. 1-29
    • Thery, C.1
  • 17
    • 84957586685 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: physiological role and signalling properties of extracellular membrane vesicles
    • 17 Iraci, N., et al. Focus on extracellular vesicles: physiological role and signalling properties of extracellular membrane vesicles. Int. J. Mol. Sci., 17, 2016, 171.
    • (2016) Int. J. Mol. Sci. , vol.17 , pp. 171
    • Iraci, N.1
  • 18
    • 0035958546 scopus 로고    scopus 로고
    • Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I
    • 18 Katzmann, D.J., et al. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 106 (2001), 145–155.
    • (2001) Cell , vol.106 , pp. 145-155
    • Katzmann, D.J.1
  • 19
    • 84942838662 scopus 로고    scopus 로고
    • ESCRTs are everywhere
    • 19 Hurley, J.H., et al. ESCRTs are everywhere. EMBO J. 34 (2015), 2398–2407.
    • (2015) EMBO J. , vol.34 , pp. 2398-2407
    • Hurley, J.H.1
  • 20
    • 84962733931 scopus 로고    scopus 로고
    • Introduction to extracellular vesicles: biogenesis, rna cargo selection, content, release, and uptake
    • 20 Abels, E.R., Breakefield, X.O., Introduction to extracellular vesicles: biogenesis, rna cargo selection, content, release, and uptake. Cell Mol. Neurobiol. 36 (2016), 1–12.
    • (2016) Cell Mol. Neurobiol. , vol.36 , pp. 1-12
    • Abels, E.R.1    Breakefield, X.O.2
  • 21
    • 67249110996 scopus 로고    scopus 로고
    • Multivesicular endosome biogenesis in the absence of ESCRTs
    • 21 Stuffers, S., et al. Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic 10 (2009), 925–937.
    • (2009) Traffic , vol.10 , pp. 925-937
    • Stuffers, S.1
  • 22
    • 84863206297 scopus 로고    scopus 로고
    • Syndecan-syntenin-ALIX regulates the biogenesis of exosomes
    • 22 Baietti, M.F., et al. Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. Nat. Cell Biol. 14 (2012), 677–685.
    • (2012) Nat. Cell Biol. , vol.14 , pp. 677-685
    • Baietti, M.F.1
  • 23
    • 77952920881 scopus 로고    scopus 로고
    • Secretory mechanisms and intercellular transfer of microRNAs in living cells
    • 23 Kosaka, N., et al. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J. Biol. Chem. 285 (2010), 17442–17452.
    • (2010) J. Biol. Chem. , vol.285 , pp. 17442-17452
    • Kosaka, N.1
  • 24
    • 40049112564 scopus 로고    scopus 로고
    • Ceramide triggers budding of exosome vesicles into multivesicular endosomes
    • 24 Trajkovic, K., et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319 (2008), 1244–1247.
    • (2008) Science , vol.319 , pp. 1244-1247
    • Trajkovic, K.1
  • 25
    • 79953136097 scopus 로고    scopus 로고
    • Rab27a and Rab27b control different steps of the exosome secretion pathway
    • 25 Ostrowski, M., et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat. Cell Biol. 12 (2010), 19–30.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 19-30
    • Ostrowski, M.1
  • 26
    • 70450170492 scopus 로고    scopus 로고
    • ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles
    • 26 Muralidharan-Chari, V., et al. ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles. Curr. Biol. 19 (2009), 1875–1885.
    • (2009) Curr. Biol. , vol.19 , pp. 1875-1885
    • Muralidharan-Chari, V.1
  • 27
    • 69849100452 scopus 로고    scopus 로고
    • Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner
    • 27 Lima, L.G., et al. Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner. Cancer Lett. 283 (2009), 168–175.
    • (2009) Cancer Lett. , vol.283 , pp. 168-175
    • Lima, L.G.1
  • 28
    • 0036906477 scopus 로고    scopus 로고
    • Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomes
    • 28 Théry, C., et al. Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomes. Nat. Immunol. 3 (2002), 1156–1162.
    • (2002) Nat. Immunol. , vol.3 , pp. 1156-1162
    • Théry, C.1
  • 29
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • 29 Alvarez-Erviti, L., et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 29 (2011), 341–345.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 341-345
    • Alvarez-Erviti, L.1
  • 30
    • 84871923602 scopus 로고    scopus 로고
    • Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells
    • 30 Ohno, S., et al. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol. Ther. 21 (2013), 185–191.
    • (2013) Mol. Ther. , vol.21 , pp. 185-191
    • Ohno, S.1
  • 31
    • 77953154769 scopus 로고    scopus 로고
    • Cellular internalization of exosomes occurs through phagocytosis
    • 31 Feng, D., et al. Cellular internalization of exosomes occurs through phagocytosis. Traffic 11 (2010), 675–687.
