메뉴 건너뛰기




Volumn 56, Issue 2, 2015, Pages 423-434

Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity

Author keywords

Adipokine; Adipose triglyceride lipase; Hormone; Hormone sensitive lipase; Lipolysis; Obesity

Indexed keywords

5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; ACYLGLYCEROL LIPASE; ADIPOSE TRIGLYCERIDE LIPASE; ATGLISTATIN; BETA 3 ADRENERGIC RECEPTOR; CAY 10499; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIACYLGLYCEROL; FATTY ACID BINDING PROTEIN 4; FATTY ACID BINDING PROTEIN AP2; ISOPRENALINE; MUTANT PROTEIN; PERILIPIN 1; PROTEIN INHIBITOR; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; CARRIER PROTEIN; DESNUTRIN PROTEIN, MOUSE; FABP4 PROTEIN, MOUSE; FATTY ACID BINDING PROTEIN; PHOSPHOPROTEIN;

EID: 84921929997     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M055798     Document Type: Article
Times cited : (122)

References (63)
  • 2
    • 33747356154 scopus 로고    scopus 로고
    • Adipose tissue: From lipid storage compartment to endocrine organ
    • Scherer, P. E. 2006 . Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes . 55 : 1537-1545 .
    • (2006) Diabetes , vol.55 , pp. 1537-1545
    • Scherer, P.E.1
  • 3
    • 44449118921 scopus 로고    scopus 로고
    • Fatty acid-binding proteins: Role in metabolic diseases and potential as drug targets
    • Furuhashi, M., and G. S. Hotamisligil . 2008 . Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat. Rev. Drug Discov. 7 : 489-503 .
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 489-503
    • Furuhashi, M.1    Hotamisligil, G.S.2
  • 4
    • 0043253165 scopus 로고    scopus 로고
    • The mammalian fatty acidbinding protein multigene family: Molecular and genetic insights into function
    • Hertzel, A. V., and D. A. Bernlohr . 2000 . The mammalian fatty acidbinding protein multigene family: molecular and genetic insights into function. Trends Endocrinol. Metab. 11 : 175-180 .
    • (2000) Trends Endocrinol. Metab. , vol.11 , pp. 175-180
    • Hertzel, A.V.1    Bernlohr, D.A.2
  • 5
    • 0029847504 scopus 로고    scopus 로고
    • Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
    • Hotamisligil, G. S., R. S. Johnson, R. J. Distel, R. Ellis, V. E. Papaioannou, and B. M. Spiegelman . 1996 . Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science . 274 : 1377-1379 .
    • (1996) Science , vol.274 , pp. 1377-1379
    • Hotamisligil, G.S.1    Johnson, R.S.2    Distel, R.J.3    Ellis, R.4    Papaioannou, V.E.5    Spiegelman, B.M.6
  • 7
    • 4544298808 scopus 로고    scopus 로고
    • Combined adipocytemacrophage fatty acid-binding protein defi ciency improves metabolism, atherosclerosis, and survival in apolipoprotein E-defi cient mice
    • Boord, J. B., K. Maeda, L. Makowski, V. R. Babaev, S. Fazio, M. F. Linton, and G. S. Hotamisligil . 2004 . Combined adipocytemacrophage fatty acid-binding protein defi ciency improves metabolism, atherosclerosis, and survival in apolipoprotein E-defi cient mice. Circulation . 110 : 1492-1498 .
    • (2004) Circulation , vol.110 , pp. 1492-1498
    • Boord, J.B.1    Maeda, K.2    Makowski, L.3    Babaev, V.R.4    Fazio, S.5    Linton, M.F.6    Hotamisligil, G.S.7
  • 8
    • 33747032339 scopus 로고    scopus 로고
    • Regulation of metabolic responses by adipocyte/macrophage fatty acid-binding proteins in leptin-defi cient mice
    • Cao, H., K. Maeda, C. Z. Gorgun, H. J. Kim, S. Y. Park, G. I. Shulman, J. K. Kim, and G. S. Hotamisligil . 2006 . Regulation of metabolic responses by adipocyte/macrophage fatty acid-binding proteins in leptin-defi cient mice. Diabetes . 55 : 1915-1922 .
