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Volumn 17, Issue 2, 2016, Pages

Focus on extracellular vesicles: New frontiers of cell-to-cell communication in cancer

Author keywords

Cancer; Ectosomes; Exosomes; Extracellular vesicles; Intercellular communication; Large oncosomes; Microvesicles; Tumor microenvironment

Indexed keywords

ADAM10 ENDOPEPTIDASE; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 6; ALDOLASE A; ALPHA SMOOTH MUSCLE ACTIN; CALCIUM ION; CD63 ANTIGEN; CD81 ANTIGEN; CD9 ANTIGEN; CHEMOKINE RECEPTOR CCR6; COFILIN 1; ENOLASE 1; EPIDERMAL GROWTH FACTOR RECEPTOR; ESCRT PROTEIN; FOCAL ADHESION KINASE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HERMES ANTIGEN; INTERLEUKIN 8; LACTATE DEHYDROGENASE A; MESSENGER RNA; METALLOPROTEINASE; MICRORNA; PEPTIDES AND PROTEINS; PHOSPHOGLYCERATE KINASE 1; PROTEIN KINASE B; RHO KINASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR MARKER; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

EID: 84957545377     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17020175     Document Type: Article
Times cited : (262)

References (122)
  • 1
    • 84900552714 scopus 로고    scopus 로고
    • Extracellular membrane vesicles as a mechanism of cell-to-cell communication: Advantages and disadvantages
    • Turturici, G.; Tinnirello, R.; Sconzo, G.; Geraci, F. Extracellular membrane vesicles as a mechanism of cell-to-cell communication: Advantages and disadvantages. Am. J. Physiol. Cell Physiol. 2014, 306, C621-C633.
    • (2014) Am. J. Physiol. Cell Physiol , vol.306
    • Turturici, G.1    Tinnirello, R.2    Sconzo, G.3    Geraci, F.4
  • 4
    • 84930008790 scopus 로고    scopus 로고
    • Cell-specific uptake of mantle cell lymphoma-derived exosomes by malignant and non-malignant B-lymphocytes
    • Hazan-Halevy, I.; Rosenblum, D.; Weinstein, S.; Bairey, O.; Raanani, P.; Peer, D. Cell-specific uptake of mantle cell lymphoma-derived exosomes by malignant and non-malignant B-lymphocytes. Cancer Lett. 2015, 364, 59-69.
    • (2015) Cancer Lett , vol.364 , pp. 59-69
    • Hazan-Halevy, I.1    Rosenblum, D.2    Weinstein, S.3    Bairey, O.4    Raanani, P.5    Peer, D.6
  • 7
    • 0018352247 scopus 로고
    • Rigid plasma-membranederived vesicles, enriched in tumour-associated surface antigens (MLR), occurring in the ascites fluid of a murine leukaemia (GRSL)
    • Van Blitterswijk, W.J.; Emmelot, P.; Hilkmann, H.A.; Hilgers, J.; Feltkamp, C.A. Rigid plasma-membranederived vesicles, enriched in tumour-associated surface antigens (MLR), occurring in the ascites fluid of a murine leukaemia (GRSL). Int. J. Cancer 1979, 23, 62-70.
    • (1979) Int. J. Cancer , vol.23 , pp. 62-70
    • Van Blitterswijk, W.J.1    Emmelot, P.2    Hilkmann, H.A.3    Hilgers, J.4    Feltkamp, C.A.5
  • 9
    • 0036830046 scopus 로고    scopus 로고
    • Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin
    • Kim, C.W.; Lee, H.M.; Lee, T.H.; Kang, C.; Kleinman, H.K.; Gho, Y.S. Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin. Cancer Res. 2002, 62, 6312-6317.
    • (2002) Cancer Res , vol.62 , pp. 6312-6317
    • Kim, C.W.1    Lee, H.M.2    Lee, T.H.3    Kang, C.4    Kleinman, H.K.5    Gho, Y.S.6
  • 11
    • 84894189683 scopus 로고    scopus 로고
    • Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer
    • Kahlert, C.; Melo, S.A.; Protopopov, A.; Tang, J.; Seth, S.; Koch, M.; Zhang, J.; Weitz, J.; Chin, L.; Futreal, A. et al. Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. J. Biol. Chem. 2014, 289, 3869-3875.
    • (2014) J. Biol. Chem. , vol.289 , pp. 3869-3875
    • Kahlert, C.1    Melo, S.A.2    Protopopov, A.3    Tang, J.4    Seth, S.5    Koch, M.6    Zhang, J.7    Weitz, J.8    Chin, L.9    Futreal, A.10
  • 13
    • 84943329388 scopus 로고    scopus 로고
    • Inhibition of oncogenic epidermal growth factor receptor kinase triggers release of exosome-like extracellular vesicles and impacts their phosphoprotein and DNA content
    • Montermini, L.; Meehan, B.; Garnier, D.; Lee, W.J.; Lee, T.H.; Guha, A.; Al-Nedawi, K.; Rak, J. Inhibition of oncogenic epidermal growth factor receptor kinase triggers release of exosome-like extracellular vesicles and impacts their phosphoprotein and DNA content. J. Biol. Chem. 2015, doi:10.1074/jbc.M115.679217.