    • (2010) Traffic , vol.11 , pp. 675-687
    • Feng, D.1
  • 32
    • 84879046970 scopus 로고    scopus 로고
    • Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid raft-mediated endocytosis negatively regulated by caveolin-1
    • 32 Svensson, K.J., et al. Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid raft-mediated endocytosis negatively regulated by caveolin-1. J. Biol. Chem. 288 (2013), 17713–17724.
    • (2013) J. Biol. Chem. , vol.288 , pp. 17713-17724
    • Svensson, K.J.1
  • 33
    • 84929353279 scopus 로고    scopus 로고
    • Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters
    • 33 Lai, C.P., et al. Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters. Nat. Commun., 6, 2015, 7029.
    • (2015) Nat. Commun. , vol.6 , pp. 7029
    • Lai, C.P.1
  • 34
    • 77957269172 scopus 로고    scopus 로고
    • Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy
    • 34 Tian, T., et al. Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy. J. Cell Biochem. 111 (2010), 488–496.
    • (2010) J. Cell Biochem. , vol.111 , pp. 488-496
    • Tian, T.1
  • 35
    • 84929506373 scopus 로고    scopus 로고
    • Ectosomes and exosomes: shedding the confusion between extracellular vesicles
    • 35 Cocucci, E., et al. Ectosomes and exosomes: shedding the confusion between extracellular vesicles. Trends Cell Biol. 25 (2015), 364–372.
    • (2015) Trends Cell Biol. , vol.25 , pp. 364-372
    • Cocucci, E.1
  • 36
    • 85026337731 scopus 로고    scopus 로고
    • Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes
    • 36 Crescitelli, R., et al. Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes. J. Extracell. Vesicles, 2013, 2 http://dx.doi.org/0.3402/jev.v2i0.20677.
    • (2013) J. Extracell. Vesicles , pp. 2
    • Crescitelli, R.1
  • 37
    • 0035933154 scopus 로고    scopus 로고
    • Horizontal transfer of oncogenes by uptake of apoptotic bodies
    • 37 Bergsmedh, A., et al. Horizontal transfer of oncogenes by uptake of apoptotic bodies. Proc. Natl. Acad. Sci. U.S.A. 98 (2001), 6407–6411.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 6407-6411
    • Bergsmedh, A.1
  • 38
    • 85013654823 scopus 로고    scopus 로고
    • Routes and mechanisms of extracellular vesicle uptake
    • 38 Mulcahy, L.A., et al. Routes and mechanisms of extracellular vesicle uptake. J. Extracell. Vesicles, 2014, 3.
    • (2014) J. Extracell. Vesicles , pp. 3
    • Mulcahy, L.A.1
  • 39
    • 0842277810 scopus 로고    scopus 로고
    • Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors
    • 39 Hawari, F.I., et al. Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors. Proc. Natl. Acad. Sci. U.S.A. 101 (2004), 1297–1302.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 1297-1302
    • Hawari, F.I.1
  • 40
    • 84890149349 scopus 로고    scopus 로고
    • Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles
    • 40 Menck, K., et al. Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles. Oncotarget 4 (2013), 2057–2066.
    • (2013) Oncotarget , vol.4 , pp. 2057-2066
    • Menck, K.1
  • 41
    • 84857968441 scopus 로고    scopus 로고
    • The majority of microRNAs detectable in serum and saliva is concentrated in exosomes
    • 41 Gallo, A., et al. The majority of microRNAs detectable in serum and saliva is concentrated in exosomes. PLoS ONE 7 (2012), 1–5.
    • (2012) PLoS ONE , vol.7 , pp. 1-5
    • Gallo, A.1
  • 42
    • 71749102668 scopus 로고    scopus 로고
    • Microenvironmental pH is a key factor for exosome traffic in tumor cells
    • 42 Parolini, I., et al. Microenvironmental pH is a key factor for exosome traffic in tumor cells. J. Biol. Chem. 284 (2009), 34211–34222.
    • (2009) J. Biol. Chem. , vol.284 , pp. 34211-34222
    • Parolini, I.1
  • 43
    • 8644286802 scopus 로고    scopus 로고
    • Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells
    • 43 Morelli, A.E., et al. Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood 104 (2004), 3257–3266.
    • (2004) Blood , vol.104 , pp. 3257-3266
    • Morelli, A.E.1
  • 44
    • 84887203299 scopus 로고    scopus 로고
    • Microparticle increase in severe obesity: not related to metabolic syndrome and unchanged after massive weight loss
    • 44 Stepanian, A., et al. Microparticle increase in severe obesity: not related to metabolic syndrome and unchanged after massive weight loss. Obesity (Silver Spring) 21 (2013), 2236–2243.