    • (2006) Diabetes , vol.55 , pp. 1915-1922
    • Cao, H.1    Maeda, K.2    Gorgun, C.Z.3    Kim, H.J.4    Park, S.Y.5    Shulman, G.I.6    Kim, J.K.7    Hotamisligil, G.S.8
  • 10
    • 51549107903 scopus 로고    scopus 로고
    • Identifi cation of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
    • Cao, H., K. Gerhold, J. R. Mayers, M. M. Wiest, S. M. Watkins, and G. S. Hotamisligil . 2008 . Identifi cation of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell . 134 : 933-944 .
    • (2008) Cell , vol.134 , pp. 933-944
    • Cao, H.1    Gerhold, K.2    Mayers, J.R.3    Wiest, M.M.4    Watkins, S.M.5    Hotamisligil, G.S.6
  • 13
    • 33646493482 scopus 로고    scopus 로고
    • A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease
    • Tuncman, G., E. Erbay, X. Hom, I. De Vivo, H. Campos, E. B. Rimm, and G. S. Hotamisligil . 2006 . A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc. Natl. Acad. Sci. USA . 103 : 6970-6975 .
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 6970-6975
    • Tuncman, G.1    Erbay, E.2    Hom, X.3    De Vivo, I.4    Campos, H.5    Rimm, E.B.6    Hotamisligil, G.S.7
  • 16
    • 77954310410 scopus 로고    scopus 로고
    • Serum adipocyte fatty acid-binding protein is independently associated with coronary atherosclerotic burden measured by intravascular ultrasound
    • Miyoshi, T., G. Onoue, A. Hirohata, S. Hirohata, S. Usui, K. Hina, H. Kawamura, M. Doi, K. F. Kusano, S. Kusachi, et al . 2010 . Serum adipocyte fatty acid-binding protein is independently associated with coronary atherosclerotic burden measured by intravascular ultrasound. Atherosclerosis . 211 : 164-169 .
    • (2010) Atherosclerosis , vol.211 , pp. 164-169
    • Miyoshi, T.1    Onoue, G.2    Hirohata, A.3    Hirohata, S.4    Usui, S.5    Hina, K.6    Kawamura, H.7    Doi, M.8    Kusano, K.F.9    Kusachi, S.10
  • 17
    • 33644545704 scopus 로고    scopus 로고
    • Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome
    • Xu, A., Y. Wang, J. Y. Xu, D. Stejskal, S. Tam, J. Zhang, N. M. Wat, W. K. Wong, and K. S. Lam . 2006 . Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin. Chem. 52 : 405-413 .
    • (2006) Clin. Chem. , vol.52 , pp. 405-413
    • Xu, A.1    Wang, Y.2    Xu, J.Y.3    Stejskal, D.4    Tam, S.5    Zhang, J.6    Wat, N.M.7    Wong, W.K.8    Lam, K.S.9
  • 18
    • 79952291504 scopus 로고    scopus 로고
    • Serum adipocyte fatty acid-binding protein is associated independently with vascular infl ammation: Analysis with (18)F-fl uorodeoxyglucose positron emission tomography
    • Yoo, H. J., S. Kim, M. S. Park, H. Y. Choi, S. J. Yang, J. A. Seo, S. G. Kim, N. H. Kim, S. H. Baik, D. S. Choi, et al . 2011 . Serum adipocyte fatty acid-binding protein is associated independently with vascular infl ammation: analysis with (18)F-fl uorodeoxyglucose positron emission tomography. J. Clin. Endocrinol. Metab. 96 : E488-E492 .
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. E488-E492
    • Yoo, H.J.1    Kim, S.2    Park, M.S.3    Choi, H.Y.4    Yang, S.J.5    Seo, J.A.6    Kim, S.G.7    Kim, N.H.8    Baik, S.H.9    Choi, D.S.10
  • 20
    • 75749108572 scopus 로고    scopus 로고
    • Fasting serum level of fatty-acid-binding protein 4 positively correlates with metabolic syndrome in patients with coronary artery disease
    • Hsu, B. G., Y. C. Chen, R. P. Lee, C. C. Lee, C. J. Lee, and J. H. Wang . 2010 . Fasting serum level of fatty-acid-binding protein 4 positively correlates with metabolic syndrome in patients with coronary artery disease. Circ. J. 74 : 327-331 .