    • (2015) J. Biol. Chem
    • Montermini, L.1    Meehan, B.2    Garnier, D.3    Lee, W.J.4    Lee, T.H.5    Guha, A.6    Al-Nedawi, K.7    Rak, J.8
  • 16
    • 84944445453 scopus 로고    scopus 로고
    • Gho, Y.S.; et al. Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells—Evidence of unique microrna cargos
    • Lunavat, T.R.; Cheng, L.; Kim, D.K.; Bhadury, J.; Jang, S.C.; Lasser, C.; Sharples, R.A.; Lopez, M.D.; Nilsson, J.; Gho, Y.S.; et al. Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells—Evidence of unique microrna cargos. RNA Biol. 2015, 12, 810-823.
    • (2015) RNA Biol , vol.12 , pp. 810-823
    • Lunavat, T.R.1    Cheng, L.2    Kim, D.K.3    Bhadury, J.4    Jang, S.C.5    Lasser, C.6    Sharples, R.A.7    Lopez, M.D.8    Nilsson, J.9
  • 17
    • 84936869846 scopus 로고    scopus 로고
    • Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines
    • Tosar, J.P.; Gambaro, F.; Sanguinetti, J.; Bonilla, B.; Witwer, K.W.; Cayota, A. Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines. Nucleic Acids Res.2015, 43, 5601-5616.
    • (2015) Nucleic Acids Res , vol.43 , pp. 5601-5616
    • Tosar, J.P.1    Gambaro, F.2    Sanguinetti, J.3    Bonilla, B.4    Witwer, K.W.5    Cayota, A.6
  • 18
    • 84945352062 scopus 로고    scopus 로고
    • Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line lim1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct
    • Xu, R.; Greening, D.W.; Rai, A.; Ji, H.; Simpson, R.J. Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line lim1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct. Methods 2015, doi:10.1016/j.ymeth.2015.04.008.
    • (2015) Methods
    • Xu, R.1    Greening, D.W.2    Rai, A.3    Ji, H.4    Simpson, R.J.5
  • 19
    • 84929285231 scopus 로고    scopus 로고
    • Extracellular vesicles in the biology of brain tumour stem cells—Implications for inter-cellular communication, therapy and biomarker development
    • Nakano, I.; Garnier, D.; Minata, M.; Rak, J. Extracellular vesicles in the biology of brain tumour stem cells—Implications for inter-cellular communication, therapy and biomarker development. Semin. Cell Dev. Biol. 2015, 40, 17-26.
    • (2015) Semin. Cell Dev. Biol. , vol.40 , pp. 17-26
    • Nakano, I.1    Garnier, D.2    Minata, M.3    Rak, J.4
  • 20
    • 0022201056 scopus 로고
    • Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
    • Pan, B.T.; Teng, K.; Wu, C.; Adam, M.; Johnstone, R.M. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J. Cell Biol. 1985, 101, 942-948.
    • (1985) J. Cell Biol , vol.101 , pp. 942-948
    • Pan, B.T.1    Teng, K.2    Wu, C.3    Adam, M.4    Johnstone, R.M.5
  • 24
    • 84919468543 scopus 로고    scopus 로고
    • Tetraspanins in extracellular vesicle formation and function. Front
    • Andreu, Z.; Yanez-Mo, M. Tetraspanins in extracellular vesicle formation and function. Front. Immunol. 2014, 5, 442.
    • (2014) Immunol , vol.5 , pp. 442
    • Andreu, Z.1    Yanez-Mo, M.2
  • 27
    • 84890458696 scopus 로고    scopus 로고
    • Raposo, G. Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles
    • Colombo, M.; Moita, C.; van Niel, G.; Kowal, J.; Vigneron, J.; Benaroch, P.; Manel, N.; Moita, L.F.; Thery, C.; Raposo, G. Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J. Cell Sci. 2013, 126, 5553-5565.
    • (2013) J. Cell Sci , vol.126 , pp. 5553-5565
    • Colombo, M.1    Moita, C.2    Van Niel, G.3    Kowal, J.4    Vigneron, J.5    Benaroch, P.6    Manel, N.7    Moita, L.F.8    Thery, C.9
  • 28
    • 34447134864 scopus 로고    scopus 로고
    • Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer
    • Young, T.W.; Rosen, D.G.; Mei, F.C.; Li, N.; Liu, J.; Wang, X.F.; Cheng, X. Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer. Clin. Cancer Res. 2007, 13, 3848-3854.
    • (2007) Clin. Cancer Res , vol.13 , pp. 3848-3854
    • Young, T.W.1    Rosen, D.G.2    Mei, F.C.3    Li, N.4    Liu, J.5    Wang, X.F.6    Cheng, X.7
  • 30
    • 0026080905 scopus 로고
    • Ectocytosis caused by sublytic autologous complement attack on human neutrophils. The sorting of endogenous plasma-membrane proteins and lipids into shed vesicles
    • Stein, J.M.; Luzio, J.P. Ectocytosis caused by sublytic autologous complement attack on human neutrophils. The sorting of endogenous plasma-membrane proteins and lipids into shed vesicles. Biochem. J. 1991, 274 Pt 2, 381-386.