    • (2013) Obesity (Silver Spring) , vol.21 , pp. 2236-2243
    • Stepanian, A.1
  • 45
    • 0036724722 scopus 로고    scopus 로고
    • Type 1 and type 2 diabetic patients display different patterns of cellular microparticles
    • 45 Sabatier, F., et al. Type 1 and type 2 diabetic patients display different patterns of cellular microparticles. Diabetes 51 (2002), 2840–2845.
    • (2002) Diabetes , vol.51 , pp. 2840-2845
    • Sabatier, F.1
  • 46
    • 40749110620 scopus 로고    scopus 로고
    • Microparticles and type 2 diabetes
    • 46 Leroyer, A.S., et al. Microparticles and type 2 diabetes. Diabetes Metab. 34:Suppl 1 (2008), S27–S32.
    • (2008) Diabetes Metab. , vol.34 , pp. S27-S32
    • Leroyer, A.S.1
  • 47
    • 84956620363 scopus 로고    scopus 로고
    • Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease
    • 47 Povero, D., et al. Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease. PLoS ONE, 9, 2014, e113651.
    • (2014) PLoS ONE , vol.9 , pp. e113651
    • Povero, D.1
  • 48
    • 84885751710 scopus 로고    scopus 로고
    • Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells
    • 48 Povero, D., et al. Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells. Sci. Signal., 6, 2013, ra88.
    • (2013) Sci. Signal. , vol.6 , pp. ra88
    • Povero, D.1
  • 49
    • 84899927111 scopus 로고    scopus 로고
    • Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages
    • 49 Kranendonk, M.E.G., et al. Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages. Obesity (Silver Spring) 22 (2014), 1296–1308.
    • (2014) Obesity (Silver Spring) , vol.22 , pp. 1296-1308
    • Kranendonk, M.E.G.1
  • 50
    • 84961884153 scopus 로고    scopus 로고
    • Extracellular vesicles: a new frontier in biomarker discovery for non-alcoholic fatty liver disease
    • 50 Ban, L.A., et al. Extracellular vesicles: a new frontier in biomarker discovery for non-alcoholic fatty liver disease. Int. J. Mol. Sci., 17, 2016, 376.
    • (2016) Int. J. Mol. Sci. , vol.17 , pp. 376
    • Ban, L.A.1
  • 51
    • 84930929895 scopus 로고    scopus 로고
    • Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease
    • 51 Ferrante, S.C., et al. Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease. Pediatr. Res. 77 (2015), 447–454.
    • (2015) Pediatr. Res. , vol.77 , pp. 447-454
    • Ferrante, S.C.1
  • 52
    • 84978153365 scopus 로고    scopus 로고
    • Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress
    • 52 Eguchi, A., et al. Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress. J. Mol. Med. (Berl) 94 (2016), 1241–1253.
    • (2016) J. Mol. Med. (Berl) , vol.94 , pp. 1241-1253
    • Eguchi, A.1
  • 53
    • 84870746025 scopus 로고    scopus 로고
    • Circulating miRNA profiles in patients with metabolic syndrome
    • 53 Karolina, D.S., et al. Circulating miRNA profiles in patients with metabolic syndrome. J. Clin. Endocrinol. Metab. 97 (2012), E2271–E2276.
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , pp. E2271-E2276
    • Karolina, D.S.1
  • 54
    • 4444226979 scopus 로고    scopus 로고
    • Identification and proteomic profiling of exosomes in human urine
    • 54 Pisitkun, T., et al. Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. U.S.A. 101 (2004), 13368–13373.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 13368-13373
    • Pisitkun, T.1
  • 55
    • 0141737555 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-IV expression and activity in human glomerular endothelial cells
    • 55 Pala, L., et al. Dipeptidyl peptidase-IV expression and activity in human glomerular endothelial cells. Biochem. Biophys. Res. Commun. 310 (2003), 28–31.
    • (2003) Biochem. Biophys. Res. Commun. , vol.310 , pp. 28-31
    • Pala, L.1
  • 56
    • 84926638859 scopus 로고    scopus 로고
    • Use and isolation of urinary exosomes as biomarkers for diabetic nephropathy
    • 56 Musante, L., et al. Use and isolation of urinary exosomes as biomarkers for diabetic nephropathy. Front. Endocrinol. (Lausanne), 5, 2014, 149.
    • (2014) Front. Endocrinol. (Lausanne) , vol.5 , pp. 149
    • Musante, L.1
  • 57
    • 84868268464 scopus 로고    scopus 로고
    • Comprehensive miRNA expression analysis in peripheral blood can diagnose liver disease
    • 57 Murakami, Y., et al. Comprehensive miRNA expression analysis in peripheral blood can diagnose liver disease. PLoS ONE, 7, 2012, e48366.