    • (2010) Circ. J. , vol.74 , pp. 327-331
    • Hsu, B.G.1    Chen, Y.C.2    Lee, R.P.3    Lee, C.C.4    Lee, C.J.5    Wang, J.H.6
  • 21
    • 79955737334 scopus 로고    scopus 로고
    • Serum levels of adipocyte fatty acid-binding protein are associated with the severity of coronary artery disease in Chinese women
    • Bao, Y., Z. Lu, M. Zhou, H. Li, Y. Wang, M. Gao, M. Wei, and W. Jia . 2011 . Serum levels of adipocyte fatty acid-binding protein are associated with the severity of coronary artery disease in Chinese women. PLoS ONE . 6 : e19115 .
    • (2011) PLoS ONE , vol.6 , pp. e19115
    • Bao, Y.1    Lu, Z.2    Zhou, M.3    Li, H.4    Wang, Y.5    Gao, M.6    Wei, M.7    Jia, W.8
  • 22
    • 84870748223 scopus 로고    scopus 로고
    • Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure
    • Liu, M., M. Zhou, Y. Bao, Z. Xu, H. Li, H. Zhang, W. Zhu, J. Zhang, A. Xu, M. Wei, et al . 2013 . Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure. Clin. Sci. (Lond.) . 124 : 115-122 .
    • (2013) Clin. Sci. (Lond.) , vol.124 , pp. 115-122
    • Liu, M.1    Zhou, M.2    Bao, Y.3    Xu, Z.4    Li, H.5    Zhang, H.6    Zhu, W.7    Zhang, J.8    Xu, A.9    Wei, M.10
  • 24
    • 84865455411 scopus 로고    scopus 로고
    • Circulating adipocyte fatty acid-binding protein levels and cardiovascular morbidity and mortality in patients with coronary heart disease: A 10-year prospective study
    • von Eynatten, M., L. P. Breitling, M. Roos, M. Baumann, D. Rothenbacher, and H. Brenner . 2012 . Circulating adipocyte fatty acid-binding protein levels and cardiovascular morbidity and mortality in patients with coronary heart disease: a 10-year prospective study. Arterioscler. Thromb. Vasc. Biol. 32 : 2327-2335 .
    • (2012) Arterioscler. Thromb. Vasc. Biol. , vol.32 , pp. 2327-2335
    • Von Eynatten, M.1    Breitling, L.P.2    Roos, M.3    Baumann, M.4    Rothenbacher, D.5    Brenner, H.6
  • 26
    • 79951676435 scopus 로고    scopus 로고
    • Serum adipocytespecifi c fatty acid-binding protein is associated with nonalcoholic fatty liver disease in apparently healthy subjects
    • Kim, Y. C., Y. K. Cho, W. Y. Lee, H. J. Kim, J. H. Park, D. I. Park, C. I. Sohn, W. K. Jeon, B. I. Kim, S. E. Park, et al . 2011 . Serum adipocytespecifi c fatty acid-binding protein is associated with nonalcoholic fatty liver disease in apparently healthy subjects. J. Nutr. Biochem. 22 : 289-292 .
    • (2011) J. Nutr. Biochem. , vol.22 , pp. 289-292
    • Kim, Y.C.1    Cho, Y.K.2    Lee, W.Y.3    Kim, H.J.4    Park, J.H.5    Park, D.I.6    Sohn, C.I.7    Jeon, W.K.8    Kim, B.I.9    Park, S.E.10
  • 29
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • Guilherme, A., J. V. Virbasius, V. Puri, and M. P. Czech . 2008 . Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9 : 367-377 .
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 30
    • 84899489259 scopus 로고    scopus 로고
    • Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance
    • Arner, P., and D. Langin . 2014 . Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance. Trends Endocrinol. Metab. 25 : 255-262 .
    • (2014) Trends Endocrinol. Metab. , vol.25 , pp. 255-262
    • Arner, P.1    Langin, D.2
  • 31
    • 80053345905 scopus 로고    scopus 로고
    • SignalP 4.0: Discriminating signal peptides from transmembrane regions
    • Petersen, T. N., S. Brunak, G. von Heijne, and H. Nielsen . 2011 . SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat. Methods . 8 : 785-786 .