    • (1991) Biochem. J , vol.274 , pp. 381-386
    • Stein, J.M.1    Luzio, J.P.2
  • 32
    • 45349096499 scopus 로고    scopus 로고
    • Cell motility through plasma membrane blebbing
    • Fackler, O.T.; Grosse, R. Cell motility through plasma membrane blebbing. J. Cell Biol. 2008, 181, 879-884.
    • (2008) J. Cell Biol , vol.181 , pp. 879-884
    • Fackler, O.T.1    Grosse, R.2
  • 35
    • 69849100452 scopus 로고    scopus 로고
    • Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner
    • Lima, L.G.; Chammas, R.; Monteiro, R.Q.; Moreira, M.E.; Barcinski, M.A. Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner. Cancer Lett. 2009, 283, 168-175.
    • (2009) Cancer Lett , vol.283 , pp. 168-175
    • Lima, L.G.1    Chammas, R.2    Monteiro, R.Q.3    Moreira, M.E.4    Barcinski, M.A.5
  • 36
    • 58549114541 scopus 로고    scopus 로고
    • Highlights of a new type of intercellular communication: Microvesicle-based information transfer
    • Pap, E.; Pallinger, E.; Pasztoi, M.; Falus, A. Highlights of a new type of intercellular communication: Microvesicle-based information transfer. Inflamm. Res. 2009, 58, 1-8.
    • (2009) Inflamm. Res. , vol.58 , pp. 1-8
    • Pap, E.1    Pallinger, E.2    Pasztoi, M.3    Falus, A.4
  • 40
    • 84869097694 scopus 로고    scopus 로고
    • RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells
    • Li, B.; Antonyak, M.A.; Zhang, J.; Cerione, R.A. RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells. Oncogene 2012, 31, 4740-4749.
    • (2012) Oncogene , vol.31 , pp. 4740-4749
    • Li, B.1    Antonyak, M.A.2    Zhang, J.3    Cerione, R.A.4
  • 41
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: A review of programmed cell death
    • Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol. 2007, 35, 495-516.
    • (2007) Toxicol. Pathol , vol.35 , pp. 495-516
    • Elmore, S.1
  • 43
    • 0032498625 scopus 로고    scopus 로고
    • Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation
    • Mills, J.C.; Stone, N.L.; Erhardt, J.; Pittman, R.N. Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation. J. Cell Biol. 1998, 140, 627-636.
    • (1998) J. Cell Biol , vol.140 , pp. 627-636
    • Mills, J.C.1    Stone, N.L.2    Erhardt, J.3    Pittman, R.N.4
  • 45
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J.F.; Wyllie, A.H.; Currie, A.R. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972, 26, 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 46
    • 0033230506 scopus 로고    scopus 로고
    • Apoptotic conversion: Evidence for exchange of genetic information between prostate cancer cells mediated by apoptosis
    • De la Taille, A.; Chen, M.W.; Burchardt, M.; Chopin, D.K.; Buttyan, R. Apoptotic conversion: Evidence for exchange of genetic information between prostate cancer cells mediated by apoptosis. Cancer Res. 1999, 59, 5461-5463.
    • (1999) Cancer Res , vol.59 , pp. 5461-5463
    • De La Taille, A.1    Chen, M.W.2    Burchardt, M.3    Chopin, D.K.4    Buttyan, R.5
  • 47
    • 84883814455 scopus 로고    scopus 로고
    • Blebs produced by actin-myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs
    • Wickman, G.R.; Julian, L.; Mardilovich, K.; Schumacher, S.; Munro, J.; Rath, N.; Zander, S.A.; Mleczak, A.; Sumpton, D.; Morrice, N. et al. Blebs produced by actin-myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs. Cell Death Differ. 2013, 20, 1293-1305.
    • (2013) Cell Death Differ , vol.20 , pp. 1293-1305
    • Wickman, G.R.1    Julian, L.2    Mardilovich, K.3    Schumacher, S.4    Munro, J.5    Rath, N.6    Zander, S.A.7    Mleczak, A.8    Sumpton, D.9    Morrice, N.10
  • 50
    • 84920167794 scopus 로고    scopus 로고
    • Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration
    • Ma, L.; Li, Y.; Peng, J.; Wu, D.; Zhao, X.; Cui, Y.; Chen, L.; Yan, X.; Du, Y.; Yu, L. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015, 25, 24-38.
    • (2015) Cell Res , vol.25 , pp. 24-38
    • Ma, L.1    Li, Y.2    Peng, J.3    Wu, D.4    Zhao, X.5    Cui, Y.6    Chen, L.7    Yan, X.8    Du, Y.9    Yu, L.10
  • 53
    • 85007427694 scopus 로고    scopus 로고
    • Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells
    • Choi, D.S.; Choi, D.Y.; Hong, B.S.; Jang, S.C.; Kim, D.K.; Lee, J.; Kim, Y.K.; Kim, K.P.; Gho, Y.S. Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells. J. Extracell. Vesicles 2012, 1, doi:10.3402/jev.v1i0.18704.