    • (2012) PLoS ONE , vol.7 , pp. e48366
    • Murakami, Y.1
  • 58
    • 84862742231 scopus 로고    scopus 로고
    • Circulating microparticles as disease-specific biomarkers of severity of inflammation in patients with hepatitis C or nonalcoholic steatohepatitis
    • 58 Kornek, M., et al. Circulating microparticles as disease-specific biomarkers of severity of inflammation in patients with hepatitis C or nonalcoholic steatohepatitis. Gastroenterology 143 (2012), 448–458.
    • (2012) Gastroenterology , vol.143 , pp. 448-458
    • Kornek, M.1
  • 59
    • 54749114466 scopus 로고    scopus 로고
    • It's not how fat you are, it's what you do with it that counts
    • 59 Virtue, S., Vidal-Puig, A., It's not how fat you are, it's what you do with it that counts. PLoS Biol., 6, 2008, e237.
    • (2008) PLoS Biol. , vol.6 , pp. e237
    • Virtue, S.1    Vidal-Puig, A.2
  • 60
    • 57749200704 scopus 로고    scopus 로고
    • Induced release of membrane vesicles from rat adipocytes containing glycosylphosphatidylinositol-anchored microdomain and lipid droplet signalling proteins
    • 60 Muller, G., et al. Induced release of membrane vesicles from rat adipocytes containing glycosylphosphatidylinositol-anchored microdomain and lipid droplet signalling proteins. Cell. Signal. 21 (2009), 324–338.
    • (2009) Cell. Signal. , vol.21 , pp. 324-338
    • Muller, G.1
  • 61
    • 20744436655 scopus 로고    scopus 로고
    • Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins
    • 61 Lancaster, G.I., Febbraio, M.A., Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins. J. Biol. Chem. 280 (2005), 23349–23355.
    • (2005) J. Biol. Chem. , vol.280 , pp. 23349-23355
    • Lancaster, G.I.1    Febbraio, M.A.2
  • 62
    • 34547121209 scopus 로고    scopus 로고
    • Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: Redox- and hormone-dependent induction of milk fat globule-epidermal growth factor 8-associated microvesicles
    • 62 Aoki, N., et al. Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: Redox- and hormone-dependent induction of milk fat globule-epidermal growth factor 8-associated microvesicles. Endocrinology 148 (2007), 3850–3862.
    • (2007) Endocrinology , vol.148 , pp. 3850-3862
    • Aoki, N.1
  • 63
    • 77955415911 scopus 로고    scopus 로고
    • Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation
    • 63 Ogawa, R., et al. Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation. Biochem. Biophys. Res. Commun. 398 (2010), 723–729.
    • (2010) Biochem. Biophys. Res. Commun. , vol.398 , pp. 723-729
    • Ogawa, R.1
  • 64
    • 84901474786 scopus 로고    scopus 로고
    • Adiponectin is partially associated with exosomes in mouse serum
    • 64 Phoonsawat, W., et al. Adiponectin is partially associated with exosomes in mouse serum. Biochem. Biophys. Res. Commun. 448 (2014), 261–266.
    • (2014) Biochem. Biophys. Res. Commun. , vol.448 , pp. 261-266
    • Phoonsawat, W.1
  • 65
    • 84993937713 scopus 로고    scopus 로고
    • Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis
    • 65 Connolly, K.D., et al. Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis. J. Extracell. Vesicles, 4, 2015, 29159.
    • (2015) J. Extracell. Vesicles , vol.4 , pp. 29159
    • Connolly, K.D.1
  • 66
    • 84930416983 scopus 로고    scopus 로고
    • Proteomic analysis of extracellular vesicles released by adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) rats
    • 66 Lee, J-E., et al. Proteomic analysis of extracellular vesicles released by adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Protein J. 34 (2015), 220–235.
    • (2015) Protein J. , vol.34 , pp. 220-235
    • Lee, J.-E.1
  • 67
    • 84896091950 scopus 로고    scopus 로고
    • Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells
    • 67 Sano, S., et al. Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells. Biochem. Biophys. Res. Commun. 445 (2014), 327–333.
    • (2014) Biochem. Biophys. Res. Commun. , vol.445 , pp. 327-333
    • Sano, S.1
  • 68
    • 84921929997 scopus 로고    scopus 로고
    • Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity
    • 68 Ertunc, M.E., et al. Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity. J. Lipid Res. 56 (2015), 423–434.
    • (2015) J. Lipid Res. , vol.56 , pp. 423-434
    • Ertunc, M.E.1
  • 69
    • 70350542786 scopus 로고    scopus 로고
    • Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance
    • 69 Deng, Z., Bin, et al. Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance. Diabetes 58 (2009), 2498–2505.
    • (2009) Diabetes , vol.58 , pp. 2498-2505
    • Deng, Z.1    Bin2
  • 70
    • 84907605880 scopus 로고    scopus 로고
    • Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells
    • 70 Kranendonk, M.E.G., et al. Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells. Obesity (Silver Spring) 22 (2014), 2216–2223.