    • (2011) Nat. Methods , vol.8 , pp. 785-786
    • Petersen, T.N.1    Brunak, S.2    Von Heijne, G.3    Nielsen, H.4
  • 33
    • 75749108288 scopus 로고    scopus 로고
    • Doublestranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
    • Nakamura, T., M. Furuhashi, P. Li, H. Cao, G. Tuncman, N. Sonenberg, C. Z. Gorgun, and G. S. Hotamisligil . 2010 . Doublestranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell . 140 : 338-348 .
    • (2010) Cell , vol.140 , pp. 338-348
    • Nakamura, T.1    Furuhashi, M.2    Li, P.3    Cao, H.4    Tuncman, G.5    Sonenberg, N.6    Gorgun, C.Z.7    Hotamisligil, G.S.8
  • 34
    • 0020995629 scopus 로고
    • Immunoelectron microscopy using thin, frozen sections: Application to studies of the intracellular transport of Semliki Forest virus spike glycoproteins
    • Griffi ths, G., K. Simons, G. Warren, and K. T. Tokuyasu . 1983 . Immunoelectron microscopy using thin, frozen sections: application to studies of the intracellular transport of Semliki Forest virus spike glycoproteins. Methods Enzymol. 96 : 466 - 485 .
    • (1983) Methods Enzymol. , vol.96 , pp. 466-485
    • Griffi Ths, G.1    Simons, K.2    Warren, G.3    Tokuyasu, K.T.4
  • 35
    • 34249053821 scopus 로고    scopus 로고
    • Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics
    • Cox, B., and A. Emili . 2006 . Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics. Nat. Protoc. 1 : 1872-1878 .
    • (2006) Nat. Protoc. , vol.1 , pp. 1872-1878
    • Cox, B.1    Emili, A.2
  • 36
    • 78650107057 scopus 로고    scopus 로고
    • Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores
    • Lass, A., R. Zimmermann, M. Oberer, and R. Zechner . 2011 . Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog. Lipid Res. 50 : 14-27 .
    • (2011) Prog. Lipid Res. , vol.50 , pp. 14-27
    • Lass, A.1    Zimmermann, R.2    Oberer, M.3    Zechner, R.4
  • 39
    • 59449101653 scopus 로고    scopus 로고
    • CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay
    • Muccioli, G. G., G. Labar, and D. M. Lambert . 2008 . CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay. ChemBioChem . 9 : 2704-2710 .
    • (2008) Chembiochem , vol.9 , pp. 2704-2710
    • Muccioli, G.G.1    Labar, G.2    Lambert, D.M.3
  • 43
    • 0347065339 scopus 로고    scopus 로고
    • Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis
    • Zhang, H. H., S. C. Souza, K. V. Muliro, F. B. Kraemer, M. S. Obin, and A. S. Greenberg . 2003 . Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis. J. Biol. Chem. 278 : 51535-51542 .
    • (2003) J. Biol. Chem. , vol.278 , pp. 51535-51542
    • Zhang, H.H.1    Souza, S.C.2    Muliro, K.V.3    Kraemer, F.B.4    Obin, M.S.5    Greenberg, A.S.6
  • 45
    • 0027415934 scopus 로고
    • Modulation of ligand binding affi nity of the adipocyte lipidbinding protein by selective mutation. Analysis in vitro and in situ
    • Sha, R. S., C. D. Kane, Z. Xu, L. J. Banaszak, and D. A. Bernlohr . 1993 . Modulation of ligand binding affi nity of the adipocyte lipidbinding protein by selective mutation. Analysis in vitro and in situ. J. Biol. Chem. 268 : 7885-7892 .
    • (1993) J. Biol. Chem. , vol.268 , pp. 7885-7892
    • Sha, R.S.1    Kane, C.D.2    Xu, Z.3    Banaszak, L.J.4    Bernlohr, D.A.5
  • 46
    • 84875275175 scopus 로고    scopus 로고
    • Arrivals and departures at the plasma membrane: Direct and indirect transport routes
    • Prydz, K., H. Tveit, A. Vedeler, and J. Saraste . 2013 . Arrivals and departures at the plasma membrane: direct and indirect transport routes. Cell Tissue Res. 352 : 5-20 .
    • (2013) Cell Tissue Res. , vol.352 , pp. 5-20
    • Prydz, K.1    Tveit, H.2    Vedeler, A.3    Saraste, J.4
  • 47
    • 67949097489 scopus 로고    scopus 로고
    • Exosomes-vesicular carriers for intercellular communication
    • Simons, M., and G. Raposo . 2009 . Exosomes-vesicular carriers for intercellular communication. Curr. Opin. Cell Biol. 21 : 575-581 .