    • (2012) J. Extracell. Vesicles , pp. 1
    • Choi, D.S.1    Choi, D.Y.2    Hong, B.S.3    Jang, S.C.4    Kim, D.K.5    Lee, J.6    Kim, Y.K.7    Kim, K.P.8    Gho, Y.S.9
  • 54
    • 84873438103 scopus 로고    scopus 로고
    • Method for isolation and molecular characterization of extracellular microvesicles released from brain endothelial cells
    • Haqqani, A.S.; Delaney, C.E.; Tremblay, T.L.; Sodja, C.; Sandhu, J.K.; Stanimirovic, D.B. Method for isolation and molecular characterization of extracellular microvesicles released from brain endothelial cells. Fluids Barriers CNS 2013, 10, doi:10.1186/2045-8118-10-4.
    • (2013) Fluids Barriers CNS , pp. 10
    • Haqqani, A.S.1    Delaney, C.E.2    Tremblay, T.L.3    Sodja, C.4    Sandhu, J.K.5    Stanimirovic, D.B.6
  • 56
    • 84957583645 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: Exosomes, the next small big thing
    • Kalra, H.; Drummen, G.P.C.; Mathivanan, S. Focus on extracellular vesicles: Exosomes, the next small big thing. Int. J. Mol. Sci. 2016, 17, doi:10.3390/ijms17020170.
    • (2016) Int. J. Mol. Sci , pp. 17
    • Kalra, H.1    Drummen, G.P.C.2    Mathivanan, S.3
  • 60
    • 75849159205 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression
    • Shimoda, M.; Mellody, K.T.; Orimo, A. Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression. Semin. Cell Dev. Biol. 2010, 21, 19-25.
    • (2010) Semin. Cell Dev. Biol , vol.21 , pp. 19-25
    • Shimoda, M.1    Mellody, K.T.2    Orimo, A.3
  • 61
    • 77956280130 scopus 로고    scopus 로고
    • Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness
    • Giannoni, E.; Bianchini, F.; Masieri, L.; Serni, S.; Torre, E.; Calorini, L.; Chiarugi, P. Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res. 2010, 70, 6945-6956.
    • (2010) Cancer Res , vol.70 , pp. 6945-6956
    • Giannoni, E.1    Bianchini, F.2    Masieri, L.3    Serni, S.4    Torre, E.5    Calorini, L.6    Chiarugi, P.7
  • 62
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell 2011, 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 64
    • 78649958307 scopus 로고    scopus 로고
    • Cancer exosomes trigger fibroblast to myofibroblast differentiation
    • Webber, J.; Steadman, R.; Mason, M.D.; Tabi, Z.; Clayton, A. Cancer exosomes trigger fibroblast to myofibroblast differentiation. Cancer Res. 2010, 70, 9621-9630.
    • (2010) Cancer Res , vol.70 , pp. 9621-9630
    • Webber, J.1    Steadman, R.2    Mason, M.D.3    Tabi, Z.4    Clayton, A.5
  • 65
    • 1342343923 scopus 로고    scopus 로고
    • The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions
    • Sidhu, S.S.; Mengistab, A.T.; Tauscher, A.N.; LaVail, J.; Basbaum, C. The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions. Oncogene 2004, 23, 956-963.
    • (2004) Oncogene , vol.23 , pp. 956-963
    • Sidhu, S.S.1    Mengistab, A.T.2    Tauscher, A.N.3    Lavail, J.4    Basbaum, C.5
  • 68
    • 80054717963 scopus 로고    scopus 로고
    • Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts. Gynecol
    • Cho, J.A.; Park, H.; Lim, E.H.; Kim, K.H.; Choi, J.S.; Lee, J.H.; Shin, J.W.; Lee, K.W. Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts. Gynecol. Oncol. 2011, 123, 379-386.
    • (2011) Oncol , vol.123 , pp. 379-386
    • Cho, J.A.1    Park, H.2    Lim, E.H.3    Kim, K.H.4    Choi, J.S.5    Lee, J.H.6    Shin, J.W.7    Lee, K.W.8
  • 69
    • 84455171408 scopus 로고    scopus 로고
    • Exosomes from breast cancer cells can convert adipose tissuederived mesenchymal stem cells into myofibroblast-like cells
    • Cho, J.A.; Park, H.; Lim, E.H.; Lee, K.W. Exosomes from breast cancer cells can convert adipose tissuederived mesenchymal stem cells into myofibroblast-like cells. Int. J. Oncol. 2012, 40, 130-138.
    • (2012) Int. J. Oncol , vol.40 , pp. 130-138
    • Cho, J.A.1    Park, H.2    Lim, E.H.3    Lee, K.W.4
  • 76
    • 70349315105 scopus 로고    scopus 로고
    • Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8+ T lymphocytes
    • Wieckowski, E.U.; Visus, C.; Szajnik, M.; Szczepanski, M.J.; Storkus, W.J.; Whiteside, T.L. Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8+ T lymphocytes. J. Immunol. 2009, 183, 3720-3730.