    • (2014) Obesity (Silver Spring) , vol.22 , pp. 2216-2223
    • Kranendonk, M.E.G.1
  • 71
    • 84931050696 scopus 로고    scopus 로고
    • Inflamed macrophage microvesicles induce insulin resistance in human adipocytes
    • 71 Zhang, Y., et al. Inflamed macrophage microvesicles induce insulin resistance in human adipocytes. Nutr. Metab. (Lond), 12, 2015, 21.
    • (2015) Nutr. Metab. (Lond) , vol.12 , pp. 21
    • Zhang, Y.1
  • 72
    • 79954424525 scopus 로고    scopus 로고
    • Microvesicles released from rat adipocytes and harboring glycosylphosphatidylinositol-anchored proteins transfer RNA stimulating lipid synthesis
    • 72 Muller, G., et al. Microvesicles released from rat adipocytes and harboring glycosylphosphatidylinositol-anchored proteins transfer RNA stimulating lipid synthesis. Cell. Signal. 23 (2011), 1207–1223.
    • (2011) Cell. Signal. , vol.23 , pp. 1207-1223
    • Muller, G.1
  • 73
    • 79960845463 scopus 로고    scopus 로고
    • Upregulation of lipid synthesis in small rat adipocytes by microvesicle-associated CD73 from large adipocytes
    • 73 Müller, G., et al. Upregulation of lipid synthesis in small rat adipocytes by microvesicle-associated CD73 from large adipocytes. Obesity (Silver Spring) 19 (2011), 1531–1544.
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 1531-1544
    • Müller, G.1
  • 74
    • 79952281587 scopus 로고    scopus 로고
    • Let's shift lipid burden-from large to small adipocytes
    • 74 Müller, G., Let's shift lipid burden-from large to small adipocytes. Eur. J. Pharmacol. 656 (2011), 1–4.
    • (2011) Eur. J. Pharmacol. , vol.656 , pp. 1-4
    • Müller, G.1
  • 75
    • 84964877834 scopus 로고    scopus 로고
    • Exosomes in liver pathology
    • 75 Sato, K., et al. Exosomes in liver pathology. J. Hepatol. 65 (2016), 213–221.
    • (2016) J. Hepatol. , vol.65 , pp. 213-221
    • Sato, K.1
  • 76
    • 84901976256 scopus 로고    scopus 로고
    • The emerging roles of microvesicles in liver diseases
    • 76 Lemoinne, S., et al. The emerging roles of microvesicles in liver diseases. Nat. Rev. Gastroenterol. Hepatol. 11 (2014), 350–361.
    • (2014) Nat. Rev. Gastroenterol. Hepatol. , vol.11 , pp. 350-361
    • Lemoinne, S.1
  • 77
    • 84882919418 scopus 로고    scopus 로고
    • Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases
    • 77 Masyuk, A.I., et al. Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases. J. Hepatol. 59 (2013), 621–625.
    • (2013) J. Hepatol. , vol.59 , pp. 621-625
    • Masyuk, A.I.1
  • 78
    • 85016490706 scopus 로고    scopus 로고
    • Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
    • 78 Wiklander, O.P.B., et al. Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting. J. Extracell. Vesicles, 4, 2015, 26316.
    • (2015) J. Extracell. Vesicles , vol.4 , pp. 26316
    • Wiklander, O.P.B.1
  • 79
    • 84975747692 scopus 로고    scopus 로고
    • Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes
    • 79 Hirsova, P., et al. Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes. Gastroenterology 150 (2016), 956–967.
    • (2016) Gastroenterology , vol.150 , pp. 956-967
    • Hirsova, P.1
  • 80
    • 84869097694 scopus 로고    scopus 로고
    • RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells
    • 80 Li, B., et al. RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells. Oncogene 31 (2012), 4740–4749.
    • (2012) Oncogene , vol.31 , pp. 4740-4749
    • Li, B.1
  • 81
    • 84912102867 scopus 로고    scopus 로고
    • Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease
    • 81 Koeck, E.S., et al. Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease. J. Surg. Res. 192 (2014), 268–275.
    • (2014) J. Surg. Res. , vol.192 , pp. 268-275
    • Koeck, E.S.1
  • 82
    • 84904304045 scopus 로고    scopus 로고
    • Isolation, characterization and potential role in beta cell-endothelium cross-talk of extracellular vesicles released from human pancreatic islets
    • 82 Figliolini, F., et al. Isolation, characterization and potential role in beta cell-endothelium cross-talk of extracellular vesicles released from human pancreatic islets. PLoS ONE, 9, 2014, e102521.
    • (2014) PLoS ONE , vol.9 , pp. e102521
    • Figliolini, F.1
  • 83
    • 84925441485 scopus 로고    scopus 로고
    • Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells
    • 83 Guay, C., et al. Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells. Cell Commun. Signal., 13, 2015, 17.
