Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic micrornas regulate cancer cell metastasis

Journal of Biological Chemistry

Volumn 288, Issue 15, 2013, Pages 10849-10859

  Kosaka, Nobuyoshi ^a   Iguchi, Haruhisa ^a,b   Hagiwara, Keitaro ^a,c   Yoshioka, Yusuke ^a   Takeshita, Fumitaka ^a   Ochiya, Takahiro ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER PROGRESSION; HORIZONTAL TRANSFER; METASTATIC CANCER CELLS; MICRORNA (MIRNA); ON-DEMAND SYSTEMS; SPHINGOMYELINASE; TARGET GENES; TUMOR MICROENVIRONMENT;

ENDOTHELIAL CELLS; GENE EXPRESSION; RNA; TUMORS;

PATHOLOGY;

MICRORNA; MICRORNA 210; NEUTRAL SPHINGOMYELINASE 2; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL TRANSFER; CONTROLLED STUDY; DRUG ACTIVITY; ENDOTHELIUM CELL; ENZYME REGULATION; ENZYME RELEASE; EXOSOME; GENE REPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; MALE; METASTASIS; METASTASIS INHIBITION; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL NICHE; TUMOR MICROENVIRONMENT;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAMMARY NEOPLASMS, ANIMAL; MICE; MICRORNAS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; RNA, NEOPLASM; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84876248584     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.446831     Document Type: Article

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