    • (2009) J. Immunol , vol.183 , pp. 3720-3730
    • Wieckowski, E.U.1    Visus, C.2    Szajnik, M.3    Szczepanski, M.J.4    Storkus, W.J.5    Whiteside, T.L.6
  • 77
    • 80052384534 scopus 로고    scopus 로고
    • Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-β1
    • Szczepanski, M.J.; Szajnik, M.; Welsh, A.; Whiteside, T.L.; Boyiadzis, M. Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-β1. Haematologica 2011, 96, 1302-1309.
    • (2011) Haematologica , vol.96 , pp. 1302-1309
    • Szczepanski, M.J.1    Szajnik, M.2    Welsh, A.3    Whiteside, T.L.4    Boyiadzis, M.5
  • 79
    • 34548162341 scopus 로고    scopus 로고
    • Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment
    • Croci, D.O.; Zacarias Fluck, M.F.; Rico, M.J.; Matar, P.; Rabinovich, G.A.; Scharovsky, O.G. Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment. Cancer Immunol. Immunother. 2007, 56, 1687-1700
    • (2007) Cancer Immunol. Immunother , vol.56 , pp. 1687-1700
    • Croci, D.O.1    Zacarias Fluck, M.F.2    Rico, M.J.3    Matar, P.4    Rabinovich, G.A.5    Scharovsky, O.G.6
  • 80
    • 0026918795 scopus 로고
    • The importance of direct immunofluorescence in the diagnosis of oral lichen planus. A clinical study and proposal of new diagnostic criteria
    • Gombos, F.; Serpico, R.; Gaeta, G.M.; Budetta, F.; de Luca, P. The importance of direct immunofluorescence in the diagnosis of oral lichen planus. A clinical study and proposal of new diagnostic criteria. Miner. Stomatol. 1992, 41, 23-32.
    • (1992) Miner. Stomatol , vol.41 , pp. 23-32
    • Gombos, F.1    Serpico, R.2    Gaeta, G.M.3    Budetta, F.4    De Luca, P.5
  • 82
    • 84900549711 scopus 로고    scopus 로고
    • WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells. Mol
    • Ekstrom, E.J.; Bergenfelz, C.; von Bulow, V.; Serifler, F.; Carlemalm, E.; Jonsson, G.; Andersson, T.; Leandersson, K. WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells. Mol. Cancer 2014, 13, doi:10.1186/1476-4598-13-88.
    • (2014) Cancer , pp. 13
    • Ekstrom, E.J.1    Bergenfelz, C.2    Von Bulow, V.3    Serifler, F.4    Carlemalm, E.5    Jonsson, G.6    Andersson, T.7    Leandersson, K.8
  • 83
    • 84890107684 scopus 로고    scopus 로고
    • Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF, and the neutralization of miR-150 attenuate tumor development
    • Liu, Y.; Zhao, L.; Li, D.; Yin, Y.; Zhang, C.Y.; Li, J.; Zhang, Y. Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF, and the neutralization of miR-150 attenuate tumor development. Protein Cell 2013, 4, 932-941.
    • (2013) Protein Cell , vol.4 , pp. 932-941
    • Liu, Y.1    Zhao, L.2    Li, D.3    Yin, Y.4    Zhang, C.Y.5    Li, J.6    Zhang, Y.7
  • 85
    • 84893851347 scopus 로고    scopus 로고
    • Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1
    • Bronisz, A.; Wang, Y.; Nowicki, M.O.; Peruzzi, P.; Ansari, K.I.; Ogawa, D.; Balaj, L.; de Rienzo, G.; Mineo, M.; Nakano, I. et al. Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. Cancer Res. 2014, 74, 738-750.
    • (2014) Cancer Res , vol.74 , pp. 738-750
    • Bronisz, A.1    Wang, Y.2    Nowicki, M.O.3    Peruzzi, P.4    Ansari, K.I.5    Ogawa, D.6    Balaj, L.7    De Rienzo, G.8    Mineo, M.9    Nakano, I.10
  • 86
    • 84922201382 scopus 로고    scopus 로고
    • Global profiling of metabolic adaptation to hypoxic stress in human glioblastoma cells
    • Kucharzewska, P.; Christianson, H.C.; Belting, M. Global profiling of metabolic adaptation to hypoxic stress in human glioblastoma cells. PLoS ONE 2015, 10, e0116740.
    • (2015) Plos ONE , vol.116 , pp. 10
    • Kucharzewska, P.1    Christianson, H.C.2    Belting, M.3
  • 87
    • 84878911644 scopus 로고    scopus 로고
    • The 786-0 renal cancer cell-derived exosomes promote angiogenesis by downregulating the expression of hepatocyte cell adhesion molecule
    • Zhang, L.; Wu, X.; Luo, C.; Chen, X.; Yang, L.; Tao, J.; Shi, J. The 786-0 renal cancer cell-derived exosomes promote angiogenesis by downregulating the expression of hepatocyte cell adhesion molecule. Mol. Med. Rep. 2013, 8, 272-276.