    • (2015) Cell Commun. Signal. , vol.13 , pp. 17
    • Guay, C.1
  • 84
    • 84864817826 scopus 로고    scopus 로고
    • Characterization of membrane-shed microvesicles from cytokine-stimulated β-cells using proteomics strategies
    • 84 Palmisano, G., et al. Characterization of membrane-shed microvesicles from cytokine-stimulated β-cells using proteomics strategies. Mol. Cell Proteomics 11 (2012), 230–243.
    • (2012) Mol. Cell Proteomics , vol.11 , pp. 230-243
    • Palmisano, G.1
  • 85
    • 84894282996 scopus 로고    scopus 로고
    • Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?
    • 85 Forterre, A., et al. Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?. PLoS ONE, 9, 2014, e84153.
    • (2014) PLoS ONE , vol.9 , pp. e84153
    • Forterre, A.1
  • 86
    • 84936766922 scopus 로고    scopus 로고
    • Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration
    • 86 Nakamura, Y., et al. Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration. FEBS Lett. 589 (2015), 1257–1265.
    • (2015) FEBS Lett. , vol.589 , pp. 1257-1265
    • Nakamura, Y.1
  • 87
    • 84949129837 scopus 로고    scopus 로고
    • Proteomic analysis of secreted proteins from skeletal muscle cells during differentiation
    • 87 Ojima, K., et al. Proteomic analysis of secreted proteins from skeletal muscle cells during differentiation. EuPA Open Proteomics 5 (2014), 1–9.
    • (2014) EuPA Open Proteomics , vol.5 , pp. 1-9
    • Ojima, K.1
  • 88
    • 84927133965 scopus 로고    scopus 로고
    • Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice
    • 88 Aswad, H., et al. Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice. Diabetologia 57 (2014), 2155–2164.
    • (2014) Diabetologia , vol.57 , pp. 2155-2164
    • Aswad, H.1
  • 89
    • 84957565613 scopus 로고    scopus 로고
    • Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice
    • 89 Jalabert, A., et al. Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice. Diabetologia 59 (2016), 1049–1058.
    • (2016) Diabetologia , vol.59 , pp. 1049-1058
    • Jalabert, A.1
  • 90
    • 84921424656 scopus 로고    scopus 로고
    • Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic?
    • 90 Gangoda, L., et al. Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic?. Proteomics 15 (2015), 260–271.
    • (2015) Proteomics , vol.15 , pp. 260-271
    • Gangoda, L.1
  • 91
    • 84867673433 scopus 로고    scopus 로고
    • Exosomal lipids impact notch signaling and induce death of human pancreatic tumoral SOJ-6 cells
    • 91 Beloribi, S., et al. Exosomal lipids impact notch signaling and induce death of human pancreatic tumoral SOJ-6 cells. PLoS ONE, 7, 2012, e47480.
    • (2012) PLoS ONE , vol.7 , pp. e47480
    • Beloribi, S.1
  • 92
    • 84929156225 scopus 로고    scopus 로고
    • Extracellular vesicles from neural stem cells transfer IFN-gamma via Ifngr1 to activate Stat1 signaling in target cells
    • 92 Cossetti, C., et al. Extracellular vesicles from neural stem cells transfer IFN-gamma via Ifngr1 to activate Stat1 signaling in target cells. Mol. Cell 56 (2014), 193–204.
    • (2014) Mol. Cell , vol.56 , pp. 193-204
    • Cossetti, C.1
  • 93
    • 84879880971 scopus 로고    scopus 로고
    • Retinal pigment epithelium (RPE) exosomes contain signaling phosphoproteins affected by oxidative stress
    • 93 Biasutto, L., et al. Retinal pigment epithelium (RPE) exosomes contain signaling phosphoproteins affected by oxidative stress. Exp. Cell Res. 319 (2013), 2113–2123.
    • (2013) Exp. Cell Res. , vol.319 , pp. 2113-2123
    • Biasutto, L.1
  • 94
    • 78650553841 scopus 로고    scopus 로고
    • Human tumor virus utilizes exosomes for intercellular communication
    • 94 Meckes, D.G., et al. Human tumor virus utilizes exosomes for intercellular communication. Proc. Natl. Acad. Sci. U.S.A. 107 (2010), 20370–20375.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 20370-20375
    • Meckes, D.G.1
  • 95
    • 70350747789 scopus 로고    scopus 로고
    • Gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activation
    • 95 Qu, J-L., et al. Gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activation. Dig. Liver Dis. 41 (2009), 875–880.
    • (2009) Dig. Liver Dis. , vol.41 , pp. 875-880
    • Qu, J.-L.1
  • 96
    • 77956867597 scopus 로고    scopus 로고
    • Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins
    • 96 Subra, C., et al. Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. J. Lipid Res. 51 (2010), 2105–2120.