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 575-581
    • Simons, M.1    Raposo, G.2
  • 48
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi, H., K. Ekstrom, A. Bossios, M. Sjostrand, J. J. Lee, and J. O. Lotvall . 2007 . Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9 : 654-659 .
    • (2007) Nat. Cell Biol. , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 50
    • 0032956241 scopus 로고    scopus 로고
    • cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel- independent pathway of glucose signaling in rat pancreatic islets
    • Yajima, H., M. Komatsu, T. Schermerhorn, T. Aizawa, T. Kaneko, M. Nagai, G. W. Sharp, and K. Hashizume . 1999 . cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel- independent pathway of glucose signaling in rat pancreatic islets. Diabetes . 48 : 1006-1012 .
    • (1999) Diabetes , vol.48 , pp. 1006-1012
    • Yajima, H.1    Komatsu, M.2    Schermerhorn, T.3    Aizawa, T.4    Kaneko, T.5    Nagai, M.6    Sharp, G.W.7    Hashizume, K.8
  • 53
    • 77953836762 scopus 로고    scopus 로고
    • Vesicular storage, vesicle traffi cking, and secretion of leptin and resistin: The similarities, differences, and interplays
    • Ye, F., A. Than, Y. Zhao, K. H. Goh, and P. Chen . 2010 . Vesicular storage, vesicle traffi cking, and secretion of leptin and resistin: the similarities, differences, and interplays. J. Endocrinol. 206 : 27-36 .
    • (2010) J. Endocrinol. , vol.206 , pp. 27-36
    • Ye, F.1    Than, A.2    Zhao, Y.3    Goh, K.H.4    Chen, P.5
  • 54
    • 79954568598 scopus 로고    scopus 로고
    • Protein targeting to exosomes/microvesicles by plasma membrane anchors
    • Shen, B., N. Wu, J. M. Yang, and S. J. Gould . 2011 . Protein targeting to exosomes/microvesicles by plasma membrane anchors. J. Biol. Chem. 286 : 14383-14395 .
    • (2011) J. Biol. Chem. , vol.286 , pp. 14383-14395
    • Shen, B.1    Wu, N.2    Yang, J.M.3    Gould, S.J.4
  • 56
    • 84870372459 scopus 로고    scopus 로고
    • Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases
    • Eichmann, T. O., M. Kumari, J. T. Haas, R. V. Farese, Jr ., R. Zimmermann, A. Lass, and R. Zechner . 2012 . Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. J. Biol. Chem. 287 : 41446-41457 .
    • (2012) J. Biol. Chem. , vol.287 , pp. 41446-41457
    • Eichmann, T.O.1    Kumari, M.2    Haas, J.T.3    Farese, R.V.4    Zimmermann, R.5    Lass, A.6    Zechner, R.7
  • 58
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Théry, C., M. Ostrowski, and E. Segura . 2009 . Membrane vesicles as conveyors of immune responses. Nat. Rev. Immunol. 9 : 581-593 .
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 581-593
    • Théry, C.1    Ostrowski, M.2    Segura, E.3
  • 61
    • 84866184236 scopus 로고    scopus 로고
    • Polysome profi ling in liver identifi es dynamic regulation of endoplasmic reticulum translatome by obesity and fasting
    • Fu, S., J. Fan, J. Blanco, A. Gimenez-Cassina, N. N. Danial, S. M. Watkins, and G. S. Hotamisligil . 2012 . Polysome profi ling in liver identifi es dynamic regulation of endoplasmic reticulum translatome by obesity and fasting. PLoS Genet. 8 : e1002902 .
    • (2012) PLoS Genet. , vol.8 , pp. e1002902
    • Fu, S.1    Fan, J.2    Blanco, J.3    Gimenez-Cassina, A.4    Danial, N.N.5    Watkins, S.M.6    Hotamisligil, G.S.7
  • 62
    • 33646862152 scopus 로고    scopus 로고
    • Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome
    • Kusunoki, J., A. Kanatani, and D. E. Moller . 2006 . Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome. Endocrine . 29 : 91-100 .
    • (2006) Endocrine , vol.29 , pp. 91-100
    • Kusunoki, J.1    Kanatani, A.2    Moller, D.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.