    • (2013) Mol. Med. Rep , vol.8 , pp. 272-276
    • Zhang, L.1    Wu, X.2    Luo, C.3    Chen, X.4    Yang, L.5    Tao, J.6    Shi, J.7
  • 88
    • 84904304045 scopus 로고    scopus 로고
    • Isolation, characterization and potential role in β cell-endothelium cross-talk of extracellular vesicles released from human pancreatic islets
    • Figliolini, F.; Cantaluppi, V.; De Lena, M.; Beltramo, S.; Romagnoli, R.; Salizzoni, M.; Melzi, R.; Nano, R.; Piemonti, L.; Tetta, C. et al. Isolation, characterization and potential role in β cell-endothelium cross-talk of extracellular vesicles released from human pancreatic islets. PLoS ONE 2014, 9, e102521.
    • (2014) Plos ONE , vol.521 , pp. 9
    • Figliolini, F.1    Cantaluppi, V.2    De Lena, M.3    Beltramo, S.4    Romagnoli, R.5    Salizzoni, M.6    Melzi, R.7    Nano, R.8    Piemonti, L.9    Tetta, C.10
  • 89
    • 84904072174 scopus 로고    scopus 로고
    • Alessandro, R. Exosomal shuttling of miR-126 in endothelial cells modulates adhesive and migratory abilities of chronic myelogenous leukemia cells
    • Taverna, S.; Amodeo, V.; Saieva, L.; Russo, A.; Giallombardo, M.; de Leo, G.; Alessandro, R. Exosomal shuttling of miR-126 in endothelial cells modulates adhesive and migratory abilities of chronic myelogenous leukemia cells. Mol. Cancer 2014, 13, doi:10.1186/1476-4598-13-169.
    • (2014) Mol. Cancer , pp. 13
    • Taverna, S.1    Amodeo, V.2    Saieva, L.3    Russo, A.4    Giallombardo, M.5    De Leo, G.6
  • 90
    • 84879419464 scopus 로고    scopus 로고
    • Leukemia cell to endothelial cell communication via exosomal miRNAs
    • Umezu, T.; Ohyashiki, K.; Kuroda, M.; Ohyashiki, J.H. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene 2013, 32, 2747-2755.
    • (2013) Oncogene , vol.32 , pp. 2747-2755
    • Umezu, T.1    Ohyashiki, K.2    Kuroda, M.3    Ohyashiki, J.H.4
  • 91
    • 84940577028 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes
    • Cui, H.; Seubert, B.; Stahl, E.; Dietz, H.; Reuning, U.; Moreno-Leon, L.; Ilie, M.; Hofman, P.; Nagase, H.; Mari, B. et al. Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes. Oncogene 2014, 34, 3640-3650.
    • (2014) Oncogene , vol.34 , pp. 3640-3650
    • Cui, H.1    Seubert, B.2    Stahl, E.3    Dietz, H.4    Reuning, U.5    Moreno-Leon, L.6    Ilie, M.7    Hofman, P.8    Nagase, H.9    Mari, B.10
  • 92
    • 84906934030 scopus 로고    scopus 로고
    • Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells
    • Lee, T.H.; Chennakrishnaiah, S.; Audemard, E.; Montermini, L.; Meehan, B.; Rak, J. Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells. Biochem. Biophys. Res. Commun. 2014, 451, 295-301.
    • (2014) Biochem. Biophys. Res. Commun , vol.451 , pp. 295-301
    • Lee, T.H.1    Chennakrishnaiah, S.2    Audemard, E.3    Montermini, L.4    Meehan, B.5    Rak, J.6
  • 93
    • 79551608032 scopus 로고    scopus 로고
    • Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences
    • Balaj, L.; Lessard, R.; Dai, L.; Cho, Y.J.; Pomeroy, S.L.; Breakefield, X.O.; Skog, J. Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat. Commun. 2011, 2, doi:10.1038/ncomms1180.
    • (2011) Nat. Commun , pp. 2
    • Balaj, L.1    Lessard, R.2    Dai, L.3    Cho, Y.J.4    Pomeroy, S.L.5    Breakefield, X.O.6    Skog, J.7
  • 94
    • 84902067416 scopus 로고    scopus 로고
    • Microvesicles mediate transfer of p-glycoprotein to paclitaxel-sensitive a2780 human ovarian cancer cells, conferring paclitaxel-resistance
    • Zhang, F.F.; Zhu, Y.F.; Zhao, Q.N.; Yang, D.T.; Dong, Y.P.; Jiang, L.; Xing, W.X.; Li, X.Y.; Xing, H.; Shi, M. et al. Microvesicles mediate transfer of p-glycoprotein to paclitaxel-sensitive a2780 human ovarian cancer cells, conferring paclitaxel-resistance. Eur. J. Pharmacol. 2014, 738, 83-90.