    • (2010) J. Lipid Res. , vol.51 , pp. 2105-2120
    • Subra, C.1
  • 97
    • 84877903383 scopus 로고    scopus 로고
    • Signaling pathways in exosomes biogenesis, secretion and fate
    • 97 Urbanelli, L., et al. Signaling pathways in exosomes biogenesis, secretion and fate. Genes (Basel) 4 (2013), 152–170.
    • (2013) Genes (Basel) , vol.4 , pp. 152-170
    • Urbanelli, L.1
  • 98
    • 43049139913 scopus 로고    scopus 로고
    • Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
    • 98 Al-Nedawi, K., et al. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat. Cell Biol. 10 (2008), 619–624.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 619-624
    • Al-Nedawi, K.1
  • 99
    • 78049293785 scopus 로고    scopus 로고
    • INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells
    • 99 Bonner, C., et al. INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. Diabetes 59 (2010), 2799–2808.
    • (2010) Diabetes , vol.59 , pp. 2799-2808
    • Bonner, C.1
  • 100
    • 44849132591 scopus 로고    scopus 로고
    • Dynamics of fat cell turnover in humans
    • 100 Spalding, K.L., et al. Dynamics of fat cell turnover in humans. Nature 453 (2008), 783–787.
    • (2008) Nature , vol.453 , pp. 783-787
    • Spalding, K.L.1
  • 101
    • 77449111670 scopus 로고    scopus 로고
    • Adipocyte turnover: relevance to human adipose tissue morphology
    • 101 Arner, E., et al. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 59 (2010), 105–109.
    • (2010) Diabetes , vol.59 , pp. 105-109
    • Arner, E.1
  • 102
    • 84957545377 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: new frontiers of cell-to-cell communication in cancer
    • 102 Ciardiello, C., et al. Focus on extracellular vesicles: new frontiers of cell-to-cell communication in cancer. Int. J. Mol. Sci., 17, 2016, 175.
    • (2016) Int. J. Mol. Sci. , vol.17 , pp. 175
    • Ciardiello, C.1
  • 103
    • 84925446437 scopus 로고    scopus 로고
    • Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes
    • 103 Webber, J.P., et al. Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes. Oncogene 34 (2015), 290–302.
    • (2015) Oncogene , vol.34 , pp. 290-302
    • Webber, J.P.1
  • 104
    • 84871563123 scopus 로고    scopus 로고
    • Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration
    • 104 Luga, V., et al. Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell 151 (2012), 1542–1556.
    • (2012) Cell , vol.151 , pp. 1542-1556
    • Luga, V.1
  • 105
    • 77954500645 scopus 로고    scopus 로고
    • Adipocyte-derived microvesicles are associated with multiple angiogenic factors and induce angiogenesis in vivo and in vitro
    • 105 Aoki, N., et al. Adipocyte-derived microvesicles are associated with multiple angiogenic factors and induce angiogenesis in vivo and in vitro. Endocrinology 151 (2010), 2567–2576.
    • (2010) Endocrinology , vol.151 , pp. 2567-2576
    • Aoki, N.1
  • 106
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • 106 Peinado, H., et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18 (2012), 883–891.
    • (2012) Nat. Med. , vol.18 , pp. 883-891
    • Peinado, H.1
  • 107
    • 84930170395 scopus 로고    scopus 로고
    • Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
    • 107 Costa-Silva, B., et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat. Cell Biol. 17 (2015), 1–7.
    • (2015) Nat. Cell Biol. , vol.17 , pp. 1-7
    • Costa-Silva, B.1
  • 108
    • 84957552185 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: development of extracellular vesicle-based therapeutic systems
    • 108 Ohno, S-I., et al. Focus on extracellular vesicles: development of extracellular vesicle-based therapeutic systems. Int. J. Mol. Sci., 17, 2016, 172.
    • (2016) Int. J. Mol. Sci. , vol.17 , pp. 172
    • Ohno, S.-I.1
  • 109
    • 84949310102 scopus 로고    scopus 로고
    • Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse
    • 109 Liu, Y., et al. Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse. Sci. Rep., 5, 2015, 17543.
    • (2015) Sci. Rep. , vol.5 , pp. 17543
    • Liu, Y.1
  • 110
    • 85013222187 scopus 로고    scopus 로고
    • Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
    • 110 Witwer, K.W., et al. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J. Extracell. Vesicles, 2013, 2, 10.3402/jev.v2i0.20360.
    • (2013) J. Extracell. Vesicles , pp. 2
    • Witwer, K.W.1
  • 111
    • 84979855846 scopus 로고    scopus 로고
    • Studying extracellular vesicle transfer by a Cre-loxP method
    • 111 Zomer, A., et al. Studying extracellular vesicle transfer by a Cre-loxP method. Nat. Protoc. 11 (2016), 87–101.
