Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice

Diabetologia

Volumn 59, Issue 5, 2016, Pages 1049-1058

  Jalabert, Audrey ^a   Vial, Guillaume ^a   Guay, Claudiane ^b   Wiklander, Oscar P B ^c   Nordin, Joel Z ^c   Aswad, Hala ^a   Forterre, Alexis ^a   Meugnier, Emmanuelle ^a   Pesenti, Sandra ^a   Regazzi, Romano ^b   Danty Berger, Emmanuelle ^a   Ducreux, Sylvie ^a   Vidal, Hubert ^a   El Andaloussi, Samir ^c,d   Rieusset, Jennifer ^a   Rome, Sophie ^a  

^a UNIVERSITÉ LYON 1   (France)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Beta cells; Diabetes; Exosomes; Extracellular vesicles; High fat diet; Insulin resistance; microRNAs; Palmitate; Skeletal muscle

Indexed keywords

GLUCOSE; INSULIN; LIPID; MESSENGER RNA; MICRORNA; MICRORNA 16; PALM OIL; PALMITIC ACID; PROTEIN PATCHED 1;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BODY WEIGHT; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EXOSOME; EXOSOME LIKE VESICLE; FEMALE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; LUCIFERASE ASSAY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CELL LINE; INSULIN RESISTANCE; METABOLISM; PHYSIOLOGY; SKELETAL MUSCLE; SKELETAL MUSCLE CELL;

ANIMALS; CELL LINE; EXOSOMES; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; MICE; MICRORNAS; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL;

EID: 84957565613     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-3882-y     Document Type: Article

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