    • (2014) Eur. J. Pharmacol. , vol.738 , pp. 83-90
    • Zhang, F.F.1    Zhu, Y.F.2    Zhao, Q.N.3    Yang, D.T.4    Dong, Y.P.5    Jiang, L.6    Xing, W.X.7    Li, X.Y.8    Xing, H.9    Shi, M.10
  • 95
    • 84867061497 scopus 로고    scopus 로고
    • Transient receptor potential channel TrpC5 is essential for p-glycoprotein induction in drug-resistant cancer cells
    • Ma, X.; Cai, Y.; He, D.; Zou, C.; Zhang, P.; Lo, C.Y.; Xu, Z.; Chan, F.L.; Yu, S.; Chen, Y. et al. Transient receptor potential channel TrpC5 is essential for p-glycoprotein induction in drug-resistant cancer cells. Proc. Natl. Acad. Sci. USA 2012, 109, 16282-16287.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 16282-16287
    • Ma, X.1    Cai, Y.2    He, D.3    Zou, C.4    Zhang, P.5    Lo, C.Y.6    Xu, Z.7    Chan, F.L.8    Yu, S.9    Chen, Y.10
  • 96
    • 84897970924 scopus 로고    scopus 로고
    • Tumor endothelial expression of p-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells
    • Dong, Y.; Pan, Q.; Jiang, L.; Chen, Z.; Zhang, F.; Liu, Y.; Xing, H.; Shi, M.; Li, J.; Li, X. et al. Tumor endothelial expression of p-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells. Biochem. Biophys. Res. Commun. 2014, 446, 85-90.
    • (2014) Biochem. Biophys. Res. Commun , vol.446 , pp. 85-90
    • Dong, Y.1    Pan, Q.2    Jiang, L.3    Chen, Z.4    Zhang, F.5    Liu, Y.6    Xing, H.7    Shi, M.8    Li, J.9    Li, X.10
  • 97
    • 84901398883 scopus 로고    scopus 로고
    • Extracellular vesicle-mediated transfer of long non-coding RNA ror modulates chemosensitivity in human hepatocellular cancer
    • Takahashi, K.; Yan, I.K.; Kogure, T.; Haga, H.; Patel, T. Extracellular vesicle-mediated transfer of long non-coding RNA ror modulates chemosensitivity in human hepatocellular cancer. FEBS Open Biol. 2014, 4, 458-467.
    • (2014) FEBS Open Biol , vol.4 , pp. 458-467
    • Takahashi, K.1    Yan, I.K.2    Kogure, T.3    Haga, H.4    Patel, T.5
  • 98
    • 84930172395 scopus 로고    scopus 로고
    • Exosomes from drug-resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs
    • Chen, W.X.; Liu, X.M.; Lv, M.M.; Chen, L.; Zhao, J.H.; Zhong, S.L.; Ji, M.H.; Hu, Q.; Luo, Z.; Wu, J.Z. et al. Exosomes from drug-resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs. PLoS ONE 2014, 9, e95240
    • (2014) Plos ONE
    • Chen, W.X.1    Liu, X.M.2    Lv, M.M.3    Chen, L.4    Zhao, J.H.5    Zhong, S.L.6    Ji, M.H.7    Hu, Q.8    Luo, Z.9    Wu, J.Z.10
  • 99
    • 27644524811 scopus 로고    scopus 로고
    • Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells
    • Safaei, R.; Larson, B.J.; Cheng, T.C.; Gibson, M.A.; Otani, S.; Naerdemann, W.; Howell, S.B. Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells. Mol. Cancer Ther. 2005, 4, 1595-1604.
    • (2005) Mol. Cancer Ther , vol.4 , pp. 1595-1604
    • Safaei, R.1    Larson, B.J.2    Cheng, T.C.3    Gibson, M.A.4    Otani, S.5    Naerdemann, W.6    Howell, S.B.7
  • 100
    • 0036176510 scopus 로고    scopus 로고
    • Mechanisms of cancer drug resistance
    • Gottesman, M.M. Mechanisms of cancer drug resistance. Annu. Rev. Med. 2002, 53, 615-627.
    • (2002) Annu. Rev. Med , vol.53 , pp. 615-627
    • Gottesman, M.M.1
  • 101
    • 84957586685 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: Physiological role and signaling properties of extracellular membrane vesicles
    • Iraci, N.; Leonardi, T.; Gessler, F.; Vega, B.; Pluchino, S. Focus on extracellular vesicles: Physiological role and signaling properties of extracellular membrane vesicles. Int. J. Mol. Sci. 2016, 17, doi:10.3390/ ijms17020171.
    • (2016) Int. J. Mol. Sci , vol.17
    • Iraci, N.1    Leonardi, T.2    Gessler, F.3    Vega, B.4    Pluchino, S.5
  • 102
    • 84957552185 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: Development of exosome-based therapeutic systems
    • Ohno, S.I.; Drummen, G.P.C.; Kuroda, M. Focus on extracellular vesicles: Development of exosome-based therapeutic systems. Int. J. Mol. Sci. 2016, 17, doi:10.3390/ijms17020172.
    • (2016) Int. J. Mol. Sci , pp. 17
    • Ohno, S.I.1    Drummen, G.P.C.2    Kuroda, M.3
  • 103
    • 84957584941 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: Exosomes and their role in protein trafficking in Alzheimer’s and Parkinson’s disease
    • Vella, L.J.; Hill, A.F.; Cheng, L. Focus on extracellular vesicles: Exosomes and their role in protein trafficking in Alzheimer’s and Parkinson’s disease. Int. J. Mol. Sci. 2016, 17, doi:10.3390/ijms17020173.