    • (2016) Nat. Protoc. , vol.11 , pp. 87-101
    • Zomer, A.1
  • 112
    • 84930225521 scopus 로고    scopus 로고
    • In vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior
    • 112 Zomer, A., et al. In vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior. Cell 161 (2015), 1046–1057.
    • (2015) Cell , vol.161 , pp. 1046-1057
    • Zomer, A.1
  • 113
    • 79251581020 scopus 로고    scopus 로고
    • The art of microRNA research
    • 113 van Rooij, E., The art of microRNA research. Circ. Res. 108 (2011), 219–234.
    • (2011) Circ. Res. , vol.108 , pp. 219-234
    • van Rooij, E.1
  • 114
    • 84907906605 scopus 로고    scopus 로고
    • Quantitative and stoichiometric analysis of the microRNA content of exosomes
    • 114 Chevillet, J.R., et al. Quantitative and stoichiometric analysis of the microRNA content of exosomes. Proc. Natl. Acad. Sci. U.S.A. 111 (2014), 14888–14893.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 14888-14893
    • Chevillet, J.R.1
  • 115
    • 84888103828 scopus 로고    scopus 로고
    • Current methods for the isolation of extracellular vesicles
    • 115 Momen-Heravi, F., et al. Current methods for the isolation of extracellular vesicles. Biol. Chem. 394 (2013), 1253–1262.
    • (2013) Biol. Chem. , vol.394 , pp. 1253-1262
    • Momen-Heravi, F.1
  • 116
    • 84964576000 scopus 로고    scopus 로고
    • Extracellular vesicle isolation and characterization: toward clinical application
    • 116 Xu, R., et al. Extracellular vesicle isolation and characterization: toward clinical application. J. Clin. Invest. 126 (2016), 1152–1162.
    • (2016) J. Clin. Invest. , vol.126 , pp. 1152-1162
    • Xu, R.1
  • 117
    • 84864411871 scopus 로고    scopus 로고
    • Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types
    • 117 Guduric-Fuchs, J., et al. Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types. BMC Genomics, 13, 2012, 357.
    • (2012) BMC Genomics , vol.13 , pp. 357
    • Guduric-Fuchs, J.1
  • 118
    • 84876248584 scopus 로고    scopus 로고
    • Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis
    • 118 Kosaka, N., et al. Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J. Biol. Chem. 288 (2013), 10849–10859.
    • (2013) J. Biol. Chem. , vol.288 , pp. 10849-10859
    • Kosaka, N.1
  • 119
    • 84890907806 scopus 로고    scopus 로고
    • Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
    • 119 Villarroya-Beltri, C., et al. Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat. Commun., 4, 2013, 2980.
    • (2013) Nat. Commun. , vol.4 , pp. 2980
    • Villarroya-Beltri, C.1
  • 120
    • 84907415649 scopus 로고    scopus 로고
    • Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes
    • 120 Koppers-Lalic, D., et al. Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes. Cell Rep. 8 (2014), 1649–1658.
    • (2014) Cell Rep. , vol.8 , pp. 1649-1658
    • Koppers-Lalic, D.1
  • 121
    • 84922527336 scopus 로고    scopus 로고
    • Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells
    • 121 Squadrito, M.L., et al. Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells. Cell Rep. 8 (2014), 1432–1446.
    • (2014) Cell Rep. , vol.8 , pp. 1432-1446
    • Squadrito, M.L.1
  • 122
    • 69949117622 scopus 로고    scopus 로고
    • Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. TL-11
    • 122 Gibbings, D.J., et al. Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. TL-11. Nat. Cell Biol. 11 VN–r (2009), 1143–1149.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1143-1149
    • Gibbings, D.J.1
  • 123
    • 0033052332 scopus 로고    scopus 로고
    • Inhibition of clathrin-coated pit assembly by an Eps15 mutant
    • 123 Benmerah, A., et al. Inhibition of clathrin-coated pit assembly by an Eps15 mutant. J. Cell Sci. 112 (1999), 1303–1311.
    • (1999) J. Cell Sci. , vol.112 , pp. 1303-1311
    • Benmerah, A.1
  • 124
    • 79551542416 scopus 로고    scopus 로고
    • Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
    • 124 Fitzner, D., et al. Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis. J. Cell Sci. 124 (2011), 447–458.
    • (2011) J. Cell Sci. , vol.124 , pp. 447-458
    • Fitzner, D.1
  • 125
    • 67049098565 scopus 로고    scopus 로고
    • Characterization of vesicles secreted from insulinoma NIT-1 cells
    • 125 Lee, H.S., et al. Characterization of vesicles secreted from insulinoma NIT-1 cells. J. Proteome Res. 8 (2009), 2851–2862.
    • (2009) J. Proteome Res. , vol.8 , pp. 2851-2862
    • Lee, H.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.