    • (2016) Int. J. Mol. Sci , pp. 17
    • Vella, L.J.1    Hill, A.F.2    Cheng, L.3
  • 104
    • 84957603483 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: Therapeutic efficacy of stem cell-derived extracellular vesicles
    • Zhang, B.; Tan, K.H.; Lim, S.K. Focus on extracellular vesicles: Therapeutic efficacy of stem cell-derived extracellular vesicles. Int. J. Mol. Sci. 2016, 17, doi:10.3390/ijms17020174.
    • (2016) Int. J. Mol. Sci , pp. 17
    • Zhang, B.1    Tan, K.H.2    Lim, S.K.3
  • 106
    • 84902161469 scopus 로고    scopus 로고
    • The overexpression of a single oncogene (ErbB2/HER2) alters the proteomic landscape of extracellular vesicles
    • Amorim, M.; Fernandes, G.; Oliveira, P.; Martins-de-Souza, D.; Dias-Neto, E.; Nunes, D. The overexpression of a single oncogene (ErbB2/HER2) alters the proteomic landscape of extracellular vesicles. Proteomics 2014, 14, 1472-1479.
    • (2014) Proteomics , vol.14 , pp. 1472-1479
    • Amorim, M.1    Fernandes, G.2    Oliveira, P.3    Martins-De-Souza, D.4    Dias-Neto, E.5    Nunes, D.6
  • 107
    • 84942931451 scopus 로고    scopus 로고
    • A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor-associated macrophages
    • Zhu, Y.; Chen, X.; Pan, Q.; Wang, Y.; Su, S.; Jiang, C.; Li, Y.; Xu, N.; Wu, L.; Lou, X. et al. A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor-associated macrophages. J. Proteome Res. 2015, 14, 4319-4331.
    • (2015) J. Proteome Res , vol.14 , pp. 4319-4331
    • Zhu, Y.1    Chen, X.2    Pan, Q.3    Wang, Y.4    Su, S.5    Jiang, C.6    Li, Y.7    Xu, N.8    Wu, L.9    Lou, X.10
  • 108
    • 0035877018 scopus 로고    scopus 로고
    • Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles
    • Thery, C.; Boussac, M.; Veron, P.; Ricciardi-Castagnoli, P.; Raposo, G.; Garin, J.; Amigorena, S. Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles. J. Immunol. 2001, 166, 7309-7318.
    • (2001) J. Immunol , vol.166 , pp. 7309-7318
    • Thery, C.1    Boussac, M.2    Veron, P.3    Ricciardi-Castagnoli, P.4    Raposo, G.5    Garin, J.6    Amigorena, S.7
  • 109
    • 84901048925 scopus 로고    scopus 로고
    • Biology and proteomics of extracellular vesicles: Harnessing their clinical potential
    • D’Souza-Schorey, C.; di Vizio, D. Biology and proteomics of extracellular vesicles: Harnessing their clinical potential. Expert Rev. Proteom. 2014, 11, 251-253.
    • (2014) Expert Rev. Proteom , vol.11 , pp. 251-253
    • D’souza-Schorey, C.1    Di Vizio, D.2
  • 112
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi, H.; Ekstrom, K.; Bossios, A.; Sjostrand, M.; Lee, J.J.; Lotvall, J.O. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 2007, 9, 654-659.
    • (2007) Nat. Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 113
    • 77952920881 scopus 로고    scopus 로고
    • Secretory mechanisms and intercellular transfer of microRNAs in living cells
    • Kosaka, N.; Iguchi, H.; Yoshioka, Y.; Takeshita, F.; Matsuki, Y.; Ochiya, T. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J. Biol. Chem. 2010, 285, 17442-17452.
    • (2010) J. Biol. Chem , vol.285 , pp. 17442-17452
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3    Takeshita, F.4    Matsuki, Y.5    Ochiya, T.6
  • 116
    • 84864411871 scopus 로고    scopus 로고
    • Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types
    • Guduric-Fuchs, J.; O’Connor, A.; Camp, B.; O'Neill, C.L.; Medina, R.J.; Simpson, D.A. Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types. BMC Genom. 2012, 13, doi:10.1186/1471-2164-13-357.
    • (2012) BMC Genom , pp. 13
    • Guduric-Fuchs, J.1    O’Connor, A.2    Camp, B.3    O'neill, C.L.4    Medina, R.J.5    Simpson, D.A.6
  • 121
    • 84978062951 scopus 로고    scopus 로고
    • Five microRNAs in plasma as novel biomarkers for screening of early-stage non-small cell lung cancer
    • Geng, Q.; Fan, T.; Zhang, B.; Wang, W.; Xu, Y.; Hu, H. Five microRNAs in plasma as novel biomarkers for screening of early-stage non-small cell lung cancer. Respir. Res. 2014, 15, doi:10.1186/s12931-014-0149-3.
    • (2014) Respir. Res , pp. 15
    • Geng, Q.1    Fan, T.2    Zhang, B.3    Wang, W.4    Xu, Y.5    Hu, H